Investigation of Electromagnetic Sub-Modeling Procedure for the Breeding Blanket System

The outcome of the electromagnetic (EM) analyses carried out during the DEMO pre-conceptual phase demonstrated that EM loads are relevant for the structural assessment of the breeding blanket (BB) and, in particular, for the definition of the boundary conditions at the attachment system with the vacuum vessel. However, within the scope of the previous campaign, the results obtained using simplified models only give a rough estimation of the EM loads inside the BB structure. This kind of data has been considered suitable for a preliminary assessment of the BB segments, but it is not considered representative as input for structural analysis in which a detailed BB internal structure (that considers cooling channels, thin plates, etc.) is analyzed. Indeed, mesh dimensions and computational time usually limit EM models that simulate a whole DEMO sector. In many cases, these constraints lead to a strong homogenization of the BB structure, not allowing the calculation of the EM loads on the internal structure with high precision. To overcome such limitations, an EM sub-modeling procedure was investigated using ANSYS EMAG. The sub-modeling feasibility is studied using the rigid boundary condition method. This method consists of running a global “coarse” mesh, including all the conducting structures that can have some impact on the component under investigation and inputting the obtained results on the detailed sub-model of the structure of interest as time-varying boundary conditions. The procedure was tested on the BB internal structure, taking as reference a DEMO 2017 baseline sector and the helium cooled pebble bed (HCPB) concept with its complex internal structure made by pins. The obtained results show that the method is also reliable in the presence of non-linear magnetic behaviour. The methodology is proposed for application in future BB system assessments

Mucopolysaccharidosis I, II, and VI: Brief review and guidelines for treatment

Mucopolysaccharidoses (MPS) are rare genetic diseases caused by the deficiency of one of the lysosomal enzymes involved in the glycosaminoglycan (GAG) breakdown pathway. This metabolic block leads to the accumulation of GAG in various organs and tissues of the affected patients, resulting in a multisystemic clinical picture, sometimes including cognitive impairment. Until the beginning of the XXI century, treatment was mainly supportive. Bone marrow transplantation improved the natural course of the disease in some types of MPS, but the morbidity and mortality restricted its use to selected cases. The identification of the genes involved, the new molecular biology tools and the availability of animal models made it possible to develop specific enzyme replacement therapies (ERT) for these diseases. At present, a great number of Brazilian medical centers from all regions of the country have experience with ERT for MPS I, II, and VI, acquired not only through patient treatment but also in clinical trials. Taking the three types of MPS together, over 200 patients have been treated with ERT in our country. This document summarizes the experience of the professionals involved, along with the data available in the international literature, bringing together and harmonizing the information available on the management of these severe and progressive diseases, thus disclosing new prospects for Brazilian patients affected by these conditions

Scenari localizzativi logistico produttivi

reserved2I mutamenti dell'economia e il crescente grado di competizione tra produttori hanno determinato l'espulsione delle attività manifatturiere e della logistica pesante dagli ambiti urbani. Le attività manifatturiere hanno assunto un indirizzo localizzativo sempre più "foot loose" su vasta scala territoriale, alla ricerca del miglior presidio dei mercati di sbocco dei prodotti, nonchè delle convenienze comparate nell'impiego dei fattori della produzione. A loro volta, le strutture logistiche tendono a rezionalizzare la propria presenza sul territorio alla ricerca di più elevate economie di concentrazione e di accessibilità.F. Boscacci; D. LuccaBoscacci, Flavio; Lucca, David

Innovative design for FAST divertor compatible with remote handling, electromagnetic and mechanical analyses

Divertor is a crucial component in Tokamaks, aiming to exhaust the heat power and particles fluxes com-ing from the plasma during discharges. This paper focuses on the optimization process of FAST divertor,aimed at achieving required thermo-mechanical capabilities and the remote handling (RH) compati-bility. Divertor RH system final layout has been chosen between different concept solutions proposedand analyzed within the principles of Theory of Inventive Problem Solving (TRIZ). The design was aidedby kinematic simulations performed using Digital Mock-Up capabilities of Catia software. Considerableelectromagnetic (EM) analysis efforts and top-down CAD approach enabled the design of a final andconsistent concept, starting from a very first dimensioning for EM loads.In the final version here presented, the divertor cassette supports a set of tungsten (W) actively cooledtiles which compose the inner and outer vertical targets, facing the plasma and exhausting the main partof heat flux. W-tiles are assembled together considering a minimum gap tolerance (0.1–0.5 mm) to bemandatorily respected. Cooling channels have been re-dimensioned to optimize the geometry and thelayout of coolant volume inside the cassette has been modified as well to enhance the general efficiency

Innovative design for FAST divertor compatible with remote handling, electromagnetic and mechanical analyses

Divertor is a crucial component in Tokamaks, aiming to exhaust the heat power and particles fluxes com-ing from the plasma during discharges. This paper focuses on the optimization process of FAST divertor,aimed at achieving required thermo-mechanical capabilities and the remote handling (RH) compati-bility. Divertor RH system final layout has been chosen between different concept solutions proposedand analyzed within the principles of Theory of Inventive Problem Solving (TRIZ). The design was aidedby kinematic simulations performed using Digital Mock-Up capabilities of Catia software. Considerableelectromagnetic (EM) analysis efforts and top-down CAD approach enabled the design of a final andconsistent concept, starting from a very first dimensioning for EM loads.In the final version here presented, the divertor cassette supports a set of tungsten (W) actively cooledtiles which compose the inner and outer vertical targets, facing the plasma and exhausting the main partof heat flux. W-tiles are assembled together considering a minimum gap tolerance (0.1\u20130.5 mm) to bemandatorily respected. Cooling channels have been re-dimensioned to optimize the geometry and thelayout of coolant volume inside the cassette has been modified as well to enhance the general efficiency

Bauhinia holophylla (Bong.) Steud. leaves-derived extracts as potent anti-dengue serotype 2

Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen and made the disease a major health concern worldwide. However, specific antiviral drugs against this arbovirose or vaccines are not yet available for treatment or prevention. Thus, here we aimed to study the antiviral activity of hydroethanolic extract, fraction ethyl acetate and subfractions of the leaves of Bauhinia holophylla (Fabaceae:Cercideae), a native plant of the Brazilian Cerrado, against DENV-2 by methylthiazolyldiphenyl-tetrazolium bromide (MTT) method in mammalian cells culture. As results, the hydroethanolic extract showed the most potent effect, with an inhibitory concentration (IC50) of 3.2 μg mL-1 and selectivity index (SI) of 27.6, approximately 16-times higher anti-DENV-2 activity than of the ribavirin (IC50 52.8 μg mL-1). Our results showed in this study appointed that B. holophylla has a promising anti-dengue activity, which was associated mainly with the presence of flavonoids.status: publishe