A geometrical model for the Monte Carlo simulation of the TrueBeam linac

Monte Carlo (MC) simulation of linacs depends on the accurate geometrical description of the head. The geometry of the Varian TrueBeam (TB) linac is not available to researchers. Instead, the company distributes phase-space files (PSFs) of the flattening-filter-free (FFF) beams tallied upstream the jaws. Yet, MC simulations based on third party tallied PSFs are subject to limitations. We present an experimentally-based geometry developed for the simulation of the FFF beams of the TB linac. The upper part of the TB linac was modeled modifying the Clinac 2100 geometry. The most important modification is the replacement of the standard flattening filters by ad hoc thin filters which were modeled by comparing dose measurements and simulations. The experimental dose profiles for the 6MV and 10MV FFF beams were obtained from the Varian Golden Data Set and from in-house measurements for radiation fields ranging from 3X3 to 40X40 cm2. Indicators of agreement between the experimental data and the simulation results obtained with the proposed geometrical model were the dose differences, the root-mean-square error and the gamma index. The same comparisons were done for dose profiles obtained from MC simulations using the second generation of PSFs distributed by Varian for the TB linac. Results of comparisons show a good agreement of the dose for the ansatz geometry similar to that obtained for the simulations with the TB PSFs for all fields considered, except for the 40X40 cm2 field where the ansatz geometry was able to reproduce the measured dose more accurately. Our approach makes possible to: (i) adapt the initial beam parameters to match measured dose profiles; (ii) reduce the statistical uncertainty to arbitrarily low values; and (iii) assess systematic uncertainties by employing different MC codes

Distribución de los Principales Minerales no Metalíferos de la República Argentina Para Las Industrias Básicas De Transformación

Fil. Aristarain, Lorenzo Francisco (†). Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata. Argentina.Fil. Cozzi, Guillermo Arturo. Instituto Nacional de Tecnología Minera. Servicio Geológico Minero Argentino. Argentina.Trabajo inédito presentado en Seminario de Información técnica sobre “Minerales para las industrias básicas de transformación”, organizado por la revista Panorama Minero entre el 12 y 14 de noviembre de 1991, y publicado sucesivamente en diferentes números de dicha revista. Tiene carácter de divulgación para un uso amplio de profesionales del sector minero y la información contenida fue recopilada de publicaciones científicas y técnicas de amplia divulgación y de fácil adquisición o acceso. La compilación de la información y la redacción fue realizada por el Centro de Investigación para las Industrias mineras del INTI, Migueletes, provincia de Bs. As

Visita Preliminar a los Afloramientos de Pórfiro Riolítico del Lote 23, Departamento Limay Mahuida, Provincia de La Pampa

Fil: Aristarain, Lorenzo Francisco (†). Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata. Argentina.Fil: Cozzi, Guillermo. Instituto Nacional de Tecnología Minera. Servicio Geológico Minero Argentino. Argentina.Informe inédito, realizado por los autores, con una evaluación preliminar del potencial para producir piedra partida, a partir de afloramientos riolíticos ubicados en el lote 23 del departamento Limay Mahuida, provincia de La Pampa. Los estudios de campo y ensayos posteriores fueron realizados en el marco de un servicio de asesoramiento a cargo del Centro de Investigación para las Industrias mineras (CIIM) del INTI, Migueletes, provincia de Bs. As

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors.

Ischemia of brain areas is a global health problem, causing death or long-term disability. Current pharmacological options have limited impact on ischemic damages. Recently, a relationship between hypoxia and carbonic anhydrase (CA) over-expression has been highlighted suggesting CA inhibition as a possible target. This study aimed to evaluate the pharmacological profile of sulfonamide and coumarin CA inhibitors in rats underwent permanent middle cerebral artery occlusion (pMCAO). The neurological score of pMCAO rats was dramatically reduced 24 h after occlusion. Repeated subcutaneous injections of the CA inhibitors 4 and 7 (1 mg kg(-1)) were able to increase the neurological score by 40%. Compound 7 showed the tendency to reduce the volume of hemisphere infarction. The standard CA inhibitor acetazolamide was ineffective. The properties of novel CA inhibitors to improve neurological functionalities after cerebral ischemic insult are shown. The CA involvement in cerebral hypoxic phenomena deserves deeper investigations

