Las actuaciones inspectivas de orientación y la informalidad laboral en Lima Metropolitana, 2021

Las actuaciones inspectivas de orientación son servicios públicos que presta la Inspección del Trabajo con el fin de orientar y/o asesorar a los empleadores y a los trabajadores sobre el mejor cumplimiento de las disposiciones legales en materia sociolaboral. La informalidad laboral por el contrario es la situación irregular de prestar trabajo fuera del marco de las normas legales. El estudio tuvo como objetivo determinar la relación existente entre las actuaciones inspectivas de orientación y la informalidad laboral en Lima Metropolitana, 2021. La investigación tiene enfoque cuantitativo, es tipo básica, de nivel correlacional y de diseño no experimental, transversal. La población estuvo integrada por cincuenta y cinco colaboradores y para efectos de la recopilación de la data se aplicó la técnica de la encuesta, empleando como instrumento el cuestionario. Los resultados estadísticos obtenidos nos indican que existe una relación significativa inversa entre las actuaciones inspectivas de orientación y la informalidad laboral, así como con las dimensiones seguridad social y condiciones de trabajo respectivamente; por lo que en dichos extremos se aceptó las hipótesis alternativas. En cuanto a la dimensión beneficios sociales no se rechazó la hipótesis nula

Spectrophotometric determination of the formation constants of calcium(II) complexes with 2,2'-bipyridyl and 1,10-phenanthroline in acetonitrile

The oxygen-evolving complex (OEC), which consists of a calcium-manganese cluster, is the reaction center of the Photosystem II. At this catalytic site, the water-splitting reaction in dioxygen and hydronium ions occurs. In order to partially reproduce the water splitting process, several studies have reported the synthesis of functional model complexes. Nevertheless, there is a small amount of reports, concerning the spectral behavior of calcium complexes or the calcium role in the cluster. In this work, in order to explore the absorption spectrum of calcium species in acetonitrile, an equilibrium study of the calcium complexes with 2,2'-bipyridyl or 1,10-phenanthroline, was carried out. The formation constants and the calculated electronic spectrum of each complex was obtained by a modified method of continuous variations consisting in a correlation of the experimental spectrophotometric data with the HypSpec software. The values of the formation constants for the calcium(II) complexes with 2,2'-bipyridyl and 1,10-phenanthroline, are Log β110 = 4.39 ± 0.02 and Log β110 = 5.94 ± 0.05, respectively

Proteinuria inducida por ejercicio físico

A partir del siglo XIX comienzan a realizarse las primeras observaciones relacionadas a los efectos de la actividad física sobre la función renal. Leube1 en 1878 observa que de 119 soldados cuya orina de la mañana estaba libre de proteínas, 14 desarrollaban proteinuria después de una larga marcha de instrucción. Collier1 en 1907, ratifica este hallazgo en remeros y los considera una alteración funcional. Unos años después se atribuye la albuminuria, que aparece tras una prueba de maratón, al trauma mecánico producido por la propia carrera; en tanto que otros consideraron a la acidosis responsable de la proteinuria o a posibles cambios en la circulación renal.Introducción: Leube en 1878 observa que de 119 soldados cuya orina de la mañana estaba libre de proteínas, 14 desarrollaban proteinuria después de una larga marcha de instrucción, por lo que con el objetivo de determinar si existe proteinuria inducida por ejercicio físico en pacientes sometidos a esfuerzo del Hospital Regional Tenancingo del ISSEMYM se realizó el presente estudio. Materiales y métodos: Se realizó un estudio de tipo transversal, observacional y descriptivo en una población de 29 individuos; 11 hombres y 18 mujeres de 42 a 76 años de edad, con diagnósticos de obesidad, diabetes mellitus tipo 2 e hipertensión arterial sistémica, que acuden al programa de ejercicio físico medico controlado en el hospital regional Tenancingo del ISSEMYM. Se realizó una determinación de proteínas en orina previo a la sesión de ejercicio en una muestra de la primer orina de la mañana. Posteriormente, se sometió al grupo de estudio a una sesión de ejercicio físico predeterminada de acuerdo al programa de ejercicio físico medico controlado del instituto. Dentro de los primeros 30 minutos posteriores a la sesión de ejercicio físico se realizó una segunda determinación de proteínas en orina. Se pidió al grupo de estudio que no realizara ejercicio físico en las 48 horas posteriores a la sesión de ejercicio y se convocó a acudir a las 48 horas de la segunda muestra, para la recolección de una tercer muestra de orina. El estudio se realizó de junio a noviembre del año 2011. Resultados: Del análisis de resultados se encuentra al 21% del grupo de estudio con proteinuria inducida por ejercicio físico. Conclusión: Del análisis de los resultados obtenidos, se muestra que en el 21% de los pacientes integrantes del grupo de estudio presentan proteinuria inducida por ejercicio físico. Indicando así probablemente una mala tolerabilidad a la intensidad de la carga aplicada en su sesión de ejercicio físico

