Global impact of COVID-19 on newborn screening programmes.

peer reviewedINTRODUCTION: The global COVID-19 pandemic has presented extraordinary disruption to healthcare services and exposed them to numerous challenges. Newborn screening (NBS) programmes were also affected; however, scarce data exist on the impact of COVID-19 on NBS. METHODS: We conducted an international survey to assess the global impact of COVID-19 on NBS, with the main aim of gathering the experiences of the COVID-19 pandemic from a large and representative number of NBS centres worldwide. RESULTS: The results of our study showed that COVID-19 impacted the NBS programmes, at least partially, in 29 out of 38 responding countries. Majority of the screening centres experienced a broad spectrum of difficulties and most were affected more in the second wave of the pandemic. Delays and unreliability with the postal service as well as flight cancellations caused delays in samples arriving to screening centres and with the provision of laboratory equipment and reagents. The availability of laboratory staff was sometimes reduced due to infection, quarantine or reassignment within the healthcare facility. Sample collection at home, second-tier tests and follow-up were also affected. Social restrictions and interruptions in public transport added to these difficulties. Only a limited number of centres managed to retain a fully functioning NBS programme. CONCLUSION: As the pandemic might continue or could recur in future years, it would be useful to develop guidelines to protect these valuable services

An exploration of the current knowledge on young people who kill: a systematic review

This exploratory systematic review assessed the quality of primary studies on young people who kill and synthesised the findings regarding the characteristics of these offenders. An electronic search yielded 12,717 hits of papers published between 1989 and 2012. Of these, 8,395 duplicates, 3,787 irrelevant hits, and 527 publications not meeting the inclusion criteria of the review were excluded (15 publications were added after searching the grey literature), leaving 23 good quality studies. From these, a further seven were removed due to their small sample size (i.e., n < 30), leaving a total of 16 studies reviewed in detail. A search update was carried out on 2 February 2014 and no further studies meeting the inclusion criteria were found. The results indicate that juvenile homicide offenders are a heterogeneous group and the risk factors for juvenile homicide are cumulative and evolve through life. The findings are mixed, but ten risk factors are identified which appear to be consistent for offenders across the studies reviewed. The limitations of the current review are highlighted and recommendations for future research are outlined, with particular consideration given to improving the quality of the literature in this field

The role of school level protective factors in overcoming cumulative risk for behaviour difficulties in children with special educational needs and disabilities

The study investigated whether school level protective factors could moderate the effects cumulative risk has upon behaviour difficulties in children with Special Educational Needs and Disabilities (SEND). The sample comprised 4288 children identified with SEND: 2660 pupils within 248 primary schools, and 1628 pupils within 57 secondary schools. Risk factors associated with increases in behaviour difficulties over an 18-month period were summed to a cumulative risk score. Various school level factors were added to multi-level models, with interaction terms computed between cumulative risk and these variables to assess their potential protective effects. The primary school model revealed a significant interaction between cumulative risk and school academic achievement in predicting behaviour difficulties. Higher levels of achievement in primary schools help reduce behaviour difficulties for children most at risk. The secondary school model evidenced a significant interaction between cumulative risk and school percentage of students eligible for free school meals (FSM). Lower proportions within a school of children eligible for FSM were associated with reductions in behaviour difficulties for children at high levels of risk. Interventions aimed at improving school level academic achievement and targeting high-risk students attending schools with large proportions of children eligible for FSM would be beneficial

Neonatal Screening in Europe Revisited: An ISNS Perspective on the Current State and Developments Since 2010

Neonatal screening (NBS) was initiated in Europe during the 1960s with the screening for phenylketonuria. The panel of screened disorders (“conditions”) then gradually expanded, with a boost in the late 1990s with the introduction of tandem mass spectrometry (MS/MS), making it possible to screen for 40–50 conditions using a single blood spot. The most recent additions to screening programmes (screening for cystic fibrosis, severe combined immunodeficiency and spinal muscular atrophy) were assisted by or realised through the introduction of molecular technologies. For this survey, we collected data from 51 European countries. We report the developments between 2010 and 2020 and highlight the achievements reached with the progress made in this period. We also identify areas where further progress can be made, mainly by exchanging knowledge and learning from experiences in neighbouring countries. Between 2010 and 2020, most NBS programmes in geographical Europe matured considerably, both in terms of methodology (modernised) and with regard to the panel of conditions screened (expanded). These developments indicate that more collaboration in Europe through European organisations is gaining momentum. We can only accomplish the timely detection of newborn infants potentially suffering from one of the many rare diseases and take appropriate action by working together

Executive functions in preschool children with aggressive behavior: impairments in inhibitory control

The question whether executive function (EF) deficits in children are associated with conduct problems remains controversial. Although the origins of aggressive behavior are to be found in early childhood, findings from EF studies in preschool children with aggressive behavior are inconsistent. The current study aimed to investigate whether preschool children with aggressive behavior show impairments in EF. From a population-based sample, 82 preschool children who were showing aggressive behavior as indicated by scores at or above the 93rd percentile on the Aggressive Behavior Scale of the CBCL 1 1/2-5 were selected. These children with aggressive behavior were matched on IQ to a group of typically developing control children (N=99). Six neuropsychological tasks were administered to assess set shifting, inhibition, working memory and verbal fluency. A factor analysis was conducted which yielded one clear factor: inhibition. Aggressive preschool children showed poorer performance on this inhibition factor than control children and boys performed worse on this factor than girls. This association between aggressive behavior and inhibition deficits was maintained after controlling for attention problems. In addition, gender differences in all EFs measured were found with boys exhibiting more impairment in EF than girls. These findings demonstrate that preschool children with aggressive behavior show impairments in inhibition, irrespective of attention problems

Correction: Loeber, Gerard. ISNS 9th International Symposium, The Hague, The Netherlands, September 11–14, 2016. Int. J. Neonatal Screen. 2016, 2, 5

n/

ISNS 9th International Symposium, The Hague, The Netherlands, September 11–14, 2016

The International Society for Neonatal Screening (ISNS) was established almost 30 years ago by a small group of international pioneers in the newborn screening field.[...

Abstracts of Presentations Scheduled for the 10th ISNS-Asia Pacific Regional Meeting, Ulaanbataar, Mongolia, 24–26 August 2017

The International Society for Neonatal Screening (ISNS) recognises six different geographical regions [...