174 research outputs found
A Wormhole at the core of an infinite cosmic string
We study a solution of Einstein's equations that describes a straight cosmic
string with a variable angular deficit, starting with a deficit at the
core. We show that the coordinate singularity associated to this defect can be
interpreted as a traversible wormhole lodging at the the core of the string. A
negative energy density gradually decreases the angular deficit as the distance
from the core increases, ending, at radial infinity, in a Minkowski spacetime.
The negative energy density can be confined to a small transversal section of
the string by gluing to it an exterior Gott's like solution, that freezes the
angular deficit existing at the matching border. The equation of state of the
string is such that any massive particle may stay at rest anywhere in this
spacetime. In this sense this is 2+1 spacetime solution.Comment: 1 tex file and 5 eps files. To be Published in Nov. in Phys.Rev.
Вопросы статики импульсной системы автоматического регулирования, содержащей ионный преобразователь, работающий на емкость
Topological Defects and Cosmology
Many particle physics models of matter admit solutions corresponding to
stable or long-lived topological defects. In the context of standard cosmology
it is then unavoidable that such defects will form during phase transitions in
the very early Universe. Certain types of defects lead to disastrous
consequences for cosmology, others may play a useful role, as possible seeds
for the formation of structure in the Universe, or in mediating baryon number
violating processes. In all cases, topological defects lead to a fruitful
interplay between particle physics and cosmology.Comment: 17 pages, no figures; Invited lectures at WHEPP-5, IUCAA, Pune,
India, Jan. 12 - 26 199
The Multiscale Morphology Filter: Identifying and Extracting Spatial Patterns in the Galaxy Distribution
We present here a new method, MMF, for automatically segmenting cosmic
structure into its basic components: clusters, filaments, and walls.
Importantly, the segmentation is scale independent, so all structures are
identified without prejudice as to their size or shape. The method is ideally
suited for extracting catalogues of clusters, walls, and filaments from samples
of galaxies in redshift surveys or from particles in cosmological N-body
simulations: it makes no prior assumptions about the scale or shape of the
structures.}Comment: Replacement with higher resolution figures. 28 pages, 17 figures. For
Full Resolution Version see:
http://www.astro.rug.nl/~weygaert/tim1publication/miguelmmf.pd
A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo
We have constructed a novel tetra-promoter vector (pBVboostFG) system that enables screening of gene/cDNA libraries for functional genomic studies. The vector enables an all-in-one strategy for gene expression in mammalian, bacterial and insect cells and is also suitable for direct use in vivo. Virus preparation is based on an improved mini Tn7 transpositional system allowing easy and fast production of recombinant baculoviruses with high diversity and negligible background. Cloning of the desired DNA fragments or libraries is based on the recombination system of bacteriophage lambda. As an example of the utility of the vector, genes or cDNAs of 18 different proteins were cloned into pBVboostFG and expressed in different hosts. As a proof-of-principle of using the vector for library screening, a chromophoric Thr(65)-Tyr-Gly(67)-stretch of enhanced green fluorescent protein was destroyed and subsequently restored by novel PCR strategy and library screening. The pBVboostFG enables screening of genome-wide libraries, thus making it an efficient new platform technology for functional genomics
Protocol: a method to study the direct reprogramming of lateral root primordia to fertile shoots
A coherent feed-forward loop drives vascular regeneration in damaged aerial organs of plants growing in a normal developmental context
Aerial organs of plants, being highly prone to local injuries, require tissue restoration to ensure their survival. However, knowledge of the underlying mechanism is sparse. In this study, we mimicked natural injuries in growing leaves and stems to study the reunion between mechanically disconnected tissues. We show that PLETHORA (PLT) and AINTEGUMENTA (ANT) genes, which encode stem cell-promoting factors, are activated and contribute to vascular regeneration in response to these injuries. PLT proteins bind to and activate the CUC2 promoter. PLT proteins and CUC2 regulate the transcription of the local auxin biosynthesis gene YUC4 in a coherent feed-forward loop, and this process is necessary to drive vascular regeneration. In the absence of this PLT-mediated regeneration response, leaf ground tissue cells can neither acquire the early vascular identity marker ATHB8, nor properly polarise auxin transporters to specify new venation paths. The PLT-CUC2 module is required for vascular regeneration, but is dispensable for midvein formation in leaves. We reveal the mechanisms of vascular regeneration in plants and distinguish between the wound-repair ability of the tissue and its formation during normal development.Peer reviewe
Ten-Year Mortality and Cardiovascular Morbidity in the Finnish Diabetes Prevention Study—Secondary Analysis of the Randomized Trial
The Finnish Diabetes Prevention Study (DPS) was a randomized controlled trial, which showed that it is possible to prevent type 2 diabetes by lifestyle changes. The aim of the present study was to examine whether the lifestyle intervention had an effect on the ten-year mortality and cardiovascular morbidity in the DPS participants originally randomized either into an intervention or control group. Furthermore, we compared these results with a population-based cohort comprising individuals of varying glucose tolerance states.Middle-aged, overweight people with IGT (n = 522) were randomized into intensive intervention (including physical activity, weight reduction and dietary counseling), or control "mini-intervention" group. Median length of the intervention period was 4 years and the mean follow-up was 10.6 years. The population-based reference study cohort included 1881 individuals (1570 with normal glucose tolerance, 183 with IGT, 59 with screen-detected type 2 diabetes, 69 with previously known type 2 diabetes) with the mean follow-up of 13.8 years. Mortality and cardiovascular morbidity data were collected from the national Hospital Discharge Register and Causes of Death Register. Among the DPS participants who consented for register linkage (n = 505), total mortality (2.2 vs. 3.8 per 1000 person years, hazard ratio HR = 0.57, 95% CI 0.21-1.58) and cardiovascular morbidity (22.9 vs. 22.0 per 1000 person years, HR = 1.04, 95% CI 0.72-1.51) did not differ significantly between the intervention and control groups. Compared with the population-based cohort with impaired glucose tolerance, adjusted HRs were 0.21 (95% CI 0.09-0.52) and 0.39 (95% CI 0.20-0.79) for total mortality, and 0.89 (95% CI 0.62-1.27) and 0.87 (0.60-1.27) for cardiovascular morbidity in the intervention and control groups of the DPS, respectively. The risk of death in DPS combined cohort was markedly lower than in FINRISK IGT cohort (adjusted HR 0.30, 95% CI 0.17-0.54), but there was no significant difference in the risk of CVD (adjusted HR 0.88, 95% CI 0.64-1.21).Lifestyle intervention among persons with IGT did not decrease cardiovascular morbidity during the first 10 years of follow-up. However, the statistical power may not be sufficient to detect small differences between the intervention and control groups. Low total mortality among participants of the DPS compared with individuals with IGT in the general population could be ascribed to a lower cardiovascular risk profile at baseline and regular follow-up.ClinicalTrials.gov NCT00518167
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