The place of historical novel for young readers within the historical and literary canon

Many issues are raised when authors set their stories in the past. First and foremost there is the balance that must be kept between the responsibility owed to historical truth and the need to write a story which in its emotional and narrative truth engages the modem reader. (Collins 2001: v

Gower's "Confessio" and the "Nova statuta Angliae": royal lessons in English law

This essay examines parallels between the discussion of kingship and law in the Confessio Amantis and the account of Edward II's deposition that opens the Nova statuta Angliae, a comparison that reveals how each text employs a hybrid discourse that creates multiple frames of reference for the reader. Manuscript copies of both texts appear to have been commissioned tar Richard II in the early 1390s, at a time when the king sought to defend against limitations of his power, and the Confessio has been depicted as a commentary on the king's fulfillment of his responsibilities. This essay shows how both texts interweave discourses of legal argument, romance narrative, advice to princes, and religious exemplum in ways that strengthen their representation of the king's sacred obligation to uphold the laws of the land, based on the English coronation oath that entered textual circulation in the fourteenth century

Conflict resolution in the "Wife of Bath's Tale" and in Gower's "Tale of Florent"

Defining the principles that apply to resolving conflicts between individuals in The Wife of Bath 's Tale and comparing them to parallel conflicts in Gower's "Tale of Florent," one discovers that The Wife of Bath 's Tale foregrounds appeals to political, social, religious, and ethical authority -all of which are questioned, discussed, and negotiated. In the "Tale of Florent," on the other hand, conflict tends to be internal rather than between individuals. Florent's conflicts are resolved by himself alone thinking about the obligations he has accepted in his various covenants, and then behaving in such a way that he does not lie or cheat or break his pledge. Conflict resolution in Gower depends upon absolute commitment to principle, the culturally sanctioned rules that govern human behavior. Conflicts in the "Tale of Florent" are not resolved through argument, debate, negotiation with an adversary as in Chaucer's text

Genius and the practice of ethical reading

There has been a tendency in Gower scholarship to emphasize what Genius is not doing in the Confessio Amantis: the stories he does not tell, the sins he fails to discuss, and the interpretations he does not pursue. Some critics view Genius's supposed deficiencies as intentional failings designed by Gower to challenge his readers; still, these readings are centered on absence rather than presence. This paper offers a new interpretation of Genius's role in the Confessio, and, in particular, of Genius's use of classical exempla, by arguing that the absence of allegorized versions of these tales is, in fact, the result of a conscious decision to use an alternate method of reading ---ethical reading- rather than allegorical interpretation. Instead of merely appropriating or desecularizing "old bokes," the process of ethical reading preserves the status of secular texts while reframing them to make them morally useful for new generations of readers

The margins in the Iberian manuscripts of John Gower's "Confessio Amantis": language, authority and readership

The pages of the Confessio Amantis display an interesting blend of English text and Latin commentary in which the Latin apparatus enhances the vernacular text forming a strongly interrelated entity. The Latin captions and the glosses in the Confessio appear in a remarkably regular way in the English manuscripts and the presentation of the elements in the pages follows, in general, a pre-established pattern of marginal and in-column annotations.However, the Iberian translations of the Confessio translated the Latin captions and skipped most of the marginal annotations, leaving behind an integral part of the work that probably carne from Gower himself. In a work such as the Confessio Amantis, in which bilingualism is central to the text as planned by its author, the absence of all the Latin elements results in an important change in the textual dynamics of the poem. Why did they fail to cross the geographical borders in an era when Latin was lingua franca? What does their absence te\l us about the origin of the translations and their intended readership

A Framework for the Optimization of Complex Cyber-Physical Systems via Directed Acyclic Graph

[EN] Mathematical modeling and data-driven methodologies are frequently required to optimize industrial processes in the context of Cyber-Physical Systems (CPS). This paper introduces the PipeGraph software library, an open-source python toolbox for easing the creation of machine learning models by using Directed Acyclic Graph (DAG)-like implementations that can be used for CPS. scikit-learn’s Pipeline is a very useful tool to bind a sequence of transformers and a final estimator in a single unit capable of working itself as an estimator. It sequentially assembles several steps that can be cross-validated together while setting different parameters. Steps encapsulation secures the experiment from data leakage during the training phase. The scientific goal of PipeGraph is to extend the concept of Pipeline by using a graph structure that can handle scikit-learn’s objects in DAG layouts. It allows performing diverse operations, instead of only transformations, following the topological ordering of the steps in the graph; it provides access to all the data generated along the intermediate steps; and it is compatible with GridSearchCV function to tune the hyperparameters of the steps. It is also not limited to (�����,�����) entries. Moreover, it has been proposed as part of the scikit-learn-contrib supported project, and is fully compatible with scikit-learn. Documentation and unitary tests are publicly available together with the source code. Two case studies are analyzed in which PipeGraph proves to be essential in improving CPS modeling and optimization: the first is about the optimization of a heat exchange management system, and the second deals with the detection of anomalies in manufacturing processes.SIEspaña : Ministerio de Economía y Competitividad : grant number DPI2016-79960-C3-2-PMCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe

Analytical Framework to Investigate Ethics, Social Responsibility and Sustainability in Engineering Project Management

[EN] Project management is part of the Engineering curricula worldwide. Frequently, project management courses are goalcentered in the pursue of a balance in the triple constrain formed by quality, cost and schedule. However, ethics, social responsibility and sustainability play a crucial role on the development of projects since their success relies on compliance with laws, regulations and local culture and values. This paper presents an in-depth analysis on the treatment of ethics, social responsibility and sustainability according to two widely-used project management standards, Project Management Book of Knowledge (PMBoK) and Individual Competence Baseline for Project, Program & Portfolio Management (ICB). We design an analytical framework to carry out a desk research to these two project management standards. Particularly, we count the number of times of appearance, present the definition, if any, determine the appearance in the different knowledge areas and process groups for PMBoK and in the different competences for ICB, and identify the proposed techniques or tools for ethics, social responsibility and sustainability management. The findings of the research demonstrate that ICB treats the three concepts more in deep than PMBoK. PMBoK refers more often to ethics and only proposes one tool for sustainability. ICB introduces the concepts throughout the standard, with repeated references to their significance. Nevertheless, the detail that standards provide can be further elaborated. As a result, we also suggest improvement proposals that could enhance the important role of these topics for students and practitioners involved in project management.S

Riesgos asociados a la utilización de antimicrobianos en personas mayores

Objetivos: Describir los cambios fisiológicos más relevantes asociados al envejecimiento, las características de las infecciones en estos pacientes así como los efectos adversos más frecuentes e interacciones farmacológicas graves de los antimicrobianos en los mayores. Material y Métodos: Se realizó una revisión bibliográfica sobre los riesgos asociados al uso de antibióticos en ancianos. La información se apoyó en la actualización de la evidencia científica y la información de las Fichas Técnicas de los medicamentos. La búsqueda se limitó a los últimos 11 años, seleccionándose documentos publicados en español, inglés o francés. Se realizó una búsqueda electrónica de fuentes secundarias (revisiones sistemáticas) y una búsqueda manual “ad hoc”, partiendo de la bibliografía recuperada, estudios primarios, informes de agencias de evaluación de medicamentos, guías de práctica clínica y documentos de Sociedades Científicas. Se utilizaron como fuentes de información: Pubmed, Embase, Iowa Drug Information Service (IDIS), WinSPIRS 5.00, Up to Date, The Cochrane Library®. Resultados: Se localizaron 321 resultados, tras eliminar los que no cumplían criterios de inclusión 52 documentos, además de las fichas técnicas de todos los antibióticos citados, se incluyeron en la revisión bibliográfica. Conclusiones: Los pacientes mayores adquieren con mayor frecuencia infecciones por patógenos multi-resistentes y sufren más complicaciones graves de las infecciones. Los antibióticos son un grupo de fármacos especialmente sensibles a los cambios fisiológicos producidos por la edad, lo que puede condicionar la respuesta a los estos y exige en muchas ocasiones modificaciones posológicas con el fin de evitar intoxicaciones y/o fracasos terapéuticos. Este trabajo aporta información sobre estos cambios fisiológicos y los riesgos de los antibióticos en las personas mayores, aspectos necesarios para elegir un tratamiento adecuado.Aim: Describe the most important physiological changes associated with aging, the characteristics of infections in these patients and the most common side effects and severe interactions with antimicrobials in older people. Material and methods: We conducted a literature review on the risks associated with the use of antibiotics in the elderly. The information was based on the update of the scientific evidence and information from the drug Sheets. The search was limited to the past 11 years, selected papers published in English, Spanish or French. We performed an electronic search of secondary sources (systematic reviews) and a manual search “ad hoc” basis of the literature retrieved, primary studies, reports of drug evaluation agencies, clinical practice guidelines and documents of Scientific Societies. Information sources: Pubmed, Embase, Iowa Drug Information Service (IDIS), WinSPIRS 5.00, Up to Date, The Cochrane Library®. Results: We identified 321 results, after eliminating those who did not meet inclusion criteria 52 papers in addition to the technical specifications of all mentioned antibiotics were included in the literature review. Conclusion: Older patients can acquire infections more frequently multi-resistant pathogens and suffer more serious complications of infections. The antibiotics is a group of drugs sensitive to the physiological changes induced by aging, which may influence the response to these and often requires dosage modifications to avoid poisoning and / or therapeutic failures. This paper provides information on these physiological changes and risks of antibiotics in the elderly, aspects necessary to choose a proper treatment.Este trabajo ha sido realizado con la co- financiación de sendos proyectos de investigación: FISS PI/10/01152 y Consejería de Salud de la Junta de Andalucía PI-0160-2010

Risks associated with the use of antimicrobials in elderly

Objetivos: Describir los cambios fisiológicos más relevantes asociados al envejecimiento, las características de las infecciones en estos pacientes así como los efectos adversos más frecuentes e interacciones farmacológicas graves de los antimicrobianos en los mayores.Material y Métodos: Se realizó una revisión bibliográfica sobre los riesgos asociados al uso de antibióticos en ancianos. La información se apoyó en la actualización de la evidencia científica y la información de las Fichas Técnicas de los medicamentos. La búsqueda se limitó a los últimos 11 años, seleccionándose documentos publicados en español, inglés o francés. Se realizó una búsqueda electrónica de fuentes secundarias (revisiones sistemáticas) y una búsqueda manual “ad hoc”, partiendo de la bibliografía recuperada, estudios primarios, informes de agencias de evaluación de medicamentos, guías de práctica clínica y documentos de Sociedades Científicas. Se utilizaron como fuentes de información: Pubmed, Embase, Iowa Drug Information Service (IDIS), WinSPIRS 5.00, Up to Date, The Cochrane Library®.Resultados: Se localizaron 321 resultados, tras eliminar los que no cumplían criterios de inclusión 52 documentos, además de las fichas técnicas de todos los antibióticos citados, se incluyeron en la revisión bibliográfica.Conclusiones: Los pacientes mayores adquieren con mayor frecuencia infecciones por patógenos multi-resistentes y sufren más complicaciones graves de las infecciones. Los antibióticos son un grupo de fármacos especialmente sensibles a los cambios fisiológicos producidos por la edad, lo que puede condicionar la respuesta a los estos y exige en muchas ocasiones modificaciones posológicas con el fin de evitar intoxicaciones y/o fracasos terapéuticos. Este trabajo aporta información sobre estos cambios fisiológicos y los riesgos de los antibióticos en las personas mayores, aspectos necesarios para elegir un tratamiento adecuado.Aim: Describe the most important physiological changes associated with aging, the characteristics of infections in these patients and the most common side effects and severe interactions with antimicrobials in older people.Material and methods: We conducted a literature review on the risks associated with the use of antibiotics in the elderly. The information was based on the update of the scientific evidence and information from the drug Sheets. The search was limited to the past 11 years, selected papers published in English, Spanish or French. We performed an electronic search of secondary sources (systematic reviews) and a manual search “ad hoc” basis of the literature retrieved, primary studies, reports of drug evaluation agencies, clinical practice guidelines and documents of Scientific Societies. Information sources: Pubmed, Embase, Iowa Drug Information Service (IDIS), WinSPIRS 5.00, Up to Date, The Cochrane Library®.Results: We identified 321 results, after eliminating those who did not meet inclusion criteria 52 papers in addition to the technical specifications of all mentioned antibiotics were included in the literature review.Conclusion: Older patients can acquire infections more frequently multi-resistant pathogens and suffer more serious complications of infections. The antibiotics is a group of drugs sensitive to the physiological changes induced by aging, which may influence the response to these and often requires dosage modifications to avoid poisoning and / or therapeutic failures. This paper provides information on these physiological changes and risks of antibiotics in the elderly, aspects necessary to choose a proper treatment

Recurrent presence of the PLCG1 S345F mutation in nodal peripheral T-cell lymphomas

This work was supported by grants from Asociación Española contra el Cancer (AECC), Ministerio de Economía y Competitividad (MINECO) (SAF2013-47416-R), Instituto Salud Carlos III (ISCIII) – Fondos FEDER, MINECO-AES(RD012/0036/0060, PI10/00621, CP11/00018). RM is supported by the Fundación Conchita Rábago de la Fundación Jiménez Díaz, Madrid (Spain). JG-R is supported by a predoctoral grant from the Fundacion Investigacion Biomedica Puerta de Hierro. Salary support to SG is provided by ISCIII-FEDER (CP11/00018). MS-B is supported by a Miguel Servet contract from ISCIII-FEDER (CP11/00018). The Instituto de Investigación Marqués de Valdecilla (IDIVAL) is partly funded by the Sociedad para el Desarrollo Regional de Cantabria (SODERCAN)