Genetic structure in the paternal lineages of South East Spain revealed by the analysis of 17 Y-STRs

Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-019-41580-9.The content of this article is part of the Ph.D. thesis of María Saiz which was conducted at the University of Granada under the doctoral programme “Biomedicine”. The authors thank all of the participants who donated buccal swabs and all those who helped in the sample collection—namely, María Luisa Aceituno Villalva, Leticia Olga Rubio Lamia, and Verónica Delgado López. In addition, the authors want to thank Xiomara Gálvez for the technical assistance in the laboratory.The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele frequencies and haplogroup frequencies were also analyzed. By AMOVA and STRUCTURE analysis, the populations of the 3 provinces could be treated genetically as a single population. The most frequent haplogroup was R1b1b2 (58.22%). By network analysis of all individuals, we observed a distribution according to haplogroup assignment. To improve the characterization of GMA population, it was compared with those of North Africa, the Iberian Peninsula, and southern Europe. In our analysis of allele frequencies and genetic distances, the GMA population lay within the Spanish population group. Further, in the STRUCTURE analysis, there was no African component in the GMA population, confirming that, based on our genetic markers, the GMA population does not reflect any male genetic influence of the North African people. The presence of African haplogroups in the GMA population is irrelevant when their frequency is compared with those in other European populations

Relación entre Antecedente Empresarial Familiar y el Emprendimiento de Micro y Pequeñas Empresas

The objective of the research was to determine the relationship between the family business background and the entrepreneurship of micro and small enterprises. A total census of 123 companies registered in the Business Incubator of the Facultad de Contaduría y Administración of the Universidad Autónoma de Chihuahua in Chihuahua, Mexico, was carried out. The research was descriptive and exploratory; using the analyticalsynthetic method, with a transectional design, performed between April and June 2016. The dependent variable was the generation of companies and the independent variable was to have a family business background. The main results indicate that the majority of entrepreneurs with companies in operation, have a family business background. However, it is not decisive to not have a relative with a company, and other factors can also influence the entrepreneurship of new companies, among which may be the support provided by the business incubator

Educação presencial com mediação virtual: uma experiência de Honduras nos dias do COVID-19

The aim of this research has been to reveal the educational proposal carried out by one of Honduras universities to virtualize its processes during COVID-19 and to determine the satisfaction of professors and students regarding the proposal. This research, under an exploratory and non-experimental descriptive design, had two phases: reconstruction of the experience and a satisfaction study using a Likert-5 point scale tool carried out to a sample n = 1156 students and n =130 professors. The results have allowed to identify three transition stages to virtualization: ensuring, reorganizing and implementing; to define face-to-face education with a virtual support as the modality study applied, and to verify a high level of satisfaction of students and professors. The results allow the transition and development of a face-to-face education with a virtual support modality as an alternative to the virtualization of educational processes in higher education.El propósito de esta investigación ha sido revelar la propuesta educativa desarrollada por una universidad de Honduras para virtualizar sus procesos durante la COVID-19, así como determinar el grado de satisfacción con esa propuesta que manifiestan sus estudiantes y docentes. Con carácter exploratorio y descriptivo no experimental, tuvo dos fases: reconstrucción de la experiencia y estudio de satisfacción a través de un instrumento tipo Likert-5 aplicado a una muestra n = 1156 estudiantes y n = 130 docentes. Los resultados han permitido identificar tres etapas en el paso a la virtualización: aseguramiento, reordenamiento e implementación; definir la modalidad de estudios implementada como una educación presencial con mediación virtual; y constatar un alto grado de satisfacción de estudiantes y docentes. Los resultados permiten avanzar hacia el desarrollo de un modelo de educación presencial con mediación virtual como alternativa para la virtualización de los procesos educativos en la educación superior.O objetivo desta investigação foi revelar a proposta educacional desenvolvida por uma universidade hondurenha para virtualizar seus processos durante a pandemia COVID-19, bem como determinar o grau de satisfação com essa proposta, que seus alunos e professores manifestam. Com caráter descritivo exploratório e não experimental, teve duas fases: reconstrução da experiência e estudo de satisfação por meio de instrumento do tipo Likert-5 aplicado a uma amostra n = 1156 alunos e n = 130 professores. Os resultados permitiram identificar três estágios para virtualização: garantia, reordenação e implementação; definir o tipo de estudo implementado como uma educação presencial com mediação virtual; e verificar um alto grau de satisfação dos alunos e professores. Os resultados permitem avançar no desenvolvimento de um modelo de ensino presencial com mediação virtual como alternativa para a virtualização de processos educacionais no ensino superior

