176 research outputs found
The Relationship between HLA-B27, HLA-Cw06, HLA-DR7 and Psoriatic Arthritis in Vietnamese Patients: Disease Progression and Therapeutic Burden
- Author
- Publication venue
- 'ID Design 2012/DOOEL Skopje'
- Publication date
- 27/01/2019
- Field of study
We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe arthritis. PsA with HLA-Cw06 (+) had a higher risk of earlier onset and shorter duration for plaque psoriasis to transform into PsA. HLA-DR7 (+) in PsA delayed the time for conversion from plaque psoriasis into PsA. These findings are quite similar to other studies in the literature
Identification of HIV-1 Epitopes that Induce the Synthesis of a R5 HIV-1 Suppression Factor by Human CD4+ T Cells Isolated from HIV-1 Immunized Hu-PBL SCID Mice
- Author
- Abdelwahab SF
- Adachi A
- Aftab A. Ansari
- Akira Kodama
- Atsushi Yoshida
- Battegay M
- Betts MR
- Blackbourn DJ
- Butera ST
- Capobianchi MR
- Chun TW
- Douek DC
- Geiben-Lynn R
- Geiben-Lynn R
- Janssen EM
- Kalams SA
- Kaufmann DE
- Kinter AL
- Koyanagi Y
- Krowka JF
- Lotti B
- Mackewicz CE
- Matloubian M
- McCune JM
- McMichael AJ
- Migueles SA
- Naoki Yamamoto
- Ohteki T
- Oxenius A
- Planz O
- Reiko Tanaka
- Rosenberg ES
- Rosenberg ES
- Rossio JL
- Rowland-Jones S
- Saha K
- Shedlock DJ
- Subramani S
- Sun JC
- Van Coillie E
- Verani A
- Wahren B
- Wilson JD
- Yoshida A
- Yuetsu Tanaka
- Zhang L
- Zhou P
- Publication venue
- Hindawi Publishing Corporation
- Publication date
- 01/01/2005
- Field of study
We have previously reported that immunization of the severe combined
immunodeficiency (SCID) mice reconstituted with human peripheral blood
mononuclear cells (PBMC) (hu-PBL-SCID mice) with inactivated human
immunodeficiency virus type-1 (HIV-1)-pulsed-autologous dendritic cells (HIV-DC)
elicits HIV-1-reactive CD4+ T cells that produce an as yet to be defined novel
soluble factor in vitro with anti-viral properties
against CCR5 tropic (R5) HIV-1
infection. These findings led us to perform studies designed to identify the lineage
of the cell that synthesizes such a factor in vitro and define the epitopes of HIV-1
protein that have specificity for the induction of such anti-viral factor. Results of
our
studies show that this property is a function of CD4+ but not
CD8+ T cells. Human
CD4+ T cells were thus recovered from the HIV-DC-immunized
hu-PBL-SCID mice
and were re-stimulated in vitro by co-culture for 2 days with
autologous adherent
PBMC as antigen presenting cells, APC previously pulsed with inactivated HIV in
IL-2-containing medium to expand HIV-1-reactive CD4+
T cells. Aliquots of these
re-stimulated CD4+ T cells were then co-cultured with
similar APC's that were
previously pulsed with 10 ÎŒg/ml of a panel of HIV peptides for
an additional 2 days,
and their culture supernatants were examined for the production of both the R5
HIV-1 suppression factor and IFN-΄. The data presented herein
show that the HIV-1
primed CD4+ T cells produced the R5 suppression factor in
response to a wide
variety of HIV-1 gag, env, pol, nef or vif peptides, depending on the donor of
the CD4+ T cells. Simultaneous production of human interferon
(IFN)-΄ was
observed in some cases. These results indicate that human
CD4+ T cells in
PBMC of HIV-1 naive donors have a wide variety of HIV-1 epitope-specific
CD4+ T
cell precursors that are capable of producing the R5 HIV-1
suppression factor upon DC-based vaccination with whole inactivated HIV-1
Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience
- Author
- Publication venue
- 'ID Design 2012/DOOEL Skopje'
- Publication date
- 27/01/2019
- Field of study
AIM: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018.
METHODS: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI).
RESULTS: The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05.
