Dust of Dark Energy

We introduce a novel class of field theories where energy always flows along timelike geodesics, mimicking in that respect dust, yet which possess non-zero pressure. This theory comprises two scalar fields, one of which is a Lagrange multiplier enforcing a constraint between the other's field value and derivative. We show that this system possesses no wave-like modes but retains a single dynamical degree of freedom. Thus, the sound speed is always identically zero on all backgrounds. In particular, cosmological perturbations reproduce the standard behaviour for hydrodynamics with vanishing sound speed. Using all these properties we propose a model unifying Dark Matter and Dark Energy in a single degree of freedom. In a certain limit this model exactly reproduces the evolution history of Lambda-CDM, while deviations away from the standard expansion history produce a potentially measurable difference in the evolution of structure.Comment: 13 pages, 3 figures. Added references, corrected language

Perbandingan Pemberian Antibiotik Profilaksis Ceftriaxon Dan Non-ceftriaxon Terhadap Kejadian Surgical Site Infection Pasca Kolesistektomi

Latar belakang : Surgical Site Infection (SSI) merupakan salah satu komplikasi pascaoperasi yang harus dihindari. Penggunaan antibiotik profilaksis diharapkan dapat mengurangi kejadian SSI. Pemilihan jenis antibiotik profilaksis yang tepat dibutuhkan agar penggunaan antibiotik menjadi rasional dan efektif.Tujuan : Membandingkan pemberian antibiotik profilaksis ceftriaxone dan non ceftriaxone terhadap kejadian SSI pada pasien kolesistolitiasis yang dilakukan laparoskopi dan laparotomi kolesistektomi.Metode : Penelitian ini merupakan penelitian observasional dengan metode penelitian cross sectional, dilaksanakan di bagian rekam medik RSUP Dr. Kariadi Semarang. Pasien dibagi menjadi kelompok yang diberikan antibiotik ceftriaxone dan non ceftriaxone baik yang dilakukan laparoskopi kolesistektomi atau laparotomi kolesistektomi. Data tersebut dianalisis dengan uji Fisher dan perhitungan risiko dengan Prevalnce Ratio menggunakan tabel 2x2.Hasil : Diantara variabel yang diteliti hanya variabel jenis kelamin yang bermakna dengan nilai p = 0,023. Sedangkan untuk perbedaan jenis pemberian antibiotik profilaksis (p = 0,636) dan jenis tindakan operasi (p = 0,066) tidak bermakna. Uji regresi logistik untuk variabel jenis kelamin dan umur tidak bisa dilakukan. Jenis operasi laparotomi kolesistektomi memiliki risiko 4,583 lebih besar untuk terjadinya SSI (Interval Kepercayaan 95% = 1,050 - 20,003)Kesimpulan : Tidak ada perbedaan yang bermakna antara pemberian antibiotik profilaksis ceftriaxone dan non ceftriaxone pada pasien kolesistolitiasis yang dilakukan laparoskopi atau laparotomi kolesistektomi terhadap kejadian SSI

Probabilities in the inflationary multiverse

Inflationary cosmology leads to the picture of a "multiverse," involving an infinite number of (spatially infinite) post-inflationary thermalized regions, called pocket universes. In the context of theories with many vacua, such as the landscape of string theory, the effective constants of Nature are randomized by quantum processes during inflation. We discuss an analytic estimate for the volume distribution of the constants within each pocket universe. This is based on the conjecture that the field distribution is approximately ergodic in the diffusion regime, when the dynamics of the fields is dominated by quantum fluctuations (rather than by the classical drift). We then propose a method for determining the relative abundances of different types of pocket universes. Both ingredients are combined into an expression for the distribution of the constants in pocket universes of all types.Comment: 18 pages, RevTeX 4, 2 figures. Discussion of the full probability in Sec.VI is sharpened; the conclusions are strengthened. Note added explaining the relation to recent work by Easther, Lim and Martin. Some references adde

Chromatin signature of widespread monoallelic expression

In mammals, numerous autosomal genes are subject to mitotically stable monoallelic expression (MAE), including genes that play critical roles in a variety of human diseases. Due to challenges posed by the clonal nature of MAE, very little is known about its regulation; in particular, no molecular features have been specifically linked to MAE. In this study, we report an approach that distinguishes MAE genes in human cells with great accuracy: a chromatin signature consisting of chromatin marks associated with active transcription (H3K36me3) and silencing (H3K27me3) simultaneously occurring in the gene body. The MAE signature is present in ∼20% of ubiquitously expressed genes and over 30% of tissue-specific genes across cell types. Notably, it is enriched among key developmental genes that have bivalent chromatin structure in pluripotent cells. Our results open a new approach to the study of MAE that is independent of polymorphisms, and suggest that MAE is linked to cell differentiation. DOI: http://dx.doi.org/10.7554/eLife.01256.00