Enantiopure Double ortho-Oligophenylethynylene-Based Helical Structures with Circularly Polarized Luminescence Activity

We thank the Ministerio de Economia y Competitividad (CTQ2017-85454-C2-1-P and CTQ2017-85454-C2-2-P), Ministerio de Ciencia e Innovacion (PID2020-113059GB-C21 and PID2020-113059GB-C22) and Junta de Andalucia (P20.00162) (Spain) for funding and P.R. and A. O. G. also for FPU contracts. Funding for open access charge is acknowledged to Universidad de Granada / CBUA.We also thank Big&Open Data Innovation Laboratory (BODaI-Lab), University of Brescia, granted by Fondazione Cariplo and Regione Lombardia, for access to resources of Computing Center CINECA (Bologna), Italy. Support from the Italian MIUR (Grant No. 2017A4XRCA) is also acknowledged.In this paper, we describe the optical and chiroptical properties of an enantiopure multipodal ortho-oligophenylethynylene (S,S,S,S)-1 presenting four chiral sulfoxide groups at the extremes. The presence of these groups together with alkynes allows the coordination with carbophilic Ag(I), and/or oxophilic Zn(II) cations, yielding double helical structures in an enantiopure way. In this sense, different behaviors in absorption, fluorescence, ECD and CPL spectra have been found depending on the stoichiometry and nature of the metal. We have observed that Zn(II) coordination favors an intensity increase of the electronic circular dichroism (ECD) spectra of compound (S,S,S,S)-1 yielding an M-helicity in the ortho-oligophenylene ethynylene (o-OPE) backbone. On the other hand, ECD spectra of final Ag(I) complex shows two different bands with an opposite sign to the free ligand, thus giving the P-helical isomer. In addition, circularly polarized luminescence (CPL) exhibit an enhanced intensity and negative sign in both complexes. Computational studies were also carried out, supporting the experimental results.Spanish Government CTQ2017-85454-C2-1-P CTQ2017-85454-C2-2-PInstituto de Salud Carlos III Spanish Government European Commission PID2020-113059GB-C21 PID2020-113059GB-C22Junta de Andalucia European Commission P20.00162University of Brescia / CBUAFondazione CariploMinistry of Education, Universities and Research (MIUR) 2017A4XRCARegione Lombardi

Spectroscopy of proton-unbound nuclei by tracking their decay products in-flight: One- and two-proton decays of 15F, 16Ne, and 19Na

14 páginas, 23 figuras, 1 tabla.-- et al.A powerful method of investigating proton-unbound nuclear states by tracking their decay products in flight is discussed in detail. To verify the method, four known levels in 15F, 16Ne, and 19Na were investigated by measuring the angular correlations between protons and the respective heavy-ion fragments stemming from the precursor decays in flight. The parent nuclei of interest were produced in nuclear reactions of one-neutron removal from 17Ne and 20Mg projectiles at energies of 410–450 A MeV. The trajectories of the respective decay products, 14O + p + p and 18Ne + p + p, were measured by applying a tracking technique with microstrip detectors. These data were used to reconstruct the angular correlations of the fragments, which provided information on energies and widths of the parent states. In addition for reproducing properties of known states, evidence for hitherto unknown excited states in 15F and 16Ne was found. This tracking technique has an advantage in studies of exotic nuclei beyond the proton drip line measuring the resonance energies and widths with a high precision although by using low-intensity beams and very thick targets.This work has been supported by Contract EURONS Nos. EC-I3 and FPA2006-13807-C02-01, FPA2007-63074 (MEC, Spain), the INTAS Grant No. 03-54-6545. L.V.G. is supported by FAIR-Russia Research Center grant, Russian Foundation for Basic Research viaGrant Nos. RFBR 08-02-00892 and 08-02-00089-a, and Russian Ministry of Industry and Science Grant No. NSh-7235.2010.2. N.K.T. acknowledges support from the UK Grant No. STFC ST/F012012/1, E.L. is supported by the LOEWE program of the State of Hessen (Helmholtz International Center for FAIR), Germany.Peer Reviewe

Interaction of 8 He with 208Pb at near-barrier energies: 4 He and 6 He production

Spanish Ministry of Economy and Competitiveness-FPA-2010-22131-CO2-01 (FINURA) y FPA2013-47327-C2-1-RMinistry of Science and Higher Education of Poland-N202 033637National Science Centre of Poland-2013/08/M/ST2/00257 (LEA-COPIGAL) y 2014/14/M/ST2/00738 (COPIN-INFN Collaboration)European Science Foundation-EUI2009-04163432 (EUROGENESIS