Theory Meets Experiment for Noncovalent Complexes: The Puzzling Case of Pnicogen Interactions

A gas-phase nitrogen\u2013nitrogen noncovalent interaction has been unveiled in the nitroethane\u2013trimethylamine complex in an environment free from solvent and matrix effects using rotational spectroscopy in supersonic expansion. Different quantum chemical models (NOCV/CD and NBO) agree in indicating that this interaction largely prevails over the C 12H c5 c5 c5O and C 12H c5 c5 c5N hydrogen bonds. Furthermore, a SAPT analysis shows that electrostatic and dispersion interactions play a comparable role in stabilizing the complex. The conformational landscape exploration and stationary points characterization have been performed using state-of-the-art quantum-chemical computations providing significant insights on structure determination

A Journey from Thermally Tunable Synthesis to Spectroscopy of Phenylmethanimine in Gas Phase and Solution

Phenylmethanimine is an aromatic imine with a twofold relevance in chemistry: organic synthesis and astrochemistry. To tackle both aspects, a multidisciplinary strategy has been exploited and a new, easily accessible synthetic approach to generate stable imine-intermediates in the gas phase and in solution has been introduced. The combination of this formation pathway, based on the thermal decomposition of hydrobenzamide, with a state-of-the-art computational characterization of phenylmethanimine laid the foundation for its first laboratory observation by means of rotational electric resonance spectroscopy. Both E and Z isomers have been accurately characterized, thus providing a reliable basis to guide future astronomical observations. A further characterization has been carried out by nuclear magnetic resonance spectroscopy, showing the feasibility of this synthetic approach in solution. The temperature dependence as well as possible mechanisms of the thermolysis process have been examined

Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

BACKGROUND: Long-term local control in Glioblastoma is rarely achieved and nearly all patients relapse. In this study we evaluated the clinical effect of different treatment approaches in recurrent patients. METHODS: Forty-three patients, with median age of 51 years were evaluated for salvage treatment: re-resection and/or re-irradiation plus chemotherapy or chemotherapy alone. Response was recorded using the Response Assessment in Neuro-Oncology criteria. Hematologic and non-hematologic toxicities were graded according to Common Terminology Criteria for Adverse Events 4.0. Twenty-one patients underwent chemotherapy combined with local treatment, surgery and/or radiation therapy, and 22 underwent chemotherapy only. RESULTS: The median follow up was 7 months (range 3–28 months). The 1 and 2-years Progression Free Survival was 65 and 10 % for combined treatment and 22 and 0 % for chemotherapy alone (p < 0.01). The 1 and 2-years overall survival was 69 and 29 % for combined and 26 and 0 % for chemotherapy alone (p < 0.01). No toxicity greater than grade 2 was recorded. CONCLUSION: These data showed that in glioblastoma recurrence the combination of several approaches in a limited group of patients is more effective than a single treatment alone. This stress the importance of multimodality treatment whenever clinically feasible

Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes.

Exendin-4 (Ex-4) is a Glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of Type 2 Diabetes (T2DM), which requires daily subcutaneous administration. In T2DM patients, GLP-1 administration is reported to reduce glycaemia and HbA1c in association with a modest, but significant weight loss. The aim of present study was to characterize the site-specific profile and metabolic effects of Ex-4 levels expressed from salivary glands (SG) in vivo, following adeno-associated virus-mediated (AAV) gene therapy in two different animal models of obesity prone to impaired glucose tolerance and T2DM, specifically, Zucker fa/fa rats and high fed diet (HFD) mice. Following percutaneous injection of AAV5 into the salivary glands, biologically active Ex-4 was detected in the blood of both animal models and expression persisted in salivary gland ductal cell until the end of the study. In treated mice, Ex-4 levels averaged 138.9±42.3 pmol/L on week 6 and in treated rats, mean circulating Ex-4 levels were 238.2±72 pmol/L on week 4 and continued to increase through week 8. Expression of Ex-4 resulted in a significant decreased weight gain in both mice and rats, significant improvement in glycemic control and/or insulin sensitivity as well as visceral adipose tissue adipokine profile. In conclusion, these results suggest that sustained site-specific expression of Ex-4 following AAV5-mediated gene therapy is feasible and may be useful in the treatment of obesity as well as trigger improved metabolic profile