Modern Going Near Application of Respiratory Exercises at Obesity for Women

У статті розглядається методика дихальної гімнастики «Бодіфлекс»під час реабілітації жінок з ожирінням.In the article the method of respiratory gymnastics of «Bodifleks»pid is examined time of rehabilitation of women with obesity

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Multidrug efflux pumps:structure, function and regulation

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities

ZASTOSOWANIE METOD BAYESOWSKICH DO MODELOWANIA ROZWOJU FARMAKOOPORNOŚCI U PACJENTÓW

In this paper, we propose a methodology for using static Bayesian networks (BN) in modeling the development of pharmacoresistance in patients with a diagnosis of epilepsy. Methods for constructing the structure of a static BN, their parametric training, validation, sensitivity analysis and “What-if” scenario analysis are considered. The model was designed in collaboration with expert doctors, as well as expert pharmacologists in the selection and quantification of input and output variables.W niniejszej pracy zaproponowano metodologię wykorzystania statycznych sieci bayesowskich (BN) w modelowaniu rozwoju farmakooporności u pacjentów z rozpoznaniem padaczki. Rozważane są metody konstruowania struktury statycznej BN, jej parametrycznego treningu, walidacji, analizy wrażliwości i analizy scenariuszy "co-jeśli". Model został zaprojektowany we współpracy z ekspertami – lekarzami, a także ekspertami – farmakologami w zakresie doboru i kwantyfikacji zmiennych wejściowych i wyjściowych

Study of the statistical properties of the detected cosmic rays

The results of statistic analysis of Cherenkov radiation detection data are presented. Some abnormalities in Fourier and wavelet spectra of the analyzed process have been found

ПРО КОНЦЕПЦІЇ СТАТИСТИЧНИХ ВИМІРІВ

There are described four concepts of the statistical measurements and the methods realizing these concepts for processing the observations. There are adduced the examples in which correct and incorrect using of the results obtained by this methods for solutions of the industrial problems are demonstrated.Описаны четыре концепции статистических измерений и реализующие эти концепции методики обработки наблюдений; приведены примеры, в которых продемонстрированы случаи правомерного и неправомерного использования при решении производственных задач результатов, полученных по этим методикам.Описано чотири концепції статистичних вимірів та методики обробки спостережень, які реалізують ці концепції; наведено приклади, в яких продемонстровано випадки правомірного і неправомірного використання при вирішенні виробничих задач результатів, отриманих по цих методиках