An Examination of Successful Socioeconomically Disadvantaged Males in a Northeast Tennessee Middle School

The purpose of this qualitative case study was to gain an in-depth understanding of the factors that contribute to positive educational outcomes as measured by the EXPLORE test for eighth grade males who qualify for free or reduced price lunch. In addition, this study was conducted for the purpose of improving the educational program at a Northeast Tennessee middle school. Archival EXPLORE data, as well as free and reduced price lunch data, were used to identify high school graduates, 6 males and 6 females, who had performed at or above expectation on the eighth grade EXPLORE test. Females were included in this study for the purpose of determining if the factors vary with respect to gender. The participants were interviewed for the purpose of gaining a rich understanding of the factors that enabled them to experience success, while the majority of their socioeconomically disadvantaged peers did not, as well as to determine if these factors varied with respect to gender. Two overarching themes emerged as a result of the interview data analysis: connection to school and support and motivation. Each of the participants reported a sense of connection to the school via of one or more of the following 5 subcategories: teachers, peers, other adults, extracurricular activities, and school structure, culture, and supports. Also, all of the participants spoke of support and motivation via 1 or more of the following 4 subcategories: parents, other adults, preparation, and ability and talent. Two factors emerged that seemed to be most important to their success: connection through relationships and outside support. Each participant was able to establish meaningful relationships during middle school, with 11 of 12 sharing accounts of their connections with school adults, and 12 of 12 discussing their peer relationships. Additionally, each spoke of feeling supported or motivated by a parent or other outside adult. There was little difference with respect to gender. Boys indicated a slightly higher proclivity towards extracurricular activities, while girls seemed to place slightly more importance upon peer relationships. However, establishing meaningful connections within school was of paramount importance for both genders

A Proposed Solar Zoning Ordinance

Sunlight travels through space unobstructed for 93,000,000 miles. Only during the last few hundred feet before it touches earth is it impeded by obstructions other than clouds, which cause shading. Since access to sunlight is critical to every solar energy system, the legal problems that may result from the obstruction of sunlight are great

Laser Ablation System for Solid Sample Analysis by Inductively Coupled Plasma Atomic Emission Spectrometry

A laser ablation sample introduction system, based on a Nd : YAG laser with an X-Y-Zdirectional sampling head, has been designed and constructed for use with inductively coupled plasma optical emission spectrometry. A study has been made of a number of parameters which affect the performance of the system to establish the optimum operating conditions. South African Reference Material (SARM) rock samples have been analysed using the system, and the results obtained have been compared with the certificate values. The importance of using closely matrix-matched samples and standards is demonstrated. Precision studies on SARM 5 (pyroxenite) show that both intra- and inter-sample precisions are typically 10% (relative standard deviation )

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors.

PurposeTo determine the maximum tolerated dose (MTD), toxicities, and pharmacodynamics effects of sirolimus combined with oral metronomic topotecan and cyclophosphamide in a pediatric population.Materials and methodsPatients who were 1 to 30 years of age with relapsed/refractory solid tumors (including CNS) were eligible. Patients received daily oral sirolimus and cyclophosphamide (25-50 mg/m2/dose) on days 1-21 and oral topotecan (0.8 mg/m2/dose) on days 1-14 in 28-day cycles. Sirolimus steady-state plasma trough concentrations of 3-7.9 ng/mL and 8-12.0 ng/mL were evaluated, with dose escalation based on a 3+3 phase 1 design. Biomarkers of angiogenesis were also evaluated.ResultsTwenty-one patients were treated (median age 18 years; range 9-30). Dose-limiting toxicities included myelosuppression, ALT elevation, stomatitis, and hypertriglyceridemia. The MTD was sirolimus with trough goal of 8-12.0 ng/mL; cyclophosphamide 25 mg/m2/dose; and topotecan 0.8 mg/m2/dose. No objective responses were observed. Four patients had prolonged stable disease > 4 cycles (range 4-12). Correlative biomarker analyses demonstrated reductions in thrombospondin-1 (p=0.043) and soluble vascular endothelial growth factor receptor-2 plasma concentrations at 21 days compared to baseline.ConclusionsThe combination of oral sirolimus, topotecan, and cyclophosphamide was well tolerated and biomarker studies demonstrated modulation of angiogenic pathways with this regimen

Attitudes and Beliefs of African-Americans Toward Genetics, Genetic Testing, and Sickle Cell Disease Education and Awareness

Research among African-Americans indicates this population perceives sickle cell (SCD) to be a serious disease and sickle cell trait (SCT) screening an important intervention. However, studies have consistently demonstrated a lower than desired uptake of SCD education, inadequate knowledge regarding personal and family trait status, and a low perceived susceptibility of giving birth to a child with the disease. We examined general attitudes and beliefs regarding genetics and genetic testing including prenatal testing and newborn screening; we used this information as the foundation to more specifically assess attitudes and beliefs regarding SCD and perceived barriers to SCD education and awareness. Thirty-five African-American adult men and women participated in one of four focus groups. Thematic analysis identified that both prenatal testing and newborn screening are acceptable forms of genetic testing. Based largely on their personal experiences, participants possessed an understanding of the natural progression of SCD but had a limited understanding of the inheritance and probable risk of giving birth to a child with the disease. Barriers to education and greater awareness of SCD were classified as personal, familial, and societal. Community based interventions focused on sharing the stories of individuals with first-hand experiences with SCD should be considered

