Percepção da população acerca das soluções propostas pelo Estado para conflitos socioambientais de minas subterrâneas de carvão em Criciúma - SC

Conflicts are inherent to the human being and when they involve environmental issues multiple stakeholders with conflicting but legitimate interests are involved. This article sought to answer: What is the perception of surface owners as to the actions taken by the state in mediating conflicts of negotiations related to environmental damage caused by surface subsidence of old coal mines? The methodological procedures adopted to answer this question involved bibliographical and documentary research and interviews with actors directly or indirectly involved in the conflicts. Today's conflicts stem from the subsidence of underground mines due to the expansion of the city on the mined areas in the past. As buildings and streets spreaded over the land surface, collapses of old mines started occcurring, opposing the interests of landowners and companies holding mining rights, this way generating conflicts. In conclusion, it was observed that, depending on the interests at stake and the bargaining power of the actors, these conflicts have been resolved via lawsuits in  the courts or through negotiation between the two major parties involved. Os conflitos são inerentes ao ser humano e quando envolvem questões socioambientais apresentam múltiplos atores geralmente com interesses contrapostos, porém legítimos. Este artigo buscou responder: qual a percepção dos superficiários quanto às ações desenvolvidas pelo Estado na intermediação de negociações de conflitos relacionados aos danos ambientais causados em superfície por subsidência de minas antigas de carvão? Os procedimentos metodológicos adotados para responder essa questão envolveram pesquisa bibliográfica e documental e entrevistas com atores direta ou indiretamente envolvidos nos conflitos. Os conflitos atuais decorrem da subsidência de minas subterrâneas devido à expansão da cidade sobre as áreas lavradas no passado. Com o aumento das construções e arruamentos em superfície ocorre o afundamento das minas antigas contrapondo os interesses das empresas detentoras dos direitos minerários e dos superficiários gerando conflitos. Como conclusão, observou-se que, dependendo dos interesses em jogo e do poder de barganha dos atores, esses conflitos têm sido resolvidos pela via judicial ou por meio de negociação entre as duas partes principais envolvidas

Luminescent Carbon Nanodots Doped with Gadolinium (III): Purification Criteria, Chemical and Biological Characterization of a New Dual Fluorescence/MR Imaging Agent

Carbon Dots (CDs) are luminescent quasi-spherical nanoparticles, possessing water solubility, high biocompatibility, and tunable chemical and physical properties for a wide range of applications, including nanomedicine and theranostics. The evaluation of new purification criteria, useful to achieve more reliable CDs, free from the interference of artifacts, is currently an object of debate in the field. Here, new CDs doped with gadolinium (Gd (III)), named Gd@CNDs, are presented as multifunctional probes for Magnetic Resonance Imaging (MRI). This new system is a case of study, to evaluate and/or combine different purification strategies, as a crucial approach to generate CDs with a better performance. Indeed, these new amorphous Gd@CNDs display good homogeneity, and they are free from emissive side products. Gd@CNDs (7-10 nm) contain 7% of Gd (III) w/w, display suitable and stable longitudinal relaxivity (r(1)) and with emissive behavior, therefore potentially useful for both MR and fluorescence imaging. They show good biocompatibility in both cellular and in vivo studies, cell permeability, and the ability to generate contrast in cellular pellets. Finally, MRI recording T-1-weighted images on mice after intravenous injection of Gd@CNDs, show signal enhancement in the liver, spleen, and kidney 30 min postinjection

BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress

Peritoneal dialysis (PD) is a current replacement therapy for end-stage kidney diseases (ESKDs). However, long-term exposure to PD fluids may lead to damage of the peritoneal membrane (PM) through mechanisms involving the activation of the inflammatory response and mesothelial-to-mesenchymal transition (MMT), leading to filtration failure. Peritoneal damage depends on a complex interaction among external stimuli, intrinsic properties of the PM, and subsequent activities of the local innate–adaptive immune system. Epigenetic drugs targeting bromodomain and extra-terminal domain (BET) proteins have shown beneficial effects on different experimental preclinical diseases, mainly by inhibiting proliferative and inflammatory responses. However the effect of BET inhibition on peritoneal damage has not been studied. To this aim, we have evaluated the effects of treatment with the BET inhibitor JQ1 in a mouse model of peritoneal damage induced by chlorhexidine gluconate (CHX). We found that JQ1 ameliorated the CHX-induced PM thickness and inflammatory cell infiltration. Moreover, JQ1 decreased gene overexpression of proinflammatory and profibrotic markers, together with an inhibition of the nuclear factor-κB (NF-κB) pathway. Additionally, JQ1 blocked the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and restored changes in the mRNA expression levels of NADPH oxidases (NOX1 and NOX4) and NRF2/target antioxidant response genes. To corroborate the in vivo findings, we evaluated the effects of the BET inhibitor JQ1 on PD patients’ effluent-derived primary mesothelial cells and on the MeT-5A cell line. JQ1 inhibited tumor necrosis factor-α (TNF-α)-induced proinflammatory gene upregulation and restored MMT phenotype changes, together with the downmodulation of oxidative stress. Taken together, these results suggest that BET inhibitors may be a potential therapeutic option to ameliorate peritoneal damage

Riesgo de hipertensión arterial en población adulta en Matamoros, Tamaulipas, México

RESUMEN Objetivo: conocer el riesgo de hipertensión en la población adulta de la ciudad de Matamoros, Tamaulipas. Método: el diseño fue de tipo descriptivo y transversal, una muestra de 1004 adultos. Se utilizó una cedula de datos sociodemográficos, donde se realizaron 3 mediciones de la presión arterial, de acuerdo a la Norma Oficial Mexicana NOM-030-SSA2-2009. Resultados: El género estuvo conformado del 38.7% de hombres y 61.3% de mujeres. Se observó una prevalencia de hipertensión arterial en 8.6% de la población. Fue mayor en el género masculino con 12.3% que el femenino de 6.3%. El grupo de 60 y más años (14.1%) presenta mayor prevalencia de hipertensión, seguido de 50 a 59 (13.8%) y finalmente el de 40 a 49 con 11.7%. El riesgo de hipertensión es de 87 (8,7%) de la muestra total; la alta presión arterial sistólica con 52 (5,1%), y alta presión arterial diastólica con 56 (5,5%) también deben ser consideradas hipertensión. Cuando se analizan en conjunto, los tres criterios de inclusión para hipertensión arterial suman el 19,4% de riesgo. Conclusión: el riesgo de hipertensión arterial en población adulta está latente, la prevalencia se ubica dentro de la más alta a nivel mundial. ABSTRACT Objective: To know the risk of hypertension in the adult population of the city of Matamoros, Tamaulipas. Method: The design was descriptive and transversal in a sample of 1004 adults. A sociodemographic data questionnaire was used and three blood pressure measurements were performed according to the Official Mexican Standard NOM-030-SSA2-2009. Results: The gender was made up of 38.7% of men and 61,3% of women. A prevalence of hypertension was observed in 8.6% of the population. It was greater in the masculine gender with 12.3% than the feminine one of 6.3%. The group of 60 and over (14.1%) had a higher prevalence of hypertension, followed by 50 to 59 (13.8%) and finally the group of 40 to 49 with 11.7%. The risk of hypertension is 87 (8.7%) of the total sample; high systolic blood pressure with 52 (5.1%), and high diastolic blood pressure with 56 (5.5%) should also be considered hypertension. When analyzed together, the three inclusion criteria for hypertension add up to a 19.4% risk. Conclusion: the risk of hypertension in the adult population is latent, the prevalence is among the highest in the world

Adicción y factores determinantes en el uso problemático del Internet, en una muestra de jóvenes universitarios

El estudio tiene como objetivo conocer la probabilidad de presentar adicción y los factores determinantes sobre el uso problemático del internet en estudiantes universitarios en la ciudad de H. Matamoros, Tamaulipas. Metodología: La población fue de 1,125 estudiantes y una muestra de 323, en una universidad pública, el instrumento utilizado fue el “Cuestionario de Uso Problemático de Internet” (CUPI) con un Alfa de Cronbach de 0.966, el diseño de estudio fue descriptivo, transversal. Resultados: se encontró que el factor de determinante “Anticipación” fue el que presento una mayor probabilidad de presentarse, y los de menor fueron “Pérdida de Control” y  “Reconocimiento de Falta de Control.

Client applications and Server Side docker for management of RNASeq and/or VariantSeq workflows and pipelines of the GPRO Suite

The GPRO suite is an in-progress bioinformatic project for -omic data analyses. As part of the continued growth of this project, we introduce a client side & server side solution for comparative transcriptomics and analysis of variants. The client side consists of two Java applications called "RNASeq" and "VariantSeq" to manage workflows for RNA-seq and Variant-seq analysis, respectively, based on the most common command line interface tools for each topic. Both applications are coupled with a Linux server infrastructure (named GPRO Server Side) that hosts all dependencies of each application (scripts, databases, and command line interface tools). Implementation of the server side requires a Linux operating system, PHP, SQL, Python, bash scripting, and third-party software. The GPRO Server Side can be deployed via a Docker container that can be installed in the user's PC using any operating system or on remote servers as a cloud solution. The two applications are available as desktop and cloud applications and provide two execution modes: a Step-by-Step mode enables each step of a workflow to be executed independently and a Pipeline mode allows all steps to be run sequentially. The two applications also feature an experimental support system called GENIE that consists of a virtual chatbot/assistant and a pipeline jobs panel coupled with an expert system. The chatbot can troubleshoot issues with the usage of each tool, the pipeline job panel provides information about the status of each task executed in the GPRO Server Side, and the expert provides the user with a potential recommendation to identify or fix failed analyses. The two applications and the GPRO Server Side combine the user-friendliness and security of client software with the efficiency of front-end & back-end solutions to manage command line interface software for RNA-seq and variant-seq analysis via interface environments

Client Applications and Server-Side Docker for Management of RNASeq and/or VariantSeq Workflows and Pipelines of the GPRO Suite

