Futsal in Field with Variable Dimensions

This study aims to verify how the variation of game area in futsal game alters the requirement for each athlete. It is an empirical study with transversal characteristics. The sample consisted of six young, male, aged between 16 and 26 years, with experience playing futsal. The independent variable was the square footage of the field per athlete. The dependent variables were the number of contacts with the ball, passing, dribbling/feints, shooting and ball stolen and the number of errors passing, dribbling/feints and shooting and total goals scored. Games were conducted with two teams in 3x3 format players with open goals. The goal was valid if they shots were after the half court. The procedures follow the criterion of game space simulation in accordance with the minimum and maximum of futsal rules in sizes from 80m2, 45m2 and 25m2 for each player dimensions. Whereas the 6 subjects, the games had spaces of 30mx16m, 24mx11m and 17.5mx8.5m respectively, totaling 480m2, 265m2 and 148.7m2. A team made more passes than other by possession. Game actions should always be relativised to have summed and actual results of what happened. The biggest field was no decrease in the shots errors. The percentage of time played was higher in the biggest field, which is more interesting for the fans and the press

Autoinflammatory syndromes: diagnosis and management

During the last decades the description of autoinflammatory syndromes induced great interest among the scientific community. Mainly rheumatologists, immunologists and pediatricians are involved in the discovery of etiopathogenesis of these syndromes and in the recognition of affected patients. In this paper we will discuss the most important clues of monogenic and non-genetic inflammatory syndromes to help pediatricians in the diagnosis and treatment of these diseases

Ontosemiotic Approach to Cognition and Mathematical Instruction: continuing education in master's and doctoral productions in Brazil (2016-2020)

Objetiva-se, neste artigo, a partir da Teoria da Abordagem Ontossemiótica da Cognição e Instrução Matemática, compreender os elementos presentes na formação continuada de professores que ensinam matemática nos anos iniciais, a partir de um estudo das dissertações e teses brasileiras produzidas entre 2016 e 2020. Justifica-se este estudo, pois a Abordagem Ontossemiótica trata-se de uma teoria recente no campo da Educação Matemática que tem mostrado um uso crescente em cursos de formação de professores no Brasil. A perspectiva metodológica de análise dos dados abordada é a qualitativa, pautada na Análise Textual Discursiva. Os resultados mostram que a formação continuada de professores de matemática, em conjunto com as ferramentas da Abordagem Ontossemiótica, desperta reflexões sobre a prática docente e a mudança da mesma, mobilizando conhecimentos para melhor desenvolvimento de posturas críticas e reflexivas dos professores nos processos de ensino e aprendizagem da matemática

Efeitos fisiológicos e hormonais do treinamento concorrente na diminuição da sarcopenia em idosos – uma revisão de literatura

Introduction: Sarcopenia is characterized by a gradual decrease in muscle mass by aging, altering musculoskeletal functionality and physical performance related to human movement. In addition, other disorders are identified: increased oxidative stress and intramuscular adipocytes, decreased protein synthesis, systemic changes and neuromuscular integrity. The incidence in Brazil varies from 5 to 32% and this disease is classified as mild, moderate and severe. Our objective was to identify the physiological and hormonal effects of concurrent training in these elderly and to verify the effectiveness of this training. Methods: All processes carried out followed the principles of the Research Ethics Committee of FHO for bibliographic review research, registered under the number 047/2018 and were developed based on studies found in the platforms Scielo, PubMed and Google Scholar, using the following nomenclatures: "sarcopenia", "elderly" and "concurrent training", "physiological effects" and "hormones" and then selecting only studies relevant to the research theme. Development: Physical training is essential and acts as an adjunct or primary element in the treatment of sarcopenia, depending on whether there is pharmacological intervention or not. One of the methodologies of physical training used in this population is concurrent training - the combination of resistance exercises and aerobic exercises, dynamic and interval, promoting several positive physiological adaptations for this public. Conclusion: Concurrent training is positive in combating sarcopenia and its causes, allowing the patient a collection of morphological, physiological and hormonal benefits that will allow increased quality of life and social self-esteem.Introdução: A sarcopenia caracteriza-se pela diminuição gradativa de massa muscular pelo envelhecimento, alterando a funcionalidade musculoesquelética e desempenho físico relacionado ao movimento humano. Ademais, outros distúrbios são identificados: aumento do estresse oxidativo e adipócitos intramusculares, diminuição na síntese proteica, alterações sistêmicas e na integridade neuromuscular. A incidência no Brasil varia de 5 a 32% e essa doença se classifica em leve, moderada e severa. Objetivo: Nosso objetivo foi identificar os efeitos fisiológicos e hormonais advindos do treinamento concorrente nestes idosos e verificar a efetividade desse treinamento. Métodos: Todos os processos realizados acataram os princípios do Comitê de Ética em Pesquisa da FHO para pesquisa de revisão bibliográfica, inscrito sob o número CEP 047/2018 e foram desenvolvidos baseados em estudos encontrados nas plataformas Scielo, PubMed e Google Acadêmico, utilizando as seguintes nomenclaturas: “sarcopenia”, “idosos” e “treinamento concorrente”, “efeitos fisiológicos” e “hormônios” e depois selecionando apenas os estudos pertinentes ao tema da pesquisa. Desenvolvimento: O treinamento físico é essencial e atua como elemento coadjuvante ou principal no tratamento da sarcopenia, dependendo se há intervenção farmacológica ou não. Uma das metodologias de treinamento físico utilizadas nessa população é o treinamento concorrente – junção de exercícios resistidos e exercícios aeróbios, de caráter dinâmico e intervalado, promovendo várias adaptações fisiológicas positivas para este público. Conclusão: O treinamento concorrente é positivo no combate da sarcopenia e suas causas, possibilitando ao paciente um acervo de benefícios morfológicos, fisiológicos e hormonais que permitirão aumento da qualidade de vida e autoestima social

