Cerclajes y enclavado intramedular en fracturas subtrocantéreas: ¿vascularización femoral o reducción anatómica?

Nuestro objetivo es valorar el beneficio y los resultados clínico-radiológicos del uso de los cerclajes y el enclavado intramedular en las fracturas subtrocantéreas tipo IIIA de Seinsheimer y compararlo con un grupo control. Se utilizaron dos grupos de 19 pacientes (grupo con cerclaje y grupo sin cerclaje) y se obtuvieron los siguientes resultados; tasas de reducción anatómica 89.5% y 84.2%; tasas de consolidación 100% y 94,7%; tiempo medio de consolidación 20 y 23.9 semanas. Los resultados utilizando la escala de Harris fueron de 62,7 y 68,3; y una tasa de complicaciones del 5.2% y del 21%. Estos resultados sugieren que el uso de cerclajes en las fracturas subtrocantéreas, no influencia de forma negativa nuestra tasa de consolidación, infección o complicaciones; sin embargo promovemos el uso de cerclajes después de intentar la reducción de manera cerrada, y siempre con un buen manejo de partes blandas.Our goal is to assess the benefit and the clinical and radiological outcomes of using cerclage and intramedullary nail in subtrochanteric fractures type IIIA of Seinsheimer and comparing with a control group. Two groups of 19 patients (cerclage group and non-cerclage group) were used and the following results were obtained; anatomic reduction rates 89.5% and 84.2; consolidation rates 100% and 94.7%; mean healing time 20 and 23.9 weeks. Our mean Harris Hip Score were 62.7 and 68.3; and a complication rate of 5.2% and 21%. The results suggest that the use of cerclage in subtrochanteric fractures does not negatively influence in the rate of consolidation, infection or complications as opposed to a subotpimal reduction. Nevertheless we emphasize open reduction and cerclage wiring after the attempt of closed reduction, and always taking care of soft tissues

The Gypsy Database (GyDB) of mobile genetic elements: release 2.0

This article introduces the second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0): a research project devoted to the evolutionary dynamics of viruses and transposable elements based on their phylogenetic classification (per lineage and protein domain). The Gypsy Database (GyDB) is a long-term project that is continuously progressing, and that owing to the high molecular diversity of mobile elements requires to be completed in several stages. GyDB 2.0 has been powered with a wiki to allow other researchers participate in the project. The current database stage and scope are long terminal repeats (LTR) retroelements and relatives. GyDB 2.0 is an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants. Among other features, in terms of the aforementioned topics, this update adds: (i) a variety of descriptions and reviews distributed in multiple web pages; (ii) protein-based phylogenies, where phylogenetic levels are assigned to distinct classified elements; (iii) a collection of multiple alignments, lineage-specific hidden Markov models and consensus sequences, called GyDB collection; (iv) updated RefSeq databases and BLAST and HMM servers to facilitate sequence characterization of new LTR retroelement and caulimovirus queries; and (v) a bibliographic server. GyDB 2.0 is available at http://gydb.org

Benchmarking microbiome transformations favors experimental quantitative approaches to address compositionality and sampling depth biases

While metagenomic sequencing has become the tool of preference to study host-associated microbial communities, downstream analyses and clinical interpretation of microbiome data remains challenging due to the sparsity and compositionality of sequence matrices. Here, we evaluate both computational and experimental approaches proposed to mitigate the impact of these outstanding issues. Generating fecal metagenomes drawn from simulated microbial communities, we benchmark the performance of thirteen commonly used analytical approaches in terms of diversity estimation, identification of taxon-taxon associations, and assessment of taxon-metadata correlations under the challenge of varying microbial ecosystem loads. We find quantitative approaches including experimental procedures to incorporate microbial load variation in downstream analyses to perform significantly better than computational strategies designed to mitigate data compositionality and sparsity, not only improving the identification of true positive associations, but also reducing false positive detection. When analyzing simulated scenarios of low microbial load dysbiosis as observed in inflammatory pathologies, quantitative methods correcting for sampling depth show higher precision compared to uncorrected scaling. Overall, our findings advocate for a wider adoption of experimental quantitative approaches in microbiome research, yet also suggest preferred transformations for specific cases where determination of microbial load of samples is not feasible

