Percepção da população acerca das soluções propostas pelo Estado para conflitos socioambientais de minas subterrâneas de carvão em Criciúma - SC

Conflicts are inherent to the human being and when they involve environmental issues multiple stakeholders with conflicting but legitimate interests are involved. This article sought to answer: What is the perception of surface owners as to the actions taken by the state in mediating conflicts of negotiations related to environmental damage caused by surface subsidence of old coal mines? The methodological procedures adopted to answer this question involved bibliographical and documentary research and interviews with actors directly or indirectly involved in the conflicts. Today's conflicts stem from the subsidence of underground mines due to the expansion of the city on the mined areas in the past. As buildings and streets spreaded over the land surface, collapses of old mines started occcurring, opposing the interests of landowners and companies holding mining rights, this way generating conflicts. In conclusion, it was observed that, depending on the interests at stake and the bargaining power of the actors, these conflicts have been resolved via lawsuits in  the courts or through negotiation between the two major parties involved. Os conflitos são inerentes ao ser humano e quando envolvem questões socioambientais apresentam múltiplos atores geralmente com interesses contrapostos, porém legítimos. Este artigo buscou responder: qual a percepção dos superficiários quanto às ações desenvolvidas pelo Estado na intermediação de negociações de conflitos relacionados aos danos ambientais causados em superfície por subsidência de minas antigas de carvão? Os procedimentos metodológicos adotados para responder essa questão envolveram pesquisa bibliográfica e documental e entrevistas com atores direta ou indiretamente envolvidos nos conflitos. Os conflitos atuais decorrem da subsidência de minas subterrâneas devido à expansão da cidade sobre as áreas lavradas no passado. Com o aumento das construções e arruamentos em superfície ocorre o afundamento das minas antigas contrapondo os interesses das empresas detentoras dos direitos minerários e dos superficiários gerando conflitos. Como conclusão, observou-se que, dependendo dos interesses em jogo e do poder de barganha dos atores, esses conflitos têm sido resolvidos pela via judicial ou por meio de negociação entre as duas partes principais envolvidas

Riesgo de hipertensión arterial en población adulta en Matamoros, Tamaulipas, México

RESUMEN Objetivo: conocer el riesgo de hipertensión en la población adulta de la ciudad de Matamoros, Tamaulipas. Método: el diseño fue de tipo descriptivo y transversal, una muestra de 1004 adultos. Se utilizó una cedula de datos sociodemográficos, donde se realizaron 3 mediciones de la presión arterial, de acuerdo a la Norma Oficial Mexicana NOM-030-SSA2-2009. Resultados: El género estuvo conformado del 38.7% de hombres y 61.3% de mujeres. Se observó una prevalencia de hipertensión arterial en 8.6% de la población. Fue mayor en el género masculino con 12.3% que el femenino de 6.3%. El grupo de 60 y más años (14.1%) presenta mayor prevalencia de hipertensión, seguido de 50 a 59 (13.8%) y finalmente el de 40 a 49 con 11.7%. El riesgo de hipertensión es de 87 (8,7%) de la muestra total; la alta presión arterial sistólica con 52 (5,1%), y alta presión arterial diastólica con 56 (5,5%) también deben ser consideradas hipertensión. Cuando se analizan en conjunto, los tres criterios de inclusión para hipertensión arterial suman el 19,4% de riesgo. Conclusión: el riesgo de hipertensión arterial en población adulta está latente, la prevalencia se ubica dentro de la más alta a nivel mundial. ABSTRACT Objective: To know the risk of hypertension in the adult population of the city of Matamoros, Tamaulipas. Method: The design was descriptive and transversal in a sample of 1004 adults. A sociodemographic data questionnaire was used and three blood pressure measurements were performed according to the Official Mexican Standard NOM-030-SSA2-2009. Results: The gender was made up of 38.7% of men and 61,3% of women. A prevalence of hypertension was observed in 8.6% of the population. It was greater in the masculine gender with 12.3% than the feminine one of 6.3%. The group of 60 and over (14.1%) had a higher prevalence of hypertension, followed by 50 to 59 (13.8%) and finally the group of 40 to 49 with 11.7%. The risk of hypertension is 87 (8.7%) of the total sample; high systolic blood pressure with 52 (5.1%), and high diastolic blood pressure with 56 (5.5%) should also be considered hypertension. When analyzed together, the three inclusion criteria for hypertension add up to a 19.4% risk. Conclusion: the risk of hypertension in the adult population is latent, the prevalence is among the highest in the world

Adicción y factores determinantes en el uso problemático del Internet, en una muestra de jóvenes universitarios

El estudio tiene como objetivo conocer la probabilidad de presentar adicción y los factores determinantes sobre el uso problemático del internet en estudiantes universitarios en la ciudad de H. Matamoros, Tamaulipas. Metodología: La población fue de 1,125 estudiantes y una muestra de 323, en una universidad pública, el instrumento utilizado fue el “Cuestionario de Uso Problemático de Internet” (CUPI) con un Alfa de Cronbach de 0.966, el diseño de estudio fue descriptivo, transversal. Resultados: se encontró que el factor de determinante “Anticipación” fue el que presento una mayor probabilidad de presentarse, y los de menor fueron “Pérdida de Control” y  “Reconocimiento de Falta de Control.

