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    El espacio vivido por las mujeres en los límites de la violencia. La maldita, la cautiva, la soñadora : tres figuras históricas a través de la literatura y del arte

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    Las mujeres no han regido la dimensión productora de la arquitectura, la historia no ha legado la memoria de ninguna mujer arquitecta hasta el siglo XX. Más allá de no haber podido expresar en forma de proyectos de arquitectura sus deseos de habitar, podemos recoger los fragmentos de unos espacios vividos a golpes de felicidad y de dolor por ellas. Entre muchas imágenes entrevistas solo en la historia, correspondientes a distintas formas de ocupación del espacio por parte de las mujeres, difícilmente mostradas por fuentes y testimonios que en general no han prestado una atención central a la experiencia femenina, la primera impresión es la de estar rastreando un objeto que se esconde. Pero ha sido a través de estos vestigios de espacios vividos, narrados por la literatura y representados por el arte, como hemos podido reconstruir tres figuras dramáticas y plenamente vigentes, cuyas vidas transcurren en los límites de la violencia y de la marginación: la mujer maldita, la mujer cautiva, la mujer soñadora. Las tres disponen de abundantes retratos históricos y, a pesar de la negatividad con la que alcanzan a revelar su existencia, permiten que reconozcamos el valor que dieron al espacio que habitaron. Permiten que entendamos la importancia del espacio en la vida y la urgencia de nuestro compromiso para apoderarnos plenamente de la posibilidad de configurarlo

    LA INSCRIPCIÓN Y LA HUELLA. LA HUELLA DE LA EXPERIENCIA FRENTE A LA INSCRIPCIÓN DE LA ARQUITECTURA EN LA CIUDAD

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    Este texto plantea la ciudad, esa creación del hombre, como un "lienzo" posible en el que se inscribe la memoria de lo físico y lo intangible del devenir humano. La huella de la vida, esa que es casi imposible de borrar, que es obstinada, insistente, olvidada, se superpone siempre ante nuestros ojos y ante nuestra posibilidad de percepción por encima del simple hecho físico. Nueva York, Guernica, y Berlín, son ejemplos de ciudades observadas desde la mirada del poeta, o el fotógrafo, el pintor, o el cineasta que muestran"las huellas del dolor sobre la ciudad y el poder de su presencia". Así como es preciso olvidar, es preciso recordar y la ciudad, ese "grande proyecto de la humanidad" al permitir que la vida se abra permanentemente camino en ella, contiene la "clave" de armonía.ABSTRACTThis text raises the city, that creation of the man, like a "possible linen cloth" in which itregisters the memory of the physical and the intangible of human happening. The track of the life, the one that is almost impossible to erase, the one that is obstinate, insistent, forgotten, is always superposed before our eyes and our possibility of perception over thesimple physical fact. New York, Guernica and Berlin are examples of cities observed fromthe glance of the poet, or the photographer, the painter, or the film director that show"the tracks of the pain on the city and the power of their presence". As well as it is preciseto forget, it is precise to remember and the city, that "great project of mankind" by allowing that the life lays way in her permanently, it contains the "key" of harmony

    Atlas QR de procedimientos básicos en clínica hospitalaria equina

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    Los códigos QR se utilizan actualmente como herramienta docente de gran utilidad ya que permiten al alumno emplear las nuevas tecnologías para el aprendizaje. Con este proyecto pretendemos acercar la actividad clínica equina al alumno de veterinaria

    Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

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    Producción CientíficaBackground: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients. Methods: Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals. Results: There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11·53, 95 per cent c.i. 4·15 to 32·08; P = 0·006) and the best area under the curve (AUC) for detecting sepsis (0·86, 95 per cent c.i. 0·80 to 0·91; P < 0·001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8·09, 1·34 to 48·91; P = 0·028) and lipocalin 2 (OR 6·62, 2·47 to 17·77; P = 0·002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0·81, 0·73 to 0·90; P < 0·001). Conclusion: MR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection.Instituto de Salud Carlos III (grants PI15/01959, PI15/01451 and PI16/01156

    Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19

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    We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak after one vaccine shot in individuals recovered from COVID-19, while a second dose is needed in naive subjects, although the latter group shows reduced levels all along the analyzed period. Despite how the neutralization capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mirrors this behavior early after vaccination, both groups show comparable neutralizing antibodies and S-specific B cell levels late post-vaccination. When studying cellular responses, naive individuals exhibit higher SARS-CoV-2-specific cytokine production, CD4+ T cell activation, and proliferation than do individuals recovered from COVID-19, with patent inverse correlations between humoral and cellular variables early post-vaccination. However, almost 8 months post-vaccination, SARS-CoV-2-specific responses are comparable between both groups. Our data indicate that a previous history of COVID-19 differentially determines the functional T and B cell-mediated responses to BNT162b2 vaccination over time.C.d.F., J.G.-P., and J.A. are supported by Instituto de Salud Carlos III (ISCII). We thank JM Ligos and Cytek Biosciences for their technical support. Research in E.L.-C.’s lab was supported by Fundación Familia Alonso, Santander Bank, Real Seguros, Fundación Mutua Madrileña, Fundación Uria, Fundación La Caixa, and Ayuntamiento de Madrid.S

    Famílies botàniques de plantes medicinals

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    Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

    Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

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    Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality
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