Respiratory tract infection is the major cause of the ambulatory visits in children

<p>Abstract</p> <p>Background</p> <p>As children represent the future, ensuring that they receive proper health care should be a primary concern of our societies. Epidemiological research underpins the importance of effective child health care strategies, and highlights the need for accurate data collection; such surveys are currently lacking in Taiwan. In our descriptive studies, we compared the differences of the ten most common diseases in the year 2000 and 2009 among Taiwanese children.</p> <p>Methods</p> <p>Data for a total of 174,651 and 142,200 visits under eighteen years old were collected from the National Health Insurance Research Database in year 2000 and 2009. A maximum of three outpatient diagnostic codes (the International Classification of Disease [ICD], ninth revision) could be listed for every visit. Data were categorized according to the principal diagnoses, age and different specialties of physicians.</p> <p>Results</p> <p>Respiratory tract infection was the most common disease (58.21% to 44.77%). Teeth (4.90% to 5.16%) and eye (2.52% to 3.15%) problems were the also in the list of top ten diseases. In year 2009, the rate of allergic rhinitis was 2.87% in 7-18 years old group. Pediatricians were the first option for consultation, followed by ear, nose and throat specialists and family physicians. However, for the school age children group, the role of pediatricians with regards to children's health care showed a decrease in its importance.</p> <p>Conclusions</p> <p>The amount of information relevant to child health care is rapidly expanding. The ten most common diseases of the present analysis may serve as baseline data for future evaluations of the changes of type of diseases among children.</p

髄芽腫細胞株ONS-76からの放射線抵抗性クローンの樹立とその癌幹細胞形質の評価

この博士学位論文は学術雑誌掲載論文から構成されていますJournal of Radiation Research, 54(1), 61–69, https://doi.org/10.1093/jrr/rrs078筑波大学 (University of Tsukuba)201

