Nas margens do Tâmega - mercado de trabalho, pobreza e exclusão, interacções e intervenções

Estudo realizado para servir de suporte à prevenção e combate à pobreza e à exclusão resultantes do desemprego, incidindo na região do Tâmaga (NUT III - Amarante, Baião, Felgueiras, Lousada, Marco de Canaveses, Paços de Ferreira, Paredes e Penafiel.Study for mutually supportive in preventing and combating poverty and social exclusion resulting from unemployment, focusing on the region of the Tâmega (NUT III - Amarante, Baião, Felgueiras Lousada, Marco Canaveses, Paços de Ferreira, Paredes and Penafiel

A mediação nos Julgados de Paz: perspetivas de alguns atores da justiça em Portugal

A investigação teve por objetivo conhecer a mediação nos Julgados de Paz (JP) do ponto de vista dos juízes de paz, mediadores e advogados. Os JP são estruturas de mediação e conciliação que visam a participação cívica e a justa composição dos litígios por acordo das partes. Seguindo uma metodologia quantitativa, procurou-se aferir até que ponto esses atores da justiça reconhecem que os JP cumprem os objetivos, em termos estruturais e operacionais. Quanto à mediação, analisaram-se as perceções desses profissionais em algumas dimensões desse processo. Os resultados apontam para uma perceção positiva sobre os JP, e a mediação é de grande utilidade face aos seus propósitos.It was the aim of the research to increase knowledge about mediation in Courts of Peace (CPs) from the perspective of the justices of the peace, mediators and lawyers. The CPs are mediating and conciliating structures that aim at the civic participation and the equitable composition of disputes by agreement between the parties involved. Following a quantitative methodology, we attempted to ascertain the extent to which these actors of justice recognise that the CPs fulfil their goals, both in structural and operational terms. As to the mediation process, we have analysed the perceptions experienced by these professionals about some of its dimensions. The results point to a positive perception on the issue of the CPs and mediation. They were also perceived as being of great usefulness in relation to their stated purposes.La recherche visait à connaître la médiation dans la Justice de Paix (JP) du point de vue des juges de paix, des médiateurs et des avocats. JP désigne des structures de médiation et de conciliation visant à la participation civique et au règlement équitable des litiges par accord des parties. Suivant une méthodologie quantitative, nous avons cherché à évaluer à quel point ces acteurs de la justice reconnaissent que la JP remplie les objectifs en termes structurels et opérationnels. Quant à la médiation, nous avons analysé les perceptions de ces professionnels dans certaines dimensions de ce processus. Les résultats indiquent une perception positive de la JP et que la médiation est utile par rapport à ses fins

Resiliencia y agresividad en estudiantes de secundaria de una institución educativa pública de Ica – 2022

The present study carried out had the general objective: to determine that there is a significant relationship between resilience and aggressiveness, applying the type of basic research, because it allowed to describe the different variables of the study: Resilience with its dimensions (ability to adapt, overcome problems and face adversity) and Aggression considering its dimensions (verbal aggression, physical aggression, anger and hostility); A non-experimental, cross-sectional, descriptive-correlational design was used. The data was collected virtually through google forms. The results regarding the resilience variable report that it can be noted that 8.2% of students show a low level of resilience; 70.0% show a medium level of resilience development and 21.8% show a high level of resilience. The results of the aggressiveness variable indicate that 37.7% of students present a very low level of aggressiveness; 35.0% show a low level of aggressiveness development; 14.6% of students show a medium level of aggressiveness; 4.5% of students show a high level of aggressiveness and 8.2% of students show a very high level of aggressivenessEl presente estudio realizado tuvo como objetivo general: determinar que existe relación significativa entre la resiliencia y la agresividad, aplicando el tipo de investigación básica, porque permitió describir las diferentes variables del estudio: Resiliencia con sus dimensiones (capacidad  de  adaptación,  superación  de  problemas  y  afrontar  adversidades) y Agresividad considerando a sus dimensiones (Agresión verbal, agresión física, ira y  hostilidad); se empleó un diseño no experimental, de corte transversal, descriptivo-correlacional. Los datos se recogieron de manera virtual a través de formularios google.  Los resultados en cuanto a la variable resiliencia reportan que se puede señalar que el 8,2% de estudiantes muestran un nivel bajo de resiliencia; el 70,0% muestran un nivel medio de desarrollo de la resiliencia y el 21,8% por su parte exteriorizan un nivel alto de resiliencia. Los resultados de la variable agresividad indican que el 37,7% de estudiantes presentan un nivel muy bajo de agresividad; el 35,0% muestran un bajo nivel de desarrollo de la agresividad; el 14,6% de estudiantes exhiben un nivel medio de agresividad; el 4,5% de estudiantes exteriorizan un nivel alto de agresividad y el 8,2% de estudiantes presentan un nivel muy alto de agresivida

Establishing Streptomycin Epidemiological Cut-Off Values for Salmonella and Escherichia coli

This study was conducted to elucidate the accuracy of the current streptomycin epidemiological cut-off value (ECOFF) for Escherichia coli and Salmonella spp. A total of 236 Salmonella enterica and 208 E. coli isolates exhibiting MICs between 4 and 32¿mg/L were selected from 12 countries. Isolates were investigated by polymerase chain reaction for aadA, strA, and strB streptomycin resistance genes. Out of 236 Salmonella isolates, 32 (13.5%) yielded amplicons for aadA (n¿=¿23), strA (n¿=¿9), and strB (n¿=¿11). None of the 60 Salmonella isolates exhibiting MIC 4¿mg/L harbored resistance genes. Of the Salmonella isolates exhibiting MICs 8¿mg/L, 16¿mg/L, and 32¿mg/L, 1.6%, 15%, and 39%, respectively, tested positive for one or more genes. For most monitoring programs, the streptomycin ECOFF for Salmonella is wild type (WT) =32 or =16¿mg/L. A cut-off value of WT =32¿mg/L would have misclassified 13.5% of the strains as belonging to the WT population, since this proportion of strains harbored resistance genes and exhibited MICs =32¿mg/L. Out of 208 E. coli strains, 80 (38.5%) tested positive for aadA (n¿=¿69), strA (n¿=¿18), and strB (n¿=¿31). Of the E. coli isolates exhibiting MICs of 4¿mg/L, 8¿mg/L, 16¿mg/L, and 32¿mg/L, 3.6%, 17.6%, 53%, and 82.3%, respectively, harbored any of the three genes. Based on the European Committee on Antimicrobial Susceptibility Testing guidelines (ECOFF =16¿mg/L), 25% of the E. coli strains presenting MIC =16¿mg/L would have been incorrectly categorized as belonging to the WT population. The authors recommend an ECOFF value of WT =16¿mg/L for Salmonella and WT =8¿mg/L for E. coli

European LeukemiaNet 2017 risk stratification for acute myeloid leukemia: validation in a risk-adapted protocol

The 2017 European LeukemiaNet (ELN 2017) guidelines for the diagnosis and management of acute myeloid leukemia (AML) have become fundamental guidelines to assess the prognosis and postremission therapy of patients. However, they have been retrospectively validated in few studies with patients included in different treatment protocols. We analyzed 861 patients included in the Cooperativo Para el Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias-12 risk-adapted protocol, which indicates cytarabine-based consolidation for patients allocated to the ELN 2017 favorable-risk group, whereas it recommends allogeneic stem cell transplantation (alloSCT) as a postremission strategy for the ELN 2017 intermediateand adverse-risk groups. We retrospectively classified patients according to the ELN 2017, with 327 (48%), 109 (16%), and 245 (36%) patients allocated to the favorable-, intermediate-, and adverse-risk group, respectively. The 2- and 5-year overall survival (OS) rates were 77% and 70% for favorable-risk patients, 52% and 46% for intermediate-risk patients, and 33% and 23% for adverse-risk patients, respectively. Furthermore, we identified a subgroup of patients within the adverse group (inv(3)/t(3;3), complex karyotype, and/or TP53 mutation/17p abnormality) with a particularly poor outcome, with a 2-year OS of 15%. Our study validates the ELN 2017 risk stratification in a large cohort of patients treated with an ELN-2017 risk-adapted protocol based on alloSCT after remission for nonfavorable ELN subgroups and identifies a genetic subset with a very poor outcome that warrants investigation of novel strategies

Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.

OBJECTIVES To characterize the genetic basis of azithromycin resistance in Escherichia coli and Salmonella collected within the EU harmonized antimicrobial resistance (AMR) surveillance programme in 2014-18 and the Danish AMR surveillance programme in 2016-19. METHODS WGS data of 1007 E. coli [165 azithromycin resistant (MIC > 16 mg/L)] and 269 Salmonella [29 azithromycin resistant (MIC > 16 mg/L)] were screened for acquired macrolide resistance genes and mutations in rplDV, 23S rRNA and acrB genes using ResFinder v4.0, AMRFinder Plus and custom scripts. Genotype-phenotype concordance was determined for all isolates. Transferability of mef(C)-mph(G)-carrying plasmids was assessed by conjugation experiments. RESULTS mph(A), mph(B), mef(B), erm(B) and mef(C)-mph(G) were detected in E. coli and Salmonella, whereas erm(C), erm(42), ere(A) and mph(E)-msr(E) were detected in E. coli only. The presence of macrolide resistance genes, alone or in combination, was concordant with the azithromycin-resistant phenotype in 69% of isolates. Distinct mph(A) operon structures were observed in azithromycin-susceptible (n = 50) and -resistant (n = 136) isolates. mef(C)-mph(G) were detected in porcine and bovine E. coli and in porcine Salmonella enterica serovar Derby and Salmonella enterica 1,4, [5],12:i:-, flanked downstream by ISCR2 or TnAs1 and associated with IncIγ and IncFII plasmids. CONCLUSIONS Diverse azithromycin resistance genes were detected in E. coli and Salmonella from food-producing animals and meat in Europe. Azithromycin resistance genes mef(C)-mph(G) and erm(42) appear to be emerging primarily in porcine E. coli isolates. The identification of distinct mph(A) operon structures in susceptible and resistant isolates increases the predictive power of WGS-based methods for in silico detection of azithromycin resistance in Enterobacterales

Breeding systems in Tolpis (Asteraceae) in the Macaronesian islands: the Azores, Madeira and the Canaries

Plants on oceanic islands often originate from self-compatible (SC) colonizers capable of seed set by self fertilization. This fact is supported by empirical studies, and is rooted in the hypothesis that one (or few) individuals could find a sexual population, whereas two or more would be required if the colonizers were self-incompatible (SI). However, a SC colonizer would have lower heterozygosity than SI colonizers, which could limit radiation and diver sification of lineages following establishment. Limited evidence suggests that several species-rich island lineages in the family Asteraceae originated from SI colonizers with some ‘‘leakiness’’ (pseudo-self-compatibility, PSC) such that some self-seed could be produced. This study of Tolpis (Asteraceae) in Macaronesia provides first reports of the breeding system in species from the Azores and Madeira, and additional insights into variation in Canary Islands. Tolpis from the Azores and Madeira are predominately SI but with PSC. This study suggests that the breeding sys tems of the ancestors were either PSC, possibly from a single colonizer, or from SI colonizers by multiple dis seminules either from a single or multiple dispersals. Long distance colonists capable of PSC combine the advantages of reproductive assurance (via selfing) in the establishment of sexual populations from even a single colonizer with the higher heterozygosity resulting from its origin from an outcrossed source population. Evolution of Tolpis on the Canaries and Madeira has generated diversity in breeding systems, including the origin of SC. Macaronesian Tolpis is an excellent system for studying breeding system evolution in a small, diverse lineage.info:eu-repo/semantics/publishedVersio

A mediação nos Julgados de Paz: perspetivas de alguns atores da justiça em Portugal

A investigação teve por objetivo conhecer a mediação nos Julgados de Paz (JP) do ponto de vista dos juízes de paz, mediadores e advogados. Os JP são estruturas de mediação e conciliação que visam a participação cívica e a justa composição dos litígios por acordo das partes. Seguindo uma metodologia quantitativa, procurou-se aferir até que ponto esses atores da justiça reconhecem que os JP cumprem os objetivos, em termos estruturais e operacionais. Quanto à mediação, analisaram-se as perceções desses profissionais em algumas dimensões desse processo. Os resultados apontam para uma perceção positiva sobre os JP, e a mediação é de grande utilidade face aos seus propósitos.It was the aim of the research to increase knowledge about mediation in Courts of Peace (CPs) from the perspective of the justices of the peace, mediators and lawyers. The CPs are mediating and conciliating structures that aim at the civic participation and the equitable composition of disputes by agreement between the parties involved. Following a quantitative methodology, we attempted to ascertain the extent to which these actors of justice recognise that the CPs fulfil their goals, both in structural and operational terms. As to the mediation process, we have analysed the perceptions experienced by these professionals about some of its dimensions. The results point to a positive perception on the issue of the CPs and mediation. They were also perceived as being of great usefulness in relation to their stated purposes.La recherche visait à connaître la médiation dans la Justice de Paix (JP) du point de vue des juges de paix, des médiateurs et des avocats. JP désigne des structures de médiation et de conciliation visant à la participation civique et au règlement équitable des litiges par accord des parties. Suivant une méthodologie quantitative, nous avons cherché à évaluer à quel point ces acteurs de la justice reconnaissent que la JP remplie les objectifs en termes structurels et opérationnels. Quant à la médiation, nous avons analysé les perceptions de ces professionnels dans certaines dimensions de ce processus. Les résultats indiquent une perception positive de la JP et que la médiation est utile par rapport à ses fins