622 research outputs found
The long arm of childhood socioeconomic deprivation on mid‐ to later‐life cognitive trajectories:A cross‐cohort analysis
Cumulative life course adversity, mental health, and cognition in the UK biobank
Abstract
The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversity (i.e., maltreatment) accumulated over the life course and cognitive flexibility, as well as two potential mediators (i.e., intra-individual variability in reaction time and depression) of this association, were investigated. Data stem from the baseline population of the UK Biobank study ( N = 73,489, Mdn age = 56, SD age = 7.628, 55.740% of women). Cumulative life course adversity (specifically maltreatment) was measured with items based on the Childhood Trauma Questionnaire (CTS-5) and items adapted from the British Crime Survey. Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9). Intra-individual variability in reaction time was measured with a reaction time test “snap game” and the Trail Making Test A and B were used as a measure of cognitive flexibility. A path analysis was performed on these data. Higher cumulative adverse experiences were associated with lower performance in cognitive flexibility (β = .016, p < .001, 95% CI [0.009, 0.024]), and this effect was partly mediated by the level of depression (22.727% of the total effect of cumulative life course adversity on cognitive flexibility was mediated by depression (β = .005, p < .001, 95% CI [0.004, 0.007])). No association between cumulative life course adverse experiences and intra-individual variability in reaction time was found, nor was any indirect association between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time. The association between cumulative life course adversity, depression, and performance in cognitive flexibility has been highlighted. In contrast, no indirect effect between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time was found, suggesting that it is not a potential mechanism underlying the association between cumulative life course adversity and executive function. </p
Purpose and mastery as predictors of perceived health and substance use problems
We explored whether purpose in life and mastery predicted perceived physical health and problematic substance use among a sample of emerging adults who reported ever using alcohol or drugs. We examined perceived stress and coping as potential mediators of these associations and explored whether parental support moderated any of these associations. In a sample of emerging adults from across the United States (N = 2,564; Mage = 20.87, standard deviation = 1.75; 49.6% male), purpose in life and mastery were associated with better‐perceived health and fewer negative consequences of drug use via lower perceived stress and coping. In addition, parental support modified the relationship between purpose in life and stress and coping. The findings suggest potential health benefits associated with a greater purpose in life and mastery and indicate that parental support may enhance these associations.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150587/1/jcop22200_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150587/2/jcop22200.pd
Evidence of Syndemics and Sexuality-Related Discrimination Among Young Sexual-Minority Women
Purpose: Syndemics, or the co-occurrence and interaction of health problems, have been examined extensively among young men who have sex with men, but their existence remain unexamined, to our knowledge, among sexual-minority (i.e., lesbian, gay, and bisexual) women. Thus, we investigated if syndemics were present among young sexual-minority women, and if sexual-orientation discrimination was an independent variable of syndemic production. Methods: A total of 467 sexual-minority women between the ages of 18 and 24 completed a cross-sectional online survey regarding their substance use, mental health, sexual behaviors, height, weight, and experiences of discrimination. We used structural equation modeling to investigate the presence of syndemics and their relationship to sexual-orientation discrimination. Results: Heavy episodic drinking, marijuana use, ecstasy use, hallucinogen use, depressive symptoms, multiple sexual partners, and history of sexually transmitted infections (STIs) comprised syndemics in this population (chi-square=24.989, P=.201; comparative fit index [CFI]=0.946; root mean square error of approximation [RMSEA]=0.023). Sexual-orientation discrimination is significantly and positively associated with the latent syndemic variable (unstandardized coefficient=0.095, P.05). Conclusions: Syndemics appear to be present and associated with sexual-orientation discrimination among young sexual-minority women. Interventions aimed at reducing discrimination or increasing healthy coping may help reduce substance use, depressive symptoms, and sexual risk behaviors in this population.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140158/1/lgbt.2014.0063.pd
Intraindividual variability and falls in older adults
Objective: We investigated whether a simple measure of reaction time intraindividual variability (IIV) was associated with falls in older adults. Falls and fall-related injuries represent a major cost to health care systems, it is therefore critically important to find measures that can readily identify older adults at greater risk of falling. Method: Cognitive and motor function were investigated in 108 adults aged 53 to 93 years (M= 73.49) recruited across the local community and hospital outpatient department. Forty-two participants had experienced either an injurious fall, or multiple falls, in the previous two years. Results: Logistic regression suggested that fallers could be distinguished from non-fallers by greater medication use, IIV, postural sway, weaker grip strength and slower gait speed. Structural equation models revealed that IIV as predictive of falls via the mediating variable of motor function (e.g., gait). IIV also predicted higher-order cognition (executive function) but higher-order cognitive function did not uniquely predict falls or account for the associations between IIV and falls. Conclusions: These findings indicate that IIV measures capture important aspects of cognitive and motor decline and may have considerable potential in identifying older adults at risk of falling in healthcare and community settings
Gas Accretion is Dominated by Warm Ionized Gas in Milky Way-Mass Galaxies at z ~ 0
We perform high-resolution hydrodynamic simulations of a Milky Way-mass
galaxy in a fully cosmological setting using the adaptive mesh refinement code,
Enzo, and study the kinematics of gas in the simulated galactic halo. We find
that the gas inflow occurs mostly along filamentary structures in the halo. The