The periodic points of ε-contractive maps in fuzzy metric spaces

[EN] In this paper, we introduce the notion of ε-contractive maps in fuzzy metric space (X, M, ∗) and study the periodicities of ε-contractive maps. We show that if (X, M, ∗) is compact and f : X −→ X is ε-contractive, then P(f) = ∩ ∞n=1f n (X) and each connected component of X contains at most one periodic point of f, where P(f) is the set of periodic points of f. Furthermore, we present two examples to illustrate the applicability of the obtained results.Project supported by NNSF of China (11761011) and NSF of Guangxi (2020GXNSFAA297010) and PYMRBAP for Guangxi CU(2021KY0651)Sun, T.; Han, C.; Su, G.; Qin, B.; Li, L. (2021). The periodic points of ε-contractive maps in fuzzy metric spaces. Applied General Topology. 22(2):311-319. https://doi.org/10.4995/agt.2021.14449OJS311319222M. Abbas, M. Imdad and D. Gopal, ψ-weak contractions in fuzzy metric spaces, Iranian J. Fuzzy Syst. 8 (2011), 141-148.I. Beg, C. Vetro, D, Gopal and M. Imdad, (Φ, ψ)-weak contractions in intuitionistic fuzzy metric spaces, J. Intel. Fuzzy Syst. 26 (2014), 2497-2504. https://doi.org/10.3233/IFS-130920A. George and P. Veeramani, On some results in fuzzy metric spaces, Fuzzy Sets Syst. 64 (1994), 395-399. https://doi.org/10.1016/0165-0114(94)90162-7M. Grabiec, Fixed points in fuzzy metric spaces, Fuzzy Sets Syst. 27 (1989), 385-389. https://doi.org/10.1016/0165-0114(88)90064-4V. Gregori and J. J. Miñana, Some remarks on fuzzy contractive mappings, Fuzzy Sets Syst. 251 (2014), 101-103. https://doi.org/10.1016/j.fss.2014.01.002V. Gregori and J. J. Miñana, On fuzzy $Psi$-contractive sequences and fixed point theorems, Fuzzy Sets Syst. 300 (2016), 93-101. https://doi.org/10.1016/j.fss.2015.12.010V. Gregori and A. Sapena, On fixed-point theorems in fuzzy metric spaces, Fuzzy Sets Syst. 125 (2002), 245-252. https://doi.org/10.1016/S0165-0114(00)00088-9J. Harjani, B. López and K. Sadarangani, Fixed point theorems for cyclic weak contractions in compact metric spaces, J. Nonl. Sci. Appl. 6 (2013), 279-284. https://doi.org/10.22436/jnsa.006.04.05X. Hu, Z. Mo and Y. Zhen, On compactnesses of fuzzy metric spaces (Chinese), J. Sichuan Norm. Univer. (Natur. Sei.) 32 (2009), 184-187.I. Kramosil and J. Michàlek, Fuzzy metrics and statistical metric spaces, Kybernetika 11 (1975), 336-344.D. Mihet, Fuzzy ψ-contractive mappings in non-Archimedean fuzzy metric spaces, Fuzzy Sets Sys. 159 (2008), 739-744. https://doi.org/10.1016/j.fss.2007.07.006D. Mihet, A note on fuzzy contractive mappings in fuzzy metric spaces, Fuzzy Sets Syst. 251 (2014), 83-91. https://doi.org/10.1016/j.fss.2014.04.010B. Schweizer and A. Sklar, Statistical metrics paces, Pacif. J. Math. 10 (1960), 385-389. https://doi.org/10.2140/pjm.1960.10.313Y. Shen, D. Qiu and W. Chen, Fixed point theorems in fuzzy metric spaces, Appl. Math. Letters 25 (2012), 138-141. https://doi.org/10.1016/j.aml.2011.08.002S. Shukla, D. Gopal and A. F. Roldán-López-de-Hierro, Some fixed point theorems in 1-M-complete fuzzy metric-like spaces, Inter. J. General Syst. 45 (2016), 815-829. https://doi.org/10.1080/03081079.2016.1153084S. Shukla, D. Gopal and W. Sintunavarat, A new class of fuzzy contractive mappings and fixed point theorems, Fuzzy Sets Syst. 359 (2018), 85-94. https://doi.org/10.1016/j.fss.2018.02.010D. Wardowski, Fuzzy contractive mappings and fixed points in fuzzy metric spaces, Fuzzy Sets Syst. 222 (2013), 108-114. https://doi.org/10.1016/j.fss.2013.01.012D. Zheng and P. Wang, On probabilistic Ψ-contractions in Menger probabilistic metric spaces, Fuzzy Sets Syst. 350 (2018), 107-110. https://doi.org/10.1016/j.fss.2018.02.011D. Zheng and P. Wang, Meir-Keeler theorems in fuzzy metric spaces, Fuzzy Sets Syst. 370 (2019), 120-128. https://doi.org/10.1016/j.fss.2018.08.01

Silica-supported quinolinium tribromide: a recoverable solid brominating reagent for regioselective monobromination of aromatic amines

Silica-supported quinolinium tribromide was synthesized and found to be an efficient, stable, and recoverable solid brominating reagent for the regioselective monobromination of aromatic amines. This protocol has advantages of high yield, mild condition and simple work-up procedure

The depth and the attracting centre for a continuous map on a fuzzy metric interval

