14,587 research outputs found

    Senior Recital: Jackson Crater, Trumpet; Lu Witzig, Piano; April 16, 2023

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    Kemp Recital HallApril 16, 2023Sunday Afternoon3:00 p.m

    A matrix-based method of moments for fitting multivariate network meta-analysis models with multiple outcomes and random inconsistency effects.

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    Random-effects meta-analyses are very commonly used in medical statistics. Recent methodological developments include multivariate (multiple outcomes) and network (multiple treatments) meta-analysis. Here, we provide a new model and corresponding estimation procedure for multivariate network meta-analysis, so that multiple outcomes and treatments can be included in a single analysis. Our new multivariate model is a direct extension of a univariate model for network meta-analysis that has recently been proposed. We allow two types of unknown variance parameters in our model, which represent between-study heterogeneity and inconsistency. Inconsistency arises when different forms of direct and indirect evidence are not in agreement, even having taken between-study heterogeneity into account. However, the consistency assumption is often assumed in practice and so we also explain how to fit a reduced model which makes this assumption. Our estimation method extends several other commonly used methods for meta-analysis, including the method proposed by DerSimonian and Laird (). We investigate the use of our proposed methods in the context of both a simulation study and a real example

    Cometary implications of recent laboratory experiments on the photochemistry of the C2H and C3H2 radicals

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    Recent laboratory results on the photodissociation of the C2H and C3H2 radicals are described. These studies show that the C2 and C3 radicals are produced by the 193 nm photolysis of the C2H and C3H2 radicals, respectively. The quantum state distributions that were determined for the C2 radicals put certain constraints on the initial conditions for any models of the observed C2 cometary spectra. Experimental observations of C2 formed by the 212.8 nm photolysis of C2H are used to calculate a range of photochemical lifetimes for the C2H radical

    Causal explanation for observed superluminal behavior of microwave propagation in free space

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    In this paper we present a theoretical analysis of an experiment by Mugnai and collaborators where superluminal behavior was observed in the propagation of microwaves. We suggest that what was observed can be well approximated by the motion of a superluminal X wave. Furthermore the experimental results are also explained by the so called scissor effect which occurs with the convergence of pairs of signals coming from opposite points of an annular region of the mirror and forming an interference peak on the intersection axis traveling at superluminal speed. We clarify some misunderstandings concerning this kind of electromagnetic wave propagation in vacuum.Comment: 9 pages, 3 figures, accepted for publication in Physics Letters

    Effective medium theory of elastic waves in random networks of rods

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    We formulate an effective medium (mean field) theory of a material consisting of randomly distributed nodes connected by straight slender rods, hinged at the nodes. Defining novel wavelength-dependent effective elastic moduli, we calculate both the static moduli and the dispersion relations of ultrasonic longitudinal and transverse elastic waves. At finite wave vector kk the waves are dispersive, with phase and group velocities decreasing with increasing wave vector. These results are directly applicable to networks with empty pore space. They also describe the solid matrix in two-component (Biot) theories of fluid-filled porous media. We suggest the possibility of low density materials with higher ratios of stiffness and strength to density than those of foams, aerogels or trabecular bone.Comment: 14 pp., 3 fig

    An infectious recombinant foot-and-mouth disease virus expressing a fluorescent marker protein

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    Foot-and-mouth disease virus (FMDV) is one of the most extensively studied animal pathogens because it remains a major threat to livestock economies worldwide. However, the dynamics of FMDV infection are still poorly understood. The application of reverse genetics provides the opportunity to generate molecular tools to further dissect the FMDV life cycle. Here, we have used reverse genetics to determine the capsid packaging limitations for a selected insertion site in the FMDV genome. We show that exogenous RNA up to a defined length can be stably introduced into the FMDV genome, whereas larger insertions are excised by recombination events. This led us to construct a recombinant FMDV expressing the fluorescent marker protein, termed iLOV. Characterization of infectious iLOV-FMDV showed the virus has a plaque morphology and rate of growth similar to the parental virus. In addition, we show that cells infected with iLOV-FMDV are easily differentiated by flow cytometry using the inherent fluorescence of iLOV and that cells infected with iLOV-FMDV can be monitored in real-time with fluorescence microscopy. iLOV-FMDV therefore offers a unique tool to characterize FMDV infection in vitro, and its applications for in vivo studies are discussed

    An analytical study of new material test method for tension under bending and compression in double side incremental forming

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    Incremental sheet forming (ISF) has attracted considerable research interests owing to its unique advantages. Double side incremental forming (DSIF) was proposed to further improve the forming accuracy and material formability. Compared with conventional sheet forming technologies, ISF provides greater process flexibility and achieves an enhanced formability. At the same time, however, ISF has exhibited a far more complicated material deformation behavior for formability enhancement. It is now widely acknowledged that the material deformation during ISF consists of stretching, bending, and shearing with cyclic effects. Continuous bending under tension (CBT) testing method was proposed by Emmens et al. [1], which proved the cyclic stretch-bending effect for formability enhancement in single point incremental forming (SPIF). However, limited research had been reported to investigate the material deformation mechanism leading to the formability improvement in DSIF. An analytical model of a new material test method, Tension Under Bending and Compression (TUBC), is proposed in this study to investigate the material deformation leading to the formability enhancement in DSIF. Under TUBC condition, a specimen is stretched by the pulling force on both ends, while multiple rollers, in contact with the strip on both sides, move backward and forward continuously to create both cyclic bending and compression loading at a localized area. The analytical model is used to investigate the maximum stable elongations under TUBC condition. Key test variables, bending depth and compressive force, imposed by the rollers, are introduced to consider the effects of continuous bending, compression, and contact between rollers and workpiece. From the results obtained, it is clear that bending and compression have determinant effects on the formability enhancement of DSIF. However, the results show varied degrees of sensitivity of formability to different test variables. The findings correlate well with experimental observations and help to explain the formability enhancement of DSIF
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