Lower mass normalization of the stellar initial mass function for dense massive early-type galaxies at z ~ 1.4

This paper aims at understanding if the normalization of the stellar initial mass function (IMF) of massive early-type galaxies (ETGs) varies with cosmic time and/or with mean stellar mass density Sigma (M*/2\pi Re^2). For this purpose we collected a sample of 18 dense (Sigma>2500 M_sun/pc^2) ETGs at 1.2<z<1.6 with available velocity dispersion sigma_e. We have constrained their mass-normalization by comparing their true stellar masses (M_true) derived through virial theorem, hence IMF independent, with those inferred through the fit of the photometry assuming a reference IMF (M_ref). Adopting the virial estimator as proxy of the true stellar mass, we have assumed for these ETGs zero dark matter (DM). However, dynamical models and numerical simulations of galaxy evolution have shown that the DM fraction within Re in dense high-z ETGs is negligible. We have considered the possible bias of virial theorem in recovering the total masses and have shown that for dense ETGs the virial masses are in agreement with those derived through more sophisticated dynamical models. The variation of the parameter Gamma = M_true/M_ref with sigma_e shows that, on average, dense ETGs at = 1.4 follow the same IMF-sigma_e trend of typical local ETGs, but with a lower mass-normalization. Nonetheless, once the IMF-sigma_e trend we have found for high-z dense ETGs is compared with that of local ETGs with similar Sigma and sigma_e, they turn out to be consistent. The similarity between the IMF-sigma_e trends of dense high-z and low-z ETGs over 9 Gyr of evolution and their lower mass-normalization with respect to the mean value of local ETGs suggest that, independently on formation redshift, the physical conditions characterizing the formation of a dense spheroid lead to a mass spectrum of new formed stars with an higher ratio of high- to low-mass stars with respect to the IMF of normal local ETGs.Comment: 9 pages, 4 figures, accepted for pubblication in A&A, updated to match final journal versio

The population of early-type galaxies: how it evolves with time and how it differs from passive and late-type galaxies

The aim of our analysis is twofold. On the one hand we are interested in addressing whether a sample of ETGs morphologically selected differs from a sample of passive galaxies in terms of galaxy statistics. On the other hand we study how the relative abundance of galaxies, the number density and the stellar mass density for different morphological types change over the redshift range 0.6<z<2.5. From the 1302 galaxies brighter than Ks=22 selected from the GOODS-MUSIC catalogue, we classified the ETGs on the basis of their morphology and the passive galaxies on the basis of their sSFR. We proved how the definition of passive galaxy depends on the IMF adopted in the models and on the assumed sSFR threshold. We find that ETGs cannot be distinguished from the other morphological classes on the basis of their low sSFR, irrespective of the IMF adopted in the models. Using the sample of 1302 galaxies morphologically classified into spheroidal galaxies (ETGs) and not spheroidal galaxies (LTGs), we find that their fractions are constant over the redshift range 0.6<z<2.5 (20-30% ETGs vs 70-80% LTGs). However, at z<1 these fractions change among the population of the most massive (M*>=10^(11) M_sol) galaxies, with the fraction of massive ETGs rising up to 40% and the fraction of massive LTGs decreasing down to 60%. Moreover, we find that the number density and the stellar mass density of the whole population of massive galaxies increase almost by a factor of ~10 between 0.6<z<2.5, with a faster increase of these densities for the ETGs than for the LTGs. Finally, we find that the number density of the highest-mass galaxies (M*>3-4x10^(11) M_sol) both ETGs and LTGs do not increase since z~2.5, contrary to the lower mass galaxies. This suggests that the population of the most massive galaxies formed at z>2.5-3 and that the assembly of such high-mass galaxies is not effective at lower redshift.Comment: 15 pages, 14 figures. Published in A&

Scaling relations of cluster elliptical galaxies at z~1.3. Distinguishing luminosity and structural evolution

