567 research outputs found
Low energy housing retrofit in North England: Overheating risks and possible mitigation strategies
In the drive to reduce space-heating demand and associated CO2 emissions as well as tackle fuel poverty, dwelling overheating and summer-time occupant thermal discomfort might be the unintended consequences of low-energy building retrofits. This paper presents the findings of a steady-state modelled low energy retrofit dwelling in northern England and its potential current and future climate overheating risks using UK Climate Projections 2009 (UKCP09) scenarios (2050 and 2080 High Emission Scenarios). Predictive findings highlight that retrofitting to low energy standards increases overheating risk over time, unless passive prevention measures are included in the retrofit design. In addition, the steady-state nature of the model might not fully capture the occupants’ exposure to actual future overheating risks. Among the most effective individual passive overheating mitigation strategies are temporary internal shading, permanent external shading, and night-time ventilation. Most effective is a combination of these adaptation measures, so that predictive overheating is minimised in a future changing climate, reducing the uptake of active cooling in retrofitted dwellings. Practical applications: Much research focuses on building overheating risks in the warmer South-east of England. However, this paper highlights how dwelling retrofit in north England (Sheffield) also can lead to increased dwelling overheating risk, unless passive design measures are included in the retrofit design. Among the most effective individual passive overheating mitigation strategies are solar shading devices and increased night-time ventilation, though ideally different measures are combined. Using future climate scenarios highlights that retrofits designed today might not be able to provide occupant thermal comfort in a future warming world
Methodology for the comparative assessment of the Satellite Power System (SPS) and alternative technologies
The energy systems concerned are the satellite power system, several coal technologies, geothermal energy, fission, fusion, terrestrial solar systems, and ocean thermal energy conversion. Guidelines are suggested for the characterization of these systems, side-by-side analysis, alternative futures analysis, and integration and aggregation of data. A description of the methods for assessing the technical, economic, environmental, societal, and institutional issues surrounding the development of the selected energy technologies is presented
Carbon regulation and pathways for institutional transition in market-led housing systems : a case study of English housebuilders and zero carbon housing policy
In this paper, we argue that current research on carbon regulation neglects the complex interactions of institutional norms and market behaviour that characterise responses to regulatory change. We draw on empirical research undertaken with English housebuilders and housing market stakeholders to examine how transitional pathways towards a low-carbon housing future might be advanced and consider the implications of such for carbon regulation and low-carbon economies. Our core proposition is that carbon regulation research can no longer ignore the impact of institutionally constituted market behaviour in shaping pathways and transitions towards low-carbon futures
Children living with ‘sustainable’ urban architectures
This paper considers the everyday geographies of children living in new large-scale urban developments in which multiple forms of ‘sustainable’ urban architecture are characteristic features. We argue that children’s experiences of living with materialities, politics and technologies of sustainability have too-often been marginalised in much chief research on childhood, youth and sustainability. Drawing on qualitative research with 8-16-year-olds living with materialities of ‘sustainable’ eco-housing, urban drainage, wind turbines and photovoltaic panelling, we explore how sustainable urban architectures are noticed, (mis)understood, cared about, and lived-with by children in the course of their everyday geographies. In so doing, we highlight the challenging prevalence and significance of architectural conservatisms, misconceptions, rumours disillusionments and urban myths relating to sustainable urban architectures
Short-range order and collective dynamics of DMPC bilayers: a comparison between molecular dynamics simulations, X-ray, and neutron scattering experiments.
Not only enthalpy: large entropy contribution to ion permeation barriers in single-file channels.
Early mobilisation versus plaster immobilisation of simple elbow dislocations: Results of the FuncSiE multicentre randomised clinical trial
Background/aim To compare outcome of early mobilisation and plaster immobilisation in patients with a simple elbow dislocation. We hypothesised that early mobilisation would result in earlier functional recovery. Methods From August 2009 to September 2012, 100 adult patients with a simple elbow dislocation were enrolled in this multicentre randomised controlled trial. Patients were randomised to early mobilisation (n=48) or 3 weeks plaster immobilisation (n=52). Primary outcome measure was the Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH) score. Secondary outcomes were the Oxford Elbow Score, Mayo Elbow Performance Index, pain, range of motion, complications and activity resumption. Patients were followed for 1 year. Results Quick-DASH scores at 1 year were 4.0 (95% CI 0.9 to 7.1) points in the early mobilisation group versus 4.2 (95% CI 1.2 to 7.2) in the plaster immobilisation group. At 6 weeks, early mobilised patients reported less disability (Quick-DASH 12 (95% CI 9 to 15) points vs 19 (95% CI 16 to 22); p<0.05) and had a larger arc of flexion and extension (121° (95% CI 115° to 127°) vs 102° (95% CI 96° to 108°); p<0.05). Patients returned to work sooner after early mobilisation (10 vs 18 days; p=0.020). Complications occurred in 12 patients; this was unrelated to treatment. No recurrent dislocations occurred. Conclusions Early active mobilisation is a safe and effective treatment for simple elbow dislocations. Patients recovered faster and returned to work earlier without increasing the complication rate. No evidence was found supporting treatment benefit at 1 year
Aquaporins: important but elusive drug targets.
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators
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