The search for innovators and early adopters of e-collaborative technologies within small and medium sized enterprises in the UK

New product diffusion theory predicts that innovators and early adopters are critical to the success of new innovations. The rate at which enterprises adopt e-Science technologies must therefore rely upon reliable market intelligence so that the critical early stages of adoption are successfully navigated by developers and planners. Failure to understand attitudes towards new technologies can lead to even useful technologies being under-adopted. This paper applies a survey based methodology to develop estimates of demand for web based virtual Collaborative technologies. We show that approximately 76% of the 1029 firms that we interviewed are technologically ready to deploy these technologies. We also show that 10% of all firms are ready look at these technologies as solutions to collaborative problem solving

Entrepreneurs'' attitude towards the computer and its effect on e-business adoption

This paper presents research exploring further the concept that many SMEs do not adopt computer based technologies due to decision maker's negative attitudes towards computers generally. Importantly, by assessing the entrepreneur's belief structure, we provide quantitative evidence how SMEs, particularly micros, are affected. Earlier research that addresses technology acceptance model (TAM) suggests that TAM parameters are particularly influential factors of e-commerce adoption, as perceived by top managers of SMEs. The model we develop is tested using a sample of 655 enterprises. The information was gathered, via a telephone survey of UK SMEs, from decisions makers in the enterprise. Technically, the paper uses k-means cluster analysis to segment respondents using the TAM perceptions, ease of use, usefulness and enjoyment. Based on two determined segments we look at the differential rate of adoption of internet, and the potential adoption of new e-collaborative technologies like video conferencing and electronic whiteboards. The diffusion of internet for low IT utility (LIT) segments was considerably slower than in the high utility segment (HIT). Similarly, the anticipated adoption of e-collaboration technologies was much lower for LIT than HIT. Interestingly, we find that LIT is populated by more micro SMEs than HIT. The results we present are limited however as our sample is considerably underweight in micro SMEs, suggesting that the problem may be much larger in the economy than our model predicts. For policy makers, this research confirms the value of knowledge transfer programs to SMEs in the form of technology support. Our research shows that organisations which have dedicated IT support will tend to be more advanced technologically than those that do not. The implication for entrepreneurs is if they can be persuaded that a technological route is beneficial to them, and that suitable support can be provided via KT, then operational efficiency gains could be made. This paper contributes to knowle

Dynamics of Post-Injection Fuel Flow in Mini-Sac Diesel Injectors Part 1: Admission of 1 External Gases and Implications for Deposit Formation

Samples of unadditized, middle distillate diesel fuel were injected through real-size optically accessible mini-sac diesel injectors into ambient air at common rail pressures of 250 bar and 350 bar respectively. High-resolution images of white light scattered from the internal mini-sac and nozzle flow were captured on a high-speed monochrome video camera. Following the end of each injection, the momentum-driven evacuation of fuel liquid from the mini-sac and nozzle holes resulted in the formation of a vapour cloud and bubbles in the mini-sac, and vapour capsules in the nozzle holes. This permitted external gas to gain entrance to the nozzle holes. The diesel fuel in the mini-sac was observed to rotate with large initial vorticity, which decayed until the fuel became stationary. The diesel fuel remaining in the nozzle holes was observed to move inwards towards the mini-sac or outwards towards the nozzle exit in concert with the rotational flow in the mini-sac. The mini-sac bubbles’ internal pressure differences revealed that the bubbles must have contained previously dissolved oxygen and nitrogen. Under diesel engine operating conditions, this multi-phase mixture would be highly reactive and could initiate local pyrolysis and/or oxidation reactions. Finally, the dynamical behaviour of the diesel fuel in the nozzle holes would support the admission of external hot combustion gases into the nozzle holes, establishing the conditions for oxidation/pyrolysis reactions with surrounding liquid fuel films

eClusters and the Role of Intermediaries in Enabling Digital Enterprise Communities of SMEs

The potential for the emergence of digital enterprise communities enabled by one or more intermediaries, termed eClusters, has been predicted from empirical research in business communities of SMEs in the UK. The role of intermediaries, which will be pivotal to the formation of eClusters, is examined in this paper and forms part of a wider research project into the nature of digital enterprise communities. One conceptualisation of the role of intermediaries is the provision of a Trust Platform. As with IT outsourcing generally it is large companies that have been early adopter of application service providers (ASPs) services with little penetration in the SME sector. It is the notion of community and emergent properties of an eCluster that could provide the ‘key’ to this market and lead to the formation of community-centric ASPs

Atypical tibial fracture in a 63-Year-old woman with intermittent use of bisphosphonate unmasking hypophosphatasia

We report an unusual case of atypical proximal tibial stress fracture (APTF) associated with intermittent use of bisphosphonates (BPs) and persistently low serum alkaline phosphatase (ALP) levels. We describe the case of a 63-year-old white woman who had experienced an APTF after 4 years of intermittent exposure to alendronate given for recurrent metatarsal stress fractures. BP administration was stopped after the diagnosis of the APTF. A review of her previous serum ALP levels revealed they had been consistently low. Adult hypophosphatasia (HPP) was diagnosed by the low serum ALP activity and elevated urine phosphoethanolamine levels. She was treated conservatively with analgesics. Adult HPP is an underrecognized condition associated with atypical insufficiency fractures, and BP use compounds this risk. To the best of our knowledge, we report the first case of intermittent BP exposure preceding an APTF in an adult patient with HPP, highlighting the uncommon site of the proximal tibia for BP-associated atypical insufficiency fractures, the need to screen for HPP in those with persistently low ALP levels before they begin BP therapy, and the importance of avoiding BP use in those with HPP

