Optically Coupled Etalons and Methods of Making and Using Same

Optical elements comprise stacked, optically matched and optically coupled etalons, at least one of the optically coupled etalons comprising first and second selectively transparent thin film mirror coatings on opposite surfaces of a bulk optic. The bulk optic defines the cavity spacing of the etalon and may, for example be formed of a monolithic body of silica or other optically transparent glass diced from a glass wafer. The bulk optic may further comprise a wedge coating of progressively increasing thickness overlying the monolithic glass body and compensating for, or offsetting non-parallelism of the bulk optic. The bulk optic may further comprise a thickness-adjustment layer of substantially uniform thickness. The disclosed optical elements optionally comprise other devices optically coupled to the stacked etalons. Novel methods are disclosed for producing the stacked etalons

Satellite Observations of Stratospheric Hydrogen Flouride and Comparisons with SLIMCAT Calculations

The vast majority of emissions of fluorine-containing molecules are anthropogenic in nature, e.g. chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), and hydrofluorocarbons (HFCs). Many of these fluorine-containing species deplete stratospheric ozone and are regulated by the Montreal Protocol. Once in the atmosphere they slowly degrade, ultimately leading to the formation of hydrogen fluoride (HF), the dominant reservoir of stratospheric fluorine due to its extreme stability. Monitoring the growth of stratospheric HF is therefore an important marker for the success of the Montreal Protocol. We report the comparison of global distributions and trends of HF measured in the Earth\u27s atmosphere by the satellite remote-sensing instruments ACE-FTS (Atmospheric Chemistry Experiment Fourier transform spectrometer), which has been recording atmospheric spectra since 2004, and HALOE (HALogen Occultation Experiment), which recorded atmospheric spectra between 1991 and 2005, with the output of SLIMCAT, a state-of-the-art three-dimensional chemical transport model. In general the agreement between observation and model is good, although the ACE-FTS measurements are biased high by  ∼  10 % relative to HALOE. The observed global HF trends reveal a substantial slowing down in the rate of increase of HF since the 1990s: 4.97 ± 0.12 % year−1 (1991–1997; HALOE), 1.12 ± 0.08 % year−1 (1998–2005; HALOE), and 0.52 ± 0.03 % year−1 (2004–2012; ACE-FTS). In comparison, SLIMCAT calculates trends of 4.01, 1.10, and 0.48 % year−1, respectively, for the same periods; the agreement is very good for all but the earlier of the two HALOE periods. Furthermore, the observations reveal variations in the HF trends with latitude and altitude; for example, between 2004 and 2012 HF actually decreased in the Southern Hemisphere below  ∼  35 km. An additional SLIMCAT simulation with repeating meteorology for the year 2000 produces much cleaner trends in HF with minimal variations with latitude and altitude. Therefore, the variations with latitude and altitude in the observed HF trends are due to variability in stratospheric dynamics on the timescale of a few years. Overall, the agreement between observation and model points towards the ongoing success of the Montreal Protocol and the usefulness of HF as a metric for stratospheric fluorine

Assessment of pesticides residues in fish (Tilapia guineensis) in the Couffo River in Djidja (Benin)

In Benin, the main cash crop is the cotton of which the level of production is largely insufficient to satisfy the national and International market. The main food crops (corn, cassava, yam, bean, rice, etc.) permit to cover the food needed globally, but remain again extensively on this side of the potentialities offered by the ecological conditions of the country. In the process to increase the agricultural production, the herbicides, insecticides and the fertilizers are used now in higher quantity that in the past. The aim of this work was to assess the level of contamination of fish (Tilapia guineensis) in the Couffo River in Djidja (Benin) by the pesticides. Nine (09) samples of fish (Tilapia guineensis) have been collected in nine (09) points along the Couffo River. The analysis of these fish has been done by gas chromatography after extraction and purification. In fish, the detected concentrations in average ranged between 0.123 µg/kg and 0.191 µg/kg for the glyphosate, from 0.095 to 0.128 µg/kg for the profenofos, between 0.112 and 0.125 µg/kg for the acetamiprid and 0.127 and 0.139 µg/kg. To assess the risk to public health, pesticides intake by fish consumption was estimated and compared with Estimated Daily Intake (EDI) values reported by the Codex Alimentarius. This comparison showed that fish consumption does not pose a risk for public health

U.S. Physician-Scientist Workforce in the 21st Century: Recommendations to Attract and Sustain the Pipeline

The U.S. physician-scientist (PS) workforce is invaluable to the nation's biomedical research effort. It is through biomedical research that certain diseases have been eliminated, cures for others have been discovered, and medical procedures and therapies that save lives have been developed. Yet, the U.S. PS workforce has both declined and aged over the last several years. The resulting decreased inflow and outflow to the PS pipeline renders the system vulnerable to collapsing suddenly as the senior workforce retires. In November 2015, the Alliance for Academic Internal Medicine hosted a consensus conference on the PS workforce to address issues impacting academic medical schools, with input from early-career PSs based on their individual experiences and concerns. One of the goals of the conference was to identify current impediments in attracting and supporting PSs and to develop a new set of recommendations for sustaining the PS workforce in 2016 and beyond. This Perspective reports on the opportunities and factors identified at the conference and presents five recommendations designed to increase entry into the PS pipeline and nine recommendations designed to decrease attrition from the PS workflow

Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells.

