1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract

Some 4-ethyl-1(2)-R-1(2)H-4,7-dihydro-triazolo[4,5-h]-quinolin-7-one-6- carboxylic acids were prepared as novel analogues of oxolinic acid, in order to discover the influence of the annelation position of the triazole ring on the antimicrobial activity that, in some isomers triazolo[4,5-f]quinoline carboxylic acids, is selective against Escherichia coli. Some interesting side reactions in the cyclization of 1(2)-R-1(2)H-benzotriazol-4-yl-aminomethylenemalonate are also described. The biological results indicate that this type of annelation is not profitable for antimicrobial activity

1,2,3-triazolo[4,5-f]quinolines: II: preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract

Some 6-ethyl-1(2)(3)-R-1(2)(3)H-triazolo[4,5-f]quinolin-9-one-8-carboxylic acids were prepared as novel analogues of oxolinic acid in order to evaluate the effect on antibacterial activity of the isosteric replacement of the dioxolic moiety with the triazole ring substituted in position 1 or 2. In vitro tests showed a good and selective activity against Escherichia coli (MIC 12.5 micrograms/ml) of compound (XVI)

Teaching the history of nursing administration: the strategy of construction timeline

Introdução: As estratégias de ensino inspiradas na Andragogia são adequadas para ensinar o conteúdo sobre a História do Ensino de Administração em Enfermagem. Objetivo: Relatar a estratégia de aprendizagem de criação de uma linha do tempo sobre “o que e para quem é ensinado o conteúdo de Administração em Enfermagem” em uma disciplina de pós-graduação “senso strito”.Método: Trata-se de um relato de experiência de aplicação de uma estratégia de ensino na disciplina História da Administração em Enfermagem, do Programa de Pós-graduação Senso Estrito realizada em maio de 2013. Utilizada a técnica de oficina, realizado o preparo do ambiente, organização dos materiais; orientações sobre a aula e execução da estratégia.Resultados: A aplicação da estratégia foi proposta testada por alunos e professora e seus principais produtos foram painéis interativos compondo a linha do tempo em história da enfermagem. Conclusão: A estratégia foi considerada adequada para a discussão do conteúdo e a organização pertinente ao proposto

Teaching the history of nursing administration: the strategy of construction timeline

Introdução: As estratégias de ensino inspiradas na Andragogia são adequadas para ensinar o conteúdo sobre a História do Ensino de Administração em Enfermagem. Objetivo: Relatar a estratégia de aprendizagem de criação de uma linha do tempo sobre “o que e para quem é ensinado o conteúdo de Administração em Enfermagem” em uma disciplina de pós-graduação “senso strito”.Método: Trata-se de um relato de experiência de aplicação de uma estratégia de ensino na disciplina História da Administração em Enfermagem, do Programa de Pós-graduação Senso Estrito realizada em maio de 2013. Utilizada a técnica de oficina, realizado o preparo do ambiente, organização dos materiais; orientações sobre a aula e execução da estratégia.Resultados: A aplicação da estratégia foi proposta testada por alunos e professora e seus principais produtos foram painéis interativos compondo a linha do tempo em história da enfermagem. Conclusão: A estratégia foi considerada adequada para a discussão do conteúdo e a organização pertinente ao proposto

The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries.

The contribution of psychological disorders to the burden of skin disease has been poorly explored, and this is a large-scale study to ascertain the association between depression, anxiety, and suicidal ideation with various dermatological diagnoses. This international multicenter observational cross-sectional study was conducted in 13 European countries. In each dermatology clinic, 250 consecutive adult out-patients were recruited to complete a questionnaire, reporting socio-demographic information, negative life events, and suicidal ideation; depression and anxiety were assessed with the Hospital Anxiety and Depression Scale. A clinical examination was performed. A control group was recruited among hospital employees. There were 4,994 participants--3,635 patients and 1,359 controls. Clinical depression was present in 10.1% patients (controls 4.3%, odds ratio (OR) 2.40 (1.67-3.47)). Clinical anxiety was present in 17.2% (controls 11.1%, OR 2.18 (1.68-2.82)). Suicidal ideation was reported by 12.7% of all patients (controls 8.3%, OR 1.94 (1.33-2.82)). For individual diagnoses, only patients with psoriasis had significant association with suicidal ideation. The association with depression and anxiety was highest for patients with psoriasis, atopic dermatitis, hand eczema, and leg ulcers. These results identify a major additional burden of skin disease and have important clinical implications.Peer reviewedFinal Published versio

Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1

Vitis vinifera represents an important and renowned source of compounds with significant biological activity. Wines and winery bioproducts, such as grape pomace, skins, and seeds, are rich in bioactive compounds against a wide range of human pathogens, including bacteria, fungi, and viruses. However, little is known about the biological properties of vine leaves. The aim of this study was the evaluation of phenolic composition and antiviral activity of Vitis vinifera leaf extract against two human viruses: the Herpes simplex virus type 1 (HSV-1) and the pandemic and currently widespread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). About 40 phenolic compounds were identified in the extract by HPLC-MS/MS analysis: most of them were quercetin derivatives, others included derivatives of luteolin, kaempferol, apigenin, isorhamnetin, myricetin, chrysoeriol, biochanin, isookanin, and scutellarein. Leaf extract was able to inhibit both HSV-1 and SARS-CoV-2 replication in the early stages of infection by directly blocking the proteins enriched on the viral surface, at a very low concentration of 10 μg/mL. These results are very promising and highlight how natural extracts could be used in the design of antiviral drugs and the development of future vaccines