Vermont School Districts Meal Service Response to COVID-19

The COVID-19 pandemic has posed many challenges worldwide, including lack of food access and security. Food insecurity in Vermont has increased from 18% to 24% since the outbreak of the pandemic. Food insecurity among families with school-aged children puts children at risk for developmental delays, poor social functioning, and poor academic performance. The goal of this project is to identify the challenges that the COVID-19 pandemic has posed for meal distribution services in school districts across Vermont, recognize the adaptations that were made by schools to address these challenges, and determine which adaptations had positive effects to encourage widespread implementation of these and other strategies to maximize food security for school-aged children nationwide.https://scholarworks.uvm.edu/comphp_gallery/1312/thumbnail.jp

The Use of Global System of Mobile Communication (GSM) Among University Students in Malaysia

This study examines the use of the Global System of Mobile Communication (GSM) among University students in Malaysia. The survey approach was used in data collection from a sample population from University Teknologi Malaysia. Fifty undergraduate and post graduate students were sampled at the university library. Results from a multiple regression analysis shows that there is a significant relationship between age, monthly income/allowance of respondents, marital status and rate of calls made and received per day (P<0.05). Gender and mode of study were found to be insignificant (P>0.05).Results from t test equally indicate that the respondents do not vary in their perception on benefits derivable from the use of GSM (t = -.483, P >0.05).Majority of the respondents also agreed that they use GSM to contact their lecturers, course mates, parents, siblings and sending of short message services (SMS).The study conclude with discussions on findings which would be relevant to education policy makers and other interest partie

Optical Light Curve of the Type Ia Supernova 1998bu in M96 and the Supernova Calibration of the Hubble Constant

We present the UBVRI light curves of the Type Ia supernova SN 1998bu which appeared in the nearby galaxy M96 (NGC 3368). M96 is a spiral galaxy in the Leo I group which has a Cepheid-based distance. Our photometry allows us to calculate the absolute magnitude and reddening of this supernova. These data, when combined with measurements of the four other well-observed supernovae with Cepheid based distances, allow us to calculate the Hubble constant with respect to the Hubble flow defined by the distant Calan/Tololo Type Ia sample. We find a Hubble constant of 64.0 +/- 2.2(internal) +/- 3.5(external) km/s/Mpc, consistent with most previous estimates based on Type Ia supernovae. We note that the two well-observed Type Ia supernovae in Fornax, if placed at the Cepheid distance to the possible Fornax spiral NGC 1365, are apparently too faint with respect to the Calan/Tololo sample calibrated with the five Type Ia supernovae with Cepheid distances to the host galaxies.Comment: AAS LaTeX, 20 pages, 4 figures, 6 tables, accepted for publication in the Astronomical Journal. Figure 1 (finding chart) not include

Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro

The blood-brain barrier (BBB), composed of brain microvascular endothelial cells (BMEC) that are tightly linked by tight junction (TJ) proteins, restricts the movement of molecules between the periphery and the central nervous system. Elevated systemic levels of neutrophils have been detected in patients with altered BBB function, but the role of neutrophils in BMEC dysfunction is unknown. Neutrophils are key players of the immune response and, when activated, produce neutrophil-derived microvesicles (NMV). NMV have been shown to impact the integrity of endothelial cells throughout the body and we hypothesize that NMV released from circulating neutrophils interact with BMEC and induce endothelial cell dysfunction. Therefore, the current study investigated the interaction of NMV with human BMEC and determined whether they altered gene expression and function in vitro. Using flow cytometry and confocal imaging, NMV were shown to be internalized by the human cerebral microvascular endothelial cell line hCMEC/D3 via a variety of energy-dependent mechanisms, including endocytosis and macropinocytosis. The internalization of NMV significantly altered the transcriptomic profile of hCMEC/D3, specifically inducing the dysregulation of genes associated with TJ, ubiquitin-mediated proteolysis and vesicular transport. Functional studies confirmed NMV significantly increased permeability and decreased the transendothelial electrical resistance (TEER) of a confluent monolayer of hCMEC/D3. These findings indicate that NMV interact with and affect gene expression of BMEC as well as impacting their integrity. We conclude that NMV may play an important role in modulating the permeability of BBB during an infection

Guard-cell-targeted overexpression of Arabidopsis \u3ci\u3eHexokinase 1\u3c/i\u3e can improve water use efficiency in field-grown tobacco plants

Water deficit currently acts as one of the largest limiting factors for agricultural productivity worldwide. Additionally, limitation by water scarcity is projected to continue in the future with the further onset of effects of global climate change. As a result, it is critical to develop or breed for crops that have increased water use efficiency and that are more capable of coping with water scarce conditions. However, increased intrinsic water use efficiency (iWUE) typically brings a trade-off with CO2 assimilation as all gas exchange is mediated by stomata, through which CO2 enters the leaf while water vapor exits. Previously, promising results were shown using guard-cell-targeted overexpression of hexokinase to increase iWUE without incurring a penalty in photosynthetic rates or biomass production. Here, two homozygous transgenic tobacco (Nicotiana tabacum) lines expressing Arabidopsis Hexokinase 1 (AtHXK1) constitutively (35SHXK2 and 35SHXK5) and a line that had guard-cell-targeted overexpression of AtHXK1 (GCHXK2) were evaluated relative to wild type for traits related to photosynthesis and yield. In this study, iWUE was significantly higher in GCHXK2 compared with wild type without negatively impacting CO2 assimilation, although results were dependent upon leaf age and proximity of precipitation event to gas exchange measurement