Strain balanced quantum posts

Quantum posts are assembled by epitaxial growth of closely spaced quantum dot layers, modulating the composition of a semiconductor alloy, typically InGaAs. In contrast with most self-assembled nanostructures, the height of quantum posts can be controlled with nanometer precision, up to a maximum value limited by the accumulated stress due to the lattice mismatch. Here we present a strain compensation technique based on the controlled incorporation of phosphorous, which substantially increases the maximum attainable quantum post height. The luminescence from the resulting nanostructures presents giant linear polarization anisotropy.Comment: Submitted to Applied Physics Letters (7th March 2011). 4 pages, 4 figure

Development of an acoustic transceiver for the KM3NeT positioning system

[EN] In this paper we describe an acoustic transceiver developed for the KM3NeT positioning system. The acoustic transceiver is composed of a commercial free flooded transducer, which works mainly in the 20-40 kHz frequency range and withstands high pressures (up to 500 bars). A sound emission board was developed that is adapted to the characteristics of the transducer and meets all requirements: low power consumption, high intensity of emission, low intrinsic noise, arbitrary signals for emission and the capacity of acquiring the receiving signals with very good timing precision. The results of the different tests made with the transceiver in the laboratory and shallow sea water are described, as well as, the activities for its integration in the Instrumentation Line of the ANTARES neutrino telescope and in a NEMO tower for the in situ tests. © 2012 Elsevier B.V. All rights reserved.This work has been supported by the Ministerio de Ciencia e Innovacion (Spanish Government), Project references FPA2009-13983-C02-02, ACI2009-1067, AIC10-D-00583, and Consolider-Ingenio Multidark (CSD2009-00064). It has also been funded by Generalitat Valenciana, Prometeo/2009/26, and the European 7th Framework Programme, Grant no. 212525.Larosa, G.; Ardid Ramírez, M.; Llorens Alvarez, CD.; Bou Cabo, M.; Martínez Mora, JA.; Adrián Martínez, S.; KM3NeT Consortium (2013). Development of an acoustic transceiver for the KM3NeT positioning system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 725:215-218. https://doi.org/10.1016/j.nima.2012.11.167S21521872