Convergent Approaches for the Synthesis of the Anti-tumoral Peptide, Kahalalide F. Study of Orthogonal Protecting Groups

Kahalalide compounds are peptides that are isolated from a Hawaiian herbivorous marine species of mollusc, Elysia rufescens, and its diet, the green alga Bryopsis sp. Kahalalide F and its synthetic analogues are the most promising compounds of the Kahalalide family because they show anti-tumoral activity. Linear solid-phase syntheses of Kahalalide F have been reported. Here we describe several new improved synthetic routes based on convergent approaches with distinct orthogonal protection schemes for the preparation of Kahaladide analogues. These strategies allow a better control and characterization of the intermediates because more reactions are performed in solution. Five derivatives of Kahalalide F were synthesized using several convergent approaches

Herpetofauna de la Reserva Natural Provincial Isla Apipé Grande (Corrientes, Argentina)

La información sobre biodiversidad es imprescindible para conocer y valorar el patrimonio natural de una región, especialmente para tomar decisiones correctas orientadas a la conservación de su biota (Aceñolaza et al., 2004). Los anfibios y reptiles están experimentando una disminución de especies y poblaciones a nivel mundial, y entre las amenazas implicadas en este declive se han mencionado la destrucción y fragmentación de los hábitats, la sobreexplotación de las especies, la introducción de especies exóticas, la contaminación ambiental y las enfermedades infecciosas (Alford y Richards, 1999; Gibbons et al., 2000; Suazo-Ortuño et al., 2008). Este serio problema ha renovado, en parte, el interés por los estudios de riqueza y abundancia de las especies de anfibios y reptiles.Fil: Zaracho, Victor Hugo. Universidad Nacional del Nordeste. Facultad de Cs.exactas Naturales y Agrimensura. Departamento de Biologia. Laboratorio de Herpetologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ingaramo, María del Rosario. Universidad Nacional del Nordeste. Facultad de Cs.exactas Naturales y Agrimensura. Departamento de Biologia. Laboratorio de Herpetologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Semhan, Romina Valeria. Fundación Miguel Lillo. Dirección de Zoología. Instituto de Herpetología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Etchepare, Eduardo Gabriel. Universidad Nacional del Nordeste. Facultad de Cs.exactas Naturales y Agrimensura. Departamento de Biologia. Laboratorio de Herpetologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acosta, José Luis. Universidad Nacional del Nordeste. Facultad de Cs.exactas Naturales y Agrimensura. Departamento de Biologia. Laboratorio de Herpetologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Falcione, Ana Camila. Universidad Nacional del Nordeste. Facultad de Cs.exactas Naturales y Agrimensura. Departamento de Biologia. Laboratorio de Herpetologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Álvarez, Blanca Beatriz. Universidad Nacional del Nordeste. Facultad de Cs.exactas Naturales y Agrimensura. Departamento de Biologia. Laboratorio de Herpetologia; Argentin

Observation of two-proton radioactivity of Mg19 by tracking the decay products

We have observed the two-proton radioactivity of the previously unknown 19Mg ground state by tracking the decay products in-flight. For the first time, the trajectories of the 2p-decay products, 17Ne+p+p, have been measured by using tracking microstrip detectors which allowed us to reconstruct the 2p-decay vertices and fragment correlations. The half-life of 19Mg deduced from the measured vertex distribution is 4.0(15) ps in the system of 19Mg. The Q value of the 2p decay of the 19Mg ground state inferred from the measured p−p−17Ne correlations is 0.75(5) MeV.MEC FPA2003-05958 FPA2006-13807-C02-0

New states in 18Na and 19Mg observed in the two-proton decay of 19Mg

Previously unknown states in 18Na and 19Mg have been studied by measuring the trajectories of their decay products with microstrip detectors. Analyzing angular correlations of the fragments provided information on decay energies and widths of the parent states. The ground state of 18Na has been detected and its one-proton decay energy of 1.23(15) MeV determined. Four previously unknown states in 19Mg at 2.1, 2.9, 3.6, and 5.2 MeV have been observed. The competition between simultaneous and sequential two-proton emission of states in 19Mg is discussed, and the conclusion of a direct mechanism of 2p radioactivity of the 19Mg ground state is confirmed.MEC EC-I3 FPA2006-13807-C02-01Ministerio de Economía y Competitividad FPA2009-0884