Decomposition of homogeneous polynomials with low rank

Let $F$ be a homogeneous polynomial of degree $d$ in $m+1$ variables defined over an algebraically closed field of characteristic zero and suppose that $F$ belongs to the $s$-th secant varieties of the standard Veronese variety $X_{m,d}\subset \mathbb{P}^{{m+d\choose d}-1}$ but that its minimal decomposition as a sum of $d$-th powers of linear forms $M_1, ..., M_r$ is $F=M_1^d+... + M_r^d$ with $r>s$. We show that if $s+r\leq 2d+1$ then such a decomposition of $F$ can be split in two parts: one of them is made by linear forms that can be written using only two variables, the other part is uniquely determined once one has fixed the first part. We also obtain a uniqueness theorem for the minimal decomposition of $F$ if the rank is at most $d$ and a mild condition is satisfied.Comment: final version. Math. Z. (to appear

Influence of the Fermi Surface Morphology on the Magnetic Field-Driven Vortex Lattice Structure Transitions in YBa2_{2}Cu3_{3}O7−δ:δ=_{7-\delta}:\delta=0, 0.15

We report small-angle neutron scattering measurements of the vortex lattice (VL) structure in single crystals of the lightly underdoped cuprate superconductor YBa2Cu3O6.85. At 2 K, and for fields of up to 16 T applied parallel to the crystal c-axis, we observe a sequence of field-driven and first-order transitions between different VL structures. By rotating the field away from the c-axis, we observe each structure transition to shift to either higher or lower field dependent on whether the field is rotated towards the [100] or [010] direction. We use this latter observation to argue that the Fermi surface morphology must play a key role in the mechanisms that drive the VL structure transitions. Furthermore, we show this interpretation is compatible with analogous results obtained previously on lightly overdoped YBa2Cu3O7. In that material, it has long-been suggested that the high field VL structure transition is driven by the nodal gap anisotropy. In contrast, the results and discussion presented here bring into question the role, if any, of a nodal gap anisotropy on the VL structure transitions in both YBa2Cu3O6.85 and YBa2Cu3O7

Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa.

G protein-coupled receptors (GPCRs) regulate facets of growth, development, and environmental sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class in these organisms is the Pth11-related, with members similar to a protein required for disease in the plant pathogen Magnaporthe oryzae. However, the Pth11-related class has not been functionally studied in any filamentous fungal species. Here, we analyze phenotypes in available mutants for 36 GPCR genes, including 20 Pth11-related, in the model filamentous fungus Neurospora crassa. We also investigate patterns of gene expression for all 43 predicted GPCR genes in available datasets. A total of 17 mutants (47%) possessed at least one growth or developmental phenotype. We identified 18 mutants (56%) with chemical sensitivity or nutritional phenotypes (11 uniquely), bringing the total number of mutants with at least one defect to 28 (78%), including 15 mutants (75%) in the Pth11-related class. Gene expression trends for GPCR genes correlated with the phenotypes observed for many mutants and also suggested overlapping functions for several groups of co-transcribed genes. Several members of the Pth11-related class have phenotypes and/or are differentially expressed on cellulose, suggesting a possible role for this gene family in plant cell wall sensing or utilization

Imperfect Dark Energy from Kinetic Gravity Braiding

We introduce a large class of scalar-tensor models with interactions containing the second derivatives of the scalar field but not leading to additional degrees of freedom. These models exhibit peculiar features, such as an essential mixing of scalar and tensor kinetic terms, which we have named kinetic braiding. This braiding causes the scalar stress tensor to deviate from the perfect-fluid form. Cosmology in these models possesses a rich phenomenology, even in the limit where the scalar is an exact Goldstone boson. Generically, there are attractor solutions where the scalar monitors the behaviour of external matter. Because of the kinetic braiding, the position of the attractor depends both on the form of the Lagrangian and on the external energy density. The late-time asymptotic of these cosmologies is a de Sitter state. The scalar can exhibit phantom behaviour and is able to cross the phantom divide with neither ghosts nor gradient instabilities. These features provide a new class of models for Dark Energy. As an example, we study in detail a simple one-parameter model. The possible observational signatures of this model include a sizeable Early Dark Energy and a specific equation of state evolving into the final de-Sitter state from a healthy phantom regime.Comment: 41 pages, 7 figures. References and some clarifying language added. This version was accepted for publication in JCA