Improvement of anterior and posterior segment ocular drug delivery: application in ocular cystinosis and age-related macular degeneration

In this doctoral thesis, hydrogel-based formulations containing cysteamine of great potential for the treatment of ocular cystinosis have been developed. The hydrogel based on hyaluronic acid polymer has been extensively characterised and its preparation has been translated to Hospital Pharmacy Departments. On the other hand, regarding the study of intravitreal injections in AMD, this thesis has demonstrated the usefulness of the PET methodology for the study of intravitreal pharmacokinetics in rats, which has been subsequently used for the evaluation of the ocular pharmacokinetics after intravitreal administration of aflibercept and bevacizumab. Moreover, intravitreal chitosan-based implants containing aflibercept which permit its extended delivery have been developed

Publicidad en radio, nuevos formatos

A lo largo de este Trabajo de Fin de Grado se muestra la evolución de la publicidad en la radio desde su aparición en España en los años 20 hasta la actualidad. Se realiza un viaje a lo largo de la historia del medio junto con la explicación de la gran variedad de formatos publicitarios que ofrece al anunciante para publicitarse. Por otro lado, se exponen las características actuales de la radio, cómo es su público, los nuevos soportes para su consumo, la publicidad, los formatos publicitarios empleados hoy en día y las tarifas publicitarias de dicho medio. Todo ello acompañado de la visión de varios profesionales de la radio.Grado en Publicidad y Relaciones Pública

Los sistemas de información geográfica en turismo

[Resumo] A internet converteuse nun dos lugares máis populares para publicar e buscar case calquera tipo de información. En particular, a información turística gañou moita atención na rede durante os últimos anos, e non só a información sobre viaxes, recursos, lugares, museos ou monumentos, senón tamén sobre turismo cultural. Neste artigo presentamos as posibilidades que ofrecen os sistemas de información xeográfica (SIX) para a publicación de información turística e o acceso a ela, a través de interfaces coa capacidade de xerar mapas interactivos que presenten información asociada a cada elemento de interese que apareza neles. Ademais, describimos como caso de estudo a viaxe virtual que se nos propón na Biblioteca Virtual Galega (http://bvg.udc.es), un sistema accesible a través da web que, por medio de tecnoloxías SIX, permite acceder a calquera información turística ou cultural de Galicia de xeito sinxelo.[Resumen] Internet se ha convertido en uno de los lugares más populares para publicar y buscar casi cualquier tipo de información. En particular, la información turística ha ganado mucha atención en la red durante los últimos años, no sólo información sobre viajes, recursos, lugares, museos o monumentos, sino también sobre turismo cultural. En este artículo presentamos las posibilidades que ofrecen los Sistemas de Información Geográfica (SIG) en la publicación y acceso a información turística, a través de interfaces con capacidades de generación de mapas interactivos con información asociada a cada elemento de interés presentado en los mapas. Además, describimos como caso de estudio el Viaje Virtual de la Biblioteca Virtual Gallega (http://bvg.udc.es), un sistema accesible a través de la Web que, utilizando tecnologías SIG, permite acceder a cualquier información turística o cultural de Galicia de manera sencilla.[Abstract] The Internet has become one of the most popular places to publish and search for almost any type of information. In particular, tourist information has received much attention in the Internet over the past few years, not only information about travel, resources, places, museums or monuments, but also about cultural tourism. In this article we discuss the potential offered by Geographic Information Systems (GIS) in the publication of and access to tourist information, through interfaces capable of generating interactive maps with information associated with each element of interest shown in the maps. In addition, as a case study, we describe the Virtual Trip of the Galician Virtual Library (http://bvg.udc.es), an Internet-accessible system which makes it possible, using GIS technologies, to easily access any tourist or cultural information about Galicia

Towards a FAIR Dataset for Spanish Non-Functional Requirements

Cursos e Congresos, C-155[Abstract] Supervised Machine Learning algorithms (ML) have enhanced the performance of the automatic non-functional requirements (NFR) classification in the Requirements Engineering domain. However, the lack of public datasets, dealing with imbalanced datasets and reproducibility are current concerns in ML experiments. We conducted a quasi-experiment to generate a dataset of NFR in the Spanish Language, following the FAIR Principles. We collected 109 requirements from an open access repository of the University of A Coru˜ na, and performed a labeling process based in the categories and subcategories of the ISO/IEC 25010 quality model. Using a Fleiss’ Kappa test we obtained a substantial agreement (0.78) at the category level and a moderate agreement (0.48) when the classification is per subcategory supervised Machine Learning algorithms (ML) have enhanced the performance of the automatic non-functional requirements (NFR) classification in the Requirements Engineering domain. However, the lack of public datasets, dealing with imbalanced datasets and reproducibility are current concerns in ML experiments. We conducted a quasi-experiment to generate a dataset of NFR in the Spanish Language, following the FAIR Principles. We collected 109 requirements from an open access repository of the University of A Coruña, and performed a labeling process based in the categories and subcategories of the ISO/IEC 25010 quality model. Using a Fleiss’ Kappa test we obtained a substantial agreement (0.78) at the category level and a moderate agreement (0.48) when the classification is per subcategoryCITIC is funded by the Xunta de Galicia through the collaboration agreement between the Conseller ´ıa de Cultura, Educaci´on, Formaci´on Profesional e Universidades and the Galician universities for the reinforcement of the research centres of the Galician University System (CIGUS

Towards a Semi-Automated Data-Driven Requirements Prioritization Approach for Reducing Stakeholder Participation in SPL Development

Presented at the 4th XoveTIC Conference, A Coruña, Spain, 7–8 October 2021.[Abstract] Requirements prioritization (RP), part of Requirements engineering (RE), is an essential activity of Software Product-Lines (SPL) paradigm. Similar to standard systems, the identification and prioritization of the user needs are relevant to the software quality and challenging in SPL due to common requirements, increasing dependencies, and diversity of stakeholders involved. As prioritization process might become impractical when the number of derived products grows, recently there has been an exponential growth in the use of Artificial Intelligence (AI) techniques in different areas of RE. The present research aims to propose a semi-automatic multiple-criteria prioritization process for functional and non-functional requirements (FR/NFR) of software projects developed within the SPL paradigm for reducing stakeholder participation

Introducing a Human Activity Recognition Dataset Gathered on Real-Life Conditions

Cursos e Congresos, C-155[Abstract] Human activity recognition (HAR) has garnered significant scientific interest in recent years. The widespread use of smartphones enabled convenient and cost-effective data collection, eliminating the need for additional wearables. Given that, this paper introduces a novel HAR dataset in which participants had freedom in choosing smartphone orientation and placement during activities, ensuring data variability. It also includes contributions from diverse individuals, reflecting unique smartphone usage habits. Moreover, it comprises measurements from accelerometer, gyroscope, magnetometer, and GPS, corresponding to one of four activities: inactive, active, walking, or driving. Unlike other datasets, the collected data in this study were obtained from smartphones used in real-life scenariosThis work was funded by CITIC is funded by the Xunta de Galicia through the collaboration agreement between the Consellería de Cultura, Educación, Formación Profesional e Universidades and the Galician universities for the reinforcement of the research centres of the Galician University System (CIGUS), Xunta de Galicia/FEDER-UE (ConectaPeme, GEMA: IN852A 2018/14), MINECO-AEI/FEDER-UE (Flatcity: TIN2016-77158-C4-3-R) and Xunta de Galicia/FEDER-UE (AXUDAS PARA A CONSOLIDACION E ESTRUTURACION DE UNIDADES DE INVESTIGACION COMPETITIVAS.GRC: ED431C 2017/58 and ED431C 2018/49).Xunta de Galicia; ED431C 2017/58Xunta de Galicia; ED431C 2018/4

A Public Domain Dataset for Real-Life Human Activity Recognition Using Smartphone Sensors

[Abstract] In recent years, human activity recognition has become a hot topic inside the scientific community. The reason to be under the spotlight is its direct application in multiple domains, like healthcare or fitness. Additionally, the current worldwide use of smartphones makes it particularly easy to get this kind of data from people in a non-intrusive and cheaper way, without the need for other wearables. In this paper, we introduce our orientation-independent, placement-independent and subject-independent human activity recognition dataset. The information in this dataset is the measurements from the accelerometer, gyroscope, magnetometer, and GPS of the smartphone. Additionally, each measure is associated with one of the four possible registered activities: inactive, active, walking and driving. This work also proposes asupport vector machine (SVM) model to perform some preliminary experiments on the dataset. Considering that this dataset was taken from smartphones in their actual use, unlike other datasets, the development of a good model on such data is an open problem and a challenge for researchers. By doing so, we would be able to close the gap between the model and a real-life application.This research was partially funded by Xunta de Galicia/FEDER-UE (ConectaPeme, GEMA: IN852A 2018/14), MINECO-AEI/FEDER-UE (Flatcity: TIN2016-77158-C4-3-R) and Xunta de Galicia/FEDER-UE (AXUDAS PARA A CONSOLIDACION E ESTRUTURACION DE UNIDADES DE INVESTIGACION COMPETITIVAS.GRC: ED431C 2017/58 and ED431C 2018/49)Xunta de Galicia; IN852A 2018/14Xunta de Galicia; ED431C 2017/58Xunta de Galicia; ED431C 2018/4

Combining Multiple Granularity Variability in a Software Product Line Approach for Web Engineering

[Abstract] Context: Web engineering involves managing a high diversity of artifacts implemented in different languages and with different levels of granularity. Technological companies usually implement variable artifacts of Software Product Lines (SPLs) using annotations, being reluctant to adopt hybrid, often complex, approaches combining composition and annotations despite their benefits. Objective: This paper proposes a combined approach to support fine and coarse-grained variability for web artifacts. The proposal allows web developers to continue using annotations to handle fine-grained variability for those artifacts whose variability is very difficult to implement with a composition-based approach, but obtaining the advantages of the composition-based approach for the coarse-grained variable artifacts. Methods: A combined approach based on feature modeling that integrates annotations into a generic composition-based approach. We propose the definition of compositional and annotative variation points with custom-defined semantics, which is resolved by a scaffolding-based derivation engine. The approach is evaluated on a real-world web-based SPL by applying a set of variability metrics, as well as discussing its quality criteria in comparison with annotations, compositional, and combined existing approaches. Results: Our approach effectively handles both fine and coarse-grained variability. The mapping between the feature model and the web artifacts promotes the traceability of the features and the uniformity of the variation points regardless of the granularity of the web artifacts. Conclusions: Using well-known techniques of SPLs from an architectural point of view, such as feature modeling, can improve the design and maintenance of variable web artifacts without the need of introducing complex approaches for implementing the underlying variability.The work of the authors from the Universidad de Málaga is supported by the projects Magic P12-TIC1814 (post-doctoral research grant), MEDEA RTI2018-099213-B-I00 (co-financed by FEDER funds), Rhea P18-FR-1081 (MCI/AEI/FEDER, UE), LEIA UMA18-FEDERIA-157, TASOVA MCIU-AEI TIN2017-90644-REDT and, European Union’s H2020 research and innovation program under grant agreement DAEMON 101017109. The work of the authors from the Universidade da Coruña has been funded by MCIN/AEI/10.13039/501100011033, NextGenerationEU/PRTR, FLATCITY-POC: PDC2021-121239-C31 ; MCIN/AEI/10.13039/501100011033 EXTRACompact: PID2020-114635RB-I00 ; GAIN/Xunta de Galicia/ERDF CEDCOVID: COV20/00604 ; Xunta de Galicia/FEDER-UE GRC: ED431C 2021/53 ; MICIU/FEDER-UE BIZDEVOPSGLOBAL: RTI-2018-098309-B-C32 ; MCIN/AEI/10.13039/501100011033 MAGIST: PID2019-105221RB-C41Junta de Andalucía; P12-TIC-1814Universidad de Málaga; UMA18-FEDERIA-157Xunta de Galicia; COV20/00604Xunta de Galicia; ED431C 2021/53Junta de Andalucía; P18-FR-108