CONCLUSION: NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone
Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study
- Author
- Abdul-Rahim A
- Ageno W
- Agnelli G
- Alberti A
- Antonenko K
- Aridon P
- Arnao V
- Bakola E
- Baldi A
- Bandini F
- Bavaud O
- Bertora P
- Buehrer M
- Caliandro P
- Canavero I
- Cappellari M
- Caselli MC
- Caso V
- Chiti A
- Ciccone A
- Cottone S
- Cronshaw R
- D'Amore C
- Dawson J
- De Marchis GM
- Del Sette M
- Denti L
- Diomedi M
- Emiliani A
- Engelter ST
- Falcou A
- Ferrari E
- Flomin Y
- Furie KL
- Gasparro A
- Genovese A
- Giannini N
- Giannopoulos S
- Giorli E
- Giustozzi M
- Grifoni E
- Grory BM
- Jayaraman M
- Kala N
- Kargiotis O
- Kosmidou M
- Kriemler L
- Lochner P
- Loos CMJ
- Lotti EM
- Lyrer P
- Mancuso M
- Mannino M
- Marcheselli S
- Masotti L
- McTaggart R
- Michel P
- Monaco S
- Mosconi MG
- Ntaios G
- Ntais E
- Ornello R
- Paciaroni M
- Padroni M
- Palaiodimou L
- Palmerini F
- Pantoni L
- Pavolucci L
- Pegoraro S
- Petraglia L
- Pezzini A
- Plocco M
- Polymeris AA
- Popovic N
- Putaala J
- Reale G
- Remillard S
- Reznik M
- Risitano A
- Rocco A
- Romoli M
- Rosa S
- Rota E
- Sacco S
- Saggese CE
- Sagris D
- Saia V
- Salerno A
- Schirinzi E
- Schomer A
- Scoditti U
- Seiffge DJ
- Silvestrelli G
- Strambo D
- Strbian D
- Stretz C
- Tassinari T
- Terruso V
- Tomppo L
- Toni D
- Traballi L
- Tsivgoulis G
- Ulivi L
- Urbini C
- Vanacker P
- Venti M
- Yaghi S
- Yperzeele L
- Zauli A
- Zedde M
- Zietz A
- Zuurbier S
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background:
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings remain uncertain.
Methods:
This prospective multicenter observational study aimed to estimate the rates of ischemic and bleeding events and their determinants in the follow-up of consecutive patients with atrial fibrillation who suffered an acute cerebrovascular ischemic event while on nonvitamin K antagonist oral anticoagulant treatment. Afterwards, we compared the estimated risks of ischemic and bleeding events between the patients in whom anticoagulant therapy was changed to those who continued the original treatment.
Results:
After a mean follow-up time of 15.0±10.9 months, 192 out of 1240 patients (15.5%) had 207 ischemic or bleeding events corresponding to an annual rate of 13.4%. Among the events, 111 were ischemic strokes, 15 systemic embolisms, 24 intracranial bleedings, and 57 major extracranial bleedings. Predictive factors of recurrent ischemic events (strokes and systemic embolisms) included CHA2DS2-VASc score after the index event (odds ratio [OR], 1.2 [95% CI, 1.0â1.3] for each point increase; P=0.05) and hypertension (OR, 2.3 [95% CI, 1.0â5.1]; P=0.04). Predictive factors of bleeding events (intracranial and major extracranial bleedings) included age (OR, 1.1 [95% CI, 1.0â1.2] for each year increase; P=0.002), history of major bleeding (OR, 6.9 [95% CI, 3.4â14.2]; P=0.0001) and the concomitant administration of an antiplatelet agent (OR, 2.8 [95% CI, 1.4â5.5]; P=0.003). Rates of ischemic and bleeding events were no different in patients who changed or not changed the original nonvitamin K antagonist oral anticoagulants treatment (OR, 1.2 [95% CI, 0.8â1.7]).
