Activation mechanisms of butyrylcholinesterase by 2,4,6-trinitrotoluene, 3,3-dimethylbutyl-N-n-butylcarbamate, and 2-trimethylsilyl-ethyl-N-n-butylcarbamate

The goal of this work was to propose a possible mechanism for the butyrylcholinesterase activation by 2,4,6-trinitrotoluene (TNT), 3,3-dimethylbutyl-N-n-butylcarbamate (1), and 2-trimethylsilyl-ethyl-N-n-butylcarbamate (2). Kinetically, TNT, and compounds 1 and 2 were characterized as the nonessential activators of butyrylcholinesterase. TNT, and compounds 1 and 2 were hydrophobic compounds and were proposed to bind to the hydrophobic activator binding site, which was located outside the active site gorge of the enzyme. The conformational change from a normal active site gorge to a more accessible active site gorge of the enzyme was proposed after binding of TNT, and compounds 1 and 2 to the activator binding site of the enzyme. Therefore, TNT, and compounds 1 and 2 may act as the excess of butyrylcholine in the substrate activator for the butyrylcholinesterase catalyzed reactions

Three-Particle Correlations from Parton Cascades in Au+Au Collisions

We present a study of three-particle correlations among a trigger particle and two associated particles in Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV using a multi-phase transport model (AMPT) with both partonic and hadronic interactions. We found that three-particle correlation densities in different angular directions with respect to the triggered particle (`center', `cone', `deflected', `near' and `near-away') increase with the number of participants. The ratio of `deflected' to `cone' density approaches to 1.0 with the increasing of number of participants, which indicates that partonic Mach-like shock waves can be produced by strong parton cascades in central Au+Au collisions.Comment: 9 pages, 6 figures; Final version to appear in Physics Letters

Di-hadron azimuthal correlation and Mach-like cone structure in parton/hadron transport model

In the framework of a multi-phase transport model (AMPT) with both partonic and hadronic interactions, azimuthal correlations between trigger particles and associated scattering particles have been studied by the mixing-event technique. The momentum ranges of these particles are $3< p^{trig}_T< 6$ GeV/$c$ and $0.15< p_{T}^{assoc} < 3$ GeV/$c$ (soft), or $2.5<p^{trig}_T<$ 4 GeV/$c$ and $1< p_{T}^{assoc} < 2.5$ GeV/$c$ (hard) in Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. A Mach-like structure has been observed in correlation functions for central collisions. By comparing scenarios with and without parton cascade and hadronic rescattering, we show that both partonic and hadronic dynamical mechanisms contribute to the Mach-like structure of the associated particle azimuthal correlations. The contribution of hadronic dynamical process can not be ignored in the emergence of Mach-like correlations of the soft scattered associated hadrons. However, hadronic rescattering alone cannot reproduce experimental amplitude of Mach-like cone on away-side, and the parton cascade process is essential to describe experimental amplitude of Mach-like cone on away-side. In addition, both the associated multiplicity and the sum of $p_{T}$ decrease, whileas the $$ increases, with the impact parameter in the AMPT model including partonic dynamics from string melting scenario.Comment: 9 pages, 5 figures; Physics Letters B 641, 362-367 (2006

Closed geodesics in Alexandrov spaces of curvature bounded from above

In this paper, we show a local energy convexity of $W^{1,2}$ maps into $CAT(K)$ spaces. This energy convexity allows us to extend Colding and Minicozzi's width-sweepout construction to produce closed geodesics in any closed Alexandrov space of curvature bounded from above, which also provides a generalized version of the Birkhoff-Lyusternik theorem on the existence of non-trivial closed geodesics in the Alexandrov setting.Comment: Final version, 22 pages, 2 figures, to appear in the Journal of Geometric Analysi

System-size scan of dihadron azimuthal correlations in ultra-relativistic heavy ion collisions

System-size dependence of dihadron azimuthal correlations in ultra-relativistic heavy ion collision is simulated by a multi-phase transport model. The structure of correlation functions and yields of associated particles show clear participant path-length dependences in collision systems with a partonic phase. The splitting parameter and root-mean-square width of away-side correlation functions increase with collision system size from $^{14}$N+$^{14}$N to $^{197}$Au+$^{197}$Au collisions. The double-peak structure of away-side correlation functions can only be formed in sufficient "large" collision systems under partonic phase. The contrast between the results with partonic phase and with hadron gas could suggest some hints to study onset of deconfinment.Comment: 8 pages, 4 figures, 1 table; Nucl. Phys. A (accepted