The generation of effective and safe nanoagents for biological applications requires their physicochemical characteristics to be tunable, and their cellular interactions to be well characterized. Here, the controlled synthesis is developed for preparing high-aspect ratio gold nanotubes (AuNTs) with tailorable wall thickness, microstructure, composition, and optical characteristics. The modulation of optical properties generates AuNTs with strong near infrared absorption. Surface modification enhances dispersibility of AuNTs in aqueous media and results in low cytotoxicity. The uptake and trafficking of these AuNTs by primary mesothelioma cells demonstrate their accumulation in a perinuclear distribution where they are confined initially in membrane-bound vesicles from which they ultimately escape to the cytosol. This represents the first study of the cellular interactions of high-aspect ratio 1D metal nanomaterials and will facilitate the rational design of plasmonic nanoconstructs as cytosolic nanoagents for potential diagnosis and therapeutic applications.BLF-Papworth Fellowship from the British Lung Foundation and the Victor Dahdaleh Foundation

MIPAS observations of ozone in the middle atmosphere

This work is distributed under the Creative Commons Attribution 4.0 License.In this paper we describe the stratospheric and mesospheric ozone (version V5r-O3-m22) distributions retrieved from MIPAS observations in the three middle atmosphere modes (MA, NLC, and UA) taken with an unapodized spectral resolution of 0.0625 cm from 2005 until April 2012. O is retrieved from microwindows in the 14.8 and 10 μm spectral regions and requires non-local thermodynamic equilibrium (non-LTE) modelling of the O and vibrational levels. Ozone is reliably retrieved from 20 km in the MA mode (40 km for UA and NLC) up to ∼105 km during dark conditions and up to ∼95 km during illuminated conditions. Daytime MIPAS O has an average vertical resolution of 3-4 km below 70 km, 6-8 km at 70-80 km, 8-10 km at 80-90, and 5-7 km at the secondary maximum (90-100 km). For nighttime conditions, the vertical resolution is similar below 70 km and better in the upper mesosphere and lower thermosphere: 4-6 km at 70-100 km, 4-5 km at the secondary maximum, and 6-8 km at 100-105 km. The noise error for daytime conditions is typically smaller than 2% below 50 km, 2-10% between 50 and 70 km, 10-20% at 70-90 km, and ∼30% above 95 km. For nighttime, the noise errors are very similar below around 70 km but significantly smaller above, being 10-20% at 75-95 km, 20-30% at 95-100 km, and larger than 30% above 100 km. The additional major O errors are the spectroscopic data uncertainties below 50 km (10-12 %) and the non-LTE and temperature errors above 70 km. The validation performed suggests that the spectroscopic errors below 50 km, mainly caused by the O air-broadened half-widths of the band, are overestimated. The non-LTE error (including the uncertainty of atomic oxygen in nighttime) is relevant only above ∼85 km with values of 15-20 %. The temperature error varies from ∼3% up to 80 km to 15-20% near 100 km. Between 50 and 70 km, the pointing and spectroscopic errors are the dominant uncertainties. The validation performed in comparisons with SABER, GOMOS, MLS, SMILES, and ACE-FTS shows that MIPAS O has an accuracy better than 5% at and below 50 km, with a positive bias of a few percent. In the 50-75 km region, MIPAS O has a positive bias of ∼10 %, which is possibly caused in part by O spectroscopic errors in the 10 μm region. Between 75 and 90 km, MIPAS nighttime O is in agreement with other instruments by 10 %, but for daytime the agreement is slightly larger, ∼10-20 %. Above 90 km, MIPAS daytime O is in agreement with other instruments by 10 %. At night, however, it shows a positive bias increasing from 10% at 90 km to 20% at 95-100 km, the latter of which is attributed to the large atomic oxygen abundance used. We also present MIPAS O distributions as function of altitude, latitude, and time, showing the major O features in the middle and upper mesosphere. In addition to the rapid diurnal variation due to photochemistry, the data also show apparent signatures of the diurnal migrating tide during both day-and nighttime, as well as the effects of the semi-Annual oscillation above ∼70 km in the tropics and mid-latitudes. The tropical. daytime O at 90 km shows a solar signature in phase with the solar cycle. © Author(s) 2018.The IAA team was supported by the Spanish MICINN under the project ESP2014-54362-P and EC FEDER funds. The IAA and IMK teams were partially supported by ESA O3-CCI and MesosphEO projects. Maya Garcia-Comas was financially supported by MINECO through its >Ramon y Cajal> subprogram. Funding for the Atmospheric Chemistry Experiment comes primarily from the Canadian Space Agency. Work at the Jet Propulsion Laboratory was performed under contract with the National Aeronautics and Space Administration