Rights by Design: Mainstreaming Human Rights Information, Education and Culture

‘Rights by Design: Mainstreaming Human Rights Information, Education and Culture’ explores the numinosity of human rights; that is, the intrinsic relationship between an individual and their rights. It is a timely reminder, in the post-Covid era of fragility, reflection, reckoning, and reawakening, that human beings are at the heart of human rights. The state-centricity of human rights discourse is increasingly giving way to and making room for authentic, post-colonial, localised voices in civil society and at grassroots, ‘glocal’ community levels, empowering the individual with the unprecedented but thus far largely unrealised power to shape a human rights future. In this future, human rights can – consciously and by design – be protected, respected, and rigorously defended from the creeping digital, ideological and political authoritarianism that is destabilising democracy and the international rules-based order on every continent in the world. To realise this power, we as individuals must be empowered with the information, knowledge, and advocacy skills to respect, protect, defend, and consciously live by human rights values in our everyday lives. In an ‘Age of Alternative Facts’, we must be equipped to counter human rights misinformation in our infospheres and reverse the global ‘information deficit’ on what human rights are and who they were designed to protect. This thesis is a call to action and a framework for empowering the individual so that we may more meaningfully integrate human rights knowledge, principles and values in our everyday social, economic and cultural lives – at home, in our family lives, and our local communities; through every stage of education, from early years, primary and secondary to tertiary, postgraduate, vocational and lifelong learning; in our digital worlds and social information environments; and in our worlds of work. It is an ambitious and original imagining of what Eleanor Roosevelt meant when she said, in 1958 on the 10th anniversary of the proclamation of the Universal Declaration of Human Rights, that human rights begin in “small places, close to home ... [in] the world of the individual person"

Superconductivity and local non-centrosymmetricity in crystal lattices

Symmetry of the crystal lattice can be a determining factor for the structure of Cooper pairs in unconventional superconductors. In this study we extend the discussion of superconductivity in non-centrosymmetric materials to the case when inversion symmetry is missing locally, but is present on a global level. Concretely, we investigate the staggered non-centrosymmetricity within a regular sublattice structure, in some analogy to the discussion of superconductivity in antiferromagnetic systems. Three crystal structures are analyzed in detail as illustrative examples for the extended classification of Cooper-pairing channels. One of the cases may be relevant for the class of iron-pnictide superconductors

Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies

The objective of this study was to review the efficacy and safety of frovatriptan (F) versus rizatriptan (R), zolmitriptan (Z) and almotriptan (A), in women with menstrually related migraine (IHS criteria) through a pooled analysis of three individual studies. Subjects with a history of migraine with or without aura were randomized to F 2.5 mg or R 10 mg (study 1), F or Z 2.5 mg (study 2), and F or A 12.5 mg (study 3). The studies had an identical multicenter, randomized, double-blind, crossover design. After treating three episodes of migraine in no more than 3 months with the first treatment, patients had to switch to the next treatment for other 3 months. 346 subjects formed intention-to-treat population of the main study; 280 of them were of a female gender, 256 had regular menses and 187 were included in the menstrual migraine subgroup analysis. Rate of pain free at 2, 4 and 24 h was 23, 52 and 67 % with F and 30, 61 and 66 % with comparators (P = NS). Pain relief episodes at 2, 4 and 24 h were 37, 60 and 66 % for F and 43, 55 and 61 % for comparators (P = NS). Rate of recurrence was significantly (P < 0.05) lower under F either at 24 h (11 vs. 24 % comparators) or at 48 h (15 vs. 26 % comparators). Number of menstrual migraine attacks associated with drug-related adverse events was equally low (P = NS) between F (5 %) and comparators (4 %)

User Response to Facebook's Custom Gender Options

Facebook’s recent implementation of “custom” gender options and gender-neutral pronouns provided transgender and gender-non-conforming users with new ways to represent gender identity online. We analyze user response to and use of these affordances. We found that while many transgender and gender non-conforming Facebook users used and appreciated the new options for gender representation, the system still constrained self-presentation for some. Additionally, use of custom gender options complicated gender identity disclosure for many participants. Results highlight tensions around the ability of classification systems to categorize identities.ye

Slope water, Gulf Stream, and seasonal influences on southern Mid-Atlantic Bight circulation during the fall-winter transition

Author Posting. © American Geophysical Union, 2005. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 110 (2005): C02009, doi:10.1029/2004JC002311.Observations from autumn, 2000, near the shelfbreak front in the Middle Atlantic Bight are used to describe the transition from stratified summer conditions to well-mixed winter conditions over the shelf. During the observational period, the front differed dramatically from climatological conditions, with buoyant Gulf Stream water found shoreward over the sub-surface shelfbreak front. Water mass analysis shows a large number of separate water masses with shelf, slope and Gulf Stream origins. The coolest shelf water was located at the shelfbreak and may be related to “cold pool” water masses observed to the north during summer. Shoreward of this shelfbreak water mass, a mid-shelf front was present which intersected the bottom at the 50 m isobath. High volume transports were associated with both the shelfbreak and mid-shelf fronts. Transport estimates from the cross-shelf sections were approximately 1 Sverdrup, which is large relative to previous estimates of shelf transport. The foot of the front was near the 130 m isobath, much deeper than the climatological position near the 75 m isobath, however this is consistent with a recent theory relating the magnitude of alongshelf transport to the depth at which the front intersects the bottom.The authors gratefully acknowledge support from the Duke University - University of North Carolina Oceanographic Consortium for ship time aboard the R/V Cape Hatteras. MSL also gratefully acknowledges support from the Office of Naval Research (N00014-01-1-0260)

Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification.

