Auditory display for the blind

A system for providing an auditory display of two-dimensional patterns as an aid to the blind is described. It includes a scanning device for producing first and second voltages respectively indicative of the vertical and horizontal positions of the scan and a further voltage indicative of the intensity at each point of the scan and hence of the presence or absence of the pattern at that point. The voltage related to scan intensity controls transmission of the sounds to the subject so that the subject knows that a portion of the pattern is being encountered by the scan when a tone is heard, the subject determining the position of this portion of the pattern in space by the frequency and interaural difference information contained in the tone

Is it possible to establish reference values for ankle muscle isokinetic strength? A meta-analytical study

BACKGROUND: The importance of measuring ankle muscle strength (AMS) has been demonstrated in a variety of clinical areas. Much data has been accumulated using the Cybex Norm isokinetic dynamometer but a uniform framework does not exist. OBJECTIVE: To identify pertinent studies which have used the Cybex Norm to measure AMS in order to establish reference values. METHODS: A narrative review of the literature was used to identify papers that have used the Cybex Norm to measure isokinetic concentric and eccentric AMS. RESULTS: Fifty five research papers were identified but each study used a different isokinetic protocol. CONCLUSIONS: It is not possible to produce AMS reference values due to the wide variation in data collection methods. This is therefore an area of research that needs further exploration

Putting the ‘digital’ in Digital Intermediaries: the role of technical infrastructure in building business models

Digital Technology Innovation and Financial Business Practices The UK economy has a huge dependence on financial services, and this is increasingly based on digital platforms. Innovating new economic models around consumer financial services through the use of digital technologies is seen as increasingly important in developed economies. There are a number of drivers for this, ranging from national economic factors to the prosaic nature of enabling cheap, speedy and timely interactions for users. The potential for these new digital solutions is that they will allay an over-reliance on the traditional banking sector, which has proved itself to be unstable and risky, and we have seen a number of national policy moves to encourage growth in this sector. Partly as a result of the 2008 banking crisis, there has been an explosion in peer-to-peer financial services for non-professional consumers. These organisations act as intermediaries between users looking to trade goods or credit. However, building self-sustaining or profitable financial services within this novel space is itself fraught with commercial, regulatory, technical and social problems. This report addresses the mutual shaping of business models and innovations in digital technical infrastructure – both client-facing and administrative back-end – in two retail financial products currently in use in the United Kingdom: peer-to-peer consumer lending and a local digital/paper hybrid currency system. The two products and their issuing firms, Zopa Limited (Zopa) and The Bristol Pound Community Interest Company (the Bristol Pound), respectively, are established leaders in their respective product areas: Zopa was established in 2005 and the Bristol Pound in 2010. Each of these firms seeks to disrupt an established financial market through the application of digital technologies and processes: consumer lending for Zopa and retail payment for the Bristol Pound. Our research has involved teams from Lancaster University examining Zopa and Brunel University focusing on the Bristol Pound over approximately a one-year period from October 2013 to October 2014. Extensive interviews, document analysis, observation of user interactions, and other methods have been employed to develop the process analyses of the firms presented here. This report is comprised of three primary sections: descriptions of the business and technological processes of each of Zopa and the Bristol Pound, and a final analytical section drawing preliminary conclusions from the research presented.3DaRoC is funded by the UK’s Digital Economy ‘Research in the Wild’ initiative. It has a substantial research budget of over £320K, with £35K of additional industrial support

Intumescent Coatings as Fire Retardants

Fire-retardant paint, when activated by the heat of fire, reacts to form a thick, low-density, polymeric coating or char layer. Water vapor and sulphur dioxide are released during the intumescent reaction

The effects of flipped learning on students in secondary education

As schools incorporate flipped instruction into the classroom, it is important to understand the effectiveness of flipped learning and its pedagogical shift. This literature review analyzed 24 peer-reviewed empirical studies out of 30 articles that explore the effectiveness of flipped learning versus a traditional learning style on student achievement and student engagement in general and the promotion of student-centered learning activities when using a flipped learning environment in particularly. Studies selected for the review were conducted in secondary classrooms after the year 2000 with sound research methodology. The major findings reveal that flipped learning can lead to higher student achievement and student engagement as a result of implementing student-centered teaching approaches. Recommendations for implementation of flipped learning and future research are discussed

Systematic discovery of structural elements governing stability of mammalian messenger RNAs.

Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour. Despite recent efforts, the vast landscape of RNA regulatory elements remains largely uncharacterized. A long-standing obstacle is the contribution of local RNA secondary structure to the definition of interaction partners in a variety of regulatory contexts, including--but not limited to--transcript stability, alternative splicing and localization. There are many documented instances where the presence of a structural regulatory element dictates alternative splicing patterns (for example, human cardiac troponin T) or affects other aspects of RNA biology. Thus, a full characterization of post-transcriptional regulatory programs requires capturing information provided by both local secondary structures and the underlying sequence. Here we present a computational framework based on context-free grammars and mutual information that systematically explores the immense space of small structural elements and reveals motifs that are significantly informative of genome-wide measurements of RNA behaviour. By applying this framework to genome-wide human mRNA stability data, we reveal eight highly significant elements with substantial structural information, for the strongest of which we show a major role in global mRNA regulation. Through biochemistry, mass spectrometry and in vivo binding studies, we identified human HNRPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1, also known as HNRNPA2B1) as the key regulator that binds this element and stabilizes a large number of its target genes. We created a global post-transcriptional regulatory map based on the identity of the discovered linear and structural cis-regulatory elements, their regulatory interactions and their target pathways. This approach could also be used to reveal the structural elements that modulate other aspects of RNA behaviour

Flares and Proper Motions of Ground-State OH Masers in W75N

The star-forming region W75N hosts bright OH masers that are observed to be variable. We present observations taken in 2008 of the ground-state OH maser transitions with the Very Long Baseline Array (VLBA) and the Multi-Element Radio-Linked Interferometer Network (MERLIN) and with the Nancay Radio Telescope in 2011. Several of the masers in W75N were observed to be flaring, with the brightest 1720-MHz maser in excess of 400 Jy. The 1720-MHz masers appear to be associated with the continuum source VLA 1, unlike the bright flaring 1665- and 1667-MHz masers, which are associated with VLA 2. The 1720-MHz masers are located in an outflow traced by water masers and are indicative of very dense molecular material near the H II region. The magnetic field strengths are larger in the 1720-MHz maser region than in most regions hosting only main-line OH masers. The density falls off along the outflow, and the order of appearance of different transitions of OH masers is consistent with theoretical models. The 1665- and 1667-MHz VLBA data are compared against previous epochs over a time baseline of over 7 years. The median maser motion is 3.5 km/s, with a scatter that is comparable to thermal turbulence. The general pattern of maser proper motions observed in the 1665- and 1667-MHz transitions is consistent with previous observations.Comment: 14 pages, accepted for publication in MNRA