Conclusions:
Patients suffering a stroke despite being on nonvitamin K antagonist oral anticoagulant therapy are at high risk of recurrent ischemic stroke and bleeding. In these patients, further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischemic stroke and bleeding
Observation of a New Excited Beauty Strange Baryon Decaying to Îb- Ï+Ï-
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Abu Zeid S
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Antchev G
- Anthony D
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Atanasov I
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrio Luna M
- Barroso Ferreira Filho M
- Bartek R
- Bartosik N
- BartĂłk M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bechtel J
- Bedoya CF
- Beghin D
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Beni N
- Benitez JF
- Benussi L
- Berenguer Antequera J
- Beretvas A
- Bergauer T
- Berger P
- Berger T
- Beri SB
- BermĂșdez MartĂnez A
- Bernardes CA
- Bernet C
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Bethani A
- Beyrouthy T
- Bhal E
- Bhardwaj A
- Bharti M
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bheesette S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bi R
- Bialkowska H
- Bianchini L
- Bianco M
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- Biino C
- Bilei GM
- Bilin B
- Bin Anuar AA
- Bin Norjoharuddeen N
- Bisello D
- Black K
- Blekman F
- Blinov V
- Bloch D
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- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boletti A
- Bologna S
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonham B
- Bonomally S
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- Bornheim A
- Borras K
- Bortignon P
- Bose T
- Bossini E
- Botta C
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- Boudoul G
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- Bourilkov D
- Bozzo M
- Bragagnolo A
- Braghieri A
- Braibant-Giacomelli S
- Brainerd C
- Brandao Malbouisson H
- Brandt S
- Branson JG
- Breedon R
- Breeze S
- Brew C
- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brondolin E
- Brooke JJ
- Brown RM
- Brunner D
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- Brzhechko D
- BrĂŒcken E
- Bucci R
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- Capeans Garrido M
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- Caspart R
- Cassese A
- Castaldi R
- Castaneda Hernandez A
- Castilla-Valdez H
- Castro A
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- Chahal GS
- Chang P
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- Chatterjee RM
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- Chaudhary G
- Chauhan S
- Chauhan S
- Chawla R
- Chazin Quero B
- Checchia P
- Chekhovsky V
- Chen C
- Chen GM
- Chen HS
- Chen KF
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- Chen PH
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- Chenarani S
- Cheng C
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- Cheung HWK
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- Chiarito B
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- Choi J
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- Choudhary BC
- Choudhury S
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- Ciocci MA
- Cipriani M
- Ciriolo V
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clement E
- Clerbaux B
- CMS Collaboration
- Cockerill DJA
- Colaleo A
- Coldham K
- Cole JE
- Colino N
- Collard C
- Colling D
- Cometti S
- Connor P
- Consuegra RodrĂguez S
- Contardo D
- Conway J
- Cooper SI
- Cooperstein S
- Corcodilos L
- Cornelis T
- Cosby C
- Cossutti F
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- Coubez X
- Couderc F
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- Covarelli R
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- Cox PT
- Cranshaw DJ
- Creanza D
- Cremonesi M
- Cristella L
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- Cummings G
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- Cutts D
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- Da Costa EM
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- Damgov J
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- Darwish MR
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- Dutta V
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- Ferencek D
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- FernĂĄndez Manteca PJ
- FernĂĄndez Ramos JP
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- Field RD
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- Filatov O
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- Finger M
- Fiore L
- Fiorendi S
- Fiori F
- Fiorina D
- Fischer B
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- Flöh K
- FlĂŒgge G
- Focardi E
- Folgueras S
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- Fontanesi E
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- Forthomme L
- Foudas C
- Fouz MC
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- Fröhlich A
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- Gadallah MMA
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- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Îb-Ï+Ï- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Îb- is reconstructed via its decays to J/ÏÎ- and J/ÏÎK-. A narrow resonance, labeled Îb(6100)-, is observed at a Îb-Ï+Ï- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Îb-) MeV, where the last uncertainty reflects the precision of the Îb- baryon mass. The upper limit on the Îb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Îb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Îc baryon states, the new Îb(6100)- resonance and its decay sequence are consistent with the orbitally excited Îb- baryon, with spin and parity quantum numbers JP=3/2-
