A Comparative Approach to Detect Macrobenthic Response to the Conversion of an Inshore Mariculture Plant into an IMTA System in the Mar Grande of Taranto (Mediterranean Sea, Italy)

The expected bioremediation effect, driven by the conversion of an inshore mariculture plant into an Integrated Multi-Trophic Aquaculture (IMTA) system, which could mitigate the fish farm impact, related to the accumulation of organic matter on the seabed, has been studied. The ecological quality status was studied following a Before-After-Control-Impact (BACI) design and variation measured through M-AMBI and compared with the results of univariate and multivariate analyses of variance, to evaluate the sensitivity of the two methodologies. Results from M-AMBI indicated a sharp change in the ecological quality status, just after one year of the conversion of the plant. By contrast, although changes were detected also utilizing univariate and multivariate statistical analysis, the natural temporal variability characterizing the area partially masked evidence of environmental amelioration

Silica-based mesoporous materials as drug delivery system for methotrexate release.

Antineoplastic methotrexate has been loaded through different soaking procedures on silica-based mesoporous materials and, successively, released mimicking an oral administration. The materials were prepared using a self-assembly mechanism in the presence of cationic surfactants with alkyl chain of 16, 12, and 10 carbon atoms in the synthesis mixture to obtain different pore diameter in the porous structure. Mesoporous materials were prepared as pure silica sample and in the presence of Al(OH)(3) in the synthesis mixture. Only alumina-silica samples were able to load methotrexate. The amounts of drug loaded and the in vitro release kinetics are a function of the pore size of the materials

Non-indigenous polychaetes along the coasts of Italy: a critical review

Non-indigenous species (NIS) represent one of the most relevant threats to biodiversity, ecosystem functioning and human activities, and their occurrence and spread have been the subject of numerous works and revisions. However, the information available is rather confused for several taxa, including polychaetes, which are characterised by having a high number of cryptogenic and questionable species. This work aims at providing a revised checklist of alien polychaetes occurring along the coasts of Italy, based on the examination of newly collected and deposited material and on the critical analysis of published and gray literature, and whenever possible on the re-examination of historical material. Of the 86 polychaete species reported as NIS in Italian waters, 25 are confirmed as alien species, while 3 are cryptogenic, and 40 should be considered questionable. Finally, 18 species were excluded from non-indigenous species checklists, either because they are native, or because they represent misidentifications of other species. The high number of cryptogenic and questionable species points at the need of molecular studies and taxonomic revisions for the majority of polychaete taxa reported as NIS, in order to clarify their taxonomy, origin, introduction pathways and spreading patterns

A bioinspired humanoid foot mechanism

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This paper introduces an innovative robotic foot design inspired by the functionality and the anatomy of the human foot. Most humanoid robots are characterized by flat, rigid feet with limited mobility, which cannot emulate the physical behavior of the foot-ground interaction. The proposed foot mechanism consists of three main bodies, to represent the heel, plant, and toes, connected by compliant joints for improved balancing and impact absorption. The functional requirements were extracted from medical literature, and were acquired through a motion capture system, and the proposed design was validated with a numerical simulation

Multidisciplinary exploration of the Tendaho Graben geothermal fields

The NW-SE trending Tendaho Graben is the major extensional feature of the Afar, Ethiopia. Rifting and volcanic activity within the graben occurred mostly between 1.8 and 0.6 Ma, but extended to at least 0.2 Ma. Very recent (0.22\u2013 0.03 Ma) activity is focused along the southern part of the younger and active Manda Hararo Rift, which is included in the north-western part of the graben. Extension gave rise to about 1600 m of vertical displacement (verified by drilling) of the basaltic Afar Stratoid sequence, over a crust with a mean thickness of about 23 km. The infill of graben, overlying the Stratoids, consists of volcanic and sedimentary deposits that have been drilled by six exploratory wells. Within the graben, two main geothermal fields have been explored by intensive geological, geochemical and geo- physical surveys over an area that approximately covers a square sector of 40x40 km. Both new and existing data sets have been integrated. The Dubti-Ayrobera system is located along the central axis of the graben. Available data, acquired in the last three decades, comprise more than two thousands gravity and magnetic stations, 229 magnetotelluric stations and structural-geological and geochemical observations. The Alalobeda system is located along the SW flank of the graben, at about 25 km from the Dubti-Ayrobera system and has been very recently stud- ied by means of gravimetric (300 stations), magnetotelluric and TDEM (140 stations) geological and geochemical surveys. The new residual magnetic anomaly map has been used to map the younger normal polarity basalt distribution and infer the location of the unknown main rift axis. The bedrock surface resulting by the 3D inversion of the new residual Bouguer anomaly enlightens the main normal faults hindered by sediments and the secondary structures represented by horsts and grabens. The three-dimensional resistivity models allow mapping the sedimentary infill of the graben, fracture zones in the Afar Stradoids bedrock and the dome-shape structure of the clay cap layer. The 2D and 3D gravimetric, magnetic and resistivity models have been integrated with the structural, geological and geochemical outcomings in order to get an updated conceptual model of the geothermal systems

