Resistance Movement in Poland during the Second World War

У статті розглядаються передумови, хід польського руху Опору в роки Другої світової війни. In the article examined preconditions, motion of Polish Motion of Resistance in the years of Second world war

Variety of narrow-leaved lupine (<i>Lupinus angustifolius L.</i>) Mezenat

The purpose of the study was to create of an early ripening variety of narrow-leaved lupine with a seed and green mass yield above the standard, resistant to unfavorable biotic and abiotic environmental factors in the North-West region of the Russian Federation. As the result of many years of breeding, an early ripening variety of narrow-leaved lupine Metsenat has been developed. In a competitive varietal trial conducted in the conditions of the Leningrad Region, the seed yield of the variety Metsenat averaged 4.3 t/ha in 2015-2017 that was 1.1 t/ha higher than the standard (Kristall), the yield of green hay was 48.4 t/ha (13.9 t/ha higher than the standard). According to the results of the structural analysis of plants, the variety Metsenat was characterized by an increased number of seeds per plant (90.4 pcs.) and a good seeding of the beans (4.4 pcs.). It is a variety of universal use, with a low content of alkaloids (0.0072 %), it is technological, resistant to lodging (7 points), to cracking of beans and shedding of seeds on the vine, resistant to anthracnose (9 points). It is characterized by a rapid growth rate of plants in the initial period of vegetation. In 2018 the Metsenat variety was included into the State Register of Breeding Achievements of the Russian Federation approved for use in agricultural production in 12 regions (Patent No. 9559)

Simulation Of Distribution Of The Maximum Of The Chentsov Field On ‘Steps’

The paper extends the results obtained by Paranjape, Park, Klesov and Kruglova. A method of finding the distribution of the maximum of a Chentsov field restriction on a polyline is suggested. To do this, it was proposed to simulate a random process that corresponds to the restriction. The suggested algorithm has high computational efficiency which is crucial due to a large number of points of division of the process trajectory. The selection of the distributions of extreme functionals from the field was performed by means of the statistical programming language R. The Weibull distribution was chosen as the most suitable distribution, which was confirmed by the Kolmogorov criterion, as well as by Q-Q and P-P diagrams

Stochastic effects at ripple formation processes in anisotropic systems with multiplicative noise

We study pattern formation processes in anisotropic system governed by the Kuramoto-Sivashinsky equation with multiplicative noise as a generalization of the Bradley-Harper model for ripple formation induced by ion bombardment. For both linear and nonlinear systems we study noise induced effects at ripple formation and discuss scaling behavior of the surface growth and roughness characteristics. It was found that the secondary parameters of the ion beam (beam profile and variations of an incidence angle) can crucially change the topology of patterns and the corresponding dynamics

Phase field modelling voids nucleation and growth in binary systems

We present a comprehensive study of voids formation, nucleation and growth in a prototype model of binary alloys subjected to irradiation by using a combined approach based on phase field and rate theories. It is shown that voids formation is caused by interaction of irradiation-produced vacancies through elastic deformation of a lattice and vacancy coupling with composition field of the alloy. Phase diagrams illustrating the formation of states related to solid solution, phase decomposition, and patterning are obtained. Formation of voids from supersaturated ensemble of vacancies is accompanied by composition rearrangement of alloy components. It was found that elastic inhomogeneity leading to the formation of anisotropic precipitates in an initially prepared binary alloy results in the formation of a void super-lattice under irradiation. It was shown that voids nucleate and grow with dose according to diffusion controlled precipitation processes, where universal dynamics of voids growth is revealed. Estimations of main quantitative and statistical characteristics of voids by using material parameters relevant to most of alloys and steels give good agreement with experimental observations.Comment: 21 pages, 10 figure