[EN] Let I be a fuzzy metric interval and f be a continuous map from I to I. Denote by R(f), Ω(f) and ω(x, f) the set of recurrent points of f, the set of non-wandering points of f and the set of ω- limit points of x under f, respectively. Write ω(f) = ∪x∈Iω(x, f), ωn+1(f) = ∪x∈ωn(f)ω(x, f) and Ωn+1(f) = Ω(f|Ωn(f)) for any positive integer n. In this paper, we show that Ω2(f) = R(f) and the depth of f is at most 2, and ω3(f) = ω2(f) and the depth of the attracting centre of f is at most 2.Project supported by NNSF of China (11761011, 71862003) and NSF of Guangxi (2018GXNSFAA294010) and SF of Guangxi University of Finance and Economics (2019QNB10).Sun, T.; Li, L.; Su, G.; Han, C.; Xia, G. (2020). The depth and the attracting centre for a continuous map on a fuzzy metric interval. Applied General Topology. 21(2):285-294. https://doi.org/10.4995/agt.2020.13126OJS285294212A. George and P. Veeramani, On some results in fuzzy metric spaces, Fuzzy Sets Sys. 64 (1994), 395-399. https://doi.org/10.1016/0165-0114(94)90162-7M. Grabiec, Fixed points in fuzzy metric spaces, Fuzzy Sets Sys. 27 (1989), 385-389. https://doi.org/10.1016/0165-0114(88)90064-4V. Gregori and J. J. Miñana, Some remarks on fuzzy contractive mappings, Fuzzy Sets Sys. 251 (2014), 101-103. https://doi.org/10.1016/j.fss.2014.01.002V. Gregori and J. J. Miñana, On fuzzy Ψ-contractive sequences and fixed point theorems, Fuzzy Sets Sys. 300 (2016), 93-101. https://doi.org/10.1016/j.fss.2015.12.010V. Gregori and A. Sapena, On fixed-point theorems in fuzzy metric spaces, Fuzzy Sets Sys. 125 (2002), 245-252. https://doi.org/10.1016/S0165-0114(00)00088-9X. Hu, Z. Mo and Y. Zhen, On compactnesses of fuzzy metric spaces (Chinese), J. Sichuan Norm. Univer. (Natur. Sei.) 32 (2009), 184-187.I. Kramosil and J. Michalek, Fuzzy metrics and statistical metric spaces, Kybernetika 11 (1975), 336-344.C. Li and Y. Zhang, On connectedness of the Hausdorff fuzzy metric spaces, Italian J. Pure Appl. Math. 42 (2019), 458-466.D. Mihet, Fuzzy Ψ-contractive mappings in non-Archimedean fuzzy metric spaces, Fuzzy Sets Sys. 159 (2008), 739-744. https://doi.org/10.1016/j.fss.2007.07.006D. Mihet, A note on fuzzy contractive mappings in fuzzy metric spaces, Fuzzy Sets Sys. 251 (2014), 83-91. https://doi.org/10.1016/j.fss.2014.04.010J. Rodríguez-López and S. Romaguera, The Hausdorff fuzzy metric on compact sets, Fuzzy Sets Sys. 147 (2004), 273-283. https://doi.org/10.1016/j.fss.2003.09.007B. Schweizer and A. Sklar, Statistical metrics paces, Pacif. J. Math. 10 (1960), 385-389. https://doi.org/10.2140/pjm.1960.10.313Y. Shen, D. Qiu and W. Chen, Fixed point theorems in fuzzy metric spaces, Appl. Math. Letters 25 (2012), 138-141. https://doi.org/10.1016/j.aml.2011.08.002D. Wardowski, Fuzzy contractive mappings and fixed points in fuzzy metric spaces, Fuzzy Sets Sys. 222 (2013), 108-114. https://doi.org/10.1016/j.fss.2013.01.012D. Zheng and P. Wang, On probabilistic Ψ-contractions in Menger probabilistic metric spaces, Fuzzy Sets Sys. 350 (2018), 107-110. https://doi.org/10.1016/j.fss.2018.02.011D. Zheng and P. Wang, Meir-Keeler theorems in fuzzy metric spaces, Fuzzy Sets Sys. 370 (2019), 120-128. https://doi.org/10.1016/j.fss.2018.08.01

Prevalence of Childhood Allergic Diseases in Central Taiwan over the Past 15 Years

BackgroundThe prevalence of asthma, allergic rhinitis and atopic eczema in children from the developed and developing countries has been increasing.MethodsThree epidemiological surveys of the prevalence of bronchial asthma, allergic rhinitis and atopic eczema in schoolchildren in Taichung, located in central Taiwan, were conducted in 1987, 1994, and 2002. The first questionnaire was used before the International Study of Asthma and Allergies in Childhood (ISAAC) written questionnaire was developed; the last two surveys were modified using ISAAC questionnaires.ResultsA total of 37,801, 75,960, and 11,580 children were studied in 1987, 1994 and 2002, respectively. The prevalence of allergic diseases had increased in the past two decades. Results indicate that the prevalence of bronchial asthma had risen, from 2.19% in 1987, and 3.54% in 1994, to 6.99% in 2002. Regardless of sex, the prevalence of bronchial asthma decreased with increasing age. The prevalence of allergic rhinitis was 5.1% in 1987, 12.46% in 1987, and 27.59% in 2002, and the prevalence of atopic eczema was 1.10% in 1987, 1.88% in 1994, and 3.35% in 2002.ConclusionThere has been a significant increase in the prevalence of bronchial asthma, allergic rhinitis and atopic dermatitis in Taichung schoolchildren from 1987 to 2002