A case of porto-sinusoidal vascular disease

Introduction: Porto-sinusoidal vascular syndrome is characterised by specific histological changes that do not include cirrhosis, with or without portal hypertension. Patients are usually asymptomatic until development of portal hypertension complications. Case description: A 69-year-old female with history of JAK2 positive essential thrombocythemia (ET) was referred to internal medicine consultation due to elevated liver enzymes. The patient had no previous history of liver disease. Seven months earlier, she had an ischaemic stroke and started treatment with atorvastatin. After discontinuing medication, liver enzymes returned to normal and atorvastatin-related drug-induced liver disease (DILI) was presumed. During a follow-up visit, iron deficiency anaemia was detected and an endoscopic study was performed. It revealed a gastric varix actively bleeding, which was successfully treated with cyanoacrylate. Two months later, the patient was admitted due to a new episode of variceal bleeding, and a portal hypertension complementary study was made. Discussion: Although the pathogenesis of porto-sinusoidal vascular disease (PSVD) remains poorly understood, vascular changes within the liver have been associated with several predisposing conditions, such as hypercoagulable states. Patients with ET, especially those with JAK2 mutation, are known to be at increased risk of non-cirrhotic vein thrombosis. Concerning PSVD, the association is not clear but it is believed that both PSVD and myeloproliferative neoplasms share a common denominator: a state characterised by hypercoagulability, inflammation, endothelial dysfunction and, in some cases, portal hypertension. Conclusion: Portal hypertension without cirrhosis is a rare condition, presenting diagnostic challenges and significant impact on the patient’s prognosis

The Case for Community Self-Governance on Access and Benefit Sharing of Digital Sequence Information

Digital sequence information (DSI),  a placeholder term commonly understood to refer to information related to genetic sequences stored in a digital format, has become a foundational component to biological research and its applications, including biodiversity conservation and biotechnological innovation. DSI results from the physical access to and use of genetic resources, which falls under the purview of the Convention on Biological Diversity (CBD) and the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization (NP). The CBD and the NP are legal frameworks governing access to genetic resources and the fair and equitable sharing of benefits arising from their use, a mechanism widely known as access and benefit sharing (ABS). Despite good intentions, a number of national regimes adopted in pursuance of the CBD and NP have created complex, ineffective frameworks that exacerbate the risk of counterproductive effects for biodiversity conservation and sustainable use. The debate on DSI focuses on what DSI includes, whether it is covered by the CBD or the NP and the possible implications of its inclusion or exclusion from these agreements. The CBD and NP parties agreed on a science- and policy-based process to debate the treatment of DSI. This process entailed the submission of views and information by parties, other governments, indigenous and local communities, and relevant organizations and stakeholders; the commissioning of technical studies; and the establishment of the Ad Hoc Technical Expert Group (AHTEG) on DSI. In the present article, we propose recommendations that can contribute to the upcoming discussion on DSI.Fil: Adler Miserendino, Rebecca A. Lewis Burke Associates; Estados UnidosFil: Meyer, Rachel Sarah. University of California; Estados UnidosFil: Zimkus, Breda M. Harvard University; Estados UnidosFil: Bates, John. Field Museum of National History; Estados UnidosFil: Silvestri, Luciana Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; ArgentinaFil: Taylor, Crispin. American Society Of Plant Biologists ; Estados UnidosFil: Blumenfield, Tami. University of New Mexico; Estados Unidos. Yunnan University; ChinaFil: Srigyan, Megha. University of California; Estados UnidosFil: Pandey, Jyotsna L. American Institute Of Biological Sciences; Estados Unido