[Abridged] We studied the size-surface brightness and the size-mass relations of a sample of 16 cluster elliptical galaxies in the mass range 10^{10}-2x10^{11} M_sun which were morphologically selected in the cluster RDCS J0848+4453 at z=1.27. Our aim is to assess whether they have completed their mass growth at their redshift or significant mass and/or size growth can or must take place until z=0 in order to understand whether elliptical galaxies of clusters follow the observed size evolution of passive galaxies. To compare our data with the local universe we considered the Kormendy relation derived from the early-type galaxies of a local Coma Cluster reference sample and the WINGS survey sample. The comparison with the local Kormendy relation shows that the luminosity evolution due to the aging of the stellar content already assembled at z=1.27 brings them on the local relation. Moreover, this stellar content places them on the size-mass relation of the local cluster ellipticals. These results imply that for a given mass, the stellar mass at z~1.3 is distributed within these ellipticals according to the same stellar mass profile of local ellipticals. We find that a pure size evolution, even mild, is ruled out for our galaxies since it would lead them away from both the Kormendy and the size-mass relation. If an evolution of the effective radius takes place, this must be compensated by an increase in the luminosity, hence of the stellar mass of the galaxies, to keep them on the local relations. We show that to follow the Kormendy relation, the stellar mass must increase as the effective radius. However, this mass growth is not sufficient to keep the galaxies on the size-mass relation for the same variation in effective radius. Thus, if we want to preserve the Kormendy relation, we fail to satisfy the size-mass relation and vice versa.Comment: Accepted for publication in A&A, updated to match final journal versio

t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders.

Through a combined approach integrating RNA-Seq, SNP-array, FISH and PCR techniques, we identified two novel t(15;21) translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12. One is a complex t(15;21)(q24;q22), with both breakpoints mapped at the nucleotide level, joining RUNX1 to SIN3A and UBL7-AS1 in a patient with myelodysplasia. The other is a recurrent t(15;21)(q21;q22), juxtaposing RUNX1 and TCF12, with an opposite transcriptional orientation, in three myeloid leukemia cases. Since our transcriptome analysis indicated a significant number of differentially expressed genes associated with both translocations, we speculate an important pathogenetic role for these alterations involving RUNX1

The AIMSS Project – III. The Stellar Populations of Compact Stellar Systems

In recent years, a growing zoo of compact stellar systems (CSSs) have been found whose physical properties (mass, size, velocity dispersion) place them between classical globular clusters (GCs) and true galaxies, leading to debates about their nature. Here we present results using a so far underutilized discriminant, their stellar population properties. Based on new spectroscopy from 8–10m telescopes, we derive ages, metallicities, and [α/Fe] of 29 CSSs. These range from GCs with sizes of merely a few parsec to compact ellipticals (cEs) larger than M32. Together with a literature compilation, this provides a panoramic view of the stellar population characteristics of early-type systems. We find that the CSSs are predominantly more metal rich than typical galaxies at the same stellar mass. At high mass, the cEs depart from the mass–metallicity relation of massive early-type galaxies, which forms a continuous sequence with dwarf galaxies. At lower mass, the metallicity distribution of ultracompact dwarfs (UCDs) changes at a few times 107 M⊙, which roughly coincides with the mass where luminosity function arguments previously suggested the GC population ends. The highest metallicities in CSSs are paralleled only by those of dwarf galaxy nuclei and the central parts of massive early types. These findings can be interpreted as CSSs previously being more massive and undergoing tidal interactions to obtain their current mass and compact size. Such an interpretation is supported by CSSs with direct evidence for tidal stripping, and by an examination of the CSS internal escape velocities

Neurological Involvement in Multisystem Inflammatory Syndrome in Children: Clinical, Electroencephalographic and Magnetic Resonance Imaging Peculiarities and Therapeutic Implications. An Italian Single-Center Experience

