Tratamentos para Covid-19: um estudo de prospecção

Covid-19 practically stopped the world for two years, bringing several disorders to the world population. During this period, numerous researches were carried out with the aim of finding an effective treatment for this disease that has killed millions of people and that continues to persist today. That said, this paper aims to carry out a search for patents and articles related to the treatment of Covid-19. Patents were searched on Espacenet and INPI and scientific articles on the database: Sciencedirect, Web of Science and Scielo. The search was carried out between the years 2017 and 2021 through the use of different descriptors. The results found demonstrate that the number of patents deposited is very small when compared to published articles and how much Brazil still needs to develop in order to be recognized as a country that seeks solutions for the treatment of Covid-19.A pandemia da Covid-19 praticamente parou o mundo durante dois anos, trazendo diversos transtornos à população mundial. Durante esse período, foram realizadas inúmeras pesquisas com o objetivo de encontrar um tratamento eficaz para essa doença que já matou milhões de pessoas e que continua a persistir na atualidade. Diante do exposto, este trabalho tem o objetivo de realizar uma busca de patentes e de artigos relacionados ao tratamento da Covid-19. As patentes foram pesquisadas na base Espacenet e no INPI e os artigos científicos na base de dados: Sciencedirect, Web of Science e a Scielo. A busca foi compreendida entre os anos de 2017 e 2021 por meio da utilização de diferentes descritores. Os resultados encontrados por este trabalho demonstram que o número de patentes depositadas é muito pequeno quando comparado aos artigos publicados e a quanto o Brasil ainda precisa se desenvolver para que seja reconhecido como um país que busca soluções para o tratamento da Covid-19.

Influência nas propriedades funcionais da película da farinha da amêndoa do coco Babaçu (Orbignya sp) / Influence on the functional properties of Babassu Coconut Almond Flour (Orbignya sp) film

A amêndoa do babaçu é um fruto que possui potencial tecnológico, desta é extraído um leite de grande valor nutritivo, aplicado no tempero de caças, peixes, e até na substituição do leite de vaca, a massa que sobra após a extração do leite é rica em nutrientes e vem sendo utilizada na alimentação de porcos e galinhas. Considerando as potencialidades da farinha, realizou-se a caracterização funcional e comparou-se os resultados das farinhas da amêndoa com e sem película objetivando-se possibilitar a sua aplicação à alimentação humana. As propriedades de solubilidade, estabilidade da emulsão, sinérese e capacidade de geleificação da farinha com película apresentaram diferença significativa a um nível de 5% de significância pelo teste de Tukey, tais alterações ocorreram pela natureza da casca da amêndoa

MicroRNA profile of pediatric pilocytic astrocytomas identifies two tumor-specific signatures when compared to non-neoplastic white matter

PurposesPilocytic astrocytoma (PA) is a low-grade neoplasm frequently found in childhood. PA is characterized by slow growth and a relatively good prognosis. Genetic mechanisms such as activation of MAPK, BRAF gene deregulation and neurofibromatosis type 1 (NF1) syndrome have been associated with PA development. Epigenetic signature and miRNA expression profile are providing new insights about different types of tumor, including PAs.MethodsIn the present study we evaluated global miRNA expression in 16 microdissected pediatric PA specimens, three NF1-associated PAs and 11 cerebral white matter (WM) samples by the microarray method. An additional cohort of 20 PAs was used to validate by qRT-PCR the expression of six miRNAs differentially expressed in the microarray data.ResultsUnsupervised hierarchical clustering analysis distinguished one cluster with nine PAs, including all NF1 cases and a second group consisting of the WM samples and seven PAs. Among 88 differentially expressed miRNAs between PAs and WM samples, the most underexpressed ones regulate classical pathways of tumorigenesis, while the most overexpressed miRNAs are related to pathways such as focal adhesion, P53 signaling pathway and gliomagenesis. The PAs/NF1 presented a subset of underexpressed miRNAs, which was also associated with known deregulated pathways in cancer such as cell cycle and hippo pathway.ConclusionsIn summary, our data demonstrate that PA harbors at least two distinct miRNA signatures, including a subgroup of patients with NF1/PA lesions1412373382CNPQ - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo471885/2013-42010/07020-

III Livro de Resultados de Pesquisa do GRAED PUCPR: trabalhos científicos em análise econômica do direito

Trata-se de obra coletiva composta por trabalhos científicos de membros e parceiros do GRAED PUCPR, que se apresenta como mecanismo de promoção de pesquisas científicas na área de Análise Econômica do Direito. Para tanto, são consolidados comunicados científicos apresentados no III Encontro de Pesquisa do GRAED PUCPR, resultados do Programa Institucional de Bolsas de Iniciação Científica (PIBIC) realizados por membros do grupo e artigos científicos avaliados por pares e cujas pesquisas relacionam-se com os projetos do grupo

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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