Client applications and Server Side docker for management of RNASeq and/or VariantSeq workflows and pipelines of the GPRO Suite

The GPRO suite is an in-progress bioinformatic project for -omic data analyses. As part of the continued growth of this project, we introduce a client side & server side solution for comparative transcriptomics and analysis of variants. The client side consists of two Java applications called "RNASeq" and "VariantSeq" to manage workflows for RNA-seq and Variant-seq analysis, respectively, based on the most common command line interface tools for each topic. Both applications are coupled with a Linux server infrastructure (named GPRO Server Side) that hosts all dependencies of each application (scripts, databases, and command line interface tools). Implementation of the server side requires a Linux operating system, PHP, SQL, Python, bash scripting, and third-party software. The GPRO Server Side can be deployed via a Docker container that can be installed in the user's PC using any operating system or on remote servers as a cloud solution. The two applications are available as desktop and cloud applications and provide two execution modes: a Step-by-Step mode enables each step of a workflow to be executed independently and a Pipeline mode allows all steps to be run sequentially. The two applications also feature an experimental support system called GENIE that consists of a virtual chatbot/assistant and a pipeline jobs panel coupled with an expert system. The chatbot can troubleshoot issues with the usage of each tool, the pipeline job panel provides information about the status of each task executed in the GPRO Server Side, and the expert provides the user with a potential recommendation to identify or fix failed analyses. The two applications and the GPRO Server Side combine the user-friendliness and security of client software with the efficiency of front-end & back-end solutions to manage command line interface software for RNA-seq and variant-seq analysis via interface environments

Client Applications and Server-Side Docker for Management of RNASeq and/or VariantSeq Workflows and Pipelines of the GPRO Suite

The GPRO suite is an in-progress bioinformatic project for -omics data analysis. As part of the continued growth of this project, we introduce a client- and server-side solution for comparative transcriptomics and analysis of variants. The client-side consists of two Java applications called 'RNASeq' and 'VariantSeq' to manage pipelines and workflows based on the most common command line interface tools for RNA-seq and Variant-seq analysis, respectively. As such, 'RNASeq' and 'VariantSeq' are coupled with a Linux server infrastructure (named GPRO Server-Side) that hosts all dependencies of each application (scripts, databases, and command line interface software). Implementation of the Server-Side requires a Linux operating system, PHP, SQL, Python, bash scripting, and third-party software. The GPRO Server-Side can be installed, via a Docker container, in the user's PC under any operating system or on remote servers, as a cloud solution. 'RNASeq' and 'VariantSeq' are both available as desktop (RCP compilation) and web (RAP compilation) applications. Each application has two execution modes: a step-by-step mode enables each step of the workflow to be executed independently, and a pipeline mode allows all steps to be run sequentially. 'RNASeq' and 'VariantSeq' also feature an experimental, online support system called GENIE that consists of a virtual (chatbot) assistant and a pipeline jobs panel coupled with an expert system. The chatbot can troubleshoot issues with the usage of each tool, the pipeline jobs panel provides information about the status of each computational job executed in the GPRO Server-Side, while the expert system provides the user with a potential recommendation to identify or fix failed analyses. Our solution is a ready-to-use topic specific platform that combines the user-friendliness, robustness, and security of desktop software, with the efficiency of cloud/web applications to manage pipelines and workflows based on command line interface software

Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study

Objectives: We describe the current epidemiology, causes, and outcomes of breakthrough invasive fungal infections (BtIFI) in patients with haematologic malignancies.Methods: BtIFI in patients with & GE; 7 days of prior antifungals were prospectively diagnosed (36 months across 13 Spanish hospitals) according to revised EORTC/MSG definitions.Results: 121 episodes of BtIFI were documented, of which 41 (33.9%) were proven; 53 (43.8%), probable; and 27 (22.3%), possible. The most frequent prior antifungals included posaconazole (32.2%), echinocandins (28.9%) and fluconazole (24.8%)-mainly for primary prophylaxis (81%). The most common haematologic malignancy was acute leukaemia (64.5%), and 59 (48.8%) patients had undergone a hematopoietic stem-cell transplantation. Invasive aspergillosis, principally caused by non-fumigatus Aspergillus, was the most fre-quent BtIFI with 55 (45.5%) episodes recorded, followed by candidemia (23, 19%), mucormycosis (7, 5.8%), other moulds (6, 5%) and other yeasts (5, 4.1%). Azole resistance/non-susceptibility was commonly found. Prior antifungal therapy widely determined BtIFI epidemiology. The most common cause of BtIFI in proven and probable cases was the lack of activity of the prior antifungal (63, 67.0%). At diagnosis, antifungal therapy was mostly changed (90.9%), mainly to liposomal amphotericin-B (48.8%). Overall, 10 0-day mor-tality was 47.1%; BtIFI was either the cause or an essential contributing factor to death in 61.4% of cases.Conclusions: BtIFI are mainly caused by non-fumigatus Aspergillus, non-albicans Candida, Mucorales and other rare species of mould and yeast. Prior antifungals determine the epidemiology of BtIFI. The exceed-ingly high mortality due to BtIFI warrants an aggressive diagnostic approach and early initiation of broad-spectrum antifungals different than those previously used.& COPY; 2023 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Propuesta de mejora del Sistema Interno de Garantía de Calidad de la Facultad de Medicina

La garantía de calidad en el ámbito universitario puede considerarse como la atención sistemática, estructurada y continua a las titulaciones ofertadas. La garantía de calidad se compromete a poner en marcha los medios que aseguren y demuestren la calidad de los programas formativos que se desarrollan en cada una de las titulaciones ofrecidas por la Universidad y así cumplir con la obligación que tiene con la sociedad. El presente proyecto nace como fruto de la responsabilidad adquirida para el cumplimiento de las funciones encomendadas y, con el objetivo de seguir adoptando una estrategia de mejora continua de la calidad de la docencia y satisfacción de los colectivos implicados en el proceso de enseñanza-aprendizaje (Profesorado, Estudiantes y PAS)

Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic reviewof the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE,CINAHL,SCOPUS,BIOSIS, andWeb of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review.Atotal of 44 globally representativegroupmembersmet in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin