1,358 research outputs found
Joint effects of storm surge and sea-level rise on US Coasts: new economic estimates of impacts, adaptation, and benefits of mitigation policy
Recent literature, the US Global Change Research Programâs National Climate Assessment, and recent events, such as Hurricane Sandy, highlight the need to take better account of both storm surge and sea-level rise (SLR) in assessing coastal risks of climate change. This study combines three modelsâa tropical cyclone simulation model; a storm surge model; and a model for economic impact and adaptationâto estimate the joint effects of storm surge and SLR for the US coast through 2100. The model is tested using multiple SLR scenarios, including those incorporating estimates of dynamic ice-sheet melting, two global greenhouse gas (GHG) mitigation policy scenarios, and multiple general circulation model climate sensitivities. The results illustrate that a large area of coastal land and property is at risk of damage from storm surge today; that land area and economic value at risk expands over time as seas rise and as storms become more intense; that adaptation is a cost-effective response to this risk, but residual impacts remain after adaptation measures are in place; that incorporating site-specific episodic storm surge increases national damage estimates by a factor of two relative to SLR-only estimates, with greater impact on the East and Gulf coasts; and that mitigation of GHGs contributes to significant lessening of damages. For a mid-range climate-sensitivity scenario that incorporates dynamic ice sheet melting, the approach yields national estimates of the impacts of storm surge and SLR of ); GHG mitigation policy reduces the impacts of the mid-range climate-sensitivity estimates by 100 billion.United States. Environmental Protection Agency. Climate Change Division (Contract EP-D-09-054)United States. Environmental Protection Agency. Climate Change Division (Contract EP-BPA-12-H-0024
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Why It Is Hard to Find Genes Associated With Social Science Traits: Theoretical and Empirical Considerations
OBJECTIVES:
We explain why traits of interest to behavioral scientists may have a genetic architecture featuring hundreds or thousands of loci with tiny individual effects rather than a few with large effects and why such an architecture makes it difficult to find robust associations between traits and genes.
METHODS:
We conducted a genome-wide association study at 2 sites, Harvard University and Union College, measuring more than 100 physical and behavioral traits with a sample size typical of candidate gene studies. We evaluated predictions that alleles with large effect sizes would be rare and most traits of interest to social science are likely characterized by a lack of strong directional selection. We also carried out a theoretical analysis of the genetic architecture of traits based on R.A. Fisher's geometric model of natural selection and empirical analyses of the effects of selection bias and phenotype measurement stability on the results of genetic association studies.
RESULTS:
Although we replicated several known genetic associations with physical traits, we found only 2 associations with behavioral traits that met the nominal genome-wide significance threshold, indicating that physical and behavioral traits are mainly affected by numerous genes with small effects.
CONCLUSIONS:
The challenge for social science genomics is the likelihood that genes are connected to behavioral variation by lengthy, nonlinear, interactive causal chains, and unraveling these chains requires allying with personal genomics to take advantage of the potential for large sample sizes as well as continuing with traditional epidemiological studies.EconomicsPsycholog
Barium abundance in red giants of NGC 6752. Non-local thermodynamic equilibrium and three-dimensional effects
(Abridged) Aims: We study the effects related to departures from non-local
thermodynamic equilibrium (NLTE) and homogeneity in the atmospheres of red
giant stars in Galactic globular cluster NGC 6752, to assess their influence on
the formation of Ba II lines. Methods: One-dimensional (1D) local thermodynamic
equilibrium (LTE) and 1D NLTE barium abundances were derived using classical 1D
ATLAS stellar model atmospheres. The three-dimensional (3D) LTE abundances were
obtained for 8 red giants on the lower RGB, by adjusting their 1D LTE
abundances using 3D-1D abundance corrections, i.e., the differences between the
abundances obtained from the same spectral line using the 3D hydrodynamical
(CO5BOLD) and classical 1D (LHD) stellar model atmospheres. Results: The mean
1D barium-to-iron abundance ratios derived for 20 giants are _{1D
NLTE} = 0.05 \pm0.06 (stat.) \pm0.08 (sys.). The 3D-1D abundance correction
obtained for 8 giants is small (~+0.05 dex), thus leads to only minor
adjustment when applied to the mean 1D NLTE barium-to-iron abundance ratio for
the 20 giants, _{3D+NLTE} = 0.10 \pm0.06(stat.) \pm0.10(sys.). The
intrinsic abundance spread between the individual cluster stars is small and
can be explained in terms of uncertainties in the abundance determinations.
