Flux through a hole from a shaken granular medium

We have measured the flux of grains from a hole in the bottom of a shaken container of grains. We find that the peak velocity of the vibration, vmax, controls the flux, i.e., the flux is nearly independent of the frequency and acceleration amplitude for a given value of vmax. The flux decreases with increasing peak velocity and then becomes almost constant for the largest values of vmax. The data at low peak velocity can be quantitatively described by a simple model, but the crossover to nearly constant flux at larger peak velocity suggests a regime in which the granular density near the container bottom is independent of the energy input to the system.Comment: 14 pages, 4 figures. to appear in Physical Review

Stress reducing effects of real and artificial nature in a hospital waiting room

Objectives: This field study investigated the potential stress-reducing effects of exposure to real or artificial nature on patients in a hospital waiting room. Additionally, it was investigated whether perceived attractiveness of the room could explain these effects. Design: In this between-patients experimental design, patients were exposed to one of the following: real plants, posters of plants, or no nature (control). These conditions were alternately applied to two waiting rooms. Location: The location of this study was two waiting rooms at the Radiology Department of a Dutch hospital. Subjects: The subjects comprised 457 patients (60% female and 40% male) who were mostly scheduled for echocardiogram, dual-energy x-ray absorptiometry, magnetic resonance imaging, computed tomography scans, or nuclear research. Results: Patients exposed to real plants, as well as patients exposed to posters of plants, report lower levels of experienced stress compared to the control condition. Further analyses show that these small but significant effects of exposure to nature are partially mediated by the perceived attractiveness of the waiting room. Conclusions: Natural elements in hospital environments have the potential to reduce patients' feelings of stress. By increasing the attractiveness of the waiting room by adding either real plants or posters of plants, hospitals can create a pleasant atmosphere that positively influences patients' well-being

Decision and function problems based on boson sampling

Boson sampling is a mathematical problem that is strongly believed to be intractable for classical computers, whereas passive linear interferometers can produce samples efficiently. So far, the problem remains a computational curiosity, and the possible usefulness of boson-sampling devices is mainly limited to the proof of quantum supremacy. The purpose of this work is to investigate whether boson sampling can be used as a resource of decision and function problems that are computationally hard, and may thus have cryptographic applications. After the definition of a rather general theoretical framework for the design of such problems, we discuss their solution by means of a brute-force numerical approach, as well as by means of non-boson samplers. Moreover, we estimate the sample sizes required for their solution by passive linear interferometers, and it is shown that they are independent of the size of the Hilbert space.Comment: Close to the version published in PR

A VLT/FLAMES survey for massive binaries in Westerlund 1. V. the X-ray selected blue stragglers Wd1-27 and -30a

Context. Recent observational studies indicate that a large number of OB stars are found within binary systems which may be expected to interact during their lifetimes. Significant mass transfer or indeed merger of both components is expected to modify evolutionary pathways, facilitating the production of exceptionally massive stars which will present as blue stragglers. Identification and characterisation of such objects is crucial if the efficiency of mass transfer is to be established; a critical parameter in determining the outcomes of binary evolutionary channels. Aims. The young and coeval massive cluster Westerlund 1 hosts a rich population of X-ray bright OB and Wolf-Rayet stars where the emission is attributed to shocks in the wind collision zones of massive binaries. Motivated by this, we instigated a study of the extremely X-ray luminous O supergiants Wd1-27 and -30a. Methods. We subjected a multi-wavelength and -epoch photometric and spectroscopic dataset to quantitative non-LTE model atmosphere and time-series analysis in order to determine fundamental stellar parameters and search for evidence of binarity. A detailed examination of the second Gaia data release was undertaken to establish cluster membership. Results. Both stars were found to be early/mid-O hypergiants with luminosities, temperatures and masses significantly in excess of other early stars within Wd1, hence qualifying as massive blue stragglers. The binary nature of Wd1-27 remains uncertain but the detection of radial velocity changes and the X-ray properties of Wd1-30a suggest that it is a binary with an orbital period ≤ 10 days. Analysis of Gaia proper motion and parallactic data indicates that both stars are cluster members; we also provide a membership list for Wd1 based on this analysis. Conclusions. The presence of hypergiants of spectral types O to M within Wd1 cannot be understood solely via single-star evolution. We suppose that the early-B and mid-O hypergiants formed via binary-induced mass-stripping of the primary and mass-transfer to the secondary, respectively. This implies that for a subset of objects massive star-formation may be regarded as a two-stage process, with binary-driven mass-transfer or merger yielding stars with masses significantly in excess of their initial ‘birth’ mass

Evaluation of critical congenital heart defects screening using pulse oximetry in the neonatal intensive care unit.

