The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Triagem auditiva escolar: identificação de alterações auditivas em crianças do primeiro ano do ensino fundamental

Resumo: OBJETIVO: caracterizar o perfil audiológico de escolares do primeiro ano do Ensino Fundamental da rede municipal da cidade de Caxias do Sul-RS, investigando e identificando a ocorrência de alterações auditivas nesta população, por meio de medidas eletroacústicas. MÉTODOS: estudo transversal, prospectivo, descritivo e quantitativo de 391 escolares do primeiro ano do Ensino Fundamental de escolas municipais da cidade de Caxias do Sul-RS. Os estudantes foram submetidos a quatro procedimentos audiológicos na Triagem Auditiva Escolar: Meatoscopia, Emissões Otoacústicas Evocadas por Estímulo Transiente, Emissões Otoacústicas - Produto de Distorção e Timpanometria. Além disso, os responsáveis pelas crianças responderam a um questionário com perguntas referentes ao desenvolvimento e aos antecedentes otológicos de cada criança. Os escolares que apresentaram alguma alteração auditiva na Triagem Auditiva foram encaminhados para avaliação otorrinolaringológica e/ou avaliação audiológica completa. RESULTADOS: das 782 orelhas avaliadas, 85,4% apresentaram normalidade nos exames realizados e 14,6% demonstraram algum tipo de alteração. Na Meatoscopia, verificou-se que 6,3% das orelhas apresentaram alterações. Passaram nas Emissões Otoacústicas Evocadas por Estímulo Transiente 94,8% das orelhas e nas Emissões Otoacústicas - Produto de Distorção 95,8%. Na Timpanometria, a curva predominante foi a tipo A, seguida pela tipo C. Foram realizados encaminhamentos para 14,6% dos escolares. CONCLUSÃO: a população desse estudo foi composta, em sua maioria, por escolares do gênero masculino, com seis anos de idade. Das 782 orelhas avaliadas, 85,4% apresentaram normalidade nos exames realizados e 14,6% demonstraram algum tipo de alteração

Triagem auditiva escolar: identificação de alterações auditivas em crianças do primeiro ano do ensino fundamental

Resumo: OBJETIVO: caracterizar o perfil audiológico de escolares do primeiro ano do Ensino Fundamental da rede municipal da cidade de Caxias do Sul-RS, investigando e identificando a ocorrência de alterações auditivas nesta população, por meio de medidas eletroacústicas. MÉTODOS: estudo transversal, prospectivo, descritivo e quantitativo de 391 escolares do primeiro ano do Ensino Fundamental de escolas municipais da cidade de Caxias do Sul-RS. Os estudantes foram submetidos a quatro procedimentos audiológicos na Triagem Auditiva Escolar: Meatoscopia, Emissões Otoacústicas Evocadas por Estímulo Transiente, Emissões Otoacústicas - Produto de Distorção e Timpanometria. Além disso, os responsáveis pelas crianças responderam a um questionário com perguntas referentes ao desenvolvimento e aos antecedentes otológicos de cada criança. Os escolares que apresentaram alguma alteração auditiva na Triagem Auditiva foram encaminhados para avaliação otorrinolaringológica e/ou avaliação audiológica completa. RESULTADOS: das 782 orelhas avaliadas, 85,4% apresentaram normalidade nos exames realizados e 14,6% demonstraram algum tipo de alteração. Na Meatoscopia, verificou-se que 6,3% das orelhas apresentaram alterações. Passaram nas Emissões Otoacústicas Evocadas por Estímulo Transiente 94,8% das orelhas e nas Emissões Otoacústicas - Produto de Distorção 95,8%. Na Timpanometria, a curva predominante foi a tipo A, seguida pela tipo C. Foram realizados encaminhamentos para 14,6% dos escolares. CONCLUSÃO: a população desse estudo foi composta, em sua maioria, por escolares do gênero masculino, com seis anos de idade. Das 782 orelhas avaliadas, 85,4% apresentaram normalidade nos exames realizados e 14,6% demonstraram algum tipo de alteração