3,172 research outputs found
Individuals with knee impairments identify items in need of clarification in the Patient Reported Outcomes Measurement Information System (PROMISÂź) pain interference and physical function item banks - a qualitative study
Background: The content and wording of the Patient Reported Outcome Measurement Information System (PROMIS) Physical Function and Pain Interference item banks have not been qualitatively assessed by individuals with knee joint impairments. The purpose of this investigation was to identify items in the PROMIS Physical Function and Pain Interference Item Banks that are irrelevant, unclear, or otherwise difficult to respond to for individuals with impairment of the knee and to suggest modifications based on cognitive interviews. Methods: Twenty-nine individuals with knee joint impairments qualitatively assessed items in the Pain Interference and Physical Function Item Banks in a mixed-methods cognitive interview. Field notes were analyzed to identify themes and frequency counts were calculated to identify items not relevant to individuals with knee joint impairments. Results: Issues with clarity were identified in 23 items in the Physical Function Item Bank, resulting in the creation of 43 new or modified items, typically changing words within the item to be clearer. Interpretation issues included whether or not the knee joint played a significant role in overall health and age/gender differences in items. One quarter of the original items (31 of 124) in the Physical Function Item Bank were identified as irrelevant to the knee joint. All 41 items in the Pain Interference Item Bank were identified as clear, although individuals without significant pain substituted other symptoms which interfered with their life. Conclusions: The Physical Function Item Bank would benefit from additional items that are relevant to individuals with knee joint impairments and, by extension, to other lower extremity impairments. Several issues in clarity were identified that are likely to be present in other patient cohorts as well
Linkages between Arctic summer circulation regimes and regional sea ice anomalies
The downward trend in overall Arctic summer sea ice extent has been substantial, particularly in the last few decades. Departures in ice extent from year to year can be very large, however, in part due to the high variability in summer atmospheric circulation patterns. Anomalies in the Pacific sector ice cover can be partially compensated by anomalies of opposite sign in the Atlantic sector. An assessment of linkages between summer atmospheric patterns and sectoral anomalies in the area of maximum open water north of 70°N demonstrates that there is asymmetry in the mechanisms. Years with low ice extent and high open water fraction are uniformly associated with positive temperature anomalies and southerly flow in both the Atlantic and Pacific sectors. However, years with high extent and low open water fraction in both sectors reveal two dominant mechanisms. Some years with anomalously low maximum open water fraction are associated with negative temperature anomalies and southerly transportâa cool summer pattern that allows ice to persist over larger areas. However, other low open water years are characterized by an âice factoryâ mechanism, wherebyâeven when meltingâice cover is continually replenished by advection from the north
Approximate Consensus in Highly Dynamic Networks: The Role of Averaging Algorithms
In this paper, we investigate the approximate consensus problem in highly
dynamic networks in which topology may change continually and unpredictably. We
prove that in both synchronous and partially synchronous systems, approximate
consensus is solvable if and only if the communication graph in each round has
a rooted spanning tree, i.e., there is a coordinator at each time. The striking
point in this result is that the coordinator is not required to be unique and
can change arbitrarily from round to round. Interestingly, the class of
averaging algorithms, which are memoryless and require no process identifiers,
entirely captures the solvability issue of approximate consensus in that the
problem is solvable if and only if it can be solved using any averaging
algorithm. Concerning the time complexity of averaging algorithms, we show that
approximate consensus can be achieved with precision of in a
coordinated network model in synchronous
rounds, and in rounds when
the maximum round delay for a message to be delivered is . While in
general, an upper bound on the time complexity of averaging algorithms has to
be exponential, we investigate various network models in which this exponential
bound in the number of nodes reduces to a polynomial bound. We apply our
results to networked systems with a fixed topology and classical benign fault
models, and deduce both known and new results for approximate consensus in
these systems. In particular, we show that for solving approximate consensus, a
complete network can tolerate up to 2n-3 arbitrarily located link faults at
every round, in contrast with the impossibility result established by Santoro
and Widmayer (STACS '89) showing that exact consensus is not solvable with n-1
link faults per round originating from the same node
Effect of floor type on the performance, physiological and behavioural responses of finishing beef steers
peer-reviewedBackground:The study objective was to investigate the effect of bare concrete slats (Control), two types of mats [(Easyfix mats (mat 1) and Irish Custom Extruder mats (mat 2)] fitted on top of concrete slats, and wood-chip to simulate deep bedding (wood-chip placed on top of a plastic membrane overlying the concrete slats) on performance, physiological and behavioral responses of finishing beef steers. One-hundred and forty-four finishing steers (503Â kg; standard deviation 51.8Â kg) were randomly assigned according to their breed (124 Continental cross and 20 HolsteinâFriesian) and body weight to one of four treatments for 148Â days. All steers were subjected to the same weighing, blood sampling (jugular venipuncture), dirt and hoof scoring pre study (day 0) and on days 23, 45, 65, 86, 107, 128 and 148 of the study. Cameras were fitted over each pen for 72Â h recording over five periods and subsequent 10Â min sampling scans were analysed.
