"Io accesi un lume"

Planteamientos filosóficos y religiosos de Campanella que se ponen de manifiesto en su obra lírica y muy especialmente en la composición que lleva el nombre de este artículo. Manifiesta junto con Giordano Bruno su convencimiento de ser un enviado para sacar a lso hombres de la ignorancia en la que les ha sumido su alejamiento de Dios y del verdadero conocimiento

Botticelli y Poliziano en el círculo de Lorenzo

El nuevo ideal que representa el neoplatonismo naciente de la mano de Marsilio Ficino, reúne en torno a Lorenzo de' Medici una serie de artistas: pensadores, pintores, escritores, entre los que destacan Botticelli y Poliziano quienes, además, se hallan unidos a través de sus obras más bellas: El nacimiento de Venus y la Primavera del pintor y las Stanze de Poliziano

The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization

The human Cranio Facial Development Protein 1 (Cfdp1) gene maps to chromosome 16q22.2-q22.3 and encodes the CFDP1 protein, which belongs to the evolutionarily conserved Bucentaur (BCNT) family. Craniofacial malformations are developmental disorders of particular biomedical and clinical interest, because they represent the main cause of infant mortality and disability in humans, thus it is important to understand the cellular functions and mechanism of action of the CFDP1 protein. We have carried out a multi-disciplinary study, combining cell biology, reverse genetics and biochemistry, to provide the first in vivo characterization of CFDP1 protein functions in human cells. We show that CFDP1 binds to chromatin and interacts with subunits of the SRCAP chromatin remodeling complex. An RNAi-mediated depletion of CFDP1 in HeLa cells affects chromosome organization, SMC2 condensin recruitment and cell cycle progression. Our findings provide new insight into the chromatin functions and mechanisms of the CFDP1 protein and contribute to our understanding of the link between epigenetic regulation and the onset of human complex developmental disorders

La vigencia de la tradición cultural mesoamericana en Milpa Alta, pueblo antiguo de la cuenca de México

En este artículo, la autora explora, a través de un trabajo de campo, la forma en que la memoria histórica se articula con la cosmovisión en Milpa Alta, un pueblo antiguo de la ciudad de México. La narración mítica que refiere al origen, se ubica en la historia de "larga duración", en el ensamblaje de la naturaleza con los ciclos de las fiestas religiosas y la relación con la tierra. La cosmovisión mesoamericana, incesantemente repetida, atraviesa el tiempo y le corresponde contar con siglos de duración, con profundidad, con una especie de semi-inmovilidad que hace que todo en Milpa Alta gravite en torno a ella.In this article, the author explores, in the field, the way in which historical memory is articulated with cosmovision in Milpa Alta, a village within the confines of what is now Mexico City. The mythic narration that refers to Milpa Alta's origins is situated in the history of "longue durée", in the interlocking of nature with the cycles of religious festivals and the relation with the land. Mesoamerican cosmovision, incessantly repeated, runs through time and has lasted for centuries, profoundly rooted with a sort of semi-immobility which means that everything in Milpa Alta gravitates towards it

Patrimonio: preservando la memoria, construyendo identidad

Por patrimonio se entiende el conjunto de bienes valiosos, materiales o inmateriales, heredados de los antepasados. Ellos reflejan el espíritu de una familia, de una época, de una comunidad, de una nación, y de la propia humanidad. El patrimonio que se va decantando de generación en generación conforma el sello distintivo de una persona, de una familia, de un pueblo. Por ello, el patrimonio constituye una manera de acercarse al conocimiento de la identidad.Trabajo perteneciente al Proyecto "Patrimonio y Educación" de la Prosecretaría de Asuntos AcadémicosPaper belonging to Project "Heritage and Education" of the Undersecretary for Academic AffairsTrabalho pertencente ao Projeto "Patrimônio e Educação"da Subsecretária da Assuntos AcadêmicosProsecretaría de Asuntos Académico

Impact of climate change on solar irradiation and variability over the Iberian Peninsula using regional climate models

As solar energy will be an increasingly important renewable energy source in the future years, the study of how climate change affects both temporal and spatial variability is very important. In this paper, we study future changes of the solar radiation resource in the Iberian Peninsula (IP) through a set of simulations from ESCENA project until mid-century. The evaluation of the simulations against observations indicates contrasting biases for the different regional climate models (RCMs) in terms of solar irradiation amount and its interannual variability. We propose a diagnostic for the quality of solar energy resource, in which the gridpoints are classified in four categories depending on the combination of solar irradiation amount and variability. The observed large percentage of points in the optimal category (high irradiation/low variability) in the IP is captured by the RCMs in general terms. The analysis of scenarios indicates a future increase in solar irradiation, although not all scenarios agree in the geographical distribution of this increase. In most projections, a shift is projected from the category with optimal resource quality towards the category with high irradiation/high variability, pointing to a certain quality loss in the solar resource. This result is not general, as a few scenarios show an opposite result. The exceptions are not linked to a particular GCM or emissions scenario. Finally, results from a first approximation to the issue of the ability of solar energy to cover power demand peaks in summer show important differences between regions of the IP. The spatially-averaged correlation of solar irradiation and summer surface temperatures for the whole IP is rather high, which is a positive result as the strong interconnections of the power grid within the IP could allow a distribution of solar power surpluses in certain regions for such high-temperature episodes

Multidecadal Modulation of ENSO Teleconnection with Europe in Late Winter: Analysis of CMIP5 Models

Many studies point to a robust ENSO signature on the North Atlantic–European (NAE) sector associated with a downstream effect of Rossby wave trains. Some of these works also address a nonstationary behavior of the aforementioned link, but only few have explored the possible modulating factors. In this study the internal causes within the ocean–atmosphere coupled system influencing the tropospheric ENSO–Euro-Mediterranean rainfall teleconnection have been analyzed. To this aim, unforced long-term preindustrial control simulations from 18 different CMIP5 models have been used. A nonstationary impact of ENSO on Euro-Mediterranean rainfall, being spatially consistent with the observational one, is found. This variable feature is explained by a changing ENSO-related Rossby wave propagation from the tropical Pacific to the NAE sector, which, in turn, is modulated by multidecadal variability of the climatological jet streams associated with the underlying sea surface temperature (SST). The results, therefore, indicate a modulation of the ENSO–Euro-Mediterranean rainfall teleconnection by the internal (and multidecadal) variability of the ocean–atmosphere coupled system.This study was supported by the European project PREFACE (603521), and the Spanish projects TRACS (CGL2009-10285) and MULCLIVAR (CGL2012- 38923-C02-01).Peer reviewe

Modelización y medida de la calidad percibida de la atención al parto en la comunidad gallega

En los últimos años hemos asistido a una auténtica “revolución” en todo lo que rodea a la asistencia al parto y, en consecuencia, al funcionamiento de los servicios hospitalarios de maternidad. Los avances tecnológicos y sanitarios incorporados al seguimiento del embarazo y al propio parto son innumerables. En nuestros días la mayoría de las mujeres dan a luz en hospitales (públicos o privados) y siempre con el apoyo continuo de personal sanitario cualificado y de diferentes elementos tecnológicos. Ello ha reducido espectacularmente las cifras de mortalidad y de las incidencias, pero ha traído consigo una sobremedicalización del proceso y una pérdida de protagonismo y control para la propia madre y la familia. Actualmente se recomienda que las intervenciones en torno al parto se basen únicamente en la evidencia científica y nunca se ejecuten de espaldas al propio usuario del servicio: las madres y sus familias. Las consecuencias acarreadas por intervenciones innecesarias terminan por convertirse en un problema, tanto en términos de salud, como de gasto de recursos