We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe arthritis. PsA with HLA-Cw06 (+) had a higher risk of earlier onset and shorter duration for plaque psoriasis to transform into PsA. HLA-DR7 (+) in PsA delayed the time for conversion from plaque psoriasis into PsA. These findings are quite similar to other studies in the literature

Bui Thi, Van

Chau Van, Tro

Dang Van, Em

Feliciani, Claudio

Gandolfi, Marco

Lotti, Torello

Ngo Minh, Vinh

Ngoc, Anh Tran

Nguyen Ngoc, Trai

Satolli, Francesca

Tirant, Michael

Vojvodic, Aleksandra

Minh, Vinh Ngo

Thi, Van Bui

Van, Tro Chau

Ngoc, Trai Nguyen

Van, Em Dang

Archivio istituzionale della Ricerca -  Università degli Studi di Parma

The Relationship between HLA-B27, HLA-Cw06, HLA-DR7 and Psoriatic Arthritis in Vietnamese Patients: Disease Progression and Therapeutic Burden

Open Access Macedonian Journal of Medical Sciences 

 
Open Access Maced J Med Sci electronic publication ahead of print,  
published on January 27, 2019 as https://doi.org/10.3889/oamjms.2019.064 
_______________________________________________________________________________________________________________________________ 
Open Access Maced J Med Sci.                                                                                                                                                                                                          1 
 
ID Design Press, Skopje, Republic of Macedonia 
Open Access Macedonian Journal of Medical Sciences. 
Special Issue: Vietnamese Dermatology 
https://doi.org/10.3889/oamjms.2019.064 
eISSN: 1857-9655 
Letter to the Editor 
 
 
  
 
The Relationship between HLA-B27, HLA-CW06, HLA-DR7 and 
Psoriatic Arthritis in Vietnamese Patients: Disease Progression 
and Therapeutic Burden 
 
 
Vinh Ngo Minh
1
, Van Bui Thi
2
, Tro Chau Van
1
, Trai Nguyen Ngoc
1
, Anh Tran Ngoc
1
, Em Dang Van
3
, Marco Gandolfi
4
, 
Francesca Satolli
4
, Claudio Feliciani
4
, Michael Tirant
5,6
, Aleksandra Vojvodic
7
, Torello Lotti
5
 
 
1
Pham Ngoc Thach University of Medicine, HCMC, Vietnam; 
2
Military Central Hospital, Hanoi City, Vietnam; 
3
Institute of 
Clinical Medical & Pharmaceutical Sciences, Hanoi City, Vietnam; 
4
Unit of Dermatology, University of Parma, Parma, Italy; 
5
University of Rome G. Marconi, Rome, Italy; 
6
Psoriasis Eczema Clinic, Melbourne, Australia; 
7
Department of Dermatology 
and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia 
 
Citation: Ngo Minh V, Bui Thi V, Chau Van T, Nguyen 
Ngoc T, Tran Ngoc A, Dang Van E, Gandolfi M, Satolli F, 
Feliciani C, Tirant M, Vojvodic A, Lotti T. The 
Relationship Between HLA-B27, HLA-CW06, HLA-DR7 
And Psoriatic Arthritis (Psa) In Vietnamese Patients. 
Disease Progression and Therapeutic Burden. Open 
Access Maced J Med Sci. 
https://doi.org/10.3889/oamjms.2019.064 
Keywords: Psoriasis; Psoriatic arthritis; HLA-B27 
*Correspondence: Marco Gandolfi. Unit of Dermatology, 
University of Parma, Parma, Italy. E-mail: 
marco.gandolfi5@gmail.com 
Received: 02-Jan-2019; Revised: 16-Jan-2019; 
Accepted: 17-Jan-2019; Online first: 27-Jan-2019 
Copyright: © 2019 Vinh Ngo Minh, Van Bui Thi, Tro 
Chau Van, Trai Nguyen Ngoc, Anh Tran Ngoc, Em Dang 
Van, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, 
Michael Tirant, Aleksandra Vojvodic, Torello Lotti. This is 
an open-access article distributed under the terms of the 
Creative Commons Attribution-NonCommercial 4.0 
International License (CC BY-NC 4.0) 
Funding: This research did not receive any financial 
support 
Competing Interests: The authors have declared that no 
competing interests exist 
 
 
 
