Synthèse et caractérisation de complexes métalliques de ruthénium, fer et cobalt à base des ligands terpyridine et bipyridine pour l'obtention de cristaux liquides

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism

Background. Integrins are transmembrane αβ heterodimer receptors that function as structural and functional bridges between the cytoskeleton and ECM (extracellular matrix) molecules. The RGD (arginine-glycine-aspartate tripeptide motif)-dependent integrin α8β1 has been shown to be involved in various cell functions in neuronal and mesenchymal-derived cell types. Its role in epithelial cells remains unknown

Coordination-driven self-assembly of polyoxometalates into discrete supramolecular triangles

Pd(II)-directed self-assembly of a 3-pyridyl grafted Lindqvist hexavanadate led to the formation of a unique trimeric species, as confirmed by a variety of techniques, including pulsed-field gradient NMR spectroscopy and high-resolution ESI mass spectrometry

Trophic structure in the northern Humboldt Current system: new perspectives from stable isotope analysis.

International audienceThe northern Humboldt Current system(NHCS) is the most productive eastern boundary upwellingsystem (EBUS) in terms of fish productivity despite havinga moderate primary production compared with otherEBUS. To understand this apparent paradox, an updatedvision of the trophic relationships in the NHCS is required.Using δ13C and δ15N as a proxy of foraging habitat andtrophic position, respectively, we focused on thirteen relevanttaxonomic groups from zooplankton to air-breathingtop predators collected off Peru from 2008 to 2011. Estimates of trophic position (TP) for the anchovetaEngraulis ringens were high (3.4–3.7), in accordance withprevious studies showing zooplankton as a major contributorto anchoveta diet and challenging the often-cited shortfood chain hypothesis for this ecosystem. The squat lobster,Pleuroncodes monodon, a little studied consumer had similarδ15N values that of anchoveta, and thus similar trophicposition. However, their differing δ13C values indicate thattheir foraging habitat do not fully overlap, which could alleviatepotential competition between these species. Giventhe current high biomass of squat lobsters in the ecosystem,we encourage that future research focus on this speciesand its role in the diet of top predators. The presentstudy provides first estimates of the relative TP of importanttaxonomic groups in the NHCS, which are needed torevisit anchoveta-centred ecosystem models for this region.Further work using amino acid compound specific stableisotope analyses is now required to confirm these TPestimates

Sex and gender differences in healthcare utilisation trajectories: a cohort study among Quebec workers living with chronic pain

Objectives Chronic pain (CP) is a poorly recognised and frequently inadequately treated condition affecting one in five adults. Reflecting on sociodemographic disparities as barriers to CP care in Canada was recently established as a federal priority. The objective of this study was to assess sex and gender differences in healthcare utilisation trajectories among workers living with CP.Design Retrospective cohort study.Participants This study was conducted using the TorSaDE Cohort which links the 2007–2016 Canadian Community Health Surveys and Quebec administrative databases (longitudinal claims). Among 2955 workers living with CP, the annual number of healthcare contacts was computed during the 3 years after survey completion.Outcome Group-based trajectory modelling was used to identify subgroups of individuals with similar patterns of healthcare utilisation over time (healthcare utilisation trajectories).Results Across the study population, three distinct 3-year healthcare utilisation trajectories were found: (1) low healthcare users (59.9%), (2) moderate healthcare users (33.6%) and (3) heavy healthcare users (6.4%). Sex and gender differences were found in the number of distinct trajectories and the stability of the number of healthcare contacts over time. Multivariable analysis revealed that independent of other sociodemographic characteristics and severity of health condition, sex—but not gender—was associated with the heavy healthcare utilisation longitudinal trajectory (with females showing a greater likelihood; OR 2.6, 95% CI 1.6 to 4.1).Conclusions Our results underline the importance of assessing sex-based disparities in help-seeking behaviours, access to healthcare and resource utilisation among persons living with CP