There is evidence that the prevalence of migraine in children and adolescents may be increasing. Current theories of migraine pathophysiology in adults suggest activation of central cortical and brainstem pathways in conjunction with the peripheral trigeminovascular system, which ultimately results in release of neuropeptides, facilitation of central pain pathways, neurogenic inflammation surrounding peripheral vessels, and vasodilatation. Although several risk factors for frequent episodic, chronic, and refractory migraine have been identified, the causes of migraine progression are not known. Migraine pathophysiology has not been fully evaluated in children. In this review, we will first discuss the evidence that early therapeutic interventions in the child or adolescent new onset migraineur, may halt or limit progression and disability. We will then review the evidence suggesting that many adults with chronic or refractory migraine developed their migraine as children or adolescents and may not have been treated adequately with migraine-specific therapy. Finally, we will show that early, appropriate and optimal treatment of migraine during childhood and adolescence may result in disease modification and prevent progression of this disease

Consolidated health economic evaluation reporting standards (CHEERS) statement

&lt;p&gt;Economic evaluations of health interventions pose a particular challenge for reporting. There is also a need to consolidate and update existing guidelines and promote their use in a user friendly manner. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement is an attempt to consolidate and update previous health economic evaluation guidelines efforts into one current, useful reporting guidance. The primary audiences for the CHEERS statement are researchers reporting economic evaluations and the editors and peer reviewers assessing them for publication.&lt;/p&gt; &lt;p&gt;The need for new reporting guidance was identified by a survey of medical editors. A list of possible items based on a systematic review was created. A two round, modified Delphi panel consisting of representatives from academia, clinical practice, industry, government, and the editorial community was conducted. Out of 44 candidate items, 24 items and accompanying recommendations were developed. The recommendations are contained in a user friendly, 24 item checklist. A copy of the statement, accompanying checklist, and this report can be found on the ISPOR Health Economic Evaluations Publication Guidelines Task Force website (www.ispor.org/TaskForces/EconomicPubGuidelines.asp).&lt;/p&gt; &lt;p&gt;We hope CHEERS will lead to better reporting, and ultimately, better health decisions. To facilitate dissemination and uptake, the CHEERS statement is being co-published across 10 health economics and medical journals. We encourage other journals and groups, to endorse CHEERS. The author team plans to review the checklist for an update in five years.&lt;/p&gt

Bibliometric Analysis of Gender Authorship Trends and Collaboration Dynamics over 30 Years of Spine 1985 to 2015

Study Design. A bibliometric analysis. Objective. The aim of this article was to study bibliometric changes over the last 30 years of Spine. These trends are important regarding academic publication productivity. Summary of Background Data. Inflation in authorship number and other bibliometric variables has been described in the scientific literature. The issue of author gender is taking on increasing importance, as efforts are being made to close the gender gap. Methods. From 1985 to 2015, 10-year incremental data for several bibliometric variables were collected, including author gender. Standard bivariate statistical analyses were performed. Trends over time were assessed by the Cochran linear trend. A P < 0.05 was considered statistically significant. Results. Inclusion criteria were met for 1566 manuscripts. The majority of the manuscripts were from North America (51.2%), Europe (25.2%), and Asia (20.8%). The number of manuscripts, authors, countries, pages, and references all increased from 1985 to 2015. There was a slight increase in female first authors over time (17.5% to 18.4%, P = 0.048). There was no gender change over time for corresponding authors (14.3% to 14.0%, P = 0.29). There was an 88% increase in the percentage of female first authors having male corresponding authors (P = 0.00004), and a 123% increase in male first authors having female corresponding authors (P = 0.0002). The 14% to 18% of female authors in Spine is higher than the ∼5% female membership of the Scoliosis Research Society and North American Spine Society. Conclusion. Manuscripts in Spine over the past 30 years have shown a significant increase in the number of authors, collaborating institutions and countries, printed pages, references, and number of times each manuscript was cited. There has been a mild increase in female first authorship, but none in corresponding authorship. Increases in female authorship will likely require recruitment of more females into the discipline rather than providing females in the discipline with authorship opportunities. Level of Evidence: N/

Case report: Rare skeletal manifestations in a child with primary hyperparathyroidism

Background: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. Case presentation: A 12year old Sri Lankan girl presented with progressive difficulty in walking since 1year. On examination she had bilateral genu valgum. Skeletal survey revealed valgus deformity of knee joints, bilateral subluxation of upper femoral epiphysis(SUFE), epiphyseal displacement of bilateral humeri, rugger jersey spine and subperiosteal bone resorptions in lateral aspects of 2nd and 3rd middle phalanges. There were no radiological manifestations of rickets. Metabolic profile revealed hypercalcemia with hypophosphatemia. Intact parathyroid hormone levels were elevated at 790pg/ml. Vitamin D levels were deficient. She had low bone mineral density with Z score of -3.4. Vitamin D supplementation resulted in worsening of hypercalcemia without reduction in PTH levels. Tc 99 Sestamibi uptake scan showed abnormal tracer retention in left inferior pole of thyroid. A large parathyroid gland was removed with histology favoring parathyroid adenoma. Post operatively she developed hypocalcemia. Bilateral osteotomy was done for SUFE and further surgeries for correction of limb deformities planned. Conclusion: PHPT in children is usually diagnosed late when irreversible organ damage has occurred. Children can present with non specific symptoms involving gastrointestinal, musculoskeletal, renal and neurological systems. PHPT can cause disarray in bone and epiphysis in children during pubertal growth spurt. Genu valgum and SUFE are rare skeletal manifestations in PHPT and only 10 cases of genu valgum and 9 cases of SUFE have been reported up to now. So far no cases have been reported on epiphyseal displacement of humeri. Awareness regarding the occurrence of these rare skeletal manifestations especially during puberty is important for early diagnosis to prevent irreversible outcomes