A New Type of Plasma Wakefield Accelerator Driven by Magnetowaves

We present a new concept for a plasma wakefield accelerator driven by magnetowaves (MPWA). This concept was originally proposed as a viable mechanism for the "cosmic accelerator" that would accelerate cosmic particles to ultra high energies in the astrophysical setting. Unlike the more familiar Plasma Wakefield Accelerator (PWFA) and the Laser Wakefield Accelerator (LWFA) where the drivers, the charged-particle beam and the laser, are independently existing entities, MPWA invokes the high-frequency and high-speed whistler mode as the driver, which is a medium wave that cannot exist outside of the plasma. Aside from the difference in drivers, the underlying mechanism that excites the plasma wakefield via the ponderomotive potential is common. Our computer simulations show that under appropriate conditions, the plasma wakefield maintains very high coherence and can sustain high-gradient acceleration over many plasma wavelengths. We suggest that in addition to its celestial application, the MPWA concept can also be of terrestrial utility. A proof-of-principle experiment on MPWA would benefit both terrestrial and celestial accelerator concepts.Comment: revtex4, 4 pages, 6 figure

Chiral Lagrangians for Radiative Decays of Heavy Hadrons

The radiative decays of heavy mesons and heavy baryons are studied in a formalism which incorporates both the heavy quark symmetry and the chiral symmetry. The chiral Lagrangians for the electromagnetic interactions of heavy hadrons consist of two pieces: one from gauging electromagnetically the strong-interaction chiral Lagrangian, and the other from the anomalous magnetic moment interactions of the heavy baryons and mesons. Due to the heavy quark spin symmetry, the latter contains only one independent coupling constant in the meson sector and two in the baryon sector. These coupling constants only depend on the light quarks and can be calculated in the nonrelativistic quark model. However, the charm quark is not heavy enough and the contribution from its magnetic moment must be included. Applications to the radiative decays $D^\ast \rightarrow D \gamma~,~B^\ast \rightarrow B \gamma~,~ \Xi^\prime_c \rightarrow \Xi_c \gamma~, \Sigma_c \rightarrow \Lambda_c \gamma$ and $\Sigma_c \rightarrow \Lambda_c \pi \gamma$ are given. Together with our previous results on the strong decay rates of $D^\ast \rightarrow D \pi$ and $\Sigma_c \rightarrow \Lambda_c \pi$, predictions are obtained for the total widths and branching ratios of $D^\ast$ and $\Sigma_c$. The decays $\Sigma^+_c \rightarrow \Lambda^+_c \pi^0 \gamma$ and $\Sigma^0_c \rightarrow \Lambda^+_c \pi^- \gamma$ are discussed to illustrate the important roles played by both the heavy quark symmetry and the chiral symmetry.Comment: 30 pages (one figure, available on request), CLNS 92/1158 and IP-ASTP-13-9

Flavor Changing Neutral Higgs Couplings and Top-Charm Production at Next Linear Collider

We explore the possibility of detecting flavor changing neutral Higgs couplings at the Next Linear Collider (NLC) through $e^+e^-\to \nu_e\bar{\nu_e} t\bar{c}$. In the framework of a general two-Higgs doublet model, we perform a complete calculation and find that $\sigma (e^+e^-\to \nu_e\nu_e t\bar{c}, \nu_e\bar{\nu_e} {\bar t}c)$ could reach $\sim 9$ fb for $\sqrt{s}=2 TeV$. This amounts to an annual production of 500 $t\bar{c}$ plus $\bar{t}c$ pairs at the NLC with an integrated luminosity of 50 fb$^{-1}$. The dependence of $tc$-production rate on the neutral scalar mixing angle is mild except when $\sin^2\alpha \to 0 or 1$. The $\nu\nu W^+W^-$ background should be manageable after $b$-tagging, while $\nu\nu t\bar t$ background should not be a problem when the signal event rate is still interesting. The process, together with $e^+e^-\to \nu_e\bar{\nu_e} W^+W^-, \nu_e\bar{\nu_e} ZZ$ studies, offer the chance of measuring the $t$-$c$-Higgs coupling.Comment: REVTEX, 18 pages, 7 figures; Report number change

Effective Lagrangian Approach to Weak Radiative Decays of Heavy Hadrons

Motivated by the observation of the decay $\bar{B}\to \bar{K}^*\gamma$ by CLEO, we have systematically analyzed the two-body weak radiative decays of bottom and charmed hadrons. There exist two types of weak radiative decays: One proceeds through the short-distance $b\to s\gamma$ transition and the other occurs through $W$-exchange accompanied by a photon emission. Effective Lagrangians are derived for the $W$-exchange bremsstrahlung processes at the quark level and then applied to various weak electromagnetic decays of heavy hadrons. Predictions for the branching ratios of $\bar{B}^0\to D^{*0} \gamma,~\Lambda_b^0\to\Sigma_c^0\gamma,~\Xi_b^0\to \Xi_c^0\gamma$ and \Xi_b^0\to\xip_c^0\gamma are given. In particular, we found ${\cal B}(\bar{B}^0 \to D^{*0}\gamma)\approx 0.9\times 10^{-6}$. Order of magnitude estimates for the weak radiative decays of charmed hadrons: $~D^0\to \bar{K}^{*0}\gamma,~\Lambda_c^+\to\Sigma^+\gamma$ and $\Xi_c^0\to\Xi^0\gamma$ are also presented. Within this approach, the decay asymmetry for antitriplet to antitriplet heavy baryon weak radiative transitions is uniquely predicted by heavy quark symmetry. The electromagnetic penguin contribution to $\Lambda_b^0\to\Lambda\gamma$ is estimated by two different methods and its branching ratio is found to be of order $1\times 10^{-5}$. We conclude that weak radiative decays of bottom hadrons are dominated by the short-distance $b\to s\gamma$ mechanism.Comment: 28 pages + 3 figures (not included), CLNS 94/1278, IP-ASTP-04-94. [Main changes in this revised version: (i) Sect 2 and subsection 4.1 are revised, (ii) A MIT bag method for calculating the decay rate of $Lambda_b \to\Lambda+gamma$ is presented, (iii) All predictions are updated using the newly available 1994 Particle Data Group, and (iv) Appendix and subsections 3.3 and 4.4 are deleted.

Corrections to Chiral Dynamics of Heavy Hadrons: (I) 1/M Correction

In earlier publications we have analyzed the strong and radiative decays of heavy hadrons in a formalism which incorporates both heavy-quark and chiral symmetries. In particular, we have derived a heavy-hadron chiral Lagrangian whose coupling constants are related by the heavy-quark flavor-spin symmetry arising from the QCD Lagrangian with infinitely massive quarks. In this paper, we re-examine the structure of the above chiral Lagrangian by including the effects of $1/m_Q$ corrections in the heavy quark effective theory. The relations among the coupling constants, originally derived in the heavy-quark limit, are modified by heavy quark symmetry breaking interactions in QCD. Some of the implications are discussed.Comment: PHYZZX, 45 pages, 1 figure (not included), CLNS 93/1192, IP-ASTP-02-93, ITP-SB-93-0

Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. A Comprehensive Analysis

Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other related genes, including TP53 rs1042522 (Arg72Pro), still present controversial results. We carried out an in depth assessment of associations between common germline variants in the TP53 pathway and bladder cancer risk. Material and Methods: We investigated 184 tagSNPs from 18 genes in 1,058 cases and 1,138 controls from the Spanish Bladder Cancer/EPICURO Study. Cases were newly-diagnosed bladder cancer patients during 1998–2001. Hospital controls were age-gender, and area matched to cases. SNPs were genotyped in blood DNA using Illumina Golden Gate and TaqMan assays. Cases were subphenotyped according to stage/grade and tumor p53 expression. We applied classical tests to assess individual SNP associations and the Least Absolute Shrinkage and Selection Operator (LASSO)-penalized logistic regression analysis to assess multiple SNPs simultaneously. Results: Based on classical analyses, SNPs in BAK1 (1), IGF1R (5), P53AIP1 (1), PMAIP1 (2), SERINPB5 (3), TP63 (3), and TP73 (1) showed significant associations at p-value#0.05. However, no evidence of association, either with overall risk or with specific disease subtypes, was observed after correction for multiple testing (p-value$0.8). LASSO selected the SNP rs6567355 in SERPINB5 with 83% of reproducibility. This SNP provided an OR = 1.21, 95%CI 1.05–1.38, p-value = 0.006, and a corrected p-value = 0.5 when controlling for over-estimation. Discussion: We found no strong evidence that common variants in the TP53 pathway are associated with bladder cancer susceptibility. Our study suggests that it is unlikely that TP53 Arg72Pro is implicated in the UCB in white Europeans. SERPINB5 and TP63 variation deserve further exploration in extended studies.This work was supported by the Fondo de Investigacion Sanitaria, Spain (grant numbers 00/0745, PI051436, PI061614, G03/174); Red Tematica de Investigacion Cooperativa en Cancer (grant number RD06/0020-RTICC), Spain; Marato TV3 (grant number 050830); European Commission (grant numbers EU-FP7-HEALTH-F2-2008-201663-UROMOL; US National Institutes of Health (grant number USA-NIH-RO1-CA089715); and the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute at the National Institutes of Health, USA; Consolider ONCOBIO (Ministerio de Economia y Competitividad, Madrid, Spain). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Heavy Top Quark Effects in Vertices with Light External Fermions

We extend our previous work on non-linear realization of the top quark field, which is a consequence of its being much heavier than any other scales. One loop effective Lagrangian to account for virtual top effects is constructed in this article, for processes where there are two external fermions, as well as any number of bosons. Particularly, we focus on those terms which have power dependence on the top mass $m_t$.Comment: PHYZZX, 56 pages, IP-ASTP-09-93. Part C of Section 4 has been revise