Social Rights of EU Migrant Citizens: Britain and Germany Compared

European migrant citizens and their social rights are strongly contested in British political debate. This article seeks to challenge some common concerns and perceptions regarding the exceptionality of the British welfare state and the alleged ‘costs’ to it from intra-EU migration. The article first provides a brief overview of the foundations for EU citizenship and associated social rights, highlighting the semi-sovereign nature of welfare states in the European Union. It then (i) rejects the significance of the often-claimed difference between contributory and non-contributory welfare states in the context of EU migration; and (ii) challenges concerns about the costs of EU migration. The article contrasts the experiences of Britain and Germany. It concludes by considering how concerns often associated with EU migration can be addressed by improving administrative and state capacities

Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.

BACKGROUND: Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such therapies may influence the risk of cancer and cardiovascular disease. We conducted a Mendelian randomization study to explore whether TNF levels are causally related to cardiovascular disease and cancer. METHODS: Single-nucleotide polymorphisms associated with TNF levels at genome-wide significance were identified from a genome-wide association study of 30 912 European-ancestry individuals. Three TNF-associated single-nucleotide polymorphisms associated with higher risk of autoimmune diseases were used as instrumental variables. Summary-level data for 14 cardiovascular diseases, overall cancer and 14 site-specific cancers were obtained from UK Biobank and consortia. FINDINGS: Genetically-predicted TNF levels were positively associated with coronary artery disease (odds ratio (OR) 2.25; 95% confidence interval (CI) 1.50, 3.37) and ischaemic stroke (OR 2.27; 95% CI 1.50, 3.43), and inversely associated with overall cancer (OR 0.54; 95% CI 0.42, 0.69), breast cancer (OR 0.51; 95% CI 0.39, 0.67), and colorectal cancer (OR 0.20; 95% CI 0.09, 0.45). There were suggestive associations of TNF with venous thromboembolism (OR 2.18; 95% CI 1.32, 3.59), endometrial cancer (OR 0.25; 95% CI 0.07, 0.94), and lung cancer (OR 0.45; 95% CI 0.21, 0.94). INTERPRETATION: This study found evidence of causal associations of increased TNF levels with higher risk of common cardiovascular diseases and lower risk of overall and certain cancers

Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study

Whether circulating fatty acids (FAs) play a causal role in the development of cardiovascular disease (CVD) remains unclear. We conducted a Mendelian randomisation study to explore the associations between plasma phospholipid FA levels and 15 CVDs. Summary-level data from the CARDIoGRAMplusC4D, MEGASTROKE, and Atrial Fibrillation consortia and UK Biobank were used. Sixteen single-nucleotide polymorphisms (SNPs) associated with ten plasma FAs were used as instrumental variables. SNPs in or close to the FADS1 gene were associated with most FAs. We performed a secondary analysis of the association between a functional variant (rs174547) in FADS1, which encodes ?5-desaturase (a key enzyme in the endogenous FA synthesis), and CVD. Genetic predisposition to higher plasma α-linolenic, linoleic, and oleic acid levels was associated with lower odds of large-artery stroke and venous thromboembolism, whereas higher arachidonic and stearic acid levels were associated with higher odds of these two CVDs. The associations were driven by SNPs in or close to FADS1. In the secondary analysis, the minor allele of rs174547 in FADS1 was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis. Genetically higher plasma α-linolenic, linoleic, and oleic acid levels are inversely associated with large-artery stroke and venous thromboembolism, whereas arachidonic and stearic acid levels are positively associated with these CVDs. The associations were driven by FADS1, which was also associated with other CVDs.Funding for this study came from the Swedish Research Council for Health, Working Life and Welfare (Forte; Grant Number 2018-00123) and the Swedish Research Council (Vetenskapsrådet; Grant Number 2019-00977). SB is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 204623/Z/16/Z)

Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts

Background: Venous thromboembolism (VTE) diagnosis would greatly benefit from the identification of novel biomarkers to complement D-dimer, a marker limited by low specificity. Neutrophil extracellular traps (NETs) have been shown to promote thrombosis and could hypothetically be used for diagnosis of acute VTE. Objectives: To assess the levels of specific markers of neutrophil activation and NETs and compare their diagnostic accuracy to D-dimer. Methods: We measured plasma levels of neutrophil activation marker neutrophil elastase (NE), the NET marker nucleosomal citrullinated histone H3 (H3Cit-DNA) and cell-free DNA in patients (n = 294) with suspected VTE (pulmonary embolism and deep vein thrombosis) as well as healthy controls (n = 30). A total of 112 VTE positive and 182 VTE negative patients from two prospective cohort studies were included. Results: Higher levels of H3Cit-DNA and NE, but not cell-free DNA, were associated with VTE. Area under receiver operating curves (AUC) were 0.90 and 0.93 for D-dimer, 0.65 and 0.68 for NE and 0.60 and 0.67 for H3Cit-DNA in the respective cohorts. Adding NE and H3Cit-DNA to a D-dimer based risk model did not improve AUC. Conclusions: Our study demonstrates the presence of neutrophil activation and NET formation in VTE using specific markers. However, the addition of NE or H3Cit-DNA to D-dimer did not improve the discrimination compared to D-dimer alone. This study provides information on the feasibility of using markers of NETs as diagnostic tools in acute VTE. Based on our findings, we believe the potential of these markers are limited in this setting

DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein, crotonaldehyde and 4-hydroxy-2-nonenal, react with DNA bases, generating promutagenic exocyclic DNA adducts, which likely contribute to the mutagenic and carcinogenic effects associated with oxidative stress-induced LPO. However, reactive aldehydes, when added to tumor cells, can exert an anticancerous effect. They act, analogously to other chemotherapeutic drugs, by forming DNA adducts and, in this way, they drive the tumor cells toward apoptosis. The aldehyde-DNA adducts, which can be observed during inflammation, play an important role by inducing epigenetic changes which, in turn, can modulate the inflammatory process. The pathogenic role of the adducts formed by the products of LPO with biological macromolecules in the breaking of immunological tolerance to self antigens and in the development of autoimmunity has been supported by a wealth of evidence. The instrumental role of the adducts of reactive LPO products with self protein antigens in the sensitization of autoreactive cells to the respective unmodified proteins and in the intermolecular spreading of the autoimmune responses to aldehyde-modified and native DNA is well documented. In contrast, further investigation is required in order to establish whether the formation of adducts of LPO products with DNA might incite substantial immune responsivity and might be instrumental for the spreading of the immunological responses from aldehyde-modified DNA to native DNA and similarly modified, unmodified and/or structurally analogous self protein antigens, thus leading to autoimmunity

Bidrag till K\ue4nnedomen om Skandinaviens Amphipoda gammaridea /

Volume: 3Start Page: 1End Page: 10

Stratified social rights limiting EU citizenship

Differences in Member States' economic development and national social protection systems can translate into significant differences in the substantive social rights of EU migrant citizens. The substantive rights of economically inactive EU migrant citizens are dependent on the ‘export’ of social rights from their country of origin to the Member State of destination, in particular during the initial phase of their residence in a new Member State as a jobseeker or a pensioner. This paper demonstrates that EU citizens' social rights are substantively stratified, not only by economic status, but also according to the Member State of origin and destination. Stratified social rights, it is argued, generate unequal opportunities to free movement and eo ipso challenge the very concept of EU citizenship. The paper concludes with a proposal for a European Minimum Income Scheme to at least partially overcome the shortcomings of existing EU citizenship

Stratified social rights limiting EU citizenship

Differences in Member States' economic development and national social protection systems can translate into significant differences in the substantive social rights of EU migrant citizens. The substantive rights of economically inactive EU migrant citizens are dependent on the ‘export’ of social rights from their country of origin to the Member State of destination, in particular during the initial phase of their residence in a new Member State as a jobseeker or a pensioner. This paper demonstrates that EU citizens' social rights are substantively stratified, not only by economic status, but also according to the Member State of origin and destination. Stratified social rights, it is argued, generate unequal opportunities to free movement and eo ipso challenge the very concept of EU citizenship. The paper concludes with a proposal for a European Minimum Income Scheme to at least partially overcome the shortcomings of existing EU citizenship

Tyre Models for Online Identification in ADAS Applications

Knowledge of the tire-road friction condition is an important key for driver safety and vehicle stability systems during ice and snow road. In particular, friction information can be used to enhance the performance of Advanced Driver-Assistance Systems (ADAS) applications providing real-time forces condition. The paper deals with a method for real-time identification of tyre/road friction condition using both Pacejka model and steady state form of distributed LuGre to obtain the friction based on recursive nonlinear optimization of the curve fitting errors. Finally, the effectiveness of the method is confirmed by real-time simulations in ice and snow conditions