ВМІСТ БІОЛОГІЧНО АКТИВНИХ РЕЧОВИН ТА ЕЛЕМЕНТНИЙ СКЛАД ТРАВИ ЗВІРОБОЮ РІЗНИХ ВИРОБНИКІВ

Мета роботи. Визначення вмісту біологічно активних речовин та елементного складу трави звіробою різних виробників, виявлення кореляцій між вмістом АФІ та мікроелементним складом трави. Матеріали і методи. У дослідженні використано стандартні зразки органічних речовин виробництва фірми Fluka, стандартні зразки іонів металів виробництва СКТБ фізико-хімічного інституту імені О. В. Богатського НАН України, зразки звіробою трави різних виробників. Аналітичне обладнання: спектрофотометр Hewlett Packard 8452A, рідинний хроматограф Shimadzu LC-20, обладнаний УФ-детектором, з використанням колонки Phenomenex Luna C18, атомно-абсорбційний спектрофотометр Solaar S4 AA (Thermo Electron Co., США). Статистичні розрахунки здійснено з використанням пакету статистичних програм IBM SPSS-19. Результати й обговорення. Досліджено вміст біологічно активних речовин (гіперицин, гіперозид, рутин, кверцетин, хлорогенова, неохлорогенова, розмаринова та кофейна кислоти) та елементний склад зразків трави звіробою чотирьох різних виробників. Зареєстрована суттєва варіація вмісту органічних речовин. Наприклад, концентрація гіперицину, що є одним з основних активних фармацевтичних інгредієнтів звіробою, змінюється у 2-5 разів. Встановлено статистично значущі позитивні або негативні кореляції між концентраціями деяких елементів (K, Mg, Fe, Mn, Cd) та вмістом органічних речовин (рутин, гіперозид, гіперицин та гідроксикоричні кислоти). Висновки. Вміст біологічно активних речовин, а саме гіперицину, рутину, гіперозиду, досліджених гідроксикоричних кислот, суттєво змінюється в залежності від походження та елементного складу зразків трави звіробою

The impact of different adjuvant intravesical therapy methods on tumor biology in patients with high-risk non-muscle-invasive bladder cancer

Expression level of the cell proliferation marker Ki-67 correlates with the degree of differentiation of tumor cells and stage in primary patients with non-muscle-invasive bladder cancer (NMIBC), but the marker is currently not used in assessing the efficacy of adjuvant intravesical therapy and risk stratification in patients with recurrent bladder tumors. Material and methods A retroprospective study included 107 patients with high-risk NMIBC; the patients were divided into 2 groups. The first group included patients who received adjuvant therapy after transurethral resection of the bladder using the Bacillus Calmette-Guérin (BCG) vaccine (BCG therapy group; n = 54), the second group consisted of patients who received hyperthermic intravesical chemotherapy (HIVEC® therapy group; n = 53) using the device for local hyperthermia Combat BRS HIVEC®. Results Tumor recurrences were recorded in 21 (39%) patients receiving intravesical BCG therapy and in 9 (17%) patients after intravesical hyperthermic chemotherapy (p = 0.012). The expression level of Ki-67 in primary tumors did not differ; in recurrent tumors it was significantly different in both groups (32.05 ±13.80 vs 11.00 ± 6.86). The frequency of recurrence-free survival (RFS) in patients receiving chemohyperthermia was significantly higher than in patients after the BCG therapy (log-rank test result: p = 0.048). Conclusions Assessment of Ki-67 expression in recurrent tumors can be a criterion for the effectiveness of intravesical bladder-preserving treatment. The use of hyperthermic chemotherapy can reduce the number of radical cystectomies in a separate group of patients with NMIBC

Assessment of Therapeutic Efficacy of 5% Sodium Hydrocarbonate Solution in Case of Nodular Dermatitis of Cattle

This article provides information on studies and evaluations of therapeutic efficacy of 5 % sodium bicarbonate solution in case of nodular dermatitis of cattle. Due to the market expansion of veterinary drugs, the periodization of unusual and new medicines as well as control methods of pathogens of farm livestock, having therapeutic and prophylactic effect, is under permanent control of specialists in the field of veterinary medicine. Recently the importance of finding modern means and methods of dealing with animal diseases aimed at the restoration of the body homeostasis has increased significantly in order to ensure the physiologically normal functioning of many enzymes, hormones and the whole body. There is a need for their rational use based on the study of changes in clinical and biochemical parameters occurring in the body under their influence and other factors contributing to the development of normal physiological status of the body (homeostasis). Based on the above, the present studies were based not only on etiological and pathogenetic, but also sanogenetic ideas about diseases with the aim of choosing the means that form the body’s normal physiological status (body homeostasis restoration), taking into account physiological characteristics of animals, and thereby providing the best medical and prophylactic efficacy [4]. Periodization of new drugs and methods to combat animal diseases that contribute to the restoration of body homeostasis is very important. This importantance has become even more significant since the increased sanitary and hygienic requirements for the use of veterinary drugs in animal husbandry, primarily for the treatment of dairy animals, which will serve as a guarantee for obtaining livestock products safe from the point of view of veterinary and sanitary norms and excellent sanitary quality