Results: Live weight gain and carcass characteristics were similar among treatments. The number of lesions on the hooves of the animals was greater (PÂ <Â 0.05) on mats 1 and 2 and wood-chip treatments compared with the animals on the slats. Dirt scores were similar for the mat and slat treatments while the wood-chip treatment had greater dirt scores. Animals housed on either slats or wood-chip had similar lying times. The percent of animals lying was greater for animals housed on mat 1 and mat 2 compared with those housed on concrete slats and wood chips. Physiological variables showed no significant difference among treatments.
Conclusions:
In this exploratory study, the performance or welfare of steers was not adversely affected by slats, differing mat types or wood-chip as underfoot material
Mining Human Prostate Cancer Datasets: The âcamcAPPâ Shiny App
Core CRUK funding: MD, AGL, ADL.
Academy of Medical Sciences Clinical Lecturer Starter Grant SGCL11 (prinicipal funder of this work): ADL
Impact of Space Weather on Climate and Habitability of Terrestrial Type Exoplanets
The current progress in the detection of terrestrial type exoplanets has
opened a new avenue in the characterization of exoplanetary atmospheres and in
the search for biosignatures of life with the upcoming ground-based and space
missions. To specify the conditions favorable for the origin, development and
sustainment of life as we know it in other worlds, we need to understand the
nature of astrospheric, atmospheric and surface environments of exoplanets in
habitable zones around G-K-M dwarfs including our young Sun. Global environment
is formed by propagated disturbances from the planet-hosting stars in the form
of stellar flares, coronal mass ejections, energetic particles, and winds
collectively known as astrospheric space weather. Its characterization will
help in understanding how an exoplanetary ecosystem interacts with its host
star, as well as in the specification of the physical, chemical and biochemical
conditions that can create favorable and/or detrimental conditions for
planetary climate and habitability along with evolution of planetary internal
dynamics over geological timescales. A key linkage of (astro) physical,
chemical, and geological processes can only be understood in the framework of
interdisciplinary studies with the incorporation of progress in heliophysics,
astrophysics, planetary and Earth sciences. The assessment of the impacts of
host stars on the climate and habitability of terrestrial (exo)planets will
significantly expand the current definition of the habitable zone to the
biogenic zone and provide new observational strategies for searching for
signatures of life. The major goal of this paper is to describe and discuss the
current status and recent progress in this interdisciplinary field and to
provide a new roadmap for the future development of the emerging field of
exoplanetary science and astrobiology.Comment: 206 pages, 24 figures, 1 table; Review paper. International Journal
of Astrobiology (2019
EXPOSURE TO NANOPARTICLES AND HORMESIS
Nanoparticles are particles with lengths that range from 1 to 100 nm. They are increasingly being manufactured and used for commercial purpose because of their novel and unique physicochemical properties. Although nanotechnology-based products are gener- ally thought to be at a pre-competitive stage, an increasing number of products and mate- rials are becoming commercially available. Human exposure to nanoparticles is therefore inevitable as they become more widely used and, as a result, nanotoxicology research is now gaining attention. However, there are many uncertainties as to whether the unique properties of nanoparticles also pose occupational health risks. These uncertainties arise because of gaps in knowledge about the factors that are essential for predicting health risks such as routes of exposure, distribution, accumulation, excretion and dose-response relationship of the nanoparticles. In particular, uncertainty remains with regard to the nature of the dose-response curve at low level exposures below the toxic threshold. In fact, in the literature, some studies that investigated the biological effects of nanoparticles, observed a hormetic dose-response. However, currently available data regarding this topic are extremely limited and fragmentary. It therefore seems clear that future studies need to focus on this issue by studying the potential adverse health effects caused by low-level exposures to nanoparticles
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