Alien Registration- Cloutier, Louise (Brunswick, Cumberland County)

https://digitalmaine.com/alien_docs/31437/thumbnail.jp

Typologie de L’insertion Professionnelle des Personnes Diplomees de L’Universite

The objectives of this paper are a) to delimit the notion of vocational integration, b) to formulate a vocational integration typology for university graduates, taking into account both the «traditional» method of integration (integration at the end of bachelor's degree and rapid stabilization on the labour market), and other methods where integration occurs in phases and stabilization on the labour market follows later, c) to demonstrate the empirical relevance of the typology. The data analysis was based on a data bank on the progression through school and labour market entry of all persons who received undergraduate degrees from Université Laval in 1986. This analysis was not conducted in order to generalize the results for the Quebec population as a whole but rather to demonstrate the typology's relevance and empirical usefulness.Les objectifs de l'article sont a) de circonscrire la notion d'insertion professionnelle, b) d'élaborer une typologie de l'insertion professionnelle des personnes diplômées universitaires qui tienne compte à la fois des modes d'insertion dits «traditionnels» (insertion au terme des études de premier cycle seulement et stabilisation rapide sur le marché de l'emploi) et d'autres modes d'insertion impliquant un échelonnement de l'insertion dans le temps et une stabilisation plus tardive et c) de démontrer la pertinence de cette typologie au plan empirique. L'analyse des données a été effectuée à partir de la banque de données sur les cheminements scolaires et l'entrée sur le marché du travail des personnes diplômées du premier cycle de l'Université Laval en 1986. L'analyse n'a pas été conduite à des fins de généralisation des résultats à l'ensemble du Québec mais dans le but de démontrer la pertinence théorique de la typologie et son utilité au plan empiriqu

Towards the optimisation of a detection system for markers linked to neural tube defects

Neural tube defects are the second most common birth defect of the central nervous system. The aim of this research is to design and optimise a novel detection system to analyse five markers that have been shown to be linked to neural tube defects. The developed detection system consists of three steps: an initial multiplex PCR, a hemi-nested multiplex PCR, and a multiplex SNE-PCR using the ABI Prism® SNaPshot™ kit. The additional step of a hemi-nested PCR has been incorporated to increase the sensitivity and specificity of the test. By detecting all five markers simultaneously, the linkage between each of the mutations can be ascertained more rapidly than if detected independently. Four different sample types were analysed, modern DNA, experimentally degraded DNA, medical specimens and archeological samples. The genotypes were successfully generated for all the samples except the archeological samples, where only partial genotypes were achieved. The designed detection system can be applied to archive medical specimens (biopsies, smears, and blood donor cards), archeological material, and other degraded samples. Future applications of this technique can include medical screening, population mapping, association studies, familial pedigrees, and the study of the evolution of diseases. This developed three step methodology can be applied to the detection of other diseases and conditions

Améliorer la compréhension et la gestion des conflits d’intérêts des experts conseillant la prise de décisions en santé publique

Étude de cas / Case studyAu Québec, au Canada et ailleurs dans le monde, des comités consultatifs d’experts conseillent et orientent les décideurs gouvernementaux dans le choix de nouveaux médicaments, de vaccins à utiliser ou encore d’interventions à mettre en place. Parallèlement, ces experts bénéficient d’un appui de plus en plus important d’entreprises privées pour réaliser leurs recherches ou en diffuser les résultats. Cette situation les met à risque de conflits d’intérêts et peut, éventuellement, miner la confiance de la population envers la prise de décision publique. Cette étude de cas suscite des réflexions pertinentes quant à ce qui constitue une gestion saine et optimale des situations de conflits d’intérêts par les membres experts et les organisations dans lesquelles ils ont un rôle-conseil.In Québec, in Canada and elsewhere in the world, expert advisory committees advise and guide government decision-makers in the choice of new drugs, vaccines to be used or interventions to be put in place. In parallel, these experts are receiving increasing support from private companies to conduct their research or to disseminate the results of their research. Such situations place them at risk of conflicts of interest and may eventually undermine confidence in public decision-making. This case study stimulates reflection into what constitutes sound and optimal management of conflict of interest situations by expert members and the organizations in which they have an advising role

Ultrafast quantitative ultrasound and shear wave elastography imaging of in vivo duck fatty livers

Multi-parametric ultrasound imaging is a promising tool for quantification of nonalcoholic fatty liver disease. In this work, a protocol of plane wave quantitative ultrasound (QUS) and shear wave elastography imaging (SWEI), quasi-simultaneously acquired, dedicated to quantification of liver steatosis on in vivo fatty duck liver is presented. Shear wave velocity was estimated to classify stiffness in duck liver tissue. QUS consisted of local attenuation coefficient slope estimated with Spectral Log Difference method, and coherent-to-diffuse signal ratio computed from homodyned-K parametric maps. After 9 days of feeding, US attenuation reached a maximum and coherent-todiffuse signal ratio reached a minimum. Coupled together, QUS and SWEI promise a strong potential in steatosis monitoring of fatty liver tissue, in ducks or humans

Pour le tutorat : questionnaire sur les instruments d’évaluation d’un cours

Ce document est une adaptation partielle d’un questionnaire produit par le Cégep à distance. Il est rempli par des tuteurs après la première année de diffusion de chaque cours. L’extrait présenté aborde spécifiquement l’évaluation en formation à distance

Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

<p>Abstract</p> <p>Background</p> <p>Nck1 and Nck2 adaptor proteins are involved in signaling pathways mediating proliferation, cytoskeleton organization and integrated stress response. Overexpression of Nck1 in fibroblasts has been shown to be oncogenic. Through the years this concept has been challenged and the consensus is now that overexpression of either Nck cooperates with strong oncogenes to transform cells. Therefore, variations in Nck expression levels in transformed cells could endorse cancer progression.</p> <p>Methods</p> <p>Expression of Nck1 and Nck2 proteins in various cancer cell lines at different stages of progression were analyzed by western blots. We created human primary melanoma cell lines overexpressing GFP-Nck2 and investigated their ability to proliferate along with metastatic characteristics such as migration and invasion. By western blot analysis, we compared levels of proteins phosphorylated on tyrosine as well as cadherins and integrins in human melanoma cells overexpressing or not Nck2. Finally, in mice we assessed tumor growth rate of human melanoma cells expressing increasing levels of Nck2.</p> <p>Results</p> <p>We found that expression of Nck2 is consistently increased in various metastatic cancer cell lines compared with primary counterparts. Particularly, we observed significant higher levels of Nck2 protein and mRNA, as opposed to no change in Nck1, in human metastatic melanoma cell lines compared with non-metastatic melanoma and normal melanocytes. We demonstrated the involvement of Nck2 in proliferation, migration and invasion in human melanoma cells. Moreover, we discovered that Nck2 overexpression in human primary melanoma cells correlates with higher levels of proteins phosphorylated on tyrosine residues, assembly of Nck2-dependent pY-proteins-containing molecular complexes and downregulation of cadherins and integrins. Importantly, we uncovered that injection of Nck2-overexpressing human primary melanoma cells into mice increases melanoma-derived tumor growth rate.</p> <p>Conclusions</p> <p>Collectively, our data indicate that Nck2 effectively influences human melanoma phenotype progression. At the molecular level, we propose that Nck2 in human primary melanoma promotes the formation of molecular complexes regulating proliferation and actin cytoskeleton dynamics by modulating kinases or phosphatases activities that results in increased levels of proteins phosphorylated on tyrosine residues. This study provides new insights regarding cancer progression that could impact on the therapeutic strategies targeting cancer.</p

A pair of Sub-Neptunes transiting the bright K-dwarf TOI-1064 characterised with CHEOPS

Funding: TGW, ACC, and KH acknowledge support from STFC consolidated grant numbers ST/R000824/1 and ST/V000861/1, and UKSA grant ST/R003203/1.We report the discovery and characterization of a pair of sub-Neptunes transiting the bright K-dwarf TOI-1064 (TIC 79748331), initially detected in the Transiting Exoplanet Survey Satellite (TESS) photometry. To characterize the system, we performed and retrieved the CHaracterising ExOPlanets Satellite (CHEOPS), TESS, and ground-based photometry, the High Accuracy Radial velocity Planet Searcher (HARPS) high-resolution spectroscopy, and Gemini speckle imaging. We characterize the host star and determine Teff,⋆=4734±67K⁠, R⋆=0.726±0.007R⊙⁠, and M⋆=0.748±0.032M⊙⁠. We present a novel detrending method based on point spread function shape-change modelling and demonstrate its suitability to correct flux variations in CHEOPS data. We confirm the planetary nature of both bodies and find that TOI-1064 b has an orbital period of Pb = 6.44387 ± 0.00003 d, a radius of Rb = 2.59 ± 0.04 R⊕, and a mass of Mb=13.5+1.7−1.8 M⊕, whilst TOI-1064 c has an orbital period of Pc=12.22657+0.00005−0.00004 d, a radius of Rc = 2.65 ± 0.04 R⊕, and a 3σ upper mass limit of 8.5 M⊕. From the high-precision photometry we obtain radius uncertainties of ∼1.6 per cent, allowing us to conduct internal structure and atmospheric escape modelling. TOI-1064 b is one of the densest, well-characterized sub-Neptunes, with a tenuous atmosphere that can be explained by the loss of a primordial envelope following migration through the protoplanetary disc. It is likely that TOI-1064 c has an extended atmosphere due to the tentative low density, however further radial velocities are needed to confirm this scenario and the similar radii, different masses nature of this system. The high-precision data and modelling of TOI-1064 b are important for planets in this region of mass–radius space, and it allow us to identify a trend in bulk density–stellar metallicity for massive sub-Neptunes that may hint at the formation of this population of planets.Publisher PDFPeer reviewe

TOI-836 : a super-Earth and mini-Neptune transiting a nearby K-dwarf

Funding: TGW, ACC, and KH acknowledge support from STFC consolidated grant numbers ST/R000824/1 and ST/V000861/1, and UKSA grant ST/R003203/1.We present the discovery of two exoplanets transiting TOI-836 (TIC 440887364) using data from TESS Sector 11 and Sector 38. TOI-836 is a bright (T = 8.5 mag), high proper motion (∼200 mas yr−1), low metallicity ([Fe/H]≈−0.28) K-dwarf with a mass of 0.68 ± 0.05 M⊙ and a radius of 0.67 ± 0.01 R⊙. We obtain photometric follow-up observations with a variety of facilities, and we use these data-sets to determine that the inner planet, TOI-836 b, is a 1.70 ± 0.07 R⊕ super-Earth in a 3.82 day orbit, placing it directly within the so-called ‘radius valley’. The outer planet, TOI-836 c, is a 2.59 ± 0.09 R⊕ mini-Neptune in an 8.60 day orbit. Radial velocity measurements reveal that TOI-836 b has a mass of 4.5 ± 0.9 M⊕, while TOI-836 c has a mass of 9.6 ± 2.6 M⊕. Photometric observations show Transit Timing Variations (TTVs) on the order of 20 minutes for TOI-836 c, although there are no detectable TTVs for TOI-836 b. The TTVs of planet TOI-836 c may be caused by an undetected exterior planet.Publisher PDFPeer reviewe