18 research outputs found

    Comedia heroica : El Rey D. Sebastian y portugues mas heroico : en tres actos

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    Precede al tít. ¨Comedia heroica. N. 10

    Evolución de los planteamientos mundiales en sustenibilidad hasta la responsabilidad de enfermería en la actualidad.

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    La importancia sobre los aspectos políticos, económicos, ecológicos y sociales para el desarrollo de la humanidad empieza a darse desde los años 70´s del siglo XX, inicialmente en estas discusiones con una perspectiva desde el desarrollo humano, en el siguiente decenio se da una evolución hacia lo que se establecería como desarrollo sostenible, paralelamente sale a la luz pública el primer informe sobre los impactos en la salud por el cambio climático, aspecto que empieza a dar cierta relevancia a la participación del sector salud en los asuntos ambientales, esto resaltándose en la cumbre de Rio en 1992 (1). En esa misma línea evolutiva, para 1995 se genera un informe sobre enfermería y ambiente por parte del Institute of Medicine (IOM) resaltando la importancia del incremento del conocimiento de las enfermeras y su acción desde sus roles (2)

    El hombre convencido a la razon, ó La mujer prudente : comedia nueva en tres actos representada ... en 1790

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    El pie de imprenta consta en el colofónFecha aproximada de impresión deducida de la actividad del impreso

    El sol de España en su oriente y toledano Moyses: comedia nueva en tres actos

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    Autor tomado del "Catálogo de comedias sueltas conservadas en la Biblioteca de la Real Academia Española", 1084Pie de imp. tomado del colofó

    Aspirin, Chance, and Results in Relation to Blood Pressure

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    El diablo predicador, y mayor contrario amigo : comedia famosa

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    A 250/163(01

    Visible Luminescence of Dedoped DBU-Treated PEDOT:PSS Films

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    Dedoping of PEDOT:PSS by a simple and physical process has been performed by the addition of 1,8-diazabicyclo­[5.4.0]­undec-7-ene (DBU), a strong organic base, in the PEDOT:PSS aqueous dispersion. The DBU-treated PEDOT:PSS samples showed a strong absorption band at 600 nm (π–π* transition) and a small band at 900 nm (polaronic band), which indicates that some PEDOT chains were being reduced. The dedoping efficiency depended of the amount of DBU added to the aqueous PEDOT:PSS dispersion. The DBU-treated PEDOT:PSS aqueous dispersions and films showed a strong yellow emission, visible with the naked eye, when they were excited with a 488 nm laser. In addition, the same emission features were observed using another reducing agent like sodium hydroxide (NaOH), which indicates that the emission originates from neutral PEDOT chains rather than artifacts. Finally, Raman and FTIR spectroscopies were used to figure out the mechanism responsible for the PEDOT reduction. The reduction of PEDOT chains is due to the formation of hydroxide anions, which come from the interaction of DBU with water present in the PEDOT:PSS aqueous solution and interact with the oxidized thiophene molecules, resulting in a neutralization of the PEDOT backbone

    Central Ghrelin Regulates Peripheral Lipid Metabolism in a Growth Hormone-Independent Fashion

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    GH plays a major role in the regulation of lipid metabolism and alterations in GH axis elicit major changes in fat distribution and mobilization. For example, in patients with GH deficiency (GHD) or in mice lacking the GH receptor, the percentage of fat is increased. In addition to the direct actions of GH on lipid metabolism, current evidence indicates that ghrelin, a stomach-derived peptide hormone with potent GH secretagogue action, increases lipogenesis in white adipose tissue (WAT) through a hypothalamic-mediated mechanism. Still, the mechanism by which GH tone modulates ghrelin actions on WAT remains unclear. Here we investigated the effect of central ghrelin administration on lipid metabolism in lipogenic tissues (liver and WAT) in the absence of GH, by using a model for the study of GHD, namely the spontaneous dwarf rat, which shows increased body fat. Our data demonstrate that central chronic ghrelin administration regulates adipose lipid metabolism, mainly in a GH-independent fashion, as a result of increased mRNA, protein expression, and activity levels of fatty acid metabolism enzymes. On the contrary, central ghrelin regulates hepatic lipogenesis de novo in a GH-independent fashion but lipid mobilization in a GH-dependent fashion because carnitine palmitoyltransferase 1 was decreased only in wild-type Lewis rats. These findings suggest the existence of a new central nervous system-based neuroendocrine circuit, regulating metabolic homeostasis of adipose tissue. Understanding the molecular mechanism underlying the interplay between GH and ghrelin and their effects on lipid metabolism will provide new strategies for the design and development of suitable drugs for the treatment of GHD, obesity, and its comorbidities
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