warm-hot (10^5 K 10^6 K) ionized gases are found to
dominate the overall mass accretion in the system (with dM/dt = 3-5 M_solar/yr)
over a large range of distances, extending from the virial radius to the
vicinity of the disk. Most of the inflowing gas (by mass) does not cool, and
the small fraction that manages to cool does so primarily close to the galaxy
(R <~ 20 kpc), perhaps comprising the neutral gas that may be detectable as,
e.g., high-velocity clouds. The neutral clouds are embedded within larger,
accreting filamentary flows, and represent only a small fraction of the total
mass inflow rate. The inflowing gas has relatively low metallicity (Z/Z_solar <
0.2). The outer layers of the filamentary inflows are heated due to compression
as they approach the disk. In addition to the inflow, we find high-velocity,
metal-enriched outflows of hot gas driven by supernova feedback. Our results
are consistent with observations of halo gas at low z.Comment: 10 pages including 5 figures, submitted to Ap
Evaluating the harmonisation potential of diverse cohort datasets
Data discovery, the ability to find datasets relevant to an analysis, increases scientific opportunity, improves rigour and accelerates activity. Rapid growth in the depth, breadth, quantity and availability of data provides unprecedented opportunities and challenges for data discovery. A potential tool for increasing the efficiency of data discovery, particularly across multiple datasets is data harmonisation.A set of 124 variables, identified as being of broad interest to neurodegeneration, were harmonised using the C-Surv data model. Harmonisation strategies used were simple calibration, algorithmic transformation and standardisation to the Z-distribution. Widely used data conventions, optimised for inclusiveness rather than aetiological precision, were used as harmonisation rules. The harmonisation scheme was applied to data from four diverse population cohorts.Of the 120 variables that were found in the datasets, correspondence between the harmonised data schema and cohort-specific data models was complete or close for 111 (93%). For the remainder, harmonisation was possible with a marginal a loss of granularity.Although harmonisation is not an exact science, sufficient comparability across datasets was achieved to enable data discovery with relatively little loss of informativeness. This provides a basis for further work extending harmonisation to a larger variable list, applying the harmonisation to further datasets, and incentivising the development of data discovery tools
Evidence for Cold Accretion: Primitive Gas Flowing onto a Galaxy at z~0.274
We present UV and optical observations from the Cosmic Origins Spectrograph
on the Hubble Space Telescope and Keck of a z= 0.27395 Lyman limit system (LLS)
seen in absorption against the QSO PG1630+377. We detect H I absorption with
log N(HI)=17.06\pm0.05 as well as Mg II, C III, Si III, and O VI in this
system. The column densities are readily explained if this is a multi-phase
system, with the intermediate and low ions arising in a very low metallicity
([Mg/ H] =-1.71 \pm 0.06) photoionized gas. We identify via Keck spectroscopy
and Large Binocular Telescope imaging a 0.3 L_* star-forming galaxy projected
37 kpc from the QSO at nearly identical redshift (z=0.27406, \Delta v = -26
\kms) with near solar metallicity ([O/ H]=-0.20 \pm 0.15). The presence of very
low metallicity gas in the proximity of a near-solar metallicity, sub-L_*
galaxy strongly suggests that the LLS probes gas infalling onto the galaxy. A
search of the literature reveals that such low metallicity LLSs are not
uncommon. We found that 50% (4/8) of the well-studied z < 1 LLSs have
metallicities similar to the present system and show sub-L_* galaxies with rho
< 100 kpc in those fields where redshifts have been surveyed. We argue that the
properties of these primitive LLSs and their host galaxies are consistent with
those of cold mode accretion streams seen in galaxy simulations.Comment: Accepted for publication in the Astrophysical Journa
Individual and Contextual Factors of Sexual Risk Behavior in Youth Perinatally Infected with HIV
Abstract This study prospectively examines the effects of maternal and child HIV infection on youth penetrative and unprotected penetrative sex, as well as the role of internal contextual, external contextual, social and self-regulatory factors in influencing the sexual behaviors of HIV?infected (PHIV+), HIV?affected (uninfected with an HIV+ caregiver), and HIV unaffected (uninfected with an HIV? caregiver) youth over time. Data (N=420) were drawn from two longitudinal studies focused on the effects of pediatric or maternal HIV on youth (51% female; 39% PHIV+) and their caregivers (92% female; 46% HIV+). PHIV+ youth were significantly less likely to engage in penetrative sex than HIV? youth at follow-up, after adjusting for contextual, social, and self-regulatory factors. Other individual- and contextual-level factors such as youth alcohol and marijuana use, residing with a biological parent, caregiver employment, caregiver marijuana use, and youth self-concept were also associated with penetrative sex. Youth who used alcohol were significantly more likely to engage in unprotected penetrative sex. Data suggest that, despite contextual, social, and self-regulatory risk factors, PHIV+ youth are less likely to engage in sexual behavior compared to HIV? youth from similar environments. Further research is required to understand delays in sexual activity in PHIV+ youth and also to understand potential factors that promote resiliency, particularly as they age into older adolescence and young adulthood.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98470/1/apc%2E2012%2E0005.pd
An Introduction to Gas Accretion onto Galaxies
Evidence for gas accretion onto galaxies can be found throughout the
universe. In this chapter, I summarize the direct and indirect signatures of
this process and discuss the primary sources. The evidence for gas accretion
includes the star formation rates and metallicities of galaxies, the evolution
of the cold gas content of the universe with time, numerous indirect indicators
for individual galaxies, and a few direct detections of inflow. The primary
sources of gas accretion are the intergalactic medium, satellite gas and
feedback material. There is support for each of these sources from observations
and simulations, but the methods with which the fuel ultimately settles in to
form stars remain murky.Comment: 14 pages, 5 figures, Invited review to appear in Gas Accretion onto
Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e,
to be published by Springe
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