Conclusions: Deviations from LTE play an important role in the formation of
barium lines in the atmospheres of red giants studied here. The role of 3D
hydrodynamical effects should not be dismissed either, even if the obtained
3D-1D abundance corrections are small. This result is a consequence of subtle
fine-tuning of individual contributions from horizontal temperature
fluctuations and differences between the average temperature profiles in the 3D
and 1D model atmospheres: owing to the comparable size and opposite sign, their
contributions nearly cancel each other.Comment: Minor typos corrected. Accepted for publication in A&A (9 pages, 3
figures, 6 tables
Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses
The original version of this Article contained an error in the title of the paper, where the word âPhylogeneticâ was incorrectly given as âPhylogenticâ. This has now been corrected in the PDF and HTML versions of the Article, and in the accompanying Supplementary Information file
The Chemical Composition and Age of the Metal-Poor Halo Star BD +17^\circ 3248
We have combined new high-resolution spectra obtained with the Hubble Space
Telescope (HST) and ground-based facilities to make a comprehensive new
abundance analysis of the metal-poor, halo star BD +17^\circ 3248. We have
detected the third r-process peak elements osmium, platinum, and (for the first
time in a metal-poor star) gold, elements whose abundances can only be reliably
determined using HST. Our observations illustrate a pattern seen in other
similar halo stars with the abundances of the heavier neutron-capture elements,
including the third r-process peak elements, consistent with a scaled solar
system r-process distribution. The abundances of the lighter neutron-capture
elements, including germanium and silver, fall below that same scaled solar
r-process curve, a result similar to that seen in the ultra-metal-poor star CS
22892--052. A single site with two regimes or sets of conditions, or perhaps
two different sites for the lighter and heavier neutron-capture elements, might
explain the abundance pattern seen in this star. In addition we have derived a
reliable abundance for the radioactive element thorium. We tentatively identify
U II at 3859 A in the spectrum of BD +17^\circ 3248, which makes this the
second detection of uranium in a very metal-poor halo star. Our combined
observations cover the widest range in proton number (from germanium to
uranium) thus far of neutron-capture elements in metal-poor Galactic halo
stars. Employing the thorium and uranium abundances in comparison with each
other and with several stable elements, we determine an average
cosmochronological age for BD +17^\circ 3248 of 13.8 +/- 4 Gyr, consistent with
that found for other similar metal-poor halo stars.Comment: 58 pages, 4 tables, 11 figures; To appear in ApJ Typo correcte
MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite heligmosomoides polygyrus
Helminth parasites remain one of the most common causes of infections worldwide, yet little is still known about the immune signaling pathways that control their expulsion. C57BL/6 mice are chronically susceptible to infection with the gastrointestinal helminth parasite Heligmosomoides polygyrus. In this article, we report that C57BL/6 mice lacking the adapter protein MyD88, which mediates signaling by TLRs and IL-1 family members, showed enhanced immunity to H. polygyrus infection. Alongside increased parasite expulsion, MyD88-deficient mice showed heightened IL-4 and IL-17A production from mesenteric lymph node CD4+ cells. In addition, MyD88-/- mice developed substantial numbers of intestinal granulomas around the site of infection, which were not seen in MyD88-sufficient C57BL/6 mice, nor when signaling through the adapter protein TRIF (TIR domain-containing adapter-inducing IFN-ÎČ adapter protein) was also ablated. Mice deficient solely in TLR2, TLR4, TLR5, or TLR9 did not show enhanced parasite expulsion, suggesting that these TLRs signal redundantly to maintain H. polygyrus susceptibility in wild-type mice. To further investigate signaling pathways that are MyD88 dependent, we infected IL-1R1-/- mice with H. polygyrus. This genotype displayed heightened granuloma numbers compared with wild-type mice, but without increased parasite expulsion. Thus, the IL-1R-MyD88 pathway is implicated in inhibiting granuloma formation; however, protective immunity in MyD88-deficient mice appears to be granuloma independent. Like IL-1R1-/- and MyD88-/- mice, animals lacking signaling through the type 1 IFN receptor (i.e., IFNAR1-/-) also developed intestinal granulomas. Hence, IL-1R1, MyD88, and type 1 IFN receptor signaling may provide pathways to impede granuloma formation in vivo, but additional MyD88-mediated signals are associated with inhibition of protective immunity in susceptible C57BL/6 mice
Bose-Einstein Correlations of Three Charged Pions in Hadronic Z^0 Decays
Bose-Einstein Correlations (BEC) of three identical charged pions were
studied in 4 x 10^6 hadronic Z^0 decays recorded with the OPAL detector at LEP.
The genuine three-pion correlations, corrected for the Coulomb effect, were
separated from the known two-pion correlations by a new subtraction procedure.
A significant genuine three-pion BEC enhancement near threshold was observed
having an emitter source radius of r_3 = 0.580 +/- 0.004 (stat.) +/- 0.029
(syst.) fm and a strength of \lambda_3 = 0.504 +/- 0.010 (stat.) +/- 0.041
(syst.). The Coulomb correction was found to increase the \lambda_3 value by
\~9% and to reduce r_3 by ~6%. The measured \lambda_3 corresponds to a value of
0.707 +/- 0.014 (stat.) +/- 0.078 (syst.) when one takes into account the
three-pion sample purity. A relation between the two-pion and the three-pion
source parameters is discussed.Comment: 19 pages, LaTeX, 5 eps figures included, accepted by Eur. Phys. J.
How Common is Common Human Reason?:The Plurality of Moral Perspectives and Kantâs Ethics
In his practical philosophy, Kant aims to systematize and ground a conception of morality that every human being already in some form is supposedly committed to in virtue of her common human reason. While Kantians especially in the last few years have explicitly acknowledged the central role of common human reason for a correct understanding of Kantâs ethics, there has been very little detailed critical discussion of the very notion of a common human reason as Kant envisages it. Sticker critically discusses in what ways Kant is committed to the notion that there are certain rational insights and rational capacities that all humans share, and thus investigates critically how Kant thinks moral normativity appears to the common human being, the rational agent who did not enjoy special education or philosophical training
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