324 research outputs found
Squared PLGA microPlates as injectable depot for the management of Post-Traumatic Osteoarthritis
The Massive and Distant Clusters of WISE Survey: SZ effect Verification with the Atacama Compact Array -- Localization and Cluster Analysis
The Massive and Distant Clusters of WISE Survey (MaDCoWS) provides a catalog
of high-redshift () infrared-selected galaxy
clusters. However, the verification of the ionized intracluster medium,
indicative of a collapsed and nearly virialized system, is made challenging by
the high redshifts of the sample members. The main goal of this work is to test
the capabilities of the Atacama Compact Array (ACA; also known as the Morita
Array) Band 3 observations, centered at about 97.5 GHz, to provide robust
validation of cluster detections via the thermal Sunyaev-Zeldovich (SZ) effect.
Using a pilot sample that comprises ten MaDCoWS galaxy clusters, accessible to
ACA and representative of the median sample richness, we infer the masses of
the selected galaxy clusters and respective detection significance by means of
a Bayesian analysis of the interferometric data. Our test of the "Verification
with the ACA - Localization and Cluster Analysis" (VACA LoCA) program
demonstrates that the ACA can robustly confirm the presence of the virialized
intracluster medium in galaxy clusters previously identified in full-sky
surveys. In particular, we obtain a significant detection of the SZ effect for
seven out of the ten VACA LoCA clusters. We note that this result is
independent of the assumed pressure profile. However, the limited angular
dynamic range of the ACA in Band 3 alone, short observational integration
times, and possible contamination from unresolved sources limit the detailed
characterization of the cluster properties and the inference of the cluster
masses within scales appropriate for the robust calibration of mass-richness
scaling relations.Comment: 19 pages (including appendices), 14 figures, and 4 tables; accepted
for publication in A&
Non periodic patterning of super-hydrophobic surfaces for the manipulation of few molecules
n/
Prognostic factors in Krukenberg tumor
BACKGROUND:
Krukenberg tumor (KT) is a rare secondary ovarian tumor. Little is known about clinicopathologic factors affecting prognosis in KT.
OBJECTIVE:
To assess the prognostic value of clinicopathologic factors in KT through a systematic review and meta-analysis.
METHODS:
Electronic databases were searched from their inception to February 2019 for studies assessing the association of clinicopathologic factors with overall survival in KT. Pooled hazard ratio (HR) was calculated for each factor; a p value < 0.05 was considered significant.
RESULTS:
Twenty-three studies with 1743 patients were included. A decreased overall survival was significantly associated with peritoneal involvement (HR 1.944; p = 0.003), ascites (HR 2.055; p = 0.034), synchronous presentation (HR 1.679; p = 0.034) and increased serum CEA levels (HR 1.380; p = 0.010), but not with age > 50 (HR 0.946; p = 0.743), menopausal status (HR 1.565; p = 0.204), gastric origin (HR 1.600; p = 0.201), size > 5 cm (HR 1.292; p = 0.119), size > 10 cm (HR 0.925; p = 0.714), bilateral ovarian involvement (HR 1.113; p = 0.347), non-peritoneal extaovarian metastases (HR 1.648; p = 0.237), liver metastases (HR 1.118, p = 0.555), predominant signet ring cell morphology (HR 1.322; p = 0.208) and levels of CA125 (HR 0.933; p = 0.828) and CA19.9 (HR 0.996; p = 0.992).
CONCLUSION:
Peritoneal involvement, synchronous presentation, ascites and increased serum CEA levels appear as unfavorable prognostic factors in KT and might affect the patient management
Management of pediatric post-infectious neurological syndromes
BackgroundPost-Infectious Neurological Syndromes (PINS) are heterogeneous neurological disorders with post or para-infectious onset. PINS diagnosis is complex, mainly related to the absence of any recognized guidelines and a univocal definition.Aim of the studyTo elaborate a diagnostic guide for PINS.Materials and methodsWe retrospectively analysed patients younger than 14years old admitted to Bambino GesU Children's Hospital in Rome for PINS from December 2005 to March 2018. Scientific literature using PubMed as research platform was analysed: the key words "Post-Infectious Neurological Syndromes" were used.ResultsA polysymptomatic presentation occurred in a percentage of 88% of the children. Motor signs and visual disturbances the most observed symptoms/signs were the most detached, followed by fever, speech disturbances, sleepiness, headache and bradipsychism. Blood investigations are compatible with inflammation, as a prodromal illnesses was documented in most cases. Normal cerebral spinal fluid (CSF) characteristics has been found in the majority of the study population. Magnetic resonance imaging (MRI) was positive for demyelinating lesions. Antibiotics, acyclovir and steroids have been given as treatment.DiscussionWe suggest diagnostic criteria for diagnosis of PINS, considering the following parameters: neurological symptoms, timing of disease onset, blood and CSF laboratory tests, MRI imaging.ConclusionsWe propose criteria to guide clinician to diagnose PINS as definitive, probable or possible. Further studies are required to validate diagnostic criteria
Precision measurement of the Dalitz plot distribution with the KLOE detector
Using fb of data collected with
the KLOE detector at DANE, the Dalitz plot distribution for the decay is studied with the world's largest sample of events. The Dalitz plot density is parametrized as a polynomial
expansion up to cubic terms in the normalized dimensionless variables and
. The experiment is sensitive to all charge conjugation conserving terms of
the expansion, including a term. The statistical uncertainty of all
parameters is improved by a factor two with respect to earlier measurements.Comment: 11 pages, 9 figures, supplement: an ascii tabl
Limit on the production of a new vector boson in , U with the KLOE experiment
The recent interest in a light gauge boson in the framework of an extra U(1)
symmetry motivates searches in the mass range below 1 GeV.