Mapping Flood-Related Mortality in the Mediterranean Basin. Results from the MEFF v2.0 DB

Recent events in Western Attica in Greece (24 deaths in November 2017), in the Balearic Islands (13 deaths in October 2018), and in southern France (15 deaths in October 2018) show that flood-related mortality remains a major concern in Mediterranean countries facing flash floods. Over the past several years, many initiatives have arisen to create databases on flood-related mortality. An international initiative started in 2011 pooling regional and national databases on flood mortality from region and/or countries bordering the Mediterranean Sea. The MEditerranean Flood Fatality Database (MEFF DB) brings together, in 2018, six Mediterranean regions/countries: Catalonia (Spain), Balearic Islands (Spain), Southern France, Calabria (Italy), Greece, and Turkey, and covers the period 1980-2018. MEFF DB is on progress and, every year, new data are included, but for this study, we kept only the preliminary data that were geolocated and validated on 31st of December 2018. This research introduces a new step in the analysis of flood-related mortality and follows the statistical description of the MEFF DB already published. The goals of this paper are to draw the spatial distribution of flood mortality through a geographical information system (GIS) at different spatial scales: country, NUTS 3 (Nomenclature of Territorial Units for Statistics. Level 3) regions, catchment areas, and grid. A fatality rate (F: number of deaths/year/million of inhabitants) is created to help this analysis. Then, we try to relate mortality to basic (human or physical) drivers such as population density, rainfall seasonality, or rainfall frequency across the Mediterranean Basin. The mapping of F shows a negative mortality gradient between the western and the eastern parts of the Mediterranean Sea. The south of France appears to be the most affected region. The maps also highlight the seasonality of flood-related deaths with the same west-east gradient. It confirms that flood mortality follows the climatological seasonal patterns across the Mediterranean Basin. Flood-related fatalities mainly occur during the early fall season in the western part of the Mediterranean area, while the Easter Basin is affected later, in November or during the winter season. Eastern Turkey introduces another pattern, as mortality is more severe in summer. Mortality maps are then compared with factors that potentially contribute to the occurrence of flood fatalities, such as precipitation intensity (rainfall hazard), to explain geographical differences in the fatality rate. The density of a fatal event is correlated to the population density and the rainfall frequency. Conversely, the average number of deaths per event depends on other factors such as prevention or crisis managemen

Flood Fatalities in Europe, 1980-2018: Variability, Features, and Lessons to Learn

Floods are still a significant threat to people, despite of the considerable developments in forecasting, management, defensive, and rescue works. In the near future, climate and societal changes as both urbanization of flood prone areas and individual dangerous behaviors could increase flood fatalities. This paper analyzes flood mortality in eight countries using a 39-year database (1980-2018) named EUFF (EUropean Flood Fatalities), which was built using documentary sources. The narratives of fatalities were investigated and standardized in the database reporting the details of the events. The entire dataset shows a stable trend on flood fatalities, despite the existence of individual increasing (Greece, Italy, and South France) and decreasing (Turkey and Catalonia) trends. The 2466 fatalities were mainly males, aged between 30-49 years and the majority of them happened outdoor. Most often people were dragged by water/mud when travelling by motor vehicles. Some cases of hazardous behaviors, such as fording rivers, were also detected. The primary cause of death was drowning, followed by heart attack. This work contributes to understand the human-flood interaction that caused fatalities. The changes in society's vulnerability highlighted throughout this study contribute to manage future risks, to improve people protection actions, and to reduce risk behaviors

Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Objective: To investigate whether exposure to inhibitors of gastric acidity, such as H2 blockers or proton pump inhibitors, can independently increase the risk of infections in very low birth weight (VLBW) preterm infants in the neonatal intensive care unit. Study design: This is a secondary analysis of prospectively collected data from a multicenter, randomized controlled trial of bovine lactoferrin (BLF) supplementation (with or without the probiotic Lactobacillus rhamnosus GG) vs placebo in prevention of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in preterm infants. Inhibitors of gastric acidity were used at the recommended dosages/schedules based on the clinical judgment of attending physicians. The distribution of days of inhibitors of gastric acidity exposure between infants with and without LOS/NEC was assessed. The mutually adjusted effects of birth weight, gestational age, duration of inhibitors of gastric acidity treatment, and exposure to BLF were controlled through multivariable logistic regression. Interaction between inhibitors of gastric acidity and BLF was tested; the effects of any day of inhibitors of gastric acidity exposure were then computed for BLF-treated vs -untreated infants. Results: Two hundred thirty-five of 743 infants underwent treatment with inhibitors of gastric acidity, and 86 LOS episodes occurred. After multivariate analysis, exposure to inhibitors of gastric acidity remained significantly and independently associated with LOS (OR, 1.03; 95% CI, 1.008-1.067; P = .01); each day of inhibitors of gastric acidity exposure conferred an additional 3.7% odds of developing LOS. Risk was significant for Gram-negative (P < .001) and fungal (P = .001) pathogens, but not for Gram-positive pathogens (P = .97). On the test for interaction, 1 additional day of exposure to inhibitors of gastric acidity conferred an additional 7.7% risk for LOS (P = .003) in BLF-untreated infants, compared with 1.2% (P = .58) in BLF-treated infants. Conclusion: Exposure to inhibitors of gastric acidity is significantly associated with the occurrence of LOS in preterm VLBW infants. Concomitant administration of BLF counteracts this selective disadvantage. Trial registration: isrctn.org: ISRCTN53107700

Engineering Reconnaissance Following the October 2016 Central Italy Earthquakes - Version 2

Between August and November 2016, three major earthquake events occurred in Central Italy. The first event, with M6.1, took place on 24 August 2016, the second (M5.9) on 26 October, and the third (M6.5) on 30 October 2016. Each event was followed by numerous aftershocks. As shown in Figure 1.1, this earthquake sequence occurred in a gap between two earlier damaging events, the 1997 M6.1 Umbria-Marche earthquake to the north-west and the 2009 M6.1 L’Aquila earthquake to the south-east. This gap had been previously recognized as a zone of elevated risk (GdL INGV sul terremoto di Amatrice, 2016). These events occurred along the spine of the Apennine Mountain range on normal faults and had rake angles ranging from -80 to -100 deg, which corresponds to normal faulting. Each of these events produced substantial damage to local towns and villages. The 24 August event caused massive damages to the following villages: Arquata del Tronto, Accumoli, Amatrice, and Pescara del Tronto. In total, there were 299 fatalities (www.ilgiornale.it), generally from collapses of unreinforced masonry dwellings. The October events caused significant new damage in the villages of Visso, Ussita, and Norcia, although they did not produce fatalities, since the area had largely been evacuated. The NSF-funded Geotechnical Extreme Events Reconnaissance (GEER) association, with co-funding from the B. John Garrick Institute for the Risk Sciences at UCLA and the NSF I/UCRC Center for Unmanned Aircraft Systems (C-UAS) at BYU, mobilized a US-based team to the area in two main phases: (1) following the 24 August event, from early September to early October 2016, and (2) following the October events, between the end of November and the beginning of December 2016. The US team worked in close collaboration with Italian researchers organized under the auspices of the Italian Geotechnical Society, the Italian Center for Seismic Microzonation and its Applications, the Consortium ReLUIS, Centre of Competence of Department of Civil Protection and the DIsaster RECovery Team of Politecnico di Torino. The objective of the Italy-US GEER team was to collect and document perishable data that is essential to advance knowledge of earthquake effects, which ultimately leads to improved procedures for characterization and mitigation of seismic risk. The Italy-US GEER team was multi-disciplinary, with expertise in geology, seismology, geomatics, geotechnical engineering, and structural engineering. The composition of the team was largely the same for the two mobilizations, particularly on the Italian side. Our approach was to combine traditional reconnaissance activities of on-ground recording and mapping of field conditions, with advanced imaging and damage detection routines enabled by state-of-the-art geomatics technology. GEER coordinated its reconnaissance activities with those of the Earthquake Engineering Research Institute (EERI), although the EERI mobilization to the October events was delayed and remains pending as of this writing (April 2017). For the August event reconnaissance, EERI focused on emergency response and recovery, in combination with documenting the effectiveness of public policies related to seismic retrofit. As such, GEER had responsibility for documenting structural damage patterns in addition to geotechnical effects. This report is focused on the reconnaissance activities performed following the October 2016 events. More information about the GEER reconnaissance activities and main findings following the 24 August 2016 event, can be found in GEER (2016). The objective of this document is to provide a summary of our findings, with an emphasis of documentation of data. In general, we do not seek to interpret data, but rather to present it as thoroughly as practical. Moreover, we minimize the presentation of background information already given in GEER (2016), so that the focus is on the effects of the October events. As such, this report and GEER (2016) are inseparable companion documents. Similar to reconnaissance activities following the 24 August 2016 event, the GEER team investigated earthquake effects on slopes, villages, and major infrastructure. Figure 1.2 shows the most strongly affected region and locations described subsequently pertaining to: 1. Surface fault rupture; 2. Recorded ground motions; 3. Landslides and rockfalls; 4. Mud volcanoes; 5. Investigated bridge structures; 6. Villages and hamlets for which mapping of building performance was performed