The GPRO suite is an in-progress bioinformatic project for -omics data analysis. As part of the continued growth of this project, we introduce a client- and server-side solution for comparative transcriptomics and analysis of variants. The client-side consists of two Java applications called 'RNASeq' and 'VariantSeq' to manage pipelines and workflows based on the most common command line interface tools for RNA-seq and Variant-seq analysis, respectively. As such, 'RNASeq' and 'VariantSeq' are coupled with a Linux server infrastructure (named GPRO Server-Side) that hosts all dependencies of each application (scripts, databases, and command line interface software). Implementation of the Server-Side requires a Linux operating system, PHP, SQL, Python, bash scripting, and third-party software. The GPRO Server-Side can be installed, via a Docker container, in the user's PC under any operating system or on remote servers, as a cloud solution. 'RNASeq' and 'VariantSeq' are both available as desktop (RCP compilation) and web (RAP compilation) applications. Each application has two execution modes: a step-by-step mode enables each step of the workflow to be executed independently, and a pipeline mode allows all steps to be run sequentially. 'RNASeq' and 'VariantSeq' also feature an experimental, online support system called GENIE that consists of a virtual (chatbot) assistant and a pipeline jobs panel coupled with an expert system. The chatbot can troubleshoot issues with the usage of each tool, the pipeline jobs panel provides information about the status of each computational job executed in the GPRO Server-Side, while the expert system provides the user with a potential recommendation to identify or fix failed analyses. Our solution is a ready-to-use topic specific platform that combines the user-friendliness, robustness, and security of desktop software, with the efficiency of cloud/web applications to manage pipelines and workflows based on command line interface software

Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study

Objectives: We describe the current epidemiology, causes, and outcomes of breakthrough invasive fungal infections (BtIFI) in patients with haematologic malignancies.Methods: BtIFI in patients with & GE; 7 days of prior antifungals were prospectively diagnosed (36 months across 13 Spanish hospitals) according to revised EORTC/MSG definitions.Results: 121 episodes of BtIFI were documented, of which 41 (33.9%) were proven; 53 (43.8%), probable; and 27 (22.3%), possible. The most frequent prior antifungals included posaconazole (32.2%), echinocandins (28.9%) and fluconazole (24.8%)-mainly for primary prophylaxis (81%). The most common haematologic malignancy was acute leukaemia (64.5%), and 59 (48.8%) patients had undergone a hematopoietic stem-cell transplantation. Invasive aspergillosis, principally caused by non-fumigatus Aspergillus, was the most fre-quent BtIFI with 55 (45.5%) episodes recorded, followed by candidemia (23, 19%), mucormycosis (7, 5.8%), other moulds (6, 5%) and other yeasts (5, 4.1%). Azole resistance/non-susceptibility was commonly found. Prior antifungal therapy widely determined BtIFI epidemiology. The most common cause of BtIFI in proven and probable cases was the lack of activity of the prior antifungal (63, 67.0%). At diagnosis, antifungal therapy was mostly changed (90.9%), mainly to liposomal amphotericin-B (48.8%). Overall, 10 0-day mor-tality was 47.1%; BtIFI was either the cause or an essential contributing factor to death in 61.4% of cases.Conclusions: BtIFI are mainly caused by non-fumigatus Aspergillus, non-albicans Candida, Mucorales and other rare species of mould and yeast. Prior antifungals determine the epidemiology of BtIFI. The exceed-ingly high mortality due to BtIFI warrants an aggressive diagnostic approach and early initiation of broad-spectrum antifungals different than those previously used.& COPY; 2023 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Presentación patológica de Situs Inversus. Revisión Bibliográfica

Pathologic presentation of Situs Inversus. Literature Review  El situs inversus es una condición congénita poco común en la que se observa una inversión especular de la posición de los órganos dentro de la cavidad abdominal y torácica. Situs solitus se refiere a la disposición normal de órganos en el cuerpo humano, mientras que situs inversus implica que todos los órganos están invertidos en su posición habitual. En estos casos, resulta fundamental emplear modalidades de imagen avanzadas que permitan evaluar con precisión los detalles anatómicos más pequeños, ya que estos desempeñan un papel crucial en la planificación de intervenciones tanto radiológicas como quirúrgicas. Realmente resulta ser un desafío llevar a cabo procedimientos como los procedimientos biliares percutáneos y la embolización de la vena porta en pacientes que presentan una enfermedad tromboembólica intratable debido a los efectos reflejados que se pueden observar. La realización de un trasplante de órganos, en particular uno de hígado, implica afrontar un reto quirúrgico sumamente complejo y difícil de abordar. Dado lo infrecuente que es y la peculiaridad de su condición, los individuos con situs inversus que requieren cirugía a menudo necesitan que el equipo médico muestre mayor adaptabilidad y pensamiento innovador. El objetivo del presente estudio es conocer la presentación patológica de situs inversus. Se usaron diferentes bases de datos medicas para obtener la recopilación de múltiples artículos científicos. Se hallaron diferentes estudios donde se reunió toda la información compatible sobre la presente patología a detallar.  &nbsp