Volwassen kankerpatienten overleven langer in Nederland. 5-jaarsoverleving 12% toegenomen tussen 1989-1993 en 2004-2008

Doel: Inzicht geven in de overleving van kankerpatiënten om verbeteringen in de kankerzorg te kunnen volgen. Opzet: Retrospectieve, bevolkingsbrede cohortstudie. Methode: Voor dit onderzoek werden gegevens van de Nederlandse Kankerregistratie gebruikt. Van alle gediagnosticeerde kankerpatiënten uit de periode 1989-2008 in Nederland werden gegevens over de vitale status verzameld in ziekenhuizen, bevolkingsregisters en de gemeentelijke basisadministratie persoonsgegevens. Per vorm van kanker werden voor de leeftijd gestandaardiseerde relatieve overlevingcijfers berekend. Resultaten: De 5-jaarsoverleving van alle patiënten samen steeg van 47% in 1989-1993 naar 59% in 2004-2008. Bij mannen was de toename in overleving groter dan bij vrouwen, respectievelijk van 40 naar 55% en van 55 naar 62%. Het meest opvallend was de verbetering in overleving bij borst-, prostaat- en darmkanker, waarschijnlijk door oorzaken die voor elk van deze kankersoorten verschillend zijn. Patiënten met chronische myeloïde leukemie lieten een grote overlevingswinst zien (toename: 43%). De overlevingskansen van oudere patiënten waren in het algemeen lager dan die van jongere, vooral bij kanker in het hoofd-halsgebied, eierstokkanker en hematologische maligniteiten. Deze kloof tussen oudere en jongere patiënten is de afgelopen 20 jaar groter geworden. De 10-jaarsoverleving was bij veel kankersoorten niet veel lager dan de 5-jaarsoverleving, behalve bij chronische en indolente hematologische maligniteiten en kanker waarbij terugkeer van de ziekte na langere tijd nog kan plaatsvinden, zoals bij borst- en prostaatkanker. Conclusie: De verbeterde overleving van kankerpatiënten in Nederland, door vroege opsporing en verbeterde behandelingen, kan wijzen op een toenemend aandeel genezen patiënten of op patiënten die langer met kanker leven. Veel winst kan nog behaald worden bij de oudere patiënt. Dit is extra van belang omdat de bevolking vergrijst

No improvement in renal cell carcinoma survival: a population-based study in the Netherlands.

Contains fulltext : 71142.pdf (publisher's version ) (Closed access)BACKGROUND: The increased finding of kidney 'incidentalomas' and more frequent surgery in patients with renal cell cancer (RCC) metastases may have improved survival from the disease. However, recent data on survival of unselected population-based series of patients with RCC are sparse. METHODS: We collected the follow-up data for all the patients registered with RCC in the population-based cancer registry held by the Comprehensive Cancer Centre East, the Netherlands. RESULTS: Patients (1504) diagnosed with RCC between 1989 and 2002 were included. Eighty-three percent of all tumours were histologically confirmed; 17% of all diagnoses were based on clinical examination only. The latter group was older, had a worse stage distribution, often did not receive any kind of therapy and showed a 5-year relative survival of 8%. Five-year relative survival for patients with a histologically confirmed RCC was 60% and did not improve over the last 15 years. A low resection rate in patients with metastasis was observed, most pronounced in elderly, without a tendency of increase in more recent years. CONCLUSION: The relative survival of RCC did not improve over the years. The resection rate in patients with metastasised disease did not increase over time, despite current knowledge concerning its benefit on tumour complications, time to progression and response to immunotherapy

[Adult cancer patients are surviving longer in the Netherlands: 5-year survival rate increased by 12% between the periods 1989-1993 and 2004-2008.]

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SuperB: A High-Luminosity Asymmetric e+e- Super Flavour Factory. Conceptual Design Report.

May 18, 2007. 480pp., Available on the World Wide Web, with figures in full color, at http://www.pi.infn.it/SuperB/?q=CDRThe physics objectives of SuperB, an asymmetric electron-positron collider with a luminosity above 10^36/cm^2/s are described, together with the conceptual design of a novel low emittance design that achieves this performance with wallplug power comparable to that of the current B Factories, and an upgraded detector capable of doing the physics in the SuperB environment

SuperB: A High-Luminosity Asymmetric e+e- Super Flavour Factory. Conceptual Design Report.

May 18, 2007. 480pp., Available on the World Wide Web, with figures in full color, at http://www.pi.infn.it/SuperB/?q=CDRThe physics objectives of SuperB, an asymmetric electron-positron collider with a luminosity above 10^36/cm^2/s are described, together with the conceptual design of a novel low emittance design that achieves this performance with wallplug power comparable to that of the current B Factories, and an upgraded detector capable of doing the physics in the SuperB environment

First Observation of CP Violation in B0->D(*)CP h0 Decays by a Combined Time-Dependent Analysis of BaBar and Belle Data

9 pages, 2 figures.International audienceWe report a measurement of the time-dependent CP asymmetry of B0->D(*)CP h0 decays, where the light neutral hadron h0 is a pi0, eta or omega meson, and the neutral D meson is reconstructed in the CP eigenstates K+ K-, K0S pi0 or K0S omega. The measurement is performed combining the final data samples collected at the Y(4S) resonance by the BaBar and Belle experiments at the asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The data samples contain ( 471 +/- 3 ) x 10^6 BB pairs recorded by the BaBar detector and ( 772 +/- 11 ) x 10^6, BB pairs recorded by the Belle detector. We measure the CP asymmetry parameters -eta_f S = +0.66 +/- 0.10 (stat.) +/- 0.06 (syst.) and C = -0.02 +/- 0.07 (stat.) +/- 0.03 (syst.). These results correspond to the first observation of CP violation in B0->D(*)CP h0 decays. The hypothesis of no mixing-induced CP violation is excluded in these decays at the level of 5.4 standard deviations

SuperB: A High-Luminosity Asymmetric e+ e- Super Flavor Factory. Conceptual Design Report.

The physics objectives of SuperB, an asymmetric electron-positron collider with a luminosity above 10^36/cm^2/s are described, together with the conceptual design of a novel low emittance design that achieves this performance with wallplug power comparable to that of the current B Factories, and an upgraded detector capable of doing the physics in the SuperB environment