Efficacy of a new technique - INtubate-RECruit-SURfactant-Extubate - "IN-REC-SUR-E" - in preterm neonates with respiratory distress syndrome: Study protocol for a randomized controlled trial

Background: Although beneficial in clinical practice, the INtubate-SURfactant-Extubate (IN-SUR-E) method is not successful in all preterm neonates with respiratory distress syndrome, with a reported failure rate ranging from 19 to 69&nbsp;%. One of the possible mechanisms responsible for the unsuccessful IN-SUR-E method, requiring subsequent re-intubation and mechanical ventilation, is the inability of the preterm lung to achieve and maintain an "optimal" functional residual capacity. The importance of lung recruitment before surfactant administration has been demonstrated in animal studies showing that recruitment leads to a more homogeneous surfactant distribution within the lungs. Therefore, the aim of this study is to compare the application of a recruitment maneuver using the high-frequency oscillatory ventilation (HFOV) modality just before the surfactant administration followed by rapid extubation (INtubate-RECruit-SURfactant-Extubate: IN-REC-SUR-E) with IN-SUR-E alone in spontaneously breathing preterm infants requiring nasal continuous positive airway pressure (nCPAP) as initial respiratory support and reaching pre-defined CPAP failure criteria. Methods/design: In this study, 206 spontaneously breathing infants born at 24+0-27+6 weeks' gestation and failing nCPAP during the first 24&nbsp;h of life, will be randomized to receive an HFOV recruitment maneuver (IN-REC-SUR-E) or no recruitment maneuver (IN-SUR-E) just prior to surfactant administration followed by prompt extubation. The primary outcome is the need for mechanical ventilation within the first 3&nbsp;days of life. Infants in both groups will be considered to have reached the primary outcome when they are not extubated within 30&nbsp;min after surfactant administration or when they meet the nCPAP failure criteria after extubation. Discussion: From all available data no definitive evidence exists about a positive effect of recruitment before surfactant instillation, but a rationale exists for testing the following hypothesis: a lung recruitment maneuver performed with a step-by-step Continuous Distending Pressure increase during High-Frequency Oscillatory Ventilation (and not with a sustained inflation) could have a positive effects in terms of improved surfactant distribution and consequent its major efficacy in preterm newborns with respiratory distress syndrome. This represents our challenge. Trial registration: ClinicalTrials.gov identifier: NCT02482766. Registered on 1 June 2015