On-Line Analysis of Electron Back Scatter Diffraction Patterns. I. Texture Analysis of Zone Refined Polysilicon

A technique has been developed for determining crystal orientations on-line from bulk polycrystalline materials using wide angle back scatter electron diffraction patterns. The patterns were imaged on a phosphor screen and viewed using a low light level television camera. A computer generated cursor superimposed on the diffraction pattern, permitted the coordinates of zone axes to be determined. These were interpreted by the computer to yield the crystal orientation. The accuracy of the technique for absolute orientation was shown to be of the order 1° and the precision for relative orientation better than 0.5°. The technique was used to investigate texture and nearest neighbour orientation relationships in polysilicon, recrystallised using a graphite strip heater technique. It was shown that the orientations become less random as the recrystallisation front proceeded along the specimen

The Psychological Type Profile of Humanists UK: Not Just the Mirror Image of Believers

A significant body of research has explored the psychological type profile of the members of religious organisations. The assumption has been made that the members of non-religious groups will present as the mirror image psychological type profile of the members of religious groups. To test such assumptions, we need to develop an understanding of the psychological type profile of communities of non-believers. The aim of this paper is to examine the psychological type profile of a sample of 1,042 members of Humanists UK (HUK). The findings demonstrate that the humanists do not present the psychological type mirror image of churchgoers nor are they representative of the broader population. An increased understanding of the psychological type profiles of communities of non-believers can enrich our understanding within the psychology of religion

Making sense of voices: a case series

The current evidence-base for the psychological treatment of distressing voices indicates the need for further clinical development. The Maastricht approach (also known as Making Sense of Voices) is popular within sections of the Hearing Voices Movement, but its clinical effectiveness has not been systematically evaluated. The aim of the approach is to develop a better understanding of the role of the voice, in part through opening a dialogue between the voice hearer and the voice. The current study was a (N=15) case series adopting a concurrent multiple baseline design. The Maastricht approach was offered for up to 9-months. The main outcome, weekly voice-related distress ratings, was not statistically significant during intervention or follow-up, although the effect size was in the moderate range. The PSYRATS Hallucination scale was associated with a large effect size both at the end of treatment, and after a 3-month follow-up period, although again the effect did not reach statistical significance. The results suggest further evaluation of the approach is warranted. However, given the large variance in individual participant outcome, it may be that a better understanding of response profiles is required before conducting a definitive randomised controlled trial

Gaussian Thermal Operations and The Limits of Algorithmic Cooling

The study of thermal operations allows one to investigate the ultimate possibilities of quantum states and of nanoscale thermal machines. Whilst fairly general, these results typically do not apply to continuous variable systems and do not take into account that, in many practically relevant settings, system-environment interactions are effectively bilinear. Here we tackle these issues by focusing on Gaussian quantum states and channels. We provide a complete characterization of the most general Gaussian thermal operation acting on an arbitrary number of bosonic modes, which turn out to be all embeddable in a Markovian dynamics, and derive necessary and sufficient conditions for state transformations under such operations in the single-mode case, encompassing states with nonzero coherence in the energy eigenbasis (i.e., squeezed states). Our analysis leads to a no-go result for the technologically relevant task of algorithmic cooling: We show that it is impossible to reduce the entropy of a system coupled to a Gaussian environment below its own or the environmental temperature, by means of a sequence of Gaussian thermal operations interspersed by arbitrary (even non-Gaussian) unitaries. These findings establish fundamental constraints on the usefulness of Gaussian resources for quantum thermodynamic processes

Using macroecological species distribution models to estimate changes in the suitability of sites for threatened species reintroduction

1. Species reintroductions often aim to establish populations of threatened taxa over the long-term. However, climate change may jeopardize reintroduction efforts by altering the conditions of a recipient site beyond the tolerances of the focal species. To aid the selection of recipient sites that will retain their suitability under climate change, species distribution models (SDMs) have been proposed as a method of locating areas with a greater likelihood of facilitating species persistence. 2. We applied SDMs to predict macroclimatic suitability changes for 13 threatened plant and invertebrate species considered for reintroduction at four lowland raised bog sites undergoing restoration. We estimated suitability based on current and projected future conditions under two greenhouse gas concentration scenarios – one low (RCP2.6) and one high (RCP8.5) – using three general circulation models, for the period 2041–2060. 3. When considering current predicted suitability, our models indicated that nine species were viable candidates for reintroduction to at least one of the restoration sites. But when accounting for potential future changes in suitability, the number of candidates was reduced to seven species, based on the RCP8.5 climate change scenario. While three of the sites received consistently similar predictions of suitability across species and scenarios, the most northerly site, Red Moss, received divergent suitability predictions for some species. This site is predicted to remain suitable for Metrioptera brachyptera and Genista anglica under at least one scenario despite substantial losses forecast across the rest of their U.K. ranges, suggesting that it could act as a macroclimatic refuge as climate change advances. 4. The findings presented here made a valuable contribution to the reintroduction planning process, by facilitating the prioritization of reintroduction efforts towards species with a greater likelihood of establishing long-term populations at the prospective recipient sites

The use of an ‘acclimatisation’ heatwave measure to compare temperature-related demand for emergency services in Australia, Botswana, Netherlands, Pakistan, and USA

Background: Heatwaves have been linked to increased risk of mortality and morbidity and are projected to increase in frequency and intensity due to climate change. The current study uses emergency department (ED) data from Australia, Botswana, Netherlands, Pakistan, and the United States of America to evaluate the impact of heatwaves on ED attendances, admissions and mortality.Methods: Routinely collected time series data were obtained from 18 hospitals. Two separate thresholds (≥4 and ≥7) of the acclimatisation excess heat index (EHIaccl) were used to define hot days . Analyses included descriptive statistics, independent samples T-tests to determine differences in case mix between hot days and other days, and threshold regression to determine which temperature thresholds correspond to large increases in ED attendances.Findings: In all regions, increases in temperature that did not coincide with time to acclimatise resulted in increases in ED attendances, and the EHIaccl performed in a similar manner. During hot days in California and The Netherlands, significantly more children ended up in the ED, while in Pakistan more elderly people attended. Hot days were associated with more patient admissions in the ages 5-11 in California, 65-74 in Karachi, and 75-84 in The Hague. During hot days in The Hague, patients with psychiatric symptoms were more likely to die. The current study did not identify a threshold temperature associated with particularly large increases in ED demand.Interpretation: The association between heat and ED demand differs between regions. A limitation of the current study is that it does not consider delayed effects or influences of other environmental factors. Given the association between heat and ED use, hospitals and governmental authorities should recognise the demands that heat can place on local health care systems. These demands differ substantially between regions, with Pakistan being the most heavily affected within our study sample

Recovery phase of magnetic storms induced by different interplanetary drivers

Statistical analysis of Dst behaviour during recovery phase of magnetic storms induced by different types of interplanetary drivers is made on the basis of OMNI data in period 1976-2000. We study storms induced by ICMEs (including magnetic clouds (MC) and Ejecta) and both types of compressed regions: corotating interaction regions (CIR) and Sheaths. The shortest, moderate and longest durations of recovery phase are observed in ICME-, CIR-, and Sheath-induced storms, respectively. Recovery phases of strong ($Dst_{min} < -100$ nT) magnetic storms are well approximated by hyperbolic functions $Dst(t)= a/(1+t/\tau_h)$ with constant $\tau_h$ times for all types of drivers while for moderate ($-100 < Dst_{min} < -50$ nT) storms $Dst$ profile can not be approximated by hyperbolic function with constant $\tau_h$ because hyperbolic time $\tau_h$ increases with increasing time of recovery phase. Relation between duration and value $Dst_{min}$ for storms induced by ICME and Sheath has 2 parts: $Dst_{min}$ and duration correlate at small durations while they anticorrelate at large durations.Comment: 18 pages, 4 figures, 2 tables, submitted to JGR special issue "Response of Geospace to High-Speed Streams

Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72 ‐ALS

Acknowledgments We gratefully acknowledge Professor Tom Gillingwater for his helpful comments and support. This work would not have been possible without the resources of the Edinburgh Brain Bank, and the people with ALS and their families who have generously donated tissue. This research was funded in part by a studentship from the Wellcome Trust (108890/Z/15/Z) to OMR and MDES, a Pathological Society and Jean Shanks foundation grant (217CHA R46564) to JMG and JO, and a Sir Henry Dale fellowship jointly funded by the Wellcome Trust and the Royal Society (215454/Z/19/Z) to CRS.Peer reviewedPublisher PD

Evaluation of the Victorian Healthy Homes Program: protocol for a randomised controlled trial.

INTRODUCTION: The evaluation of the Victorian Healthy Homes Program (VHHP) will generate evidence about the efficacy and cost-effectiveness of home upgrades to improve thermal comfort, reduce energy use and produce health and economic benefits to vulnerable households in Victoria, Australia. METHODS AND ANALYSIS: The VHHP evaluation will use a staggered, parallel group clustered randomised controlled trial to test the home energy intervention in 1000 households. All households will receive the intervention either before (intervention group) or after (control group) winter (defined as 22 June to 21 September). The trial spans three winters with differing numbers of households in each cohort. The primary outcome is the mean difference in indoor average daily temperature between intervention and control households during the winter period. Secondary outcomes include household energy consumption and residential energy efficiency, self-reported respiratory symptoms, health-related quality of life, healthcare utilisation, absences from school/work and self-reported conditions within the home. Linear and logistic regression will be used to analyse the primary and secondary outcomes, controlling for clustering of households by area and the possible confounders of year and timing of intervention, to compare the treatment and control groups over the winter period. Economic evaluation will include a cost-effectiveness and cost-benefit analysis. ETHICS AND DISSEMINATION: Ethical approval was received from Victorian Department of Human Services Human Research Ethics Committee (reference number: 04/17), University of Technology Sydney Human Research Ethics Committee (reference number: ETH18-2273) and Australian Government Department of Veterans Affairs. Study results will be disseminated in a final report and peer-reviewed journals. TRIAL REGISTRATION NUMBER: ACTRN12618000160235

Geoeffectiveness and efficiency of CIR, Sheath and ICME in generation of magnetic storms

We investigate relative role of various types of solar wind streams in generation of magnetic storms. On the basis of the OMNI data of interplanetary measurements for the period of 1976-2000 we analyze 798 geomagnetic storms with Dst < -50 nT and their interplanetary sources: corotating interaction regions (CIR), interplanetary CME (ICME) including magnetic clouds (MC) and Ejecta and compression regions Sheath before both types of ICME. For various types of solar wind we study following relative characteristics: occurrence rate; mass, momentum, energy and magnetic fluxes; probability of generation of magnetic storm (geoeffectiveness) and efficiency of process of this generation. Obtained results show that despite magnetic clouds have lower occurrence rate and lower efficiency than CIR and Sheath they play an essential role in generation of magnetic storms due to higher geoeffectiveness of storm generation (i.e higher probability to contain large and long-term southward IMF Bz component).Comment: 23 pages, 4 figures, 3 tables, submitted to JGR special issue "Response of Geospace to High-Speed Streams