1,963 research outputs found

    Body Image Dissatisfaction among Pediatric Patients with Inflammatory Bowel Disease

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    Objectives: To determine risk factors for body image dissatisfaction among pediatric patients with inflammatory bowel disease (IBD). Study design: We performed a cross-sectional study of children aged 9-18 years in the IBD Partners Kids & Teens cohort. Participants completed surveys including demographics, disease characteristics and activity indices, and psychosocial outcomes measured by IMPACT-III questionnaires. We defined body image dissatisfaction if participants answered ?I look awful? or ?I look bad.? Bivariate analyses assessed associations between body image dissatisfaction and demographic, disease-related and psychosocial factors; logistic regression models evaluated associations between risk factors and body image dissatisfaction. Results: IMPACT-III was completed by 664 patients, with 74 (11.1%) reporting body image dissatisfaction. Patients with body image dissatisfaction were more likely to be female (P < .01), older (median age 15 vs 13 years, P < .01), and diagnosed with IBD at an older age (12 vs 10 years, P < .01). Those with body image dissatisfaction had greater body mass index percentile (P = .02), more active disease (P < .01), more current steroid use (P < .01), and more depression and anxiety (P < .01). Female sex (OR 2.31; 95% CI 1.22-4.39), depression (OR 4.73; 95% CI 2.41-9.26), and anxiety (OR 5.42; 95% CI 2.48-11.80) were independently associated with body image dissatisfaction. Conclusions: In this cohort, risk factors for body image dissatisfaction include female sex, older age at diagnosis, active disease, current steroid use, greater body mass index, and comorbid mood disorder. Interventions targeting modifiable risk factors for body image dissatisfaction may improve quality of life in pediatric patients with body image dissatisfaction

    Effectiveness of the global protected area network in representing species diversity

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    The Fifth World Parks Congress in Durban, South Africa, announced in September 2003 that the global network of protected areas now covers 11.5% of the planet's land surface. This surpasses the 10% target proposed a decade earlier, at the Caracas Congress, for 9 out of 14 major terrestrial biomes. Such uniform targets based on percentage of area have become deeply embedded into national and international conservation planning. Although politically expedient, the scientific basis and conservation value of these targets have been questioned. In practice, however, little is known of how to set appropriate targets, or of the extent to which the current global protected area network fulfils its goal of protecting biodiversity. Here, we combine five global data sets on the distribution of species and protected areas to provide the first global gap analysis assessing the effectiveness of protected areas in representing species diversity. We show that the global network is far from complete, and demonstrate the inadequacy of uniform—that is, 'one size fits all'—conservation targets

    Crystal structure, magnetic properties, and the magnetocaloric effect of Gd5Rh4 and GdRh

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    The crystal structures of Gd5Rh4 and GdRh have been studied by powder and single crystal x-ray diffraction. The results show that Gd5Rh4 is isotypic with Pu5Rh4 and the bond length of the short Rh-Rh dimer is 2.943(4) Å. According to heat capacity measurements in zero magnetic field, the magnetic ordering temperature of Gd5Rh4 is 13 K, in agreement with magnetization measurements. Both the heat capacity peak shape and the positive slope of the Arrott plots at Curie temperature (TC) indicate the second-order nature of the magnetic transition. The temperature dependence of magnetization of Gd5Rh4 measured in 1 kOe applied field indicates noncollinear magnetic ordering that may change into nearly collinear ferromagnetic ordering by increasing the magnetic field. GdRh is ferromagnetic below T C  = 22 K. Moderate magnetocaloric effects and relatively high refrigerant capacities are observed in Gd5Rh4 and GdRh

    Determination of the parameters of semiconducting CdF2:In with Schottky barriers from radio-frequency measurements

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    Physical properties of semiconducting CdF_2 crystals doped with In are determined from measurements of the radio-frequency response of a sample with Schottky barriers at frequencies 10 - 10^6 Hz. The dc conductivity, the activation energy of the amphoteric impurity, and the total concentration of the active In ions in CdF_2 are found through an equivalent-circuit analysis of the frequency dependencies of the sample complex impedance at temperatures from 20 K to 300 K. Kinetic coefficients determining the thermally induced transitions between the deep and the shallow states of the In impurity and the barrier height between these states are obtained from the time-dependent radio-frequency response after illumination of the material. The results on the low-frequency conductivity in CdF_2:In are compared with submillimeter (10^{11} - 10^{12} Hz) measurements and with room-temperature infrared measurements of undoped CdF_2. The low-frequency impedance measurements of semiconductor samples with Schottky barriers are shown to be a good tool for investigation of the physical properties of semiconductors.Comment: 9 pages, 7 figure

    Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease

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    Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies

    Brane world corrections to Newton's law

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    We discuss possible variations of the effective gravitational constant with length scale, predicted by most of alternative theories of gravity and unified models of physical interactions. After a brief general exposition, we review in more detail the predicted corrections to Newton's law of gravity in diverse brane world models. We consider various configurations in 5 dimensions (flat, de Sitter and AdS branes in Einstein and Einstein-Gauss-Bonnet theories, with and without induced gravity and possible incomplete graviton localization), 5D multi-brane systems and some models in higher dimensions. A common feature of all models considered is the existence of corrections to Newton's law at small radii comparable with the bulk characteristic length: at such radii, gravity on the brane becomes effectively multidimensional. Many models contain superlight perturbation modes, which modify gravity at large scale and may be important for astrophysics and cosmology.Comment: Brief review, 16 pages, 92 references. Some description and references adde

    BCI-Based Navigation in Virtual and Real Environments

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    A Brain-Computer Interface (BCI) is a system that enables people to control an external device with their brain activity, without the need of any muscular activity. Researchers in the BCI field aim to develop applications to improve the quality of life of severely disabled patients, for whom a BCI can be a useful channel for interaction with their environment. Some of these systems are intended to control a mobile device (e. g. a wheelchair). Virtual Reality is a powerful tool that can provide the subjects with an opportunity to train and to test different applications in a safe environment. This technical review will focus on systems aimed at navigation, both in virtual and real environments.This work was partially supported by the Innovation, Science and Enterprise Council of the Junta de Andalucía (Spain), project P07-TIC-03310, the Spanish Ministry of Science and Innovation, project TEC 2011-26395 and by the European fund ERDF
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