 
Abstract 
We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from 
January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and 
therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe 
arthritis. PsA with HLA-Cw06 (+) had a higher risk of earlier onset and shorter duration for plaque psoriasis to 
transform into PsA. HLA-DR7 (+) in PsA delayed the time for conversion from plaque psoriasis into PsA. These 
findings are quite similar to other studies in the literature. 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Dear Editor,  
 
We conducted a prospective, cross-sectional 
study at Ho Chi Minh City Hospital of Dermato 
Venereology from January 2016 to March 2017 in 40 
PsA patients, 37 plaque psoriasis patients, and 33 
healthy people. They were tested HLA-B27, HLA-
Cw06, HLA-DR7 by Sequence Specific Primer-
Polymerase Chain Reaction (SSP-PCR) technique. 
The rate of HLA-B27 in PsA was 32.5%, in 
plaque psoriasis was 1.92%, in the healthy group was 
9.09%. The rate of HLA-Cw06 in PsA was 7.5%, in 
plaque psoriasis was 18.92%, in healthy group was 
3.03%. The rate of HLA-DR7 in PsA was 32.5%, in 
plaque psoriasis was 27.30%, in healthy group was 
24.24%. HLA-B27 (+) patients had a high risk of PsA 
with RR = 1.6. PsA with HLA-B27 (+) had a threat of 
severe arthritis. PsA with HLA-Cw06 (+) had a higher 
risk of earlier onset and shorter duration for plaque 
psoriasis to transform into PsA. HLA-DR7 (+) in PsA 
delayed the time for conversion from plaque psoriasis 
into PsA.  
Many types of research show the relationship 
between HLA-B27, HLA-Cw06, and PsA. HLA-B27 
took high percentage in PsA and related to early onset 
of arthritis, spondylitis (spinal joint, sacroiliac joint), 
Letter to the Editor 
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distal interphalangeal joint arthritis and uveitis, 
affecting more frequently males and with poor 
prognosis; HLA-Cw06 involved the early onset of skin 
psoriasis, late arthritis, extensive cutaneous lesions, 
often happened in patients which positive family 
history for psoriasis. HLA-DR7 involved the progress 
of PsA. According to many scientists, HLA-DR7 and 
B22 are protective factors.  
Alenius et al., [1] researched clinical signs 
and HLA in 88 PsA patients in Switzerland in which 
25.7% of patients were HLA-B27 (+). Danafa et al., [2] 
researched the relationship between HLA and PsA in 
158 PsA patients in which 15.8% patients were HLA-
B27 (+). 
Fitzgerald at al., [3] in 2015 showed that the 
rate of HLA-Cw06 (+) was 28.5%. Another research of 
Danafa et al., [2] showed the relationship between 
HLA and PsA in 158 PsA patients concluded that 12% 
of patients had HLA-Cw06 (+) and demonstrated the 
relationship between HLA-B27 and PsA. 
Alenius and his associates found that healthy 
people with HLA-B27 (+) had a greater risk of PsA (p 
= 0.017). 
This is the first study that analyses the HLA 
pattern of psoriatic patients in Vietnam and correlates 
with disease progression and therapeutic burden. 
 
 
References 
 
1. Alenius GM, Jidell E, Nordmark L, Dahlqvist SR. Disease 
manifestations and HLA antigens in psoriatic arthritis in northern 
Sweden. Clinical Rheumatology. 2002; 21(5):357-62. 
https://doi.org/10.1007/s100670200097 PMid:12223981  
2. Gladman DD, Farewell VT. The role of HLA antigens as 
indicators of disease progression in psoriatic arthritis. Arthritis & 
Rheumatism: Official Journal of the American College of 
Rheumatology. 1995; 38(6):845-50. 
https://doi.org/10.1002/art.1780380619 
 
3. FitzGerald O, Haroon M, Giles JT, Winchester R. Concepts of 
pathogenesis in psoriatic arthritis: genotype determines clinical 
phenotype. Arthritis research & therapy. 2015; 17(1):115. 
https://doi.org/10.1186/s13075-015-0640-3 PMid:25948071 
PMCid:PMC4422545 
 
 


The Relationship between HLA-B27, HLA-Cw06, HLA-DR7 and Psoriatic Arthritis in Vietnamese Patients: Disease Progression and Therapeutic Burden

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Open Access Macedonian Journal of Medical Sciences