We present a search for such a particle, the dark photon, in , U based on 28 million
events collected at DANE
by the KLOE experiment. The production by initial-state radiation
compensates for a loss of sensitivity of previous KLOE , searches due to the small branching ratios in
the resonance region. We found no evidence for a signal and set a
limit at 90\% CL on the mixing strength between the photon and the dark photon,
, in the U mass range between and ~MeV. Above 700 MeV
this new limit is more stringent than previous ones.Comment: 6 pages, 9 figures, 1 table, submitted to Phys. Lett.
Measurement of the transition form factor with the KLOE detector
A measurement of the vector to pseudoscalar conversion decay with the KLOE experiment is presented. A sample of signal
events was selected from a data set of 1.7 fb of collisions at
collected at the DANE collider. These
events were used to obtain the first measurement of the transition form factor
and a new measurement of the branching ratio of the
decay: . The result improves
significantly on previous measurements and is in agreement with theoretical
predictions.Comment: 13 pages, 4 figures; matches published versio
Squamous cell carcinoma of the lower lip: FAS/FASL expression, lymphocyte subtypes and outcome.
Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck region. Tumour thickness, grading and perineural invasion are significant prognostic indicators. However, there is still the need of new reliable biological markers able to predict the prognosis of the single cases with an unfavourable biological behaviour unpredictable by the classic clinical-pathological parameters. 32 cases of (SCC) of the lower lip were analysed for their clinicopathologic features, and immunohistochemical expression of Fas/FasL in neoplastic cells and in inflammatory infiltrate. Moreover the density and phenotype of tumour-infiltrating lymphocytes (TIL) were analysed. The results were related with the follow-up of the patients ranging from 2 to 6 years. The cases with over-expression of Fas/FasL in neoplastic cells and Fas+ in T cells preferentially showed a more aggressive clinical behaviour (p<0.01). Moreover we found an alteration of the normal expression of CD4 and CD8 lymphocyte types in ten cases. This data suggest that the Fas/FasL pathway is involved in the close relation between neoplastic cells and T cells and so in the biological behaviour of these tumours
High-resolution, High-sensitivity, Low-frequency uGMRT View of Coma Cluster of Galaxies
We present high-resolution, high-sensitivity upgraded Giant Metrewave Radio Telescope observations of the Coma cluster (A1656) at 250-500 MHz and 550-850 MHz. At 250-500 MHz, 135 sources have extensions >0.'45 (with peak-to-local-noise ratio >4). Of these, 24 sources are associated with Coma-member galaxies. In addition, we supplement this sample of 24 galaxies with 20 ram pressure stripped (RPS) galaxies from (Chen et al. 2020, eight are included in the original extended radio source sample) and an additional five are detected and extended. We present radio morphologies, radio spectra, spectral index maps, and equipartition properties for these two samples. In general, we find the equipartition properties lie within a narrow range (e.g., Pmin = 1-3 × 10- 13 dynes cm-2). Only NGC 4874, one of the two brightest central Coma cluster galaxies, has a central energy density and pressure about five times higher and a radio source age about 50% lower than that of the other Coma galaxies. We find a diffuse tail of radio emission trailing the dominant galaxy of the merging NGC 4839 group that coincides with the slingshot tail seen in X-rays. The southwestern radio relic, B1253+275, has a large extent ≍32' × 10' (≃1.08 × 0.34 Mpc2). For NGC 4789, whose long radio tails merge into the relic and may be a source of its relativistic seed electrons, we find a transverse radio spectral gradient, a steepening from southwest to northeast across the width of the radio source. Finally, radio morphologies of the extended and RPS samples suggest that these galaxies are on their first infall into Coma on (predominantly) radial orbits
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