Effect of thermal treatment on Zn nanodisks

Artículo asociado a tesis de Doctorado del estudiante Pedro Estanislao Acuña AvilaMetallic Zn nanodisks with hexagonal morphology were obtained onto glass sub- strate under vacuum thermal evaporation. A thermal characterization of Zn nanodiks showed a lower oxidation temperature than source powder Zn. Different thermal treatment on Zn nanodisks played an important role on the morphology, crystal size and surface vibrational modes of ZnO. The growth of ZnO nanoneedles started at the edge of metallic zinc hexagonal structures according with SEM images, the higher temperature the longer needles were grown. XRD diffractogram confirmed the wurtzite structure of ZnO with metallic nuclei. A wide band between 530 and 580 cm−1 of Raman scattering corresponded at surface vibrational modes not observed at higher temperatur

Gamifying massive online courses: effects on the social networks and course completion rates

This paper analyzes the e ects of gamification in the social network of a massive online course. An educational social-networking platform gathered information about the contributions of participants and about the social networks that were formed during the course. A gamification layer with three game elements (points, badges, and leaderboard) was then implemented in the online learning platform. Social network analysis (SNA) and principal component analysis (PCA) were used to analyze the di erences between a treatment and a comparison group (N = 591 and N = 427), using a set of 20 variables for each participant which quantified contributions to the learning platform as well as position and influence in the social network. The results of SNA show that gamification influences the structure of the social network of the course. The results also suggest that the variables cluster similarly for each group and that the linear combination of variables called the first component (F1) is a good descriptor of students’ work and position in the network. F1 can be used to build predictive models of course completion. The models show that the probability of passing the course increases more rapidly in the treatment (gamified) group.Spanish Ministry of Economic A airs and Digital Transformation (Grant TIN2014-54874-R) and Government of Comunidad de Madrid (Grant CM/JIN/2019-037).info:eu-repo/semantics/publishedVersio

Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge

Porcine rubulavirus (PRV) is a contagious virus that affects the Mexican swine industry. This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-day- old suckling piglets against PRV lethal challenge. Three sows were immunized with rHN-PorPV formulated with immune-stimulating complex (ISCOMs) and two sows with rHN- PorPV protein alone as well as a mock-immunized pregnant sow (negative control). Quantitative ELISA detected a high concentration of anti-rHN-PorPV Immunoglobulin G (IgG) antibodies in sow sera after the second dose of vaccine administered on day 14 until farrowing, showing viral-neutralizing and cross-neutralization activity against different variants of PRV. Sera samples from piglets of immunized sows (with or without adjuvant), showed high concentrations of IgG antibodies. As expected, piglets from the negative control sow (n=5), exhibited severe signs of disease and 100% of mortality after PRV challenge study. Conversely, 75% and 87.5% of the piglets born from the rHN-PorPV and the rHN-PorPV-ISCOMs-immunized sows (n= 8), survived, respectively, showing milder PRV clinical signs. Our data indicate that rHN-PorPV candidate vaccine produced in Escherichia coli induces efficient humoral response in pregnant sows and that the maternally derived immunity provides high protection to suckling piglets against PRV lethal challenge

Prognostic microRNAs in upper tract urothelial carcinoma: multicenter and international validation study

Objective: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients.Patients and Methods: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR. Normalized miRNA expression values were evaluated by multivariate forward stepwise Cox regression analysis. Kaplan Meier curves were used to discriminate between two groups of patients with a different probability of tumour progression.Results: The mean age (range) of the series was 67 (33-94) years. Overall, 45 patients (43.7%) developed tumour progression and 32 patients (31.2%) died, 20 of these (62.5%) due to their UTUC, after a median follow-up of 36 months. The mean time for tumour progression and cancer-specific survival were 15 and 20 months, respectively. Five year tumour progression free survival and cancer-specific survival were 58% for <= pT2, 36% for pT3 and 0% for pT4 and 67.8% for <= pT2, 50.6% for pT3 and 0% for pT4, respectively. In the multivariate analysis, expression of miR-31-5p was found to be an independent prognostic factor of tumour progression (HR 1.1; 95% CI 1.039-1.273; p=0.02). Kaplan Meier curve shows that miR-31-5p expression values are able to discriminate between two groups of UTUC patients with a different probability of tumour progression (p=0.007).Conclusions: We have been able to validate our previous results in an independent multicentre international cohort of UTUC patients, suggesting that miRNA-31-5p could be a useful prognostic marker of UTUC progression. The application of miRNA expression values to clinical practice could refine the currently used clinicopathological-based approach for predicting UTUC patients' outcome