WR 110: A Single Wolf-Rayet Star With Corotating Interaction Regions In Its Wind?

A 30-day contiguous photometric run with the MOST satellite on the WN5-6b star WR 110 (HD 165688) reveals a fundamental periodicity of P = 4.08 +/- 0.55 days along with a number of harmonics at periods P/n, with n ~ 2,3,4,5 and 6, and a few other possible stray periodicities and/or stochastic variability on timescales longer than about a day. Spectroscopic RV studies fail to reveal any plausible companion with a period in this range. Therefore, we conjecture that the observed light-curve cusps of amplitude ~ 0.01 mag that recur at a 4.08 day timescale may arise in the inner parts, or at the base of, a corotating interaction region (CIR) seen in emission as it rotates around with the star at constant angular velocity. The hard X-ray component seen in WR 110 could then be a result of a high velocity component of the CIR shock interacting with the ambient wind at several stellar radii. Given that most hot, luminous stars showing CIRs have two CIR arms, it is possible that either the fundamental period is 8.2 days or, more likely in the case of WR 110, there is indeed a second weaker CIR arm for P = 4.08 days, that occurs ~ two thirds of a rotation period after the main CIR. If this interpretation is correct, WR 110 therefore joins the ranks with three other single WR stars, all WN, with confirmed CIR rotation periods (WR 1, WR 6, and WR 134), albeit with WR 110 having by far the lowest amplitude photometric modulation. This illustrates the power of being able to secure intense, continuous high-precision photometry from space-based platforms such as MOST. It also opens the door to revealing low-amplitude photometric variations in other WN stars, where previous attempts have failed. If all WN stars have CIRs at some level, this could be important for revealing sources of magnetism or pulsation in addition to rotation periods.Comment: 25 pages, 8 figures, 2 tables, accepted in Ap

Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease?

Reports that bacteria within the Firmicutes phylum, especially the species Faecalibacterium prausnitzii, are less abundant in Crohn’s disease (CD) patients and supernatants from cultures of this bacterium are anti-inflammatory prompted the investigation of the possible correlations between the abundance of F.prausnitzii and the response to treatment in patients with gut diseases and healthy controls. In a randomized, double-blind trial, faeces were collected from healthy volunteers, and from patients with active CD, ulcerative colitis (UC) and irritable bowel syndrome before and after treatment. The levels of F. prausnitzii DNA in faecal suspensions were determined by PCR. Treatment by an elemental diet was effective, resulting in decreases in both the Harvey and Bradshaw index (P<0.001) and the concentrations of serum C-reactive protein (P<0.05). The total levels of F. prausnitzii in faecal samples from CD patients at presentation were lower than those in the other groups both before and after the treatment. There was no correlation between F. prausnitzii abundance and the severity of CD before treatment. Clinical improvement unexpectedly correlated with a significant decrease in the abundance of F. prausnitzii, especially the A2-165 subgroup (P<0.05). Our data suggest that a paucity of F. prausnitzii in the gastrointestinal microbial communities is likely to be a minor aetiological factor in CD: recovery following elemental diet is attributed to lower levels of gut flora

Non-Scanning Radiometer Results for Earth Radiation Budget Investigations

The Earth Radiation Budget Experiment (ERBE) included non-scanning radiometers (Luther, 1986) flown aboard a dedicated mission of Earth Radiation Budget Satellite, and the NOAA-9 and -10 operational meteorological spacecraft (Barkstrom and Smith, 1986). The radiometers first began providing Earth radiation budget data in November 1984 and have remained operational, providing a record of nearly 8 years of data to date for researchers. Although they do not produce measurements with the resolution given by the scanning radiometers, the results from the non-scanning radiometers are extremely useful for climate research involving long-term radiation data sets. This paper discusses the non-scanning radiometers, their stability, the method of analyzing the data, and brief scientific results from the data

Phase separation in star polymer-colloid mixtures

We examine the demixing transition in star polymer-colloid mixtures for star arm numbers f=2,6,16,32 and different star-colloid size ratios. Theoretically, we solve the thermodynamically self-consistent Rogers-Young integral equations for binary mixtures using three effective pair potentials obtained from direct molecular computer simulations. The numerical results show a spinodal instability. The demixing binodals are approximately calculated, and found to be consistent with experimental observations.Comment: 4 pages, 4 figures, submitted to PR

A Spectroscopic Survey of WNL Stars in the LMC: General Properties and Binary Status

We report the results of an intense, spectroscopic survey of all 41 late-type, nitrogen-rich Wolf-Rayet (WR) stars in the Large Magellanic Cloud (LMC) observable with ground-based telescopes. This survey concludes the decade-long effort of the Montr\'eal Massive Star Group to monitor every known WR star in the Magellanic Clouds except for the 6 crowded WNL stars in R136, which will be discussed elsewhere. The focus of our survey was to monitor the so-called WNL stars for radial-velocity (RV) variability in order to identify the short- to intermediate-period (P \la 200 days) binaries among them. Our results are in line with results of previous studies of other WR subtypes, and show that the binary frequency among LMC WNL stars is statistically consistent with that of WNL stars in the Milky Way. We have identified four previously unknown binaries, bringing the total number of known WNL binaries in the LMC to nine. Since it is very likely that none but one of the binaries are classical, helium-burning WNL stars, but rather superluminous, hence extremely massive, hydrogen-burning objects, our study has dramatically increased the number of known binaries harbouring such objects, and thus paved the way to determine their masses through model-independent, Keplerian orbits. It is expected that some of the stars in our binaries will be among the most massive known. With the binary status of each WR star now known, we also studied the photometric and X-ray properties of our program stars using archival MACHO photometry as well as Chandra and ROSAT data. We find that one of our presumably single WNL stars is among the X-ray brightest WR sources known. We also identify a binary candidate from its RV variability and X-ray luminosity which harbours the most luminous WR star known in the Local Group.Comment: 25 pages, 11 figures; accepted for MNRA