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of Ï Leptons in pp collisions at sqrt[s]=13ââTeV
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- Ăzçelik Ă
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the Ï lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13ââTeV and corresponding to an integrated luminosity of 138ââfb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two Ï leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Conceptual bases in restoration of scientific vertebrate collections
- Author
- BARBAGLI F
- BORGO E
- BRANDI C
- BRUNSTETTER RT
- CATO P
- CATO P
- CLEVEDON BROWN J
- COETZEE CG
- COOPER A
- COUSIN R
- DAUXOIS T
- DE WET E
- FLORIAN ME
- FRANĂA JS
- GRAHAM F
- GUIMARĂES L
- GĂTHS S
- HAWKS C
- HERHOLDT EM
- HOFREITER M
- HORIE CV
- HĂSS M
- JA Oliveira
- JANNETT JUNIOR FJ
- KRISHTALKA L
- LANGE CANHOS D
- LAPA R
- LFB Oliveira
- LOTTI S
- MARCHETTI S
- MARMUR J
- MICHALSKI S
- MUGNAI R
- PILETTE R
- R Mugnai
- RAGIONIERI R
- ROSE C
- ROSE CL
- SCROCCHI G
- SIMMONS JE
- VAN VEEN O
- WARTELL RM
- WILLIAMS SL
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Recommended from our members
Evidence for tWZ production in proton-proton collisions at âs=13 TeV in multilepton final states
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- Aarrestad TK
- Aarup Petersen H
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- Zoi I
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- Zygala L
- Publication venue
- Elsevier BV
- Publication date
- 21/06/2024
- Field of study
Data availability - https://www.sciencedirect.com/science/article/pii/S0370269324003733?via%3Dihub#dav0001 [Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open access policy (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2)]The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016â2018 in proton-proton collisions at âs=13 TeV, and correspond to an integrated luminosity of 138 fbâ1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.SCOAP
Recommended from our members
Measurement of inclusive and differential cross sections for single top quark production in association with a W boson in proton-proton collisions at sâ = 13 TeV
- Author
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- Ălvarez FernĂĄndez A
- Publication venue
- Springer Nature
- Publication date
- 06/11/2022
- Field of study
A preprint version of the article is available at arXiv:2208.00924v2 [hep-ex], https://arxiv.org/abs/2208.00924v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-21-010 (CMS Public Pages). Report number: CMS-TOP-21-010, CERN-EP-2022-158.Measurements of the inclusive and normalised differential cross sections are presented for the production of single top quarks in association with a W boson in proton-proton collisions at a centre-of-mass energy of 13 TeV. The data used were recorded with the CMS detector at the LHC during 2016-2018, and correspond to an integrated luminosity of 138 fb^{â1}. Events containing one electron and one muon in the final state are analysed. For the inclusive measurement, a multivariate discriminant, exploiting the kinematic properties of the events is used to separate the signal from the dominant ttÂŻ background. A cross section of 79.2 ± 0.9 (stat) +7.7â8.0 (syst) ± 1.2 (lumi) pb is obtained, consistent with the predictions of the standard model. For the differential measurements, a fiducial region is defined according to the detector acceptance, and the requirement of exactly one jet coming from the fragmentation of a bottom quark. The resulting distributions are unfolded to particle level and agree with the predictions at next-to-leading order in perturbative quantum chromodynamics.SCOAP3
Observation of triple J/Ï meson production in proton-proton collisions
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- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/01/2023
- Field of study
Data availability:
Tabulated results are provided in the HEPData record for this analysis71. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in CMS data preservation, re-use and open access policy.Code availability:
The CMS core software is publically available at https://github.com/cms-sw/cmssw.Copyright . Protons consist of three valence quarks, two up-quarks and one down-quark, held together by gluons and a sea of quark-antiquark pairs. Collectively, quarks and gluons are referred to as partons. In a proton-proton collision, typically only one parton of each proton undergoes a hard scattering â referred to as single-parton scattering â leaving the remainder of each proton only slightly disturbed. Here, we report the study of double- and triple-parton scatterings through the simultaneous production of three J/Ï mesons, which consist of a charm quark-antiquark pair, in proton-proton collisions recorded with the CMS experiment at the Large Hadron Collider. We observed this process â reconstructed through the decays of J/Ï mesons into pairs of oppositely charged muons â with a statistical significance above five standard deviations. We measured the inclusive fiducial cross-section to be 272+141â104(stat)±17(syst)fb, and compared it to theoretical expectations for triple-J/Ï meson production in single-, double- and triple-parton scattering scenarios. Assuming factorization of multiple hard-scattering probabilities in terms of single-parton scattering cross-sections, double- and triple-parton scattering are the dominant contributions for the measured process.SCOAP3.Change history:
27 February 2023A Correction to this paper has been published: https://doi.org/10.1038/s41567-023-01992-
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