\u3ci\u3eIn situ\u3c/i\u3e Synthesis of Oligonucleotide Arrays on Surfaces Coated with Crosslinked Polymer Multilayers

We report an approach to the in situ synthesis of oligonucleotide arrays on surfaces coated with crosslinked polymer multilayers. Our approach makes use of methods for the reactive layer-by-layer assembly of thin, amine-reactive multilayers using branched polyethyleneimine (PEI) and the azlactone-functionalized polymer poly(2-vinyl-4,4′-dimethylazlactone) (PVDMA). Postfabrication treatment of film-coated glass substrates with d-glucamine or 4-amino-1-butanol yielded hydroxyl-functionalized films suitable for the Maskless Array Synthesis (MAS) of oligonucleotide arrays. Glucamine-functionalized films yielded arrays of oligonucleotides with fluorescence intensities and signal-to-noise ratios (after hybridization with fluorescently labeled complementary strands) comparable to those of arrays fabricated on conventional silanized glass substrates. These arrays could be exposed to multiple hybridization/dehybridization cycles with only moderate loss of hybridization density. The versatility of the layer-by-layer approach also permitted synthesis directly on thin sheets of film-coated poly(ethylene terephthalate) (PET) to yield flexible oligonucleotide arrays that could be readily manipulated (e.g., bent) and cut into smaller arrays. To our knowledge, this work presents the first use of polymer multilayers as a substrate for the multistep synthesis of complex molecules. Our results demonstrate that these films are robust and able to withstand the ∼450 individual chemical processing steps associated with MAS (as well as manipulations required to hybridize, image, and dehybridize the arrays) without large-scale cracking, peeling, or delamination of the thin films. The combination of layer-by-layer assembly and MAS provides a means of fabricating functional oligonucleotide arrays on a range of different materials and substrates. This approach may also prove useful for the fabrication of supports for the solid-phase synthesis and screening of other macromolecular or small-molecule agents

Sensitive VLBI Studies of the OH Megamaser Emission from IRAS 17208-0014

We present phase-referenced VLBI results on the radio continuum and the OH 18 cm megamaser emission from the Ultra-Luminous Infrared Galaxy, IRAS 17208--0014. The observations were carried out at 1599 MHz using the Very Long Baseline Array, the phased VLA, and the Green Bank Telescope. The highest resolution radio continuum results show several compact sources with brightness temperatures on the order of $10^{6}$ K. These sources are more likely to be clustered supernova remnants and/or luminous radio supernovae. However, the agreement between the number of observed and expected compact sources above the 5 $\sigma$ level supports the possibility that each one of the compact sources could be dominated by a recently detonated luminous radio supernova. The continuum results suggest that there is no radio-loud AGN in the nuclear region of this galaxy. The OH 18 cm megamaser emission in IRAS 17208--0014 is detected at various angular resolutions. It has an extent of $170 \times 110$ pc, and is mostly localized in two regions separated by 61 pc. The structure and dynamics of the maser emission seem to be consistent with a clumpy, rotating, ring-like geometry, with the two dominant maser regions marking the tangential points of the proposed rotating-ring distribution. Assuming Keplerian motion for the rotating maser ring, the enclosed dynamical mass and the mass density within a radius of 30.5 pc, are about {$3 \times 10^7 ({\rm sin}^{-2}i) M{_\odot}$}, and $281 ({\rm sin}^{-2} i) M{_\odot} {\rm pc}^{-3}$, respectively.Comment: 8 pages, 5 figures. ApJ Accepte

Probing MHD Shocks with high-J CO observations: W28F

Context. Observing supernova remnants (SNRs) and modelling the shocks they are associated with is the best way to quantify the energy SNRs re-distribute back into the Interstellar Medium (ISM). Aims. We present comparisons of shock models with CO observations in the F knot of the W28 supernova remnant. These comparisons constitute a valuable tool to constrain both the shock characteristics and pre-shock conditions. Methods. New CO observations from the shocked regions with the APEX and SOFIA telescopes are presented and combined. The integrated intensities are compared to the outputs of a grid of models, which were combined from an MHD shock code that calculates the dynamical and chemical structure of these regions, and a radiative transfer module based on the 'large velocity gradient' (LVG) approximation. Results. We base our modelling method on the higher J CO transitions, which unambiguously trace the passage of a shock wave. We provide fits for the blue- and red-lobe components of the observed shocks. We find that only stationary, C-type shock models can reproduce the observed levels of CO emission. Our best models are found for a pre-shock density of 104 cm-3, with the magnetic field strength varying between 45 and 100 {\mu}G, and a higher shock velocity for the so-called blue shock (\sim25 km s-1) than for the red one (\sim20 km s-1). Our models also satisfactorily account for the pure rotational H2 emission that is observed with Spitzer.Comment: 8 pages, 6 figures, 1 table, accepted for A&A SOFIA/GREAT Special Issu

State-of-the-art in product service-systems

A Product Service-System (PSS) is an integrated combination of products and services. This western concept embraces a service-led competitive strategy, environmental sustainability, and the basis to differentiate from competitors who simply offer lower priced products. This paper aims to report the state-of-the-art of PSS research by presenting a clinical review of literature currently available on this topic. The literature is classified and the major outcomes of each study are addressed and analysed. On this basis, this paper defines the PSS concept, reports on its origin and features, gives examples of applications along with potential benefits and barriers to adoption, summarises available tools and methodologies, and identifies future research challenges