ObjectiveTo evaluate the implementation of early screening for critical congenital heart defects (CCHDs) in the neonatal intensive care unit (NICU) and potential exclusion of sub-populations from universal screening.Study designProspective evaluation of CCHD screening at multiple time intervals was conducted in 21 NICUs across five states (n=4556 infants).ResultsOf the 4120 infants with complete screens, 92% did not have prenatal CHD diagnosis or echocardiography before screening, 72% were not receiving oxygen at 24 to 48 h and 56% were born ⩾2500 g. Thirty-seven infants failed screening (0.9%); none with an unsuspected CCHD. False positive rates were low for infants not receiving oxygen (0.5%) and those screened after weaning (0.6%), yet higher among infants born at <28 weeks (3.8%). Unnecessary echocardiograms were minimal (0.2%).ConclusionGiven the majority of NICU infants were ⩾2500 g, not on oxygen and not preidentified for CCHD, systematic screening at 24 to 48 h may be of benefit for early detection of CCHD with minimal burden

Spectral Simplicity of Apparent Complexity, Part I: The Nondiagonalizable Metadynamics of Prediction

Virtually all questions that one can ask about the behavioral and structural complexity of a stochastic process reduce to a linear algebraic framing of a time evolution governed by an appropriate hidden-Markov process generator. Each type of question---correlation, predictability, predictive cost, observer synchronization, and the like---induces a distinct generator class. Answers are then functions of the class-appropriate transition dynamic. Unfortunately, these dynamics are generically nonnormal, nondiagonalizable, singular, and so on. Tractably analyzing these dynamics relies on adapting the recently introduced meromorphic functional calculus, which specifies the spectral decomposition of functions of nondiagonalizable linear operators, even when the function poles and zeros coincide with the operator's spectrum. Along the way, we establish special properties of the projection operators that demonstrate how they capture the organization of subprocesses within a complex system. Circumventing the spurious infinities of alternative calculi, this leads in the sequel, Part II, to the first closed-form expressions for complexity measures, couched either in terms of the Drazin inverse (negative-one power of a singular operator) or the eigenvalues and projection operators of the appropriate transition dynamic.Comment: 24 pages, 3 figures, 4 tables; current version always at http://csc.ucdavis.edu/~cmg/compmech/pubs/sdscpt1.ht

An overview of a systems model of cassava and cassava pests in Africa

A systems model is described for cassava, Manihot esculenta Crantz, two of its introduced herbivores, the cassava green mite (CGM), Mononychellus tanajoa (Bondar), sensu lato, and the cassava mealybug (CM), Phenacoccus manihoti Mat.-Ferr., the introduced CM parasitoid, Epidinocarsis lopezi (DeSantis) and coccinellid predator of the genus Hyperaspis. The systems model includes the effects of weather, soil nitrogen and water levels on the interactions of the system's components. The model simulates the distribution of developmental times of cohorts initated at the same time, as well as the number and biomass (energy) dynamics of all populations over time. Biomass acquisition and allocation at the population and organism subunit levels (e.g. leaves, fruit, ova) were also simulated. A common acquisition (i.e. functional response) submodel was used to estimate daily photosynthetic as well as nitrogen and water uptake rates in cassava, in addition to herbivory, parasitism and predation rates for the arthropod species. This paper presents an overview of the systems model. Simulation results for the plant under pest free conditions were compared to field data. In addition, the model was used to estimate tuber yield losses due to CM and CGM feeding, and to examine the beneficial effects of introduced CM natural enemies as measured by reductions in tuber yield losse

UEG's prospects for the future Strategic plan 2023-2026

Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Signal transduction in a covalent post-assembly modification cascade

Natural reaction cascades control the movement of biomolecules between cellular compartments. Inspired by these systems, we report a synthetic reaction cascade employing post-assembly modification reactions to direct the partitioning of supramolecular complexes between phases. The system is composed of a self-assembled tetrazine-edged FeII8L12 cube and a maleimide-functionalized FeII4L6 tetrahedron. Norbornadiene (NBD) functions as the stimulus that triggers the cascade, beginning with the inverse-electron-demand Diels–Alder reaction of NBD with the tetrazine moieties of the cube. This reaction generates cyclopentadiene as a transient by-product, acting as a relay signal that subsequently undergoes a Diels–Alder reaction with the maleimide-functionalized tetrahedron. Cyclooctyne can selectively inhibit the cascade by outcompeting NBD as the initial trigger. Initiating the cascade with 2-octadecyl NBD leads to selective alkylation of the tetrahedron upon cascade completion. The increased lipophilicity of the C18-tagged tetrahedron drives this complex into a non-polar phase, allowing its isolation from the initially inseparable mixture of complexes.B.S.P. acknowledges the Herchel Smith Research Fellowship, the Royal Commission for the Exhibition of 1851 Research Fellowship and the Fellowship from Corpus Christi College, Cambridge. D.A.R. acknowledges support from the Gates Cambridge Trust. This work was also supported by the UK Engineering and Physical Sciences Research Council (EPSRC, EP/M008258/1). The authors thank Diamond Light Source (UK) for synchrotron beamtime on I19 (MT11397), the NMR facility at the University of Cambridge Chemistry Department, and the EPSRC UK National Mass Spectrometry Facility at Swansea University

Experience with custom processors in space flight applications

The Applied Physics Laboratory (APL) has developed a magnetometer instrument for a swedish satellite named Freja with launch scheduled for August 1992 on a Chinese Long March rocket. The magnetometer controller utilized a custom microprocessor designed at APL with the Genesil silicon compiler. The processor evolved from our experience with an older bit-slice design and two prior single chip efforts. The architecture of our microprocessor greatly lowered software development costs because it was optimized to provide an interactive and extensible programming environment hosted by the target hardware. Radiation tolerance of the microprocessor was also tested and was adequate for Freja's mission -- 20 kRad(Si) total dose and very infrequent latch-up and single event upset events