Intelligent tracking control of a DC motor driver using self-organizing TSK type fuzzy neural networks

[[abstract]]In this paper, a self-organizing Takagi–Sugeno–Kang (TSK) type fuzzy neural network (STFNN) is proposed. The self-organizing approach demonstrates the property of automatically generating and pruning the fuzzy rules of STFNN without the preliminary knowledge. The learning algorithms not only extract the fuzzy rule of STFNN but also adjust the parameters of STFNN. Then, an adaptive self-organizing TSK-type fuzzy network controller (ASTFNC) system which is composed of a neural controller and a robust compensator is proposed. The neural controller uses an STFNN to approximate an ideal controller, and the robust compensator is designed to eliminate the approximation error in the Lyapunov stability sense without occurring chattering phenomena. Moreover, a proportional-integral (PI) type parameter tuning mechanism is derived to speed up the convergence rates of the tracking error. Finally, the proposed ASTFNC system is applied to a DC motor driver on a field-programmable gate array chip for low-cost and high-performance industrial applications. The experimental results verify the system stabilization and favorable tracking performance, and no chattering phenomena can be achieved by the proposed ASTFNC scheme.[[notice]]補正完畢[[incitationindex]]SCI[[booktype]]紙本[[booktype]]電子

Scaling of anisotropy flows in intermediate energy heavy ion collisions

Anisotropic flows ($v_1$, $v_2$ and $v_4$) of light nuclear clusters are studied by a nucleonic transport model in intermediate energy heavy ion collisions. The number-of-nucleon scalings of the directed flow ($v_1$) and elliptic flow ($v_2$) are demonstrated for light nuclear clusters. Moreover, the ratios of $v_4/v_2^2$ of nuclear clusters show a constant value of 1/2 regardless of the transverse momentum. The above phenomena can be understood by the coalescence mechanism in nucleonic level and are worthy to be explored in experiments.Comment: Invited talk at "IX International Conference on Nucleus-Nucleus Collisions", Rio de Janeiro, Aug 28- Sept 1, 2006; to appear on the proceeding issue in Nuclear Physics

Scaling of Anisotropic Flow and Momentum-Space Densities for Light Particles in Intermediate Energy Heavy Ion Collisions

Anisotropic flows ($v_2$ and $v_4$) of light nuclear clusters are studied by Isospin-Dependent Quantum Molecular Dynamics model for the system of $^{86}$Kr + $^{124}$Sn at intermediate energy and large impact parameters. Number-of-nucleon scaling of the elliptic flow ($v_2$) are demonstrated for the light fragments up to $A$ = 4, and the ratio of $v_4/v_2^2$ shows a constant value of 1/2. In addition, the momentum-space densities of different clusters are also surveyed as functions of transverse momentum, in-plane transverse momentum and azimuth angle relative to the reaction plane. The results can be essentially described by momentum-space power law. All the above phenomena indicate that there exists a number-of-nucleon scaling for both anisotropic flow and momentum-space densities for light clusters, which can be understood by the coalescence mechanism in nucleonic degree of freedom for the cluster formation.Comment: 8 pages, 3 figures; to be published in Physics Letters

Dark Matter Assimilation into the Baryon Asymmetry

Pure singlets are typically disfavored as dark matter candidates, since they generically have a thermal relic abundance larger than the observed value. In this paper, we propose a new dark matter mechanism called "assimilation", which takes advantage of the baryon asymmetry of the universe to generate the correct relic abundance of singlet dark matter. Through assimilation, dark matter itself is efficiently destroyed, but dark matter number is stored in new quasi-stable heavy states which carry the baryon asymmetry. The subsequent annihilation and late-time decay of these heavy states yields (symmetric) dark matter as well as (asymmetric) standard model baryons. We study in detail the case of pure bino dark matter by augmenting the minimal supersymmetric standard model with vector-like chiral multiplets. In the parameter range where this mechanism is effective, the LHC can discover long-lived charged particles which were responsible for assimilating dark matter.Comment: 27 pages, 9 figures, 4 tables; v2, references added, switched to JCAP format; v3, references added, version published in JCA