Quality of life as a prognostic marker in pulmonary arterial hypertension

Background: Improvement in quality of life together with better survival are the ultimate goals in the treatment of pulmonary arterial hypertension (PAH) patients. the objective of this study was to evaluate the health-related quality of life (HRQL) of pulmonary arterial hypertension (PAH) patients with the SF-36 generic questionnaire and to identify the prognostic implication of this assessment.Methods: Fifty-four consecutive newly diagnosed PAH patients (WHO classification group I) in a single PAH reference center were included. Patients were evaluated at baseline for clinical and hemodynamic parameters, and they subsequently received first-line therapy with either an endothelin receptor antagonist or a phosphodiesterase-5 inhibitor. After 16 weeks of specific PAH therapy, all patients were re-evaluated using a 6MWT and a SF 36 questionnaire, and then they were followed up for at least 36 months.Results: After treatment, the patients demonstrated an improved 6MWT (414 +/- 124 m vs. 440 +/- 113 m, p = 0.001). Specific PAH therapy also improved the HRQL scores.Patients with a baseline Physical Component Score (PCS) higher than 32 had a better survival rate than those who had a score under 32 (p = 0.04). Similarly, patients with a PCS of at least a 38 after the 16 week therapy period had a better survival rate when compared with those who did not achieve this value (p = 0.016). Unlike the absolute PCS values, the post-treatment PCS variability was unable to predict better survival rates (p = 0.58).Conclusions: Our findings suggest that HRQL is associated with prognosis in PAH. Furthermore, achieving pre-determined PCS scores might represent a specific goal to be reached in treatment-to-target strategies.Univ São Paulo, Sch Med, Pulm Dept, Inst Heart, BR-05403000 São Paulo, BrazilUniversidade Federal de São Paulo, Rheumatol Dept, São Paulo, BrazilUniversidade Federal de São Paulo, Rheumatol Dept, São Paulo, BrazilWeb of Scienc

Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis

To describe the 6-year safety and efficacy of etanercept (ETN) in children with extended oligoarticular juvenile idiopathic arthritis (eoJIA), enthesitis-related arthritis (ERA), and psoriatic arthritis (PsA) METHODS: Patients who completed the 2-year, open-label, phase III CLinical Study In Pediatric Patients of Etanercept for Treatment of ERA, PsA, and Extended Oligoarthritis (CLIPPER) were allowed to enroll in its 8-year long-term extension (CLIPPER2). Children received ETN at a once-weekly dose of 0.8 mg/kg, up to a maximum dose of 50 mg/week. Efficacy assessments included the JIA core set of outcomes, the JIA American College of Rheumatology response criteria (JIA-ACR), and the Juvenile Arthritis Disease Activity Score (JADAS). Efficacy data are reported as responder analyses using a hybrid method for missing data imputation and as observed cases. Safety assessments included treatment-emergent adverse events (TEAEs).Out of 127 patients originally enrolled in CLIPPER, 109 (86%) entered CLIPPER2. After 6 years of trial participation (2 years in CLIPPER and 4 years in CLIPPER2), 41 (32%) patients were still taking ETN, 13 (11%) entered the treatment withdrawal phase after achieving low/inactive disease (of whom 7 had to restart ETN), 36 (28%) discontinued treatment for other reasons but are still being observed, and 37 (29%) discontinued treatment permanently. According to the hybrid imputation analysis, proportions of patients achieving JIA ACR90, JIA ACR100, and JADAS inactive disease after the initial 2 years of treatment were 58%, 48%, and 32%, respectively. After the additional 4 years, those proportions in patients who remained in the trial were 46%, 35%, and 24%. Most frequently reported TEAEs [n (%), events per 100 patient-years] were headache [28 (22%), 5.3], arthralgia [24 (19%), 4.6], and pyrexia [20 (16%), 3.8]. Number and frequency of TEAEs, excluding infections and injection site reactions, decreased over the 6-year period from 193 and 173.8, respectively, during year 1 to 37 and 61.3 during year 6. A single case of malignancy (Hodgkin's lymphoma) and no cases of active tuberculosis, demyelinating disorders, or deaths were reported.Open-label etanercept treatment for up to 6 years was safe, well tolerated, and effective in patients with eoJIA, ERA, and PsA.ClinicalTrials.gov: CLIPPER, NCT00962741 , registered 20 August, 2009, CLIPPER2, NCT01421069 , registered 22 August, 2011