ReverCSP: Time-Travelling in CSP Computations

[EN] This paper presents reverCSP, a tool to animate both forward and backward CSP computations. This ability to reverse computations can be done step by step or backtracking to a given desired state of interest. reverCSP allows us to reverse computations exactly in the same order in which they happened, or also in a causally-consistent way. Therefore, reverCSP is a tool that can be especially useful to comprehend, analyze, and debug computations. reverCSP is an open-source project publicly available for the community. We describe the tool and its functionality, and we provide implementation details so that it can be reimplemented for other languages.This work has been partially supported by the EU (FEDER) and the Spanish MCI/AEI under grants TIN2016-76843-C4-1-R and PID2019- 104735RB-C41, and by the Generalitat Valenciana under grant Prometeo/2019/098 (DeepTrust).Galindo-Jiménez, CS.; Nishida, N.; Silva, J.; Tamarit, S. (2020). ReverCSP: Time-Travelling in CSP Computations. Springer. 239-245. https://doi.org/10.1007/978-3-030-52482-1_14S239245Bernadet, A., Lanese, I.: A modular formalization of reversibility for concurrent models and languages. In: Proceedings of ICE 2016, EPTCS (2016)Brown, G., Sabry, A.: Reversible communicating processes. Electron. Proc. Theor. Comput. Sci. 203, 45–59 (2016)Conserva Filhoa, M., Oliveira, M., Sampaio, A., Cavalcanti, A.: Compositional and local livelock analysis for CSP. Inf. Process. Lett 133, 21–25 (2018)Danos, V., Krivine, J.: Reversible communicating systems. In: Gardner, P., Yoshida, N. (eds.) CONCUR 2004. LNCS, vol. 3170, pp. 292–307. Springer, Heidelberg (2004). https://doi.org/10.1007/978-3-540-28644-8_19Elnozahy, E.N.M., Alvisi, L., Wang, Y.-M., Johnson, D.B.: A survey of rollback- recovery protocols in message-passing systems. ACM Comput. Surv. 34(3), 375–408 (2002)Fang, Y., Zhu, H., Zeyda, F., Fei, Y.: Modeling and analysis of the disruptor framework in csp. In: Proceedings of CCWC 2018. IEEE Computer Society (2018)Ladkin, P.B., Simons, B.B.: Static deadlock analysis for CSP-type communications. In: Fussell, D.S., Malek, M. (eds.) Responsive Computer Systems: Steps Toward Fault-Tolerant Real-Time Systems. The Springer International Series in Engineering and Computer Science, vol. 297, pp. 89–102. Springer, Boston (1995). https://doi.org/10.1007/978-1-4615-2271-3_5Landauer, R.: Irreversibility and heat generation in the computing process. IBM J. Res. Dev. 5, 183–191 (1961)Lanese, I., Antares Mezzina, C., Tiezzi, F.: Causal-consistent reversibility. Bull. EATCS 114, 17 (2014)Lanese, I., Nishida, N., Palacios, A., Vidal, G.: CauDEr: a causal-consistent reversible debugger for erlang. In: Gallagher, J.P., Sulzmann, M. (eds.) FLOPS 2018. LNCS, vol. 10818, pp. 247–263. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-90686-7_16Lanese, I., Palacios, A., Vidal, G.: Causal-consistent replay debugging for message passing programs. In: Pérez, J.A., Yoshida, N. (eds.) FORTE 2019. LNCS, vol. 11535, pp. 167–184. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-21759-4_10Llorens, M., Oliver, J., Silva, J., Tamarit, S.: Dynamic slicing of concurrent specification languages. Parallel Comput. 53, 1–22 (2016)Llorens, M., Oliver, J., Silva, J., Tamarit, S.: Tracking CSP computations. J. Log. Algebr. Meth. Program. 102, 138–175 (2019)Perera, R., Garg, D., Cheney, J.: Causally consistent dynamic slicing. In Proceedings of CONCUR 2016, LIPIcs, vol. 59, pp. 18:1–18:15 (2016)Phillips, I., Ulidowski, I., Yuen, S.: A reversible process calculus and the modelling of the ERK signalling pathway. In: Glück, R., Yokoyama, T. (eds.) RC 2012. LNCS, vol. 7581, pp. 218–232. Springer, Heidelberg (2013). https://doi.org/10.1007/978-3-642-36315-3_18Roscoe, A.W.: The Theory and Practice of Concurrency. Prentice Hall PTR, Upper Saddle River (1997)Zhao, H., Zhu, H., Yucheng, F., Xiao, L.: Modeling and verifying storm using CSP. In: Proceedings of HASE 2019. IEEE Computer Society (2019

Study of association between Pre-Senile cataracts and the polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish population

To determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development. Methods We have performed a retrospective study over three groups of patients. The group with presenile cataract formed by 72 patients younger than 55 with cataract surgery. The group with senile cataract formed by 101 patients older than 55 with cataract surgery. The group without cataract was formed by 42 subjects older than 55 without lens opacities. We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes. Results The comparison of the genotype distribution in XPC, within the different groups, did not show any statistically significant association in any of our analysis (p>0, 05). The comparison of the genotype distribution in p53 within the different groups did not show any statistically significant association (p>0, 05); except for the comparison between the pre-senile cataract group and the group with senile cataract where the genotype Pro/Pro (C/C) in the recessive inheritance model showed a higher risk for developing pre-senile cataract (p = 0, 031; OR = 1.04-15.97). This association decreased when we performed the analysis adjusting by the studied risk factors (p = 0.056). Conclusions Allelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract. The presence of the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract