Column-row addressing of thermo-optic phase shifters for controlling large silicon photonic circuits

We demonstrate a time-multiplexed row-column addressing scheme to drive thermo-optic phase shifters in a silicon photonic circuit. By integrating a diode in series with the heater, we can connect $N \times M$ heaters in an matrix topology to $N$ row and $M$ column lines. The heaters are digitally driven with pulse-width modulation, and time-multiplexed over different channels. This makes it possible to drive the circuit without digital-to-analog converters, and using only $M+N$ wires. We demonstrate this concept with a $1 \times 16$ power splitter tree with 15 thermo-optic phase shifters that are controlled in a $3 \times 5$ matrix, connected through 8 bond pads. This technique is especially useful in silicon photonic circuits with many tuners but limited space for electrical connections

Global Alliance for the Promotion of Physical Activity: the Hamburg Declaration

Non-communicable diseases (NCDs), including coronary heart disease, stroke, hypertension, type 2 diabetes, dementia, depression and cancers, are on the rise worldwide and are often associated with a lack of physical activity (PA). Globally, the levels of PA among individuals are below WHO recommendations. A lack of PA can increase morbidity and mortality, worsen the quality of life and increase the economic burden on individuals and society. In response to this trend, numerous organisations came together under one umbrella in Hamburg, Germany, in April 2021 and signed the 'Hamburg Declaration'. This represented an international commitment to take all necessary actions to increase PA and improve the health of individuals to entire communities. Individuals and organisations are working together as the 'Global Alliance for the Promotion of Physical Activity' to drive long-term individual and population-wide behaviour change by collaborating with all stakeholders in the community: active hospitals, physical activity specialists, community services and healthcare providers, all achieving sustainable health goals for their patients/clients. The 'Hamburg Declaration' calls on national and international policymakers to take concrete action to promote daily PA and exercise at a population level and in healthcare settings

miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia

MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia (CLL). RNAs from primary cells of 50 treatment-naive CLL patients and peripheral B cells of 14 healthy donors were applied to miRNA expression profiling using bead chip technology. In CLL cells, a set of 7 up- and 19 down-regulated miRNAs was identified. Among the miRNAs down-regulated in CLL cells, 6 of 10 miRNA promoters examined showed gain of methylation compared with normal B-cell controls. Subsequent target prediction of deregulated miRNAs revealed a highly significant binding prediction at the 3′ untranslated region of the pleomorphic adenoma gene 1 (PLAG1) oncogene. Luciferase reporter assays including site-directed mutagenesis of binding sites revealed a significant regulation of PLAG1 by miR-181a, miR-181b, miR-107, and miR-424. Although expression of PLAG1 mRNA was not affected, PLAG1 protein expression was shown to be significantly elevated in CLL cells compared with the levels in healthy donor B cells. In summary, we could demonstrate disruption of miRNA-mediated translational control, partly due to epigenetic transcriptional silencing of miRNAs, with subsequent overexpression of the oncogenic transcription factor PLAG1 as a putative novel mechanism of CLL pathogenesis

Global Alliance for the Promotion of Physical Activity: the Hamburg Declaration

Non-communicable diseases (NCDs), including coronary heart disease, stroke, hypertension, type 2 diabetes, dementia, depression and cancers, are on the rise worldwide and are often associated with a lack of physical activity (PA). Globally, the levels of PA among individuals are below WHO recommendations. A lack of PA can increase morbidity and mortality, worsen the quality of life and increase the economic burden on individuals and society. In response to this trend, numerous organisations came together under one umbrella in Hamburg, Germany, in April 2021 and signed the ‘Hamburg Declaration’. This represented an international commitment to take all necessary actions to increase PA and improve the health of individuals to entire communities. Individuals and organisations are working together as the ‘Global Alliance for the Promotion of Physical Activity’ to drive long-term individual and population-wide behaviour change by collaborating with all stakeholders in the community: active hospitals, physical activity specialists, community services and healthcare providers, all achieving sustainable health goals for their patients/clients. The ‘Hamburg Declaration’ calls on national and international policymakers to take concrete action to promote daily PA and exercise at a population level and in healthcare settings

Search for the lightest chargino at root s=130 and 136 GeV

A search for pair production of the lightest chargino at root-s = 130.4 and 136.3 GeV has been carried out using the data sample corresponding to the 5.92 pb(-1) recorded by the DELPHI detector during the high energy run of LEP in the last period of 1995. The theoretical reference model has been the Minimal Supersymmetric Standard Model with R-parity conservation. The three topologies expected for the decay of a pair of charginos, namely two acoplanar leptons plus missing energy (ll), two jets and an isolated lepton plus missing (jjl) and missing energy in a hadronic environment (root-s), were investigated. No evidence of a signal was found. Lower mass limits were derived for various scenarios, including the case of a low mass difference between the chargino and the neutralino and of a light sneutrino. The mass limits range between 56.3 GeV/c(2) and the kinetic limit