Preliminary Report on Admission Profiles for Children Under 5 Years Old in Taiwan: Disparities between 2000 and 2009

Background/PurposeData on hospital admissions for children under 5 years old, concerning the admission rate, leading diagnoses, categories of disease, average hospitalization days, costs and between-year differences are scarce. Our study aims to investigate such admission profiles.MethodsFive percent of admission data for children under 5 years old in 2000 and 2009 was collected from the National Health Insurance Research Database in Taiwan. We calculated the admission rate in regards to total admission, the patients' gender, the ten leading diagnoses, the ten most systemic common categories of disease, and the average hospitalization days and costs. The differences of the rates between 2000 and 2009 were evaluated by incidence rate ratios (IRR).ResultsThe admission rate per thousand children (population) was higher in 2009 (172.9) than 2000 (153.1). The ten most common systemic categories of disease were similar in both years. Furthermore, it was observed that the hospitalization days decreased by 3.7% in 2009, while medical expenditures increased by 10.9%.ConclusionsEfforts should be made to decrease the admission rate and hospitalization days in Taiwan to the levels of well-developed countries. Our data may serve as baseline data for future evaluations of child morbidity

The cardiorespiratory response and physiological determinants of the assisted 6-minute handbike cycle test in adult males with muscular dystrophy

Introduction: The assisted 6-minute cycle test (A6MCT) distance was assessed in adults with muscular dystrophy (MD). Methods: Forty-eight males, including those with Duchenne MD (DMD), limb-girdle MD (LGMD), fascioscapulohumeral MD (FSHD), and Becker MD (BMD), as well as a group without MD (CTRL), completed handgrip strength (HGS), lung function [forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC)], body fat, and biceps thickness assessments. During the A6MCT, ventilation (VE), oxygen uptake (VO2), carbon dioxide (VCO2), and heart rate (HR) were recorded. Results: A6MCT and HGS were lower in MD than CTRL subjects. FEV1, FVC, and biceps thickness were lower in MD than CTRL; lower in DMD than BMD, LGMD, and FSHD; but were not different between BMD, LGMD, and FSHD. A6MCT correlated with HGS, FEV1, FVC, body fat, VO2, VCO2, HR, and VE (r 5 0.455–0.708) in pooled BMD, LGMD, and FSHD participants. Discussion: A shorter A6MCT distance in adult males with MD was attributable to HGS and lung function. The A6MCT is appropriate for assessment of physical function in adults with MD

Dose-dependent decrease in anti-oxidant capacity of whole blood after irradiation: A novel potential marker for biodosimetry

Many reports have demonstrated that radiation stimulates reactive oxygen species (ROS) production by mitochondria for a few hours to a few days after irradiation. However, these studies were performed using cell lines, and there is a lack of information about redox homeostasis in irradiated animals and humans. Blood redox homeostasis reflects the body condition well and can be used as a diagnostic marker. However, most redox homeostasis studies have focused on plasma or serum, and the anti-oxidant capacity of whole blood has scarcely been investigated. Here, we report changes in the anti-oxidant capacity of whole blood after X-ray irradiation using C57BL/6 J mice. Whole-blood anti-oxidant capacity was measured by electron spin resonance (ESR) spin trapping using a novel spin-trapping agent, 2-diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-oxide (DPhPMPO). We found that whole-blood anti-oxidant capacity decreased in a dose-dependent manner (correlation factor, r > 0.9; P < 0.05) from 2 to 24 days after irradiation with 0.5–3 Gy. We further found that the red blood cell (RBC) glutathione level decreased and lipid peroxidation level increased in a dose-dependent manner from 2 to 6 days after irradiation. These findings suggest that blood redox state may be a useful biomarker for estimating exposure doses during nuclear and/or radiation accidents