Nucleon to Delta Weak Excitation Amplitudes in the Non-relativistic Quark Model

We investigate the nucleon to Delta(1232) vector and axial vector amplitudes in the non-relativistic quark model of the Isgur-Karl variety. A particular interest is to investigate the SU(6) symmetry breaking, due to color hyperfine interaction. We compare the theoretical estimates to recent experimental investigation of the Adler amplitudes by neutrino scattering.Comment: \documentstyle[aps]{revtex}, 21pages; 11 postscript figures. Accepted for publication by Phys. Rev.

The mass-to-light ratio of rich star clusters

We point out a strong time-evolution of the mass-to-light conversion factor eta commonly used to estimate masses of unresolved star clusters from observed cluster spectro-photometric measures. We present a series of gas-dynamical models coupled with the Cambridge stellar evolution tracks to compute line-of-sight velocity dispersions and half-light radii weighted by the luminosity. We explore a range of initial conditions, varying in turn the cluster mass and/or density, and the stellar population's IMF. We find that eta, and hence the estimated cluster mass, may increase by factors as large as 3 over time-scales of 50 million years. We apply these results to an hypothetic cluster mass distribution function (d.f.) and show that the d.f. shape may be strongly affected at the low-mass end by this effect. Fitting truncated isothermal (Michie-King) models to the projected light profile leads to over-estimates of the concentration parameter c of delta c ~ 0.3 compared to the same functional fit applied to the projected mass density.Comment: 6 pages, 2 figures, to appear in the proceedings of the "Young massive star clusters", Granada, Spain, September 200

Search for π0→νμνˉμ\pi^0 \to \nu_{\mu}\bar\nu_{\mu} Decay in LSND

We observe a net beam-excess of $8.7 \pm 6.3$ (stat) $\pm 2.4$ (syst) events, above 160 MeV, resulting from the charged-current reaction of $\nu_{\mu}$ and/or $\bar\nu_{\mu}$ on C and H in the LSND detector. No beam related muon background is expected in this energy regime. Within an analysis framework of $\pi^0 \to \nu_{\mu}\bar\nu_{\mu}$, we set a direct upper limit for this branching ratio of $\Gamma(\pi^0 \to \nu_\mu \bar\nu_\mu) / \Gamma(\pi^0 \to all) < 1.6 \times 10^{-6}$ at 90% confidence level.Comment: 4 pages, 4 figure

Population genomics of domestic and wild yeasts

The natural genetics of an organism is determined by the distribution of sequences of its genome. Here we present one- to four-fold, with some deeper, coverage of the genome sequences of over seventy isolates of the domesticated baker&#x27;s yeast, _Saccharomyces cerevisiae_, and its closest relative, the wild _S. paradoxus_, which has never been associated with human activity. These were collected from numerous geographic locations and sources (including wild, clinical, baking, wine, laboratory and food spoilage). These sequences provide an unprecedented view of the population structure, natural (and artificial) selection and genome evolution in these species. Variation in gene content, SNPs, indels, copy numbers and transposable elements provide insights into the evolution of different lineages. Phenotypic variation broadly correlates with global genome-wide phylogenetic relationships however there is no correlation with source. _S. paradoxus_ populations are well delineated along geographic boundaries while the variation among worldwide _S. cerevisiae_ isolates show less differentiation and is comparable to a single _S. paradoxus_ population. Rather than one or two domestication events leading to the extant baker&#x27;s yeasts, the population structure of _S. cerevisiae_ shows a few well defined geographically isolated lineages and many different mosaics of these lineages, supporting the notion that human influence provided the opportunity for outbreeding and production of new combinations of pre-existing variation

Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting plasmodium falciparum cytoadherence

Cytoadhesion of Plasmodium falciparum-infected erythrocytes (IEs) to the endothelial lining of blood vessels protects parasites from splenic destruction, but also leads to detrimental inflammation and vessel occlusion. Surface display of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion ligands exposes them to host antibodies and serum proteins. PfEMP1 are important targets of acquired immunity to malaria, and through evolution, the protein family has expanded and diversified to bind a select set of host receptors through antigenically diversified receptor-binding domains. Here, we show that complement component 1s (C1s) in serum cleaves PfEMP1 at semiconserved arginine motifs located at interdomain regions between the receptor-binding domains, rendering the IE incapable of binding the two main PfEMP1 receptors, CD36 and endothelial protein C receptor (EPCR). Bioinformatic analyses of PfEMP1 protein sequences from 15 P. falciparum genomes found the C1s motif was present in most PfEMP1 variants. Prediction of C1s cleavage and loss of binding to endothelial receptors was further corroborated by testing of several different parasite lines. These observations suggest that the parasites have maintained susceptibility for cleavage by the serine protease, C1s, and provides evidence for a complex relationship between the complement system and the P. falciparum cytoadhesion virulence determinant