Objective: To describe neurological involvement in multisystem inflammatory syndrome in children (MIS-C) and to evaluate whether neurological manifestations are related to the degree of multiorgan involvement and inflammation. Methods: The authors conducted a retrospective analysis of clinical, electroencephalographic (EEG), neuroradiological (MRI), and CSF parameters in 62 children with MIS-C (45 M, age 8 months—17 years, mean age 9 years) hospitalized between October 1, 2020 and March 31, 2022. Results: Neurological involvement was documented in 58/62 (93.5%) patients. Altered mental status was observed in 29 (46.7%), focal neurological signs in 22 (35.4%), and non-specific symptoms in 54 (87%). EEG was performed in 26/62 children: 20 showed EEG slowing, diffuse or predominantly over the posterior regions. Ten patients underwent brain MRI: three showed a cytotoxic lesion of the corpus callosum. CSF analysis, performed in six patients, was normal. On the basis of the clinical and EEG findings, two profiles of neurological involvement were identified: 16/62 (26%) patients presented encephalitis with rapid-onset encephalopathy, focal neurological signs, and EEG slowing; 42/62 (68%) showed mild neurological involvement with mild or non-specific neurological signs. All patients received intravenous immunoglobulin and methylprednisolone (MTP), low-molecular-weight heparin, and therapeutic-dose anticoagulant treatment. Children with severe encephalopathy received intravenous MTP at 30 mg/kg/day for 3 days, obtaining rapid clinical and EEG improvement. Neurological assessment at discharge was normal in all cases. Children with encephalitis were younger than those without (median age 5 and 10 years, respectively); no differences between the two groups were found in the other parameters: comorbidities, fever, number of organs and systems involved, shock, hospitalization, pediatric intensive care unit admission, non-invasive ventilation, inotropic support, laboratory data. Conclusion: Neurological involvement in MIS-C is frequent but not serious in most cases: around two thirds of the affected children had mild and short-lasting symptoms. It seems to be related to age, but not to the degree of multiorgan involvement and inflammation. In children with acute immune-mediated encephalitis, the clinical picture was dominated by encephalopathy that disappeared with immunomodulatory therapy. Neurological assessment allowed timely diagnosis and treatment

Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer

The mechanism for generating double minutes chromosomes (dmin) and homogeneously staining regions (hsr) in cancer is still poorly understood. Through an integrated approach combining next-generation sequencing, single nucleotide polymorphism array, fluorescent in situ hybridization and polymerase chain reaction-based techniques, we inferred the fine structure of MYC-containing dmin/hsr amplicons harboring sequences from several different chromosomes in seven tumor cell lines, and characterized an unprecedented number of hsr insertion sites. Local chromosome shattering involving a single-step catastrophic event (chromothripsis) was recently proposed to explain clustered chromosomal rearrangements and genomic amplifications in cancer. Our bioinformatics analyses based on the listed criteria to define chromothripsis led us to exclude it as the driving force underlying amplicon genesis in our samples. Instead, the finding of coexisting heterogeneous amplicons, differing in their complexity and chromosome content, in cell lines derived from the same tumor indicated the occurrence of a multi-step evolutionary process in the genesis of dmin/hsr. Our integrated approach allowed us to gather a complete view of the complex chromosome rearrangements occurring within MYC amplicons, suggesting that more than one model may be invoked to explain the origin of dmin/hsr in cancer. Finally, we identified PVT1 as a target of fusion events, confirming its role as breakpoint hotspot in MYC amplification

A few StePS forward in unveiling the complexity of galaxy evolution: Light-weighted stellar ages of intermediate-redshift galaxies with WEAVE

The upcoming new generation of optical spectrographs on four-meter-class telescopes will provide invaluable information for reconstructing the history of star formation in individual galaxies up to redshifts of about 0.7. We aim at defining simple but robust and meaningful physical parameters that can be used to trace the coexistence of widely diverse stellar components: younger stellar populations superimposed on the bulk of older ones. We produce spectra of galaxies closely mimicking data from the forthcoming Stellar Populations at intermediate redshifts Survey (StePS), a survey that uses the WEAVE spectrograph on the William Herschel Telescope. First, we assess our ability to reliably measure both ultraviolet and optical spectral indices in galaxies of different spectral types for typically expected signal-to-noise levels. Then, we analyze such mock spectra with a Bayesian approach, deriving the probability density function of r- and u-band light-weighted ages as well as of their difference. We find that the ultraviolet indices significantly narrow the uncertainties in estimating the r- and u-band light-weighted ages and their difference in individual galaxies. These diagnostics, robustly retrievable for large galaxy samples even when observed at moderate signal-to-noise ratios, allow us to identify secondary episodes of star formation up to an age of ~0.1 Gyr for stellar populations older than ~1.5 Gyr, pushing up to an age of ~1 Gyr for stellar populations older than ~5 Gyr. The difference between r-band and u-band light-weighted ages is shown to be a powerful diagnostic to characterize and constrain extended star-formation histories and the presence of young stellar populations on top of older ones. This parameter can be used to explore the interplay between different galaxy star-formation histories and physical parameters such as galaxy mass, size, morphology, and environment