Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

A study of π-conjugation in Chichibabin's - and Schlenk's - like hydrocarbons with ESR : Part I

Analysis of the ESR spectrum of the radical cation, derived from p, p'-bis-{phenyl(triphenylphosphorylidene)methyl}biphenyl reveals that spin density is found at both 31P nuclei. Zero spin density is indicated for the outer phenyl rings. In the radical cation, derived from the corresponding m,m'-isomer the spin density is delocalized over one half of the molecule and interaction is found with only one phosphorus atom. In this system the spin density in the outside ring exceeds that in the biphenyl ring. The localization of the odd electron on one half of the molecule must be caused by a strong Jahn-Teller effect. The assignment of the hyperfine coupling constants was based on spin density calculations according to the Unrestricted Hartree-Fock (UHF) method. From these calculations we also obtained an indication of the geometry of the radicals. The synthesis of these compounds is reported

A model study of the role of the CONH2-group in the redox coenzyme NAD(P)+-NAD(P)H.Chirality in 2,4-dimethyl-3-carbamoylpyridinium cations

Experimental verification of chirality in 2,4-dimethyl-3-carbamoylpyridinium cations

Synthesis of 2-[2-aryl-2-(p-toluenesulfonyl)ethyl]-1,3-dioxolanes

No abstract

Omroepbeleid met en tegen de tijd. Interacties en instituties in het Nederlandse omroepbestel, 1919-1999

Item does not contain fulltextUniversiteit Leiden, 29 april 1999Promotor : Bekke, A.J.G.M.325 p

A model study of the role of the CONH2-group in the redox coenzyme NAD(P)-NAD(P)H

A model is offered for the role of the CONH2-group in the stereospecific incorporation of hydride at C(4) in NAD(P)+-like compounds

Diagnostic performance of biopsy-based methods for determination of Helicobacter pylori infection without a reference standard

Item does not contain fulltex

Stereoselective hydride uptake in model systems related to the redox-couple NAD+/NADH

The present work deals with the mechanistic investigations of the hydride transfer reactions concerning the redox couple NAD+/NADH. Based on the theoretical and experimental investigatins of NAD(H) model compounds as 3-carbamoyl pyridinium cations (3-carbamoyl-1,4-dihydropyridine) it was found that the out-of-plane rotation of the carbonyl function controls the stereo-and regiospecificity of the introduced hydride anion. It was found that the hydride anion transfered in the reaction, is always syn-positioned with respect to the carbonyl group. The unique stereoselectivity exhibits a strong coherence with the recent crystallographic 3D-data for the ternary complex of NAD bonded horse liver alcohol dehydrogenase. The results show that the amide group is 30° out of the plane with the carbonyl directed toward the A side. There are observations that the absolute configuration of the introduced chirality in the 3-carbamoyl pyridinium cations selects between the hydride uptake coresponding with the enzymatic A or B specificity

Investigation of a Q fever outbreak in a rural area of The Netherlands.

Contains fulltext : 80096timen.pdf (publisher's version ) (Closed access)A Q fever outbreak occurred in the southeast of The Netherlands in spring and summer 2007. Risk factors for the acquisition of a recent Coxiella burnetii infection were studied. In total, 696 inhabitants in the cluster area were invited to complete a questionnaire and provide a blood sample for serological testing of IgG and IgM phases I and II antibodies against C. burnetii, in order to recruit seronegative controls for a case-control study. Questionnaires were also sent to 35 previously identified clinical cases. Limited environmental sampling focused on two goat farms in the area. Living in the east of the cluster area, in which a positive goat farm, cattle and small ruminants were situated, smoking and contact with agricultural products were associated with a recent infection. Information leaflets were distributed on a large scale to ruminant farms, including hygiene measures to reduce the risk of spread between animals and to humans