Metascreen-Based Acoustic Passive Phased Array

Conventional phased arrays require a large number of sources in forming a complex wave front, resulting in complexity and a high cost to operate the individual sources. We present a passive phased array using an acoustic metascreen that transmits sound energy from a single source and steers the transmitted wave front to form the desired fields. The metascreen is composed of elements that have a discrete resolution along the screen at an order smaller than the wavelength, allowing for fine wave-front shaping beyond the paraxial approximation. The performance is verified in experiment by forming a self-bending beam. Our metascreen-based passive array with its simplicity and capability has applications in places where conventional active arrays are complex and have limitations.Acoustical Society of AmericaNational Basic Research Program of China (973 Program) 2010CB327803 2012CB921504National Natural Science Foundation of China 11174138 11174139 11222442 81127901 11274168Physic

Personalized Estimate of Chemotherapy-Induced Nausea and Vomiting: Development and External Validation of a Nomogram in Cancer Patients Receiving Highly/Moderately Emetogenic Chemotherapy.

Chemotherapy-induced nausea and vomiting (CINV) is presented in over 30% of cancer patients receiving highly/moderately emetogenic chemotherapy (HEC/MEC). The currently recommended antiemetic therapy is merely based on the emetogenic level of chemotherapy, regardless of patient's individual risk factors. It is, therefore, critical to develop an approach for personalized management of CINV in the era of precision medicine.A number of variables were involved in the development of CINV. In the present study, we pooled the data from 2 multi-institutional investigations of CINV due to HEC/MEC treatment in Asian countries. Demographic and clinical variables of 881 patients were prospectively collected as defined previously, and 862 of them had full documentation of variables of interest. The data of 548 patients from Chinese institutions were used to identify variables associated with CINV using multivariate logistic regression model, and then construct a personalized prediction model of nomogram; while the remaining 314 patients out of China (Singapore, South Korea, and Taiwan) entered the external validation set. C-index was used to measure the discrimination ability of the model.The predictors in the final model included sex, age, alcohol consumption, history of vomiting pregnancy, history of motion sickness, body surface area, emetogenicity of chemotherapy, and antiemetic regimens. The C-index was 0.67 (95% CI, 0.62-0.72) for the training set and 0.65 (95% CI, 0.58-0.72) for the validation set. The C-index was higher than that of any single predictor, including the emetogenic level of chemotherapy according to current antiemetic guidelines. Calibration curves showed good agreement between prediction and actual occurrence of CINV.This easy-to-use prediction model was based on chemotherapeutic regimens as well as patient's individual risk factors. The prediction accuracy of CINV occurrence in this nomogram was well validated by an independent data set. It could facilitate the assessment of individual risk, and thus improve the personalized management of CINV

A practical phosphorus-based anode material for high-energy lithium-ion batteries

State-of-the-art lithium-ion batteries cannot satisfy the increasing energy demand worldwide because of the low specific capacity of the graphite anode. Silicon and phosphorus both show much higher specific capacity; however, their practical use is significantly hindered by their large volume changes during charge/discharge. Although significant efforts have been made to improve their cycle life, the initial coulombic efficiencies of the reported Si-based and P-based anodes are still unsatisfactory (<90%). Here, by using a scalable high-energy ball milling approach, we report a practical hierarchical micro/nanostructured P-based anode material for high-energy lithium-ion batteries, which possesses a high initial coulombic efficiency of 91% and high specific capacity of ~2500 mAh g−1 together with long cycle life and fast charging capability. In situ high-energy X-ray diffraction and in situ single-particle charging/discharging were used to understand its superior lithium storage performance. Moreover, proof-of-concept full-cell lithium-ion batteries using such an anode and a LiNi0.6Co0.2Mn0.2O2 cathode were assembled to show their practical use. The findings presented here can serve as a good guideline for the future design of high-performance anode materials for lithium-ion batteries

Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer

Background Malignant transformation and progression of cancer are driven by the co-evolution of cancer cells and their dysregulated tumor microenvironment (TME). Recent studies on immunotherapy demonstrate the efficacy in reverting the anti-tumoral function of T cells, highlighting the therapeutic potential in targeting certain cell types in TME. However, the functions of other immune cell types remain largely unexplored. Results We conduct a single-cell RNA-seq analysis of cells isolated from tumor tissue samples of non-small cell lung cancer (NSCLC) patients, and identify subtypes of tumor-infiltrated B cells and their diverse functions in the progression of NSCLC. Flow cytometry and immunohistochemistry experiments on two independent cohorts confirm the co-existence of the two major subtypes of B cells, namely the naïve-like and plasma-like B cells. The naïve-like B cells are decreased in advanced NSCLC, and their lower level is associated with poor prognosis. Co-culture of isolated naïve-like B cells from NSCLC patients with two lung cancer cell lines demonstrate that the naïve-like B cells suppress the growth of lung cancer cells by secreting four factors negatively regulating the cell growth. We also demonstrate that the plasma-like B cells inhibit cancer cell growth in the early stage of NSCLC, but promote cell growth in the advanced stage of NSCLC. The roles of the plasma-like B cell produced immunoglobulins, and their interacting proteins in the progression of NSCLC are further validated by proteomics data. Conclusion Our analysis reveals versatile functions of tumor-infiltrating B cells and their potential clinical implications in NSCLC

In Situ Construction of an Ultrarobust and Lithiophilic Li-Enriched Li–N Nanoshield for High-Performance Ge-Based Anode Materials

Alloy-based materials are promising anodes for rechargeable batteries because of their higher theoretical capacities in comparison to graphite. Unfortunately, the huge volume changes during cycling cause serious structural degradation and undesired parasitic reactions with electrolytes, resulting in fragile solid-electrolyte interphase formation and serious capacity decay. This work proposes to mitigate the volume changes and suppress the interfacial reactivity of Ge anodes without sacrificing the interfacial Li+ transport, through in situ construction of an ultrarobust and lithiophilic Li-enriched Li–N nanoshield, which demonstrated improved chemical, electrochemical, mechanical, and environmental stability. Therefore, it can serve as a versatile interlayer to facilitate Li+ transport and effectively block the attack of electrolyte solvents, thus boosting the long-term cycle stability and fast charging capability of Ge anodes. This work offers an alternative methodology to tune the interfaces of other electrode materials as well by screening for more N-containing compounds that can react with Li+ during battery operation

Boosting Superior Lithium Storage Performance of Alloy‐Based Anode Materials via Ultraconformal Sb Coating–Derived Favorable Solid‐Electrolyte Interphase

Alloy materials such as Si and Ge are attractive as high‐capacity anodes for rechargeable batteries, but such anodes undergo severe capacity degradation during discharge–charge processes. Compared to the over‐emphasized efforts on the electrode structure design to mitigate the volume changes, understanding and engineering of the solid‐electrolyte interphase (SEI) are significantly lacking. This work demonstrates that modifying the surface of alloy‐based anode materials by building an ultraconformal layer of Sb can significantly enhance their structural and interfacial stability during cycling. Combined experimental and theoretical studies consistently reveal that the ultraconformal Sb layer is dynamically converted to Li3Sb during cycling, which can selectively adsorb and catalytically decompose electrolyte additives to form a robust, thin, and dense LiF‐dominated SEI, and simultaneously restrain the decomposition of electrolyte solvents. Hence, the Sb‐coated porous Ge electrode delivers much higher initial Coulombic efficiency of 85% and higher reversible capacity of 1046 mAh g−1 after 200 cycles at 500 mA g−1, compared to only 72% and 170 mAh g−1 for bare porous Ge. The present finding has indicated that tailoring surface structures of electrode materials is an appealing approach to construct a robust SEI and achieve long‐term cycling stability for alloy‐based anode materials

<span style="mso-bidi-language:HI">Purification and characterization of trehalose-6-phosphate synthase from <i><span style="mso-bidi-language:HI">Saccharomycopsis </span></i><i><span style="mso-bidi-font-family:Arial;mso-bidi-language:HI">fibuligera </span></i><span style="mso-bidi-language:HI">A<span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">11 </span></span></span>

289-294Mutant <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">A11, a mutant of Saccharomycopsis fibuligera Sdu with low acid and neutral trehalase was found to <span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">accumulate over 18% (w/w) trehalose <span style="mso-bidi-font-family:Arial;mso-bidi-language: HI">from starch in its cells. In this study, trehalose-6-phosphate synthase <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">(Tps1) was purified to homogeneity from this mutant, with a 30-fold increase in the specific enzyme activity, as compared to the concentrated cell-free extract, from initial cells. The molecular mass of the purified enzyme as determined by SDS-PAGE was 66 <span style="mso-bidi-font-family:Arial;mso-bidi-language: HI">kDa. The optimum pH and temperature of the purified enzyme were 6.6 and 37°C, respectively. The enzyme was activated by Ca<span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">2<span style="mso-bidi-language: HI">+, K+ and Mg2+, with K+ showing the highest activation at 35 mM. On the other hand, Mn<span style="mso-bidi-font-family:Arial;mso-bidi-language: HI">2+, Cu<span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">2<span style="mso-bidi-language: HI">+, Fe3+, Hg2+ and Co<span style="mso-bidi-font-family:Arial;mso-bidi-language: HI">2+ inhibited the enzyme. The enzyme was also strongly inhibited by protease inhibitors